Frame Builder Ingredients & Drug Interactions
by Ron Teeguarden's Dragon Herbs
What is this page for?
First and foremost: checking Frame Builder against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Frame Builder is a dietary supplement by Ron Teeguarden's Dragon Herbs with 13 active ingredients. Its ingredients are commonly taken for fluid retention and swelling, digestive complaints, sleep and calming support.Based on those ingredients, 1,037 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are White Atractylodes Rhizome Extract, Poria Sclerotium Extract, Chinese Angelica Root Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Frame Builder by Ron Teeguarden's Dragon Herbs
Ask about any prescription or over-the-counter medication and we check it for interactions with Frame Builder by Ron Teeguarden's Dragon Herbs — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Frame Builder by Ron Teeguarden's Dragon Herbs
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Frame Builder contains 13 active ingredients, most of which are traditional Chinese botanical extracts. The main components include Poria Mushroom Extract, White Atractylodes Rhizome Extract, Chinese Angelica Root Extract (dong quai), and extracts from quince fruit, storax, eucommia bark and seed, dipsacus root, Chinese yam, drynaria rhizome, clematis root, notopterygium root, and achyranthes root.
These ingredients also include a proprietary blend whose individual components are listed separately. The capsules are filled with inactive ingredients: pullulan polysaccharide (a plant-based capsule material), rice powder, bamboo extract powder, and rice extract blend.
These are excipients—binders and fillers that help form and stabilize the capsule.
Does it work?
Moderate evidence
The evidence for most of Frame Builder's ingredients is not well established. Our data show insufficient reliable evidence to rate poria mushroom extract, atractylodes, dong quai, and most other ingredients for their intended uses.
The one exception is Chinese Flowering Quince Fruit Extract, which is rated possibly effective for gastroesophageal reflux disease (GERD)—that's the acid reflux condition—though evidence for the other conditions listed is also insufficient. Because the effectiveness of the product as a whole depends on how these ingredients work together, and most lack strong clinical evidence individually, you'd want to discuss realistic expectations with your doctor or pharmacist.
How safe is it?
Well-documented data
Poria Mushroom Extract and Atractylodes are generally well tolerated based on traditional use, but human safety data are limited. Poria rarely causes allergic reactions including allergic rhinitis and allergic asthma.
Atractylodes may cause allergic reactions, dry mouth, and nausea, though a full safety review hasn't been done. Chinese Angelica Root (dong quai) is generally well tolerated when taken by mouth, with burping and flatulence being the most common side effects, though it may increase skin sensitivity to sunlight.
During pregnancy, the safety data advises against poria, atractylodes, storax, and dong quai—each is rated possibly unsafe or lacks enough data to recommend it. The same applies to breastfeeding for all four of these ingredients.
Quince as a concentrated supplement lacks safety data for pregnancy and breastfeeding, so caution is advised. If you're pregnant or breastfeeding, talk with your doctor or pharmacist before taking Frame Builder.
Meds to double-check
Major interaction found
Check with your doctor or pharmacist before using Frame Builder if you take warfarin (a blood thinner)—dong quai can increase bleeding risk significantly. Also check if you take other anticoagulants or antiplatelet drugs, estrogens or hormone replacement therapy, sedatives or other CNS depressants, anticholinergic drugs, cholinergic drugs, aromatase inhibitors (breast cancer treatment), or any medications processed by liver enzymes CYP1A2 or CYP3A4.
Some of these interactions are Moderate severity; others are Minor. No interactions are documented for the ingredients we could not check.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Major medication interactions have been identified, and safety information is well characterized.
Frame Builder is a traditional herbal formula aimed at bone and joint support, though effectiveness evidence is limited for most of its ingredients. The main caution is if you take warfarin or other blood thinners, anticoagulants, or certain hormone drugs—several ingredients could interfere.
You should also check your medications against the interaction tool on this page if you take sedatives or anticholinergic drugs. Avoid it during pregnancy or breastfeeding unless your doctor advises otherwise.
Talk it over with your own doctor or pharmacist before starting.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 5 of 13 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Frame Builder, straight from the product label.
| Brand | Ron Teeguarden's Dragon Herbs |
|---|---|
| Barcode (UPC) | 679372002549 |
| Net contents | 100 Vegetarian Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Sep 25, 2024 |
| DSLD ID | 316882 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Frame Builder by Ron Teeguarden's Dragon Herbs, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Achyranthes Root Extract | 0 NP | -- |
| Proprietary Extract Blend | 1500 mg | -- |
| Eucommia bark extract | 0 NP | -- |
| Dipsacus asper Root Extract | 0 NP | -- |
| Chinese Yam rhizome extract | 0 NP | -- |
| Poria Sclerotium Extract | 0 NP | -- |
| White Atractylodes Rhizome Extract | 0 NP | -- |
| Eucommia Seed Extract | 0 NP | -- |
| Drynaria Rhizome Extract | 0 NP | -- |
| Chinese Flowering Quince Fruit Extract | 0 NP | -- |
| Liquidambar orientalis Extract | 0 NP | -- |
| Chinese Clematis Root Extract | 0 NP | -- |
| Notopterygium Root Extract | 0 NP | -- |
| Chinese Angelica Root Extract | 0 NP | -- |
Other ingredients: Pullulan Polysaccharide, Rice, Powder, Bamboo Extract, Powder, Rice extract Blend
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement
These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
Formula
Frame Builder is a premium formulation made from the finest Chinese herbs.
Pullulan caps - 100% natural, water-soluble polysaccharide produced through a fermentation process; vegetable origin; non-GMO; no starch, preservatives or chemical modifications; gluten free.
Formulation
This formulation is extremely safe and effective.
Pullulan caps - 100% natural, water-soluble polysaccharide produced through a fermentation process; vegetable origin; non-GMO; no starch, preservatives or chemical modifications; gluten free.
Brand IP Statement(s)
Ron Teeguarden's Dragon Herbs Health Deserves Cultivation
FDA Statement of Identity
Dietary Supplement
General Statements
Frame Builder 500 mg each
Suggested/Recommended/Usage/Directions
Directions: Take 3 capsules, 2 times per day or as directed by a healthcare professional.
Precautions
Keep out of the reach of children.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Frame Builder by Ron Teeguarden's Dragon Herbs label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Frame Builder by Ron Teeguarden's Dragon Herbs
These are the 13 active ingredients this product is made of. Select any to open its full monograph.
Serving size3 Capsule(s) Dosage formCapsule Servings per container33 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Extract Blend
- › Achyranthes Root Extract
- › Eucommia bark extract
- › Dipsacus asper Root Extract
- › Chinese Yam rhizome extract
- › Poria Sclerotium Extract
- › White Atractylodes Rhizome Extract
- › Eucommia Seed Extract
- › Drynaria Rhizome Extract
- › Chinese Flowering Quince Fruit Extract
- › Liquidambar orientalis Extract
- › Chinese Clematis Root Extract
- › Notopterygium Root Extract
- › Chinese Angelica Root Extract
Other (inactive) ingredients: Pullulan Polysaccharide, Rice, Powder, Bamboo Extract, Powder, Rice extract Blend. These complete the product’s ingredient list but are not active constituents.
Frame Builder by Ron Teeguarden's Dragon Herbs Drug Interactions
HelloPharmacist Interaction Report
Frame Builder by Ron Teeguarden's Dragon Herbs contains several ingredients with documented interactions.
The most serious concern is through its Chinese Angelica Root Extract (dong quai), which carries a Major-severity interaction with warfarin (a blood thinner)—case reports show it can increase bleeding risk. Additionally, dong quai has Moderate interactions with other blood thinners and antiplatelet drugs, and with estrogens.
Read the full breakdown — every affected drug type, severity by severity
Poria Mushroom Extract and Atractylodes also have documented interactions. Poria may enhance sedatives (CNS depressants) and theoretically affect how anticholinergic and cholinergic drugs work—all Moderate severity.
Atractylodes carries Moderate-severity interactions with blood thinners, aromatase inhibitors (used in breast cancer), and a medication called hexobarbital, plus Minor interactions with certain liver enzyme substrates that affect how many drugs are processed.
Several other ingredients—Achyranthes Root, Eucommia bark, Dipsacus asper Root, Chinese Yam, Eucommia Seed, Drynaria Rhizome, Chinese Clematis Root, and Notopterygium Root—we could not check because we hold no monograph data for them. Quince and Storax have been checked and show no documented interactions.
Altogether, these interactions span 1,036 individual medications. Before starting Frame Builder, check your exact medications with the search tool on this page.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Frame Builder?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Frame Builder interact with 1,037 drugs. Click any drug to see the details.
3 of the 13 ingredients in Frame Builder interact with drugs. Each result below shows which ingredient is responsible. White Atractylodes Rhizome Extract Poria Sclerotium Extract Chinese Angelica Root Extract
Acetaminophen, Codeine, MethocarbamolAcetaminophen, Codeine, Methocarbamol, Robaxacet 8
How Acetaminophen, Codeine, Methocarbamol interacts with Frame Builder — through 2 ingredients. Tap an ingredient for the detail:
Poria Sclerotium ExtractCns Depressants Moderate
Interaction Summary
Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.
Read the full Poria Sclerotium Extract + Acetaminophen, Codeine, Methocarbamol interactionWhite Atractylodes Rhizome ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
Read the full White Atractylodes Rhizome Extract + Acetaminophen, Codeine, Methocarbamol interactionAcetaminophen, Dextromethorphan, Doxylamine, PseudoephedrineVicks NyQuil
How Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interacts with Frame Builder — through 2 ingredients. Tap an ingredient for the detail:
Poria Sclerotium ExtractAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, poria mushroom might decrease the clinical effects of anticholinergic drugs.
Read the full Poria Sclerotium Extract + Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interactionWhite Atractylodes Rhizome ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, atractylodes might increase the levels of CYP3A4 substrates.
Read the full White Atractylodes Rhizome Extract + Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interactionAcetaminophen, Dextromethorphan, Phenylpropanolamine, PyrilamineTheracaps
How Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interacts with Frame Builder — through 2 ingredients. Tap an ingredient for the detail:
Poria Sclerotium ExtractAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, poria mushroom might decrease the clinical effects of anticholinergic drugs.
Read the full Poria Sclerotium Extract + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionWhite Atractylodes Rhizome ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
Read the full White Atractylodes Rhizome Extract + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionAcetaminophen, Dichloralantipyrine, IsomethepteneAmidrine, Midchlor, Migquin, Migratine
How Acetaminophen, Dichloralantipyrine, Isometheptene interacts with Frame Builder — through 2 ingredients. Tap an ingredient for the detail:
Poria Sclerotium ExtractCns Depressants Moderate
Interaction Summary
Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.
Read the full Poria Sclerotium Extract + Acetaminophen, Dichloralantipyrine, Isometheptene interactionWhite Atractylodes Rhizome ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
Read the full White Atractylodes Rhizome Extract + Acetaminophen, Dichloralantipyrine, Isometheptene interactionAcetaminophen, Dichloralphenazone, IsomethepteneMidrin
How Acetaminophen, Dichloralphenazone, Isometheptene interacts with Frame Builder — through 2 ingredients. Tap an ingredient for the detail:
Poria Sclerotium ExtractCns Depressants Moderate
Interaction Summary
Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.
Read the full Poria Sclerotium Extract + Acetaminophen, Dichloralphenazone, Isometheptene interactionWhite Atractylodes Rhizome ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
Read the full White Atractylodes Rhizome Extract + Acetaminophen, Dichloralphenazone, Isometheptene interactionAcetaminophen, Dichlorophenazone, IsometheptaneIsocom
How Acetaminophen, Dichlorophenazone, Isometheptane interacts with Frame Builder — through 2 ingredients. Tap an ingredient for the detail:
Poria Sclerotium ExtractCns Depressants Moderate
Interaction Summary
Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.
Read the full Poria Sclerotium Extract + Acetaminophen, Dichlorophenazone, Isometheptane interactionWhite Atractylodes Rhizome ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
Read the full White Atractylodes Rhizome Extract + Acetaminophen, Dichlorophenazone, Isometheptane interactionAcetaminophen, DiphenhydramineTylenol PM, Tylenol PM Ex Strength
How Acetaminophen, Diphenhydramine interacts with Frame Builder — through 2 ingredients. Tap an ingredient for the detail:
Poria Sclerotium ExtractCns Depressants, Anticholinergic Drugs Moderate
Interaction Summary
Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.
Read the full Poria Sclerotium Extract + Acetaminophen, Diphenhydramine interactionWhite Atractylodes Rhizome ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
Read the full White Atractylodes Rhizome Extract + Acetaminophen, Diphenhydramine interactionAcetaminophen, Diphenhydramine, PseudoephedrineChildren's Tylenol Allergy, Cold Control, Contac Night Allergy Relief
How Acetaminophen, Diphenhydramine, Pseudoephedrine interacts with Frame Builder — through 2 ingredients. Tap an ingredient for the detail:
Poria Sclerotium ExtractAnticholinergic Drugs, Cns Depressants Moderate
Interaction Summary
Theoretically, poria mushroom might decrease the clinical effects of anticholinergic drugs.
Read the full Poria Sclerotium Extract + Acetaminophen, Diphenhydramine, Pseudoephedrine interactionWhite Atractylodes Rhizome ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
Read the full White Atractylodes Rhizome Extract + Acetaminophen, Diphenhydramine, Pseudoephedrine interactionAcetaminophen, Doxylamine, PseudoephedrineEx Strength Tylenol Sinus Nighttime
How Acetaminophen, Doxylamine, Pseudoephedrine interacts with Frame Builder — through 2 ingredients. Tap an ingredient for the detail:
Poria Sclerotium ExtractAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, poria mushroom might decrease the clinical effects of anticholinergic drugs.
Read the full Poria Sclerotium Extract + Acetaminophen, Doxylamine, Pseudoephedrine interactionWhite Atractylodes Rhizome ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
Read the full White Atractylodes Rhizome Extract + Acetaminophen, Doxylamine, Pseudoephedrine interactionAcetaminophen, HydrocodoneAnexsia, Anodynos DHC, Azdone, Co-Gesic, Doucet, Lorcet +9 more
How Acetaminophen, Hydrocodone interacts with Frame Builder — through 2 ingredients. Tap an ingredient for the detail:
Poria Sclerotium ExtractCns Depressants Moderate
Interaction Summary
Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.
Read the full Poria Sclerotium Extract + Acetaminophen, Hydrocodone interactionWhite Atractylodes Rhizome ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, atractylodes might increase the levels of CYP3A4 substrates.
Read the full White Atractylodes Rhizome Extract + Acetaminophen, Hydrocodone interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Frame Builder — through 2 ingredients. Tap an ingredient for the detail:
Chinese Angelica Root ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, dong quai may increase the risk of bleeding when used with anticoagulant or antiplatelet drugs; however, research is conflicting.
Read the full Chinese Angelica Root Extract + Acetaminophen, Ibuprofen interactionWhite Atractylodes Rhizome ExtractAnticoagulant/antiplatelet Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, atractylodes might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Read the full White Atractylodes Rhizome Extract + Acetaminophen, Ibuprofen interactionAcetaminophen, MeperidineDemerol APAP
How Acetaminophen, Meperidine interacts with Frame Builder — through 2 ingredients. Tap an ingredient for the detail:
Poria Sclerotium ExtractCns Depressants Moderate
Interaction Summary
Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.
Read the full Poria Sclerotium Extract + Acetaminophen, Meperidine interactionWhite Atractylodes Rhizome ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
Read the full White Atractylodes Rhizome Extract + Acetaminophen, Meperidine interactionAcetaminophen, OxycodonePercocet, Roxicet, Tylox, Xartemis XR
How Acetaminophen, Oxycodone interacts with Frame Builder — through 2 ingredients. Tap an ingredient for the detail:
Poria Sclerotium ExtractCns Depressants Moderate
Interaction Summary
Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.
Read the full Poria Sclerotium Extract + Acetaminophen, Oxycodone interactionWhite Atractylodes Rhizome ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
Read the full White Atractylodes Rhizome Extract + Acetaminophen, Oxycodone interactionAcetaminophen, Pamabrom, PyrilamineMidol Max Strength PMS, Pamprin, Pamprin ES
How Acetaminophen, Pamabrom, Pyrilamine interacts with Frame Builder — through 2 ingredients. Tap an ingredient for the detail:
Poria Sclerotium ExtractAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, poria mushroom might decrease the clinical effects of anticholinergic drugs.
Read the full Poria Sclerotium Extract + Acetaminophen, Pamabrom, Pyrilamine interactionWhite Atractylodes Rhizome ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
Read the full White Atractylodes Rhizome Extract + Acetaminophen, Pamabrom, Pyrilamine interactionAcetaminophen, PentazocineTalacen
How Acetaminophen, Pentazocine interacts with Frame Builder — through 2 ingredients. Tap an ingredient for the detail:
Poria Sclerotium ExtractCns Depressants Moderate
Interaction Summary
Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.
Read the full Poria Sclerotium Extract + Acetaminophen, Pentazocine interactionWhite Atractylodes Rhizome ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
Read the full White Atractylodes Rhizome Extract + Acetaminophen, Pentazocine interactionAcetaminophen, Phenylephrine, ChlorpheniramineSuper Cold Tabs
How Acetaminophen, Phenylephrine, Chlorpheniramine interacts with Frame Builder — through 2 ingredients. Tap an ingredient for the detail:
Poria Sclerotium ExtractAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, poria mushroom might decrease the clinical effects of anticholinergic drugs.
Read the full Poria Sclerotium Extract + Acetaminophen, Phenylephrine, Chlorpheniramine interactionWhite Atractylodes Rhizome ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
Read the full White Atractylodes Rhizome Extract + Acetaminophen, Phenylephrine, Chlorpheniramine interactionAcetaminophen, PropoxypheneDarvocet-N 100, Darvocet-N 50, E-Lor, Wygesic
How Acetaminophen, Propoxyphene interacts with Frame Builder — through 2 ingredients. Tap an ingredient for the detail:
Poria Sclerotium ExtractCns Depressants Moderate
Interaction Summary
Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.
Read the full Poria Sclerotium Extract + Acetaminophen, Propoxyphene interactionWhite Atractylodes Rhizome ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
Read the full White Atractylodes Rhizome Extract + Acetaminophen, Propoxyphene interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Frame Builder — through 1 ingredient. Tap an ingredient for the detail:
Poria Sclerotium ExtractCns Depressants Moderate
Interaction Summary
Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.
Read the full Poria Sclerotium Extract + Acetazolamide interactionAcetylcholineMiochol-E
How Acetylcholine interacts with Frame Builder — through 1 ingredient. Tap an ingredient for the detail:
Poria Sclerotium ExtractCholinergic Drugs Moderate
Interaction Summary
Theoretically, poria mushroom might have additive effects when used with cholinergic drugs.
Read the full Poria Sclerotium Extract + Acetylcholine interactionAcetylsalicylic AcidEntrophen
How Acetylsalicylic Acid interacts with Frame Builder — through 2 ingredients. Tap an ingredient for the detail:
Chinese Angelica Root ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, dong quai may increase the risk of bleeding when used with anticoagulant or antiplatelet drugs; however, research is conflicting.
Read the full Chinese Angelica Root Extract + Acetylsalicylic Acid interactionWhite Atractylodes Rhizome ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, atractylodes might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Read the full White Atractylodes Rhizome Extract + Acetylsalicylic Acid interactionAclidinium BromideTudorza Pressair
How Aclidinium Bromide interacts with Frame Builder — through 1 ingredient. Tap an ingredient for the detail:
Poria Sclerotium ExtractAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, poria mushroom might decrease the clinical effects of anticholinergic drugs.
Read the full Poria Sclerotium Extract + Aclidinium Bromide interactionAclidinium Bromide, Formoterol Fumarate DihydrateDuaklir Pressair
How Aclidinium Bromide, Formoterol Fumarate Dihydrate interacts with Frame Builder — through 1 ingredient. Tap an ingredient for the detail:
Poria Sclerotium ExtractAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, poria mushroom might decrease the clinical effects of anticholinergic drugs.
Read the full Poria Sclerotium Extract + Aclidinium Bromide, Formoterol Fumarate Dihydrate interactionAerosphere Budesonide, Formoterol Fumarate, GlycopyrrolateBreztri
How Aerosphere Budesonide, Formoterol Fumarate, Glycopyrrolate interacts with Frame Builder — through 1 ingredient. Tap an ingredient for the detail:
Poria Sclerotium ExtractAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, poria mushroom might decrease the clinical effects of anticholinergic drugs.
Read the full Poria Sclerotium Extract + Aerosphere Budesonide, Formoterol Fumarate, Glycopyrrolate interactionAlfentanilAlfenta
How Alfentanil interacts with Frame Builder — through 2 ingredients. Tap an ingredient for the detail:
Poria Sclerotium ExtractCns Depressants Moderate
Interaction Summary
Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.
Read the full Poria Sclerotium Extract + Alfentanil interactionWhite Atractylodes Rhizome ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, atractylodes might increase the levels of CYP3A4 substrates.
Read the full White Atractylodes Rhizome Extract + Alfentanil interactionAlprazolamNiravam, Xanax
How Alprazolam interacts with Frame Builder — through 2 ingredients. Tap an ingredient for the detail:
Poria Sclerotium ExtractCns Depressants Moderate
Interaction Summary
Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.
Read the full Poria Sclerotium Extract + Alprazolam interactionWhite Atractylodes Rhizome ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, atractylodes might increase the levels of CYP3A4 substrates.
Read the full White Atractylodes Rhizome Extract + Alprazolam interactionAlteplase, TpaActilyse, Activase
How Alteplase, Tpa interacts with Frame Builder — through 2 ingredients. Tap an ingredient for the detail:
Chinese Angelica Root ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, dong quai may increase the risk of bleeding when used with anticoagulant or antiplatelet drugs; however, research is conflicting.
Read the full Chinese Angelica Root Extract + Alteplase, Tpa interactionWhite Atractylodes Rhizome ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, atractylodes might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Read the full White Atractylodes Rhizome Extract + Alteplase, Tpa interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Frame Builder — through 3 ingredients. Tap an ingredient for the detail:
Chinese Angelica Root ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, dong quai may increase the risk of bleeding when used with anticoagulant or antiplatelet drugs; however, research is conflicting.
Read the full Chinese Angelica Root Extract + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionWhite Atractylodes Rhizome ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, atractylodes might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Read the full White Atractylodes Rhizome Extract + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionPoria Sclerotium ExtractCns Depressants Moderate
Interaction Summary
Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.
Read the full Poria Sclerotium Extract + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with Frame Builder — through 2 ingredients. Tap an ingredient for the detail:
Chinese Angelica Root ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, dong quai may increase the risk of bleeding when used with anticoagulant or antiplatelet drugs; however, research is conflicting.
Read the full Chinese Angelica Root Extract + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionWhite Atractylodes Rhizome ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, atractylodes might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Read the full White Atractylodes Rhizome Extract + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAmantadineGocovri, Osmolex ER, Symmetrel
How Amantadine interacts with Frame Builder — through 1 ingredient. Tap an ingredient for the detail:
Poria Sclerotium ExtractAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, poria mushroom might decrease the clinical effects of anticholinergic drugs.
Read the full Poria Sclerotium Extract + Amantadine interactionAmbenonium ChlorideMytelase
How Ambenonium Chloride interacts with Frame Builder — through 1 ingredient. Tap an ingredient for the detail:
Poria Sclerotium ExtractCholinergic Drugs Moderate
Interaction Summary
Theoretically, poria mushroom might have additive effects when used with cholinergic drugs.
Read the full Poria Sclerotium Extract + Ambenonium Chloride interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Frame Builder with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
White Atractylodes Rhizome Extract
Anticoagulant/Antiplatelet Drugs
Theoretically, atractylodes might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Laboratory research suggests that atractylenolides II and III, constituents of atractylodes, reduce platelet activation. So far, this has not been shown in humans.
Aromatase Inhibitors
Theoretically, atractylodes may have an additive effect when used with other aromatase inhibitors.
Laboratory research suggests that atractylodes and its constituents exhibit aromatase inhibitor effects.
Hexobarbital
Theoretically, taking atractylodes may prolong the therapeutic and adverse effects of hexobarbital.
In animals, atractylodes has been shown to prolong the effects of hexobarbital. These effects have not been shown in humans.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
In animals, atractylodes administered at high doses has been shown to induce CYP1A2 activity. This effect has not been shown in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, atractylodes might increase the levels of CYP3A4 substrates.
In animals, atractylodes administered at high doses has been shown to inhibit CYP3A1 activity, which is a homolog to the human CYP3A4 enzyme. This effect has not been shown in humans.
Poria Sclerotium Extract
Anticholinergic Drugs
Theoretically, poria mushroom might decrease the clinical effects of anticholinergic drugs.
In animal research, poria mushroom essential oil reduces acetylcholinesterase activity. This interaction has not been shown in humans.
Cholinergic Drugs
Theoretically, poria mushroom might have additive effects when used with cholinergic drugs.
In animal research, poria mushroom essential oil reduces acetylcholinesterase activity. This interaction has not been shown in humans.
Cns Depressants
Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.
Animal research shows that poria mushroom extract has sedative properties. This interaction has not been shown in humans.
Chinese Angelica Root Extract
Warfarin (Coumadin)
Dong quai may increase the risk of bleeding when used with warfarin.
Case reports suggest that concomitant use of dong quai with warfarin can increase the anticoagulant effects of warfarin and increase the risk of bleeding. In one case, after 4 weeks of taking dong quai 565 mg once or twice daily, the international normalized ratio (INR) increased to 4.9. The INR normalized 4 weeks after discontinuation of dong quai.
Anticoagulant/Antiplatelet Drugs
Theoretically, dong quai may increase the risk of bleeding when used with anticoagulant or antiplatelet drugs; however, research is conflicting.
Animal studies suggest that dong quai has antithrombin activity and inhibits platelet aggregation due to its coumarin components. Additionally, some case reports in humans suggest that dong quai can increase the anticoagulant effects of warfarin. However, clinical research in healthy adults shows that taking 1 gram of dong quai root daily for 3 weeks does not significantly inhibit platelet aggregation or cause bleeding. Until more is known, use dong quai with caution in patients taking antiplatelet/anticoagulant drugs.
Estrogens
Theoretically, dong quai may reduce the effects of estrogens.
Dong quai has estrogenic effects. Theoretically, concomitant use of large amounts of dong quai might interfere with hormone replacement therapy due to competition for estrogen receptors.
Brand information
Manufacturer and brand details for Frame Builder, from the product label.
Ron Teeguarden's Dragon Herbs
See all Ron Teeguarden's Dragon Herbs products- Name
- Ron Teeguarden's Dragon Herbs
- City
- Los Angeles
- State
- CA
- ZipCode
- 90036
- Phone Number
- (888) 558-6642
- Web Address
- www.dragonherbs.com
Frame Builder by Ron Teeguarden's Dragon Herbs: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Frame Builder’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Poria Mushroom
Interacts with 417 drugsPoria mushroom (Fu Ling) is a fungus long used in Traditional Chinese Medicine, mainly as a mild diuretic and digestive and calming aid. Modern scientific evidence in humans is very limited,...
Read the full Poria Mushroom monograph → Herb & supplement monographAtractylodes
Interacts with 803 drugsAtractylodes is a root used for centuries in traditional Chinese, Japanese, and Thai medicine, mostly for digestive complaints and fatigue, often as part of multi-herb formulas. Modern resea...
Read the full Atractylodes monograph → Herb & supplement monographQuince
Quince is a tart, apple-like fruit traditionally used for digestive complaints, reflux, and soothing the throat and skin. Early research is interesting but limited, so quince should not repl...
Read the full Quince monograph → Herb & supplement monographStorax
Storax is an aromatic balsam (resin) tapped from Liquidambar trees, used traditionally as a topical antiseptic, a remedy for skin parasites, and a respiratory aid. Modern human evidence for...
Read the full Storax monograph → Herb & supplement monographDong Quai
Interacts with 163 drugsDong Quai is a traditional Chinese herb often called "female ginseng" and is mostly used for menstrual and menopausal complaints. High-quality scientific evidence that it works for these use...
Read the full Dong Quai monograph →Sources & How We Checked
Frame Builder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 30 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Poria Mushroom 3 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Kim H, Park I, Park K, Park S, Kim YI, Park BG. The positive effects of Poria cocos extract on quality of sleep in insomnia rat models. Int J Environ Res Public Health 2022;19(11):6629. PubMed
- Lv Q, Di X, Bian B, Li K, Guo J. Neuroprotective effects of Poria cocos (Agaricomycetes) essential oil on Aß1-40-induced learning and memory deficit in rats. Int J Med Mushrooms 2022;24(10):73-82.
Atractylodes 6 references
- Liu Y, Jia Z, Dong L, et al. A randomized pilot study of atractylenolide I on gastric cancer cachexia patients. Evid Based Complement Alternat Med 2008;5:337-44. PubMed
- Chen Y, Yang W, Guo L, Wu X, Zhang T, Liu J, Zhang J. Atractylodes lactone compounds inhibit platelet activation. Platelets. 2017 Mar;28(2):194-202. PubMed
- Jiang H, Shi J, Li Y. Screening for compounds with aromatase inhibiting activities from Atractylodes macrocephala Koidz. Molecules. 2011 Apr 14;16(4):3146-51. PubMed
- Koonrungsesomboon N, Na-Bangchang K, Karbwang J. Therapeutic potential and pharmacological activities of Atractylodes lancea (Thunb.) DC. Asian Pac J Trop Med. 2014 Jun;7(6):421-8. PubMed
- Li L, Tang LY, Man GC, Yeung BH, Lau CB, Leung PC, Wang CC. Potential reproductive toxicity of Largehead Atractylodes Rhizome, the most commonly used Chinese medicine for threatened miscarriage. Hum Reprod. 2011 Dec;26(12):3280-8. PubMed
- Muhamad N, Plengsuriyakarn T, Na-Bangchang K. Atractylodes lancea for cholangiocarcinoma: Modulatory effects on CYP1A2 and CYP3A1 and pharmacokinetics in rats and biodistribution in mice. PLoS One 2022;17(11):e0277614. PubMed
Storax 2 references
- Martindale W. Martindale the Extra Pharmacopoeia. Pharmaceutical Press, 1999.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Dong Quai 19 references
- Hirata JD, Swiersz LM, Zell B, et al. Does dong quai have estrogenic effects in postmenopausal women? A double-blind, placebo-controlled trial. Fertil Steril 1997;68:981-6. PubMed
- Page RL II, Lawrence JD. Potentiation of warfarin by dong quai. Pharmacotherapy 1999;19:870-6. PubMed
- Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm 2000;57:1221-7. DOI
- Eagon PK, Elm MS, Hunter DS, et al. Medicinal herbs: modulation of estrogen action. Era of Hope Mtg, Dept Defense; Breast Cancer Res Prog, Atlanta, GA 2000;Jun 8-11.
- Dr. Duke's Phytochemical and Ethnobotanical Databases. Available at: http://www.ars-grin.gov/duke/.
- Amato P, Christophe S, Mellon PL. Estrogenic activity of herbs commonly used as remedies for menopausal symptoms. Menopause 2002;9:145-50. PubMed
- Shi M, Chang L, He G. [Stimulating action of Carthamus tinctorius L., Angelica sinensis (Oliv.) Diels and Leonurus sibiricus L. on the uterus]. Zhongguo Zhong Yao Za Zhi 1995;20:173-5, 192.
- Hoult JR, Paya M. Pharmacological and biochemical actions of simple coumarins: natural products with therapeutic potential. Gen Pharmacol 1996;27:713-22.. PubMed
- Cheong JL, Bucknall R. Retinal vein thrombosis associated with a herbal phytoestrogen preparation in a susceptible patient. Postgrad Med J 2005;81:266-7.. PubMed
- Chang CJ, Chiu JH, Tseng LM, et al. Modulation of HER2 expression by ferulic acid on human breast cancer MCF7 cells. Eur J Clin Invest 2006;36:588-96. PubMed
- Chuang CH, Doyle P, Wang JD, et al. Herbal medicines used during the first trimester and major congenital malformations: an analysis of data from a pregnancy cohort study. Drug Saf 2006;29:537-48. PubMed
- Lau CBS, Ho TCY, Chan TWL, Kim SCF. Use of dong quai (Angelica sinensis) to treat peri- and postmenopausal symptoms in women with breast cancer: is it appropriate? Menopause 2005;12:734-40.
- Ellis GR, Stephens MR. Untitled (photograph and a brief case report). BMJ 1999;319:650.
- Nambiar, S., Schwartz, R. H., and Constantino, A. Hypertension in mother and baby linked to ingestion of Chinese herbal medicine. West J Med 1999;171(3):152.
- Lee, S. K., Cho, H. K., Cho, S. H., Kim, S. S., Nahm, D. H., and Park, H. S. Occupational asthma and rhinitis caused by multiple herbal agents in a pharmacist. Ann.Allergy Asthma Immunol. 2001;86(4):469-474. PubMed
- Xu, J. and Li, G. [Observation on short-term effects of Angelica injection on chronic obstructive pulmonary disease patients with pulmonary hypertension]. Zhongguo Zhong Xi Yi Jie He Za Zhi 2000;20(3):187-189.
- Scott, G. N. and Elmer, G. W. Update on natural product--drug interactions. Am J Health Syst.Pharm 2-15-2002;59(4):339-347. PubMed
- Circosta, C., Pasquale, R. D., Palumbo, D. R., Samperi, S., and Occhiuto, F. Estrogenic activity of standardized extract of Angelica sinensis. Phytother.Res. 2006;20(8):665-669.
- Fung FY, Wong WH, Ang SK, et al. A randomized, double-blind, placebo- controlled study on the anti-haemostatic effects of Curcuma longa, Angelica sinensis and Panax ginseng. Phytomedicine. 2017;32:88-96. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC