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Dietary supplement

Fortify Adult Probiotic 50 Billion Extra-Strength Ingredients & Drug Interactions

by Nature's Way

Fortify Adult Probiotic 50 Billion Extra-Strength label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Fortify Adult Probiotic 50 Billion Extra-Strength against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Fortify Adult Probiotic 50 Billion Extra-Strength is a dietary supplement by Nature's Way with 2 active ingredients.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Fortify Adult Probiotic 50 Billion Extra-Strength by Nature's Way

Ask about any prescription or over-the-counter medication and we check it for interactions with Fortify Adult Probiotic 50 Billion Extra-Strength by Nature's Way — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Fortify Adult Probiotic 50 Billion Extra-Strength by Nature's Way

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 10 active ingredients.
  • “Bifidobacteria Blend” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “Lactobacilli Blend” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “Fortify Daily Proprietary Probiotic Blend” is a proprietary blend — the label gives one combined amount (525 mg) without saying how much of each component you get.

This product contains 10 active probiotic ingredients — beneficial live bacteria strains designed to support your gut health. The main ones we have detailed information on are L. acidophilus LA-14 and Lacticaseibacillus casei Lc-11, plus several other Lactobacillus and Bifidobacterium strains.

Together they deliver 50 billion colony-forming units per dose. The inactive ingredients — cellulose, hypromellose, gellan gum, magnesium stearate, and silica — are standard capsule materials and binders.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Supports regularity and promotes gut comfort.
  • We looked for evidence on: Constipation, Antibiotic-associated diarrhea, Irritable bowel syndrome (IBS), Lactose intolerance, Digestive health, Gut microbiome balance — and 1 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Irritable bowel syndrome (IBS).
  • Also on file: Lactobacillus Acidophilus is rated "Insufficient Reliable Evidence To Rate" for Constipation, Lactose intolerance.

L. acidophilus is possibly effective for irritable bowel syndrome (IBS), Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis. For Lacticaseibacillus casei, the evidence on file doesn't yet support claims for antibiotic-associated diarrhea, cancer, fatty liver disease, constipation, depression, or eczema — the data are insufficient to rate it either way.

The other ingredients in this formula don't have effectiveness ratings in the data we hold.

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L. acidophilus is generally well tolerated in healthy adults and children. However, because these are live microorganisms, there's a theoretical risk of infection in certain patients — rare cases of serious infections like bacteremia or sepsis have been documented, though most occur when bacteria translocate from places they naturally live in the body.

Gastrointestinal side effects like abdominal pain, bloating, gas, and diarrhea can happen when you combine multiple probiotic strains, but they're uncommon. Lacticaseibacillus casei carries similar cautions: it's generally well tolerated but needs extra care if you have a weakened immune system or serious illness.

No pregnancy or breastfeeding safety data are on file for either ingredient, so talk with your doctor or pharmacist before use if you're pregnant or nursing.

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Lactobacillus Acidophilus, Lacticaseibacillus Casei.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check any antibiotic drugs (Moderate severity) before taking this probiotic — antibiotics can kill the live bacteria in the supplement and reduce its benefit. Space them apart by a couple of hours if your doctor or pharmacist approves.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This probiotic makes sense if you're looking to support gut health, especially if you've had antibiotic-associated diarrhea or IBS — the evidence is promising for those uses. Be careful if you have a compromised immune system, and definitely check your antibiotic medications before you start, since they can interfere with each other.

If you're pregnant, nursing, or have any serious health condition, talk to your pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 10 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Fortify Adult Probiotic 50 Billion Extra-Strength, straight from the product label.

Brand Nature's Way
Barcode (UPC) 033674106730
Net contents 30 Delayed Release Capsule(s)
Market status On market
Date entered into DSLD Jun 25, 2025
DSLD ID 327963
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Fortify Adult Probiotic 50 Billion Extra-Strength by Nature's Way, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
033674106730
IngredientAmount% DV
L. acidophilus LA-140 NP--
L. plantarum LP-1150 NP--
Bifidobacteria Blend0 NP--
Lactobacilli Blend0 NP--
B. animalis lactis BL-040 NP--
L. paracasei LPC-370 NP--
L. rhamnosus GG0 NP--
Lacticaseibacillus casei Lc-110 NP--
B. animalis lactis BI-070 NP--
Fortify Daily Proprietary Probiotic Blend525 mg--
HOWARU0 NP--
Bifidobacterium0 NP--
HOWARU0 NP--

Other ingredients: Cellulose, Hypromellose, Gellan Gum, Magnesium Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Supports regularity, reduces occasional constipation & promotes gut comfort

The probiotic strains contained in this product are manufactured by IFF. Bottled and tested in the USA

Gluten Free. No soy, dairy, or artificial colors.

Certfied Gluten Free GFCO.org Non GMO Project Verified nongmoproject.org

Fortify Adult Probiotic 50 Billion Extra-Strength Compared to Fortify Daily 30 Billion Probiotic Formula

Wellness starts with a healthy gut Promotes healthy gut bacteria Plant-derived, delayed-release capsule survives stomach acid to distribute live cultures where they're needed most - in the intestine and colon

Reduces occasional gas and digestive discomfort

Precautions

Keep out of reach of children.

Safety sealed with inner seal. Do not use if seal is broken or missing.

If you are pregnant, nursing, or taking any medications, consult a healthcare professional before use.

Storage

Keep tightly closed. Can be stored at room temperature or refrigerated. Avoid excessive heat and direct sunlight.

No refrigeration needed

Brand IP Statement(s)

HOWARU is a registered trademark of IFF and is used under license. HN019 and HN001 are trademarks of the Fonterra Group of companies used under license. Copyright 2023

Formula

HOWARU Probiotic Quality you can feel

50 Billion live cultures

Fortify promotes gut comfort

Guarantees 50 billion live probiotic cultures through the date of expiration Formulated with 11 diverse probiotic strains Contains plant-based prebiotic fiber, food for good bacteria

Extra-strength probiotic for digestive health & gut comfort Promotes gut comfort with clinically studied probiotic strain B. lactis HN019 Supports digestive balance and immune health with clinically studied probiotic strains L. rhamnosus GG, B. lactis Bi-07, and B. lactis BL-04 Contains the doctor-preferred probiotic for regularity Based on an IQVIA ProVoice survey of primary care physicians, HOWARU B. lactis HN019 is the doctor-preferred probiotic strain for regularity as compared to other strains in leading probiotic brands, 52-week sales MULO, ending 8/13/23; August 2023.

4 Clinically studied probiotic strains with plant-based prebiotic fiber

Seals/Symbols

HOWARU Probiotic Quality you can feel

Certfied Gluten Free GFCO.org Non GMO Project Verified nongmoproject.org

FDA Disclaimer Statement

These statements have not been evaluated by the Food & Drug Administration. This product is not intend to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Probiotic Supplement

Suggested/Recommended/Usage/Directions

Recommendation: Adults take 1 capsule daily. May be taken at any time, with or without food.

General Statements

LHBN10673.A01 BLK9179A

Explore more products at naturesway.com

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Fortify Adult Probiotic 50 Billion Extra-Strength by Nature's Way label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Fortify Adult Probiotic 50 Billion Extra-Strength label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Fortify Adult Probiotic 50 Billion Extra-Strength by Nature's Way

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Fortify Daily Proprietary Probiotic Blend

525 mg per serving
  • › Bifidobacteria Blend
  • › Lactobacilli Blend

Other (inactive) ingredients: Cellulose, Hypromellose, Gellan Gum, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Fortify Adult Probiotic 50 Billion Extra-Strength by Nature's Way Drug Interactions

Want to check YOUR meds against Fortify Adult Probiotic 50 Billion Extra-Strength?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Individual Drug Interactions

The ingredients in Fortify Adult Probiotic 50 Billion Extra-Strength interact with 182 drugs. Click any drug to see the details.

0 of the 2 ingredients in Fortify Adult Probiotic 50 Billion Extra-Strength interact with drugs. Each result below shows which ingredient is responsible.

Each ingredient & the kinds of drugs it affects

For each ingredient in Fortify Adult Probiotic 50 Billion Extra-Strength with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

The maker

Brand information

Manufacturer and brand details for Fortify Adult Probiotic 50 Billion Extra-Strength, from the product label.

Nature's Way

See all Nature's Way products
Name
Nature's Way Brands, LLC
City
Green Bay
State
WI
ZipCode
54311
Phone Number
1-800-962-8873
Web Address
fortifyprobiotics.com
Pharmacist Counseling Corner

Fortify Adult Probiotic 50 Billion Extra-Strength by Nature's Way: Common Questions

Does Fortify Adult Probiotic 50 Billion Extra-Strength by Nature's Way interact with any medications?
Yes. Based on its ingredients, Fortify Adult Probiotic 50 Billion Extra-Strength has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Fortify Adult Probiotic 50 Billion Extra-Strength contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this with my antibiotic?
Not at the same time. Antibiotics kill the live bacteria in the probiotic, which defeats the purpose. Ask your pharmacist about spacing them — typically a couple of hours apart works, but check with them on your exact situation.
Does this really help with IBS?
L. acidophilus, one of the main ingredients here, is possibly effective for IBS based on the evidence we have. It's not a sure thing for everyone, but it's a reasonable option to try if you're dealing with IBS symptoms.
What are the side effects?
Most people tolerate it well. Some folks get mild digestive discomfort — bloating, gas, stomach pain — when they first start probiotics, but that's uncommon. Serious infections from the live bacteria are very rare and happen mostly in people with weakened immune systems.
Is it safe if I'm pregnant or breastfeeding?
We don't have safety data on file for these ingredients during pregnancy or breastfeeding. Talk with your doctor or pharmacist — they can give you personalized advice based on your situation.
What's inside this that makes it 'extra-strength'?
It delivers 50 billion colony-forming units per capsule — that's a higher dose of live bacteria than many standard probiotics. The blend includes 10 different probiotic strains to cover more bases in your gut.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Fortify Adult Probiotic 50 Billion Extra-Strength is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Fortify Adult Probiotic 50 Billion Extra-Strength label
Sources

Sources & How We Checked

Fortify Adult Probiotic 50 Billion Extra-Strength's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 25 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Lacticaseibacillus Casei 10 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Orkaby AR, Chen B, Iliaki EF, Sulis CA, Oates DJ. A curious case of Lactobacillus casei in a prosthetic joint: was it the yogurt? J Am Geriatr Soc. 2012;60(6):1177-8.
  3. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  4. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  5. Topcuoglu S, Gursoy T, Ovali F, Serce O, Karatekin G. A new risk factor for neonatal vancomycin-resistant Enterococcus colonisation: bacterial probiotics. J Matern Fetal Neonatal Med. 2015;28(12):1491-4. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  8. de Seynes C, Dutronc H, Cremer P, Dupon M. Lactobacillus casei prosthetic joint infection. Med Mal Infect 2018;48(6):422-423. PubMed
  9. Russo A, Angeletti S, Lorino G, et al. A case of Lactobacillus casei bacteraemia associated with aortic dissection: is there a link?. New Microbiol 2010;33(2):175-8.
  10. Rahman A, Alqaisi S, Nath J. A Case of Lactobacillus casei endocarditis associated with probiotic intake in an immunocompromised patient. Cureus. 2023;15(4):e38049. PubMed

See these in context on the Lacticaseibacillus Casei monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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