Formula 573 Ingredients & Drug Interactions
by DC
What is this page for?
First and foremost: checking Formula 573 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Formula 573 is a dietary supplement by DC with 1 active ingredient. Its ingredients are commonly taken for blood sugar support in type 2 diabetes, weight loss and appetite control, insulin sensitivity.Based on those ingredients, 178 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Chromium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Formula 573 by DC
Ask about any prescription or over-the-counter medication and we check it for interactions with Formula 573 by DC — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
Ask the Pharmacist
A licensed pharmacist will answer your question by email — free, usually within 24 hours.
Got it — thank you!
A licensed pharmacist will answer within 24 hours. Keep an eye on your email (worth checking spam, just in case).
HelloPharmacist Scorecard of Formula 573 by DC
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Formula 573 contains 2 active ingredients, both forms of chromium. Trivalent chromium is the form we have interaction and effectiveness data for.
We also could not fully check pure crystalline chromium picolinate against our database. The tablet also contains inactive ingredients — calcium carbonate, vegetable cellulose, vegetable stearic acid, and vegetable magnesium silicate — which are fillers and binders.
Does it work?
Strong evidence
For chromium deficiency, trivalent chromium is considered likely effective based on available evidence. For type 2 diabetes, it's rated possibly effective — some research suggests chromium may help lower blood glucose, especially in people whose diabetes isn't well controlled.
For prediabetes (impaired glucose tolerance), schizophrenia, and high blood pressure, the evidence is rated possibly ineffective, meaning the data doesn't support a clear benefit.
How safe is it?
Well-documented data
Chromium is generally well tolerated at typical supplement doses, though high or long-term doses may carry risks for some people. The most common side effects are gastrointestinal irritation, headaches, insomnia, irritability, and mood changes.
Rare serious effects include kidney or liver damage, muscle breakdown (rhabdomyolysis), and low platelet counts. Skin rashes and hives have also been reported, especially with chromium picolinate in people with chromium contact allergies.
Regarding pregnancy and breastfeeding, small amounts from food or prenatal vitamins are generally considered acceptable, but extra supplement doses should be avoided unless your doctor recommends them — safety data on higher doses is limited.
Meds to double-check
Moderate interaction found
Before taking this product, double-check with your doctor or pharmacist if you take insulin or antidiabetes drugs (due to moderate risk of low blood sugar), levothyroxine or other thyroid medication (due to moderate absorption concerns), NSAIDs like ibuprofen or naproxen, or aspirin. These are the medication types with documented interactions we can verify.
The bottom line
Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This product may be worth considering if you have a confirmed chromium deficiency or want to explore it for blood sugar support, but it's not a substitute for diabetes medication. If you take insulin, diabetes drugs, levothyroxine, or regular NSAIDs or aspirin, check with your doctor or pharmacist before starting — the interactions could affect how well your medications work.
Talk it over with your own healthcare provider to see if it fits your situation.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Formula 573, straight from the product label.
| Brand | DC |
|---|---|
| Barcode (UPC) | 052301573905 |
| Net contents | 90 Tablet(s) |
| Market status | On market |
| Date entered into DSLD | Jun 16, 2022 |
| DSLD ID | 266926 |
| Product type | Mineral |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Formula 573 by DC, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Chromium | 200 mcg | 167% |
| Trivalent Chromium | 200 mcg | -- |
| pure Crystalline Chromium Picolinate | 1.67 mg | -- |
Other ingredients: Calcium Carbonate, Vegetable Cellulose, Vegetable Stearic Acid, Vegetable Magnesium Silicate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Dee Cee Chromium Picolinate is a biologically active source of chromium and is the highest quality and purity available.
Chromium picolinate 200 mcg
Precautions
Tamper Evident: Do not use this product if imprinted foil seal under cap is broken or missing.
Keep out of reach of children.
Warning: Diabetics/hypoglycemics use only under a doctor's supervision.
If you are pregnant or nursing, do not take this product.
Storage
Keep tightly closed. Store at room temperature: 59 degrees - 86 degrees F (15 degrees to 30 degrees C).
Formulation
Conforms to USP <2091> for weight. Meets USP <2040> disintegration for maximum bioavailability.
Gluten free
Use as part of your diet to help maintain a healthy blood sugar level
Mfg. in an FDA Registered FAcility using Good Manufacturing Practices (GMPs) Made in USA
Brand IP Statement(s)
As Chromax (chromium picolinate) Chromax and the Chromax logo are registered trademarks of Nutrition 21, Inc. US Patents Nos. 5,087,623; 5,087,624; and 5,175,156.
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Seals/Symbols
Quali Pure
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Directions: As a dietary supplement, take 1 tablet daily.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Formula 573 by DC label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Formula 573 by DC
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container90 Amounts shown are per serving.
Chromium
Interacts with178 drugs
Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control i...
Chromium monograph & interactions- › Trivalent Chromium
- › Pure Crystalline Chromium Picolinate
Other (inactive) ingredients: Calcium Carbonate, Vegetable Cellulose, Vegetable Stearic Acid, Vegetable Magnesium Silicate. These complete the product’s ingredient list but are not active constituents.
Formula 573 by DC Drug Interactions
HelloPharmacist Interaction Report
Formula 573 by DC contains trivalent chromium, which interacts with several common medication types.
The most serious interaction is with insulin and antidiabetes drugs (like metformin, sulfonylureas, and GLP-1 agonists), where chromium may add to their blood-sugar-lowering effect and raise the risk of low blood sugar (hypoglycemia).
Read the full breakdown — every affected drug type, severity by severity
Chromium also moderately interacts with levothyroxine (Synthroid), a thyroid medication. Research shows chromium can bind levothyroxine in your gut and reduce how much your body absorbs — in one study, chromium reduced levothyroxine levels by 17%.
Taking your levothyroxine at least 2 hours apart from this supplement may help, but you'll want to confirm the exact timing with your doctor or pharmacist.
Minor interactions occur with nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and naproxen, as well as aspirin — these may increase how much chromium your body holds onto. We could not check the ingredient pure crystalline chromium picolinate against our interaction database.
Altogether, these interactions span 178 individual medications. Use the search tool on this page to check your exact prescriptions before starting.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Formula 573?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Formula 573 interact with 178 drugs. Click any drug to see the details.
1 of the 1 ingredient in Formula 573 interact with drugs. Each result below shows which ingredient is responsible. Chromium
AcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Formula 573 — through 1 ingredient. Tap an ingredient for the detail:
Trivalent ChromiumAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Trivalent Chromium + Acarbose interactionAcetohexamideDymelor
How Acetohexamide interacts with Formula 573 — through 1 ingredient. Tap an ingredient for the detail:
Trivalent ChromiumAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Trivalent Chromium + Acetohexamide interactionAlbiglutideTanzeum
How Albiglutide interacts with Formula 573 — through 1 ingredient. Tap an ingredient for the detail:
Trivalent ChromiumAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Trivalent Chromium + Albiglutide interactionAlogliptinNesina
How Alogliptin interacts with Formula 573 — through 1 ingredient. Tap an ingredient for the detail:
Trivalent ChromiumAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Trivalent Chromium + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Formula 573 — through 1 ingredient. Tap an ingredient for the detail:
Trivalent ChromiumAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Trivalent Chromium + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Formula 573 — through 1 ingredient. Tap an ingredient for the detail:
Trivalent ChromiumAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Trivalent Chromium + Alogliptin, Pioglitazone interactionAntidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
How Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interacts with Formula 573 — through 1 ingredient. Tap an ingredient for the detail:
Trivalent ChromiumAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Trivalent Chromium + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionCanagliflozinInvokana
How Canagliflozin interacts with Formula 573 — through 1 ingredient. Tap an ingredient for the detail:
Trivalent ChromiumAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Trivalent Chromium + Canagliflozin interactionCanagliflozin, MetforminInvokamet
How Canagliflozin, Metformin interacts with Formula 573 — through 1 ingredient. Tap an ingredient for the detail:
Trivalent ChromiumAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Trivalent Chromium + Canagliflozin, Metformin interactionCanagliflozin, Metformin HydrochlorideInvokamet XR
How Canagliflozin, Metformin Hydrochloride interacts with Formula 573 — through 1 ingredient. Tap an ingredient for the detail:
Trivalent ChromiumAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Trivalent Chromium + Canagliflozin, Metformin Hydrochloride interactionChlorpropamideChlorpropam, Diabinese
How Chlorpropamide interacts with Formula 573 — through 1 ingredient. Tap an ingredient for the detail:
Trivalent ChromiumAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Trivalent Chromium + Chlorpropamide interactionDapagliflozinFarxiga
How Dapagliflozin interacts with Formula 573 — through 1 ingredient. Tap an ingredient for the detail:
Trivalent ChromiumAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Trivalent Chromium + Dapagliflozin interactionDapagliflozin Propanediol, MetforminXigduo XR
How Dapagliflozin Propanediol, Metformin interacts with Formula 573 — through 1 ingredient. Tap an ingredient for the detail:
Trivalent ChromiumAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Trivalent Chromium + Dapagliflozin Propanediol, Metformin interactionDapagliflozin Propanediol, Saxagliptin HydrochlorideQtern
How Dapagliflozin Propanediol, Saxagliptin Hydrochloride interacts with Formula 573 — through 1 ingredient. Tap an ingredient for the detail:
Trivalent ChromiumAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Trivalent Chromium + Dapagliflozin Propanediol, Saxagliptin Hydrochloride interactionDapagliflozin, Metformin Hydrochloride, Saxagliptin HydrochlorideQternmet XR
How Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interacts with Formula 573 — through 1 ingredient. Tap an ingredient for the detail:
Trivalent ChromiumAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Trivalent Chromium + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionDasiglucagon HydrochlorideZegalogue
How Dasiglucagon Hydrochloride interacts with Formula 573 — through 1 ingredient. Tap an ingredient for the detail:
Trivalent ChromiumAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Trivalent Chromium + Dasiglucagon Hydrochloride interactionDulaglutideTrulicity
How Dulaglutide interacts with Formula 573 — through 1 ingredient. Tap an ingredient for the detail:
Trivalent ChromiumAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Trivalent Chromium + Dulaglutide interactionEmpagliflozinJardiance
How Empagliflozin interacts with Formula 573 — through 1 ingredient. Tap an ingredient for the detail:
Trivalent ChromiumAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Trivalent Chromium + Empagliflozin interactionEmpagliflozin, Linagliptin, Metformin HydrochlorideTrijardy XR
How Empagliflozin, Linagliptin, Metformin Hydrochloride interacts with Formula 573 — through 1 ingredient. Tap an ingredient for the detail:
Trivalent ChromiumAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Trivalent Chromium + Empagliflozin, Linagliptin, Metformin Hydrochloride interactionEmpagliflozin, MetforminSynjardy
How Empagliflozin, Metformin interacts with Formula 573 — through 1 ingredient. Tap an ingredient for the detail:
Trivalent ChromiumAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Trivalent Chromium + Empagliflozin, Metformin interactionEmpagliflozin, Metformin HydrochlorideSynjardy XR
How Empagliflozin, Metformin Hydrochloride interacts with Formula 573 — through 1 ingredient. Tap an ingredient for the detail:
Trivalent ChromiumAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Trivalent Chromium + Empagliflozin, Metformin Hydrochloride interactionErtugliflozinSteglatro
How Ertugliflozin interacts with Formula 573 — through 1 ingredient. Tap an ingredient for the detail:
Trivalent ChromiumAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Trivalent Chromium + Ertugliflozin interactionErtugliflozin, Metformin HydrochlorideSegluromet
How Ertugliflozin, Metformin Hydrochloride interacts with Formula 573 — through 1 ingredient. Tap an ingredient for the detail:
Trivalent ChromiumAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Trivalent Chromium + Ertugliflozin, Metformin Hydrochloride interactionExenatideBydureon, Byetta
How Exenatide interacts with Formula 573 — through 1 ingredient. Tap an ingredient for the detail:
Trivalent ChromiumAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Trivalent Chromium + Exenatide interactionExenatide SyntheticBydureon BCISE
How Exenatide Synthetic interacts with Formula 573 — through 1 ingredient. Tap an ingredient for the detail:
Trivalent ChromiumAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Trivalent Chromium + Exenatide Synthetic interactionGliclazideDiamicron
How Gliclazide interacts with Formula 573 — through 1 ingredient. Tap an ingredient for the detail:
Trivalent ChromiumAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Trivalent Chromium + Gliclazide interactionGlimepirideAmaryl
How Glimepiride interacts with Formula 573 — through 1 ingredient. Tap an ingredient for the detail:
Trivalent ChromiumAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Trivalent Chromium + Glimepiride interactionGlipizideGlucotrol, Glucotrol XL
How Glipizide interacts with Formula 573 — through 1 ingredient. Tap an ingredient for the detail:
Trivalent ChromiumAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Trivalent Chromium + Glipizide interactionGlipizide, MetforminMetaglip
How Glipizide, Metformin interacts with Formula 573 — through 1 ingredient. Tap an ingredient for the detail:
Trivalent ChromiumAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Trivalent Chromium + Glipizide, Metformin interactionGlucagonBaqsimi, Glucagon
How Glucagon interacts with Formula 573 — through 1 ingredient. Tap an ingredient for the detail:
Trivalent ChromiumAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Trivalent Chromium + Glucagon interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Formula 573 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Chromium
Antidiabetes Drugs
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Some research shows that taking chromium might lower blood glucose levels, especially in patients with poorly controlled type 2 diabetes.
Insulin
Theoretically, concomitant use of chromium and insulin might increase the risk of hypoglycemia.
In clinical research, chromium has been shown to increase insulin sensitivity,
Levothyroxine (Synthroid, Others)
Chromium might bind levothyroxine in the intestinal tract and decrease levothyroxine absorption.
Clinical research in healthy volunteers shows that taking chromium picolinate 1000 mcg with levothyroxine 1 mg decreases serum levels of levothyroxine by 17% when compared to taking levothyroxine alone. Advise patients to take levothyroxine at least 30 minutes before or 3-4 hours after taking chromium.
Aspirin
Theoretically, aspirin might increase chromium absorption.
Animal research suggests that aspirin may increase chromium absorption and chromium levels in the blood.
Nonsteroidal Anti-Inflammatory Drugs (Nsaids)
NSAIDs might increase chromium levels in the body.
Drugs that are prostaglandin inhibitors, such as NSAIDs, seem to increase chromium absorption and retention.
Brand information
Manufacturer and brand details for Formula 573, from the product label.
DC
See all DC products- Name
- Dee Cee Laboratories, Inc.
- Street Address
- 304 Dee Cee Ct.
- City
- White House
- State
- TN
- ZipCode
- 37188
Formula 573 by DC: Common Questions
Does Formula 573 by DC interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does this chromium actually help with diabetes?
What are the most common side effects?
Is it safe to take during pregnancy?
Can I take this with levothyroxine (Synthroid)?
What does trivalent chromium do in the body?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Formula 573 is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Formula 573’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Formula 573's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 53 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Chromium 53 references
- Cerulli J, Grabe DW, Gauthier I, et al. Chromium picolinate toxicity. Ann Pharmacother 1998;32:428-31. PubMed
- Urberg M, Zemel MB. Evidence for synergism between chromium and nicotinic acid in the control of glucose tolerance in elderly humans. Metabolism 1987;36:896-9. PubMed
- Mohamedshah FY, Moser-Veillon PB, Yamini S, et al. Distribution of a stable isotope of chromium (53Cr) in serum, urine, and breast milk in lactating women. Am J Clin Nutr 1998;67:1250-5. PubMed
- Wasser WG, Feldman NS, D'Agati VD. Chronic renal failure after ingestion of over-the-counter chromium picolinate. [letter]. Ann Intern Med 1997;126:410. PubMed
- Mertz W. Interaction of chromium with insulin: a progress report. Nutr Rev 1998;56:174-7. PubMed
- Anderson RA. Chromium, glucose intolerance and diabetes. J Am Coll Nutr 1998;17:548-55. PubMed
- McLeod MN, Gaynes BN, Golden RN. Chromium potentiation of antidepressant pharmacotherapy for dysthymic disorder in 5 patients. J Clin Psych 1999;60:237-40. PubMed
- Fowler JF Jr. Systemic contact dermatitis caused by oral chromium picolinate. Cutis 2000;65:116. DOI
- Trent LK, Thieding-Cancel D. Effects of chromium picolinate on body composition. J Sports Med Phys Fitness 1995;35:273-80.
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
- Rabinovitz H, Friedensohn A, Leibovitz A, et al. Effect of chromium supplementation on blood glucose and lipid levels in type 2 diabetes mellitus elderly patients. Int J Vitam Nutr Res 2004;74:178-82. PubMed
- Lanca S, Alves A, Vieira AI, et al. Chromium-induced toxic hepatitis. Eur J Intern Med 2002;13:518-20. PubMed
- Kockler DR, McCarthy MW, Lawson CL. Seizure activity and unresponsiveness after hydroxycut ingestion. Pharmacotherapy 2001;21:647-51.. PubMed
- Davidson JR, Abraham K, Connor KM, McLeod MN. Effectiveness of chromium in atypical depression: a placebo-controlled trial. Biol Psychiatry 2003;53:261-4.. PubMed
- Food Standards Agency. Medicines and Healthcare products Regulatory Agency (MHRA). Expert Group on Vitamins and Minerals. Available at: http://cot.food.gov.uk/sites/default/files/vitmin2003.pdf.
- Mouser JF, Hak EB, Helms RA, et al. Chromium and zinc concentrations in pediatric patients receiving long-term parenteral nutrition. Am J Health Syst Pharm 1999;56:1950-6. PubMed
- Stevens T, Qadri A, Zein NN. Two patients with acute liver injury associated with use of the herbal weight-loss supplement hydroxycut. Ann Intern Med 2005;142:477-8. PubMed
- Wani S, Weskamp C, Marple J, Spry L. Acute tubular necrosis associated with chromium picolinate-containing dietary supplement. Ann Pharmacother 2006;40:563-6. PubMed
- Kleefstra N, Houweling ST, Jansman FG, et al. Chromium treatment has no effect in patients with poorly controlled, insulin-treated type 2 diabetes in an obese Western population: a randomized, double-blind, placebo-controlled trial. Diabetes Care 2006;29: PubMed
- Martin J, Wang ZQ, Zhang XH, et al. Chromium picolinate supplementation attenuates body weight gain and increases insulin sensitivity in subjects with type 2 diabetes. Diabetes Care 2006;29:1826-32. PubMed
- Singer GM, Geohas J. The effect of chromium picolinate and biotin supplementation on glycemic control in poorly controlled patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized trial. Diabetes Technol Ther 2006;8:636-43. PubMed
- John-Kalarickal J, Pearlman G, Carlson HE. New medications which decrease levothyroxine absorption. Thyroid 2007;17:763-5. PubMed
- Yazaki Y, Faridi Z, Ma Y, et al. A pilot study of chromium picolinate for weight loss. J Altern Complement Med 2010;16:291-9. PubMed
- Davis ML, Seaborn CD, and Stoecker BJ. Effects of over-the-counter drugs on chromium retention and urinary excretion in rats. Nutrition Research 1995;15(2):201-210.
- Young P, Turiansky G, Bonner M, and et al. Acute generalized exanthematous pustulosis induced by chromium picolinate. J.Am Acad.Dermatol. 1999;41(5 Pt 2):820-823. PubMed
- Gibb, H. J., Lees, P. S., Pinsky, P. F., and Rooney, B. C. Lung cancer among workers in chromium chemical production. Am J Ind.Med 2000;38(2):115-126. DOI
- Gibb, H. J., Lees, P. S., Pinsky, P. F., and Rooney, B. C. Clinical findings of irritation among chromium chemical production workers. Am J Ind.Med 2000;38(2):127-131. PubMed
- Pittler, M. H. and Ernst, E. Dietary supplements for body-weight reduction: a systematic review. Am.J.Clin Nutr. 2004;79(4):529-536. PubMed
- Pei, D., Hsieh, C. H., Hung, Y. J., Li, J. C., Lee, C. H., and Kuo, S. W. The influence of chromium chloride-containing milk to glycemic control of patients with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled trial. Metabolism 2 PubMed
- Hisatomi, K., Ishii, H., Hashiguchi, K., Seki, M., Ide, M., Sugiyama, K., Ishimoto, H., Nakayama, S., Mukae, H., and Kohno, S. Interstitial pneumonia caused by inhalation of fumes of nickel and chrome. Respirology. 2006;11(6):814-817. PubMed
- Kleefstra, N., Houweling, S. T., Bakker, S. J., Verhoeven, S., Gans, R. O., Meyboom-de Jong, B., and Bilo, H. J. Chromium treatment has no effect in patients with type 2 diabetes in a Western population: a randomized, double-blind, placebo-controlled tri DOI
- Parsons, A., Ingram, J., Inglis, J., Aveyard, P., Johnstone, E., Brown, K., Franklin, M., and Bermudez, I. A proof of concept randomised placebo controlled factorial trial to examine the efficacy of St John's wort for smoking cessation and chromium to pr
- Bagdon RE and Hazen RE. Skin permeation and cutaneous hypersensitivity as a basis for making risk assessments of chromium as a soil contaminant. Environ.Health Perspect. 1991;92:111-119. PubMed
- Bharmal, S. V., Moyes, V., Ahmed, S., and Grossman, A. Hypoglycaemia: possible mediation by chromium salt medication. Hormones.(Athens.) 2010;9(2):181-183. PubMed
- Krol, E., Krejpcio, Z., Byks, H., Bogdanski, P., and Pupek-Musialik, D. Effects of chromium brewer's yeast supplementation on body mass, blood carbohydrates, and lipids and minerals in type 2 diabetic patients. Biol.Trace Elem.Res. 2011;143(2):726-737.
- Unisa, S., Jagannath, P., Dhir, V., Khandelwal, C., Sarangi, L., and Roy, T. K. Population-based study to estimate prevalence and determine risk factors of gallbladder diseases in the rural Gangetic basin of North India. HPB (Oxford) 2011;13(2):117-125. PubMed
- Noda, S., Asano, Y., and Sato, S. Lichen planus in a patient with long-term exposure to chrome. Eur.J.Dermatol. 2011;21(3):417-418. PubMed
- Xiang, J., Sun, Z., and Huan, J. N. Intensive chromic acid burns and acute chromium poisoning with acute renal failure. Chin Med.J.(Engl.) 7-5-2011;124(13):2071-2073.
- Chhabra, D., Oda, K., Jagannath, P., Utsunomiya, H., Takekoshi, S., and Nimura, Y. Chronic heavy metal exposure and gallbladder cancer risk in India, a comparative study with Japan. Asian Pac.J.Cancer Prev. 2012;13(1):187-190. PubMed
- Huszonek, J. Over-the-counter chromium picolinate. Am J Psychiatry 1993;150(10):1560-1561. PubMed
- Bunner S and McGinnis R. Chromium-induced hypoglycemia. Psychosomatics 1998;39(3):298-299. PubMed
- Martin, W. R. and Fuller, R. E. Suspected chromium picolinate-induced rhabdomyolysis. Pharmacotherapy 1998;18(4):860-862. DOI
- Proctor, D. M., Fredrick, M. M., Scott, P. K., Paustenbach, D. J., and Finley, B. L. The prevalence of chromium allergy in the United States and its implications for setting soil cleanup: a cost-effectiveness case study. Regul.Toxicol Pharmacol 1998;28(1 PubMed
- De Marchi S, Cecchin E, De Marchi SU. Systemic allergic dermatitis resulting from oral administration of chromium with a food supplement. Contact Dermatitis 2014;70(2):123-5. PubMed
- Hedberg YS, Gumulka M, Lind ML, Matura M, Lidén C. Severe occupational chromium allergy despite cement legislation. Contact Dermatitis. 2014;70(5):321-3. PubMed
- Thyssen JP, Jellesen MS, Møller P, Menné T, Johansen JD. Allergic chromium dermatitis from wearing 'chromium-free' footwear. Contact Dermatitis 2014;70(3):185-7. PubMed
- Liu Y, Cotillard A, Vatier C, et al. A Dietary Supplement Containing Cinnamon, Chromium and Carnosine Decreases Fasting Plasma Glucose and Increases Lean Mass in Overweight or Obese Pre-Diabetic Subjects: A Randomized, Placebo-Controlled Trial. PLoS One.
- Jamilian M, Asemi Z. Chromium Supplementation and the Effects on Metabolic Status in Women with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial. Ann Nutr Metab. 2015;67(1):42-8. PubMed
- Guimarães MM, Carvalho AC, Silva MS. Effect of chromium supplementation on the glucose homeostasis and anthropometry of type 2 diabetic patients: Double blind, randomized clinical trial: Chromium, glucose homeostasis and anthropometry. J Trace Elem Med Bi PubMed
- Paiva AN, Lima JG, Medeiros AC, et al. Beneficial effects of oral chromium picolinate supplementation on glycemic control in patients with type 2 diabetes: A randomized clinical study. J Trace Elem Med Biol. 2015;32:66-72. PubMed
- Yin RV, Phung OJ. Effect of chromium supplementation on glycated hemoglobin and fasting plasma glucose in patients with diabetes mellitus. Nutr J. 2015;14:14. PubMed
- Jamilian M, Zadeh Modarres S, Amiri Siavashani M, et al. The influences of chromium supplementation on glycemic control, markers of cardio-metabolic risk, and oxidative stress in infertile polycystic ovary syndrome women candidate for in vitro fertilizati
- Alinaghi F, Thyssen JP, Zachariae C, Johansen JD. No immediate effect of regulatory reduction of chromium in leather among adult patients with chromium allergy. Contact Dermatitis 2021;85(5):514-522. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC