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Dietary supplement

Full Spectrum Tribulus Fruit 500 mg Ingredients & Drug Interactions

by Swanson

Full Spectrum Tribulus Fruit 500 mg label
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Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Full Spectrum Tribulus Fruit 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Full Spectrum Tribulus Fruit 500 mg is a dietary supplement by Swanson with 1 active ingredient. Its ingredients are commonly taken for low libido and sexual function, athletic performance and muscle building, testosterone support.Based on those ingredients, 259 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Tribulus terrestris. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Full Spectrum Tribulus Fruit 500 mg by Swanson

Ask about any prescription or over-the-counter medication and we check it for interactions with Full Spectrum Tribulus Fruit 500 mg by Swanson — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Full Spectrum Tribulus Fruit 500 mg by Swanson

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains a single active ingredient: tribulus terrestris fruit (500 mg per capsule). Tribulus is a plant sometimes used to support sexual function and athletic performance.

The capsule also contains inactive ingredients — gelatin, rice flour, calcium laurate, and silica — which serve as the capsule shell and flow agents.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: support sexual health in men and women.
  • We looked for evidence on: Erectile dysfunction (ED), Sexual dysfunction, Male infertility, Premature ejaculation, Menopausal symptoms, female sexual function — and 2 related terms.
  • The strongest evidence on file: Tribulus is rated "Possibly Effective" for Sexual dysfunction (Natural Medicines).
  • Also on file: Tribulus is rated "Insufficient Reliable Evidence To Rate" for Erectile dysfunction (ED), Menopausal symptoms, Premature ejaculation, Male infertility.

Tribulus shows possibly effective evidence for sexual dysfunction, though the data we hold doesn't specify which aspects of sexual function it may help with. For athletic performance, the evidence leans toward possibly ineffective.

For benign prostatic hyperplasia (enlarged prostate), we don't have enough reliable evidence to rate it one way or another.

The evidence, ingredient by ingredient Tribulus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Tribulus is often well tolerated in the short term for healthy adults, but long-term safety data and product quality vary widely. Serious side effects are rare but have been reported — including liver and kidney injury, seizures, and in one case, a patient taking very large amounts developed weakness, seizures, and kidney damage that improved after stopping it.

More commonly, you might notice stomach discomfort, nausea, or changes in bowel habits, though in trials these complaints were similar to placebo. Avoid tribulus during pregnancy because it may affect hormones and safety isn't established.

Don't use it while breastfeeding — there isn't enough reliable safety information. If you're pregnant, planning pregnancy, or nursing, talk with your doctor or pharmacist before considering this product.

Side effects, ingredient by ingredient Tribulus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Tribulus.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; lithium.
  • For scale: 259 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take blood pressure medication, diabetes medication, or lithium. Tribulus can lower blood pressure and blood sugar, and may raise lithium levels — all Moderate concerns that may require dose adjustments or closer monitoring.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Tribulus may help with sexual dysfunction, though evidence is modest. If you take blood pressure medication, diabetes medication, or lithium, you'll need to check with your doctor or pharmacist first — this herb can affect how all three work.

For otherwise healthy adults using it short-term, it's generally well tolerated, but long-term safety data are sparse. Have a conversation with your own doctor or pharmacist before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Full Spectrum Tribulus Fruit 500 mg, straight from the product label.

Brand Swanson
Barcode (UPC) 087614111537
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Feb 22, 2024
DSLD ID 308574
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Full Spectrum Tribulus Fruit 500 mg by Swanson, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
90
UPC/BARCODE
087614111537
IngredientAmount% DV
Tribulus terrestris500 mg--

Other ingredients: Gelatin, Rice Flour, Calcium Laurate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Traditionally used to support sexual health Used by both men and women Full Spectrum whole fruit formula

Sexual health

Brand IP Statement(s)

Science-backed quality since 1969

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take one capsule per day with meals.

Precautions

Warning: For adults only. Keep out of reach of children.

Consult your healthcare provider before using this or any product if you are pregnant or nursing, taking medication or have a medical condition.

Do not use if seal is broken.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Herbal Supplement

Formula

Full Spectrum Tribulus Fruit 500 mg per capsule

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Full Spectrum Tribulus Fruit 500 mg by Swanson label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Full Spectrum Tribulus Fruit 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Full Spectrum Tribulus Fruit 500 mg by Swanson

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Tribulus terrestris

Interacts with
259 drugs
500 mg per serving

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims...

Tribulus terrestris monograph & interactions

Other (inactive) ingredients: Gelatin, Rice Flour, Calcium Laurate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Full Spectrum Tribulus Fruit 500 mg by Swanson Drug Interactions

Want to check YOUR meds against Full Spectrum Tribulus Fruit 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
259Drugs
259 Moderate

Ingredients driving the most interactions

Tribulus terrestris 259

Individual Drug Interactions

The ingredients in Full Spectrum Tribulus Fruit 500 mg interact with 259 drugs. Click any drug to see the details.

1 of the 1 ingredient in Full Spectrum Tribulus Fruit 500 mg interact with drugs. Each result below shows which ingredient is responsible. Tribulus terrestris

Each ingredient & the kinds of drugs it affects

For each ingredient in Full Spectrum Tribulus Fruit 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Tribulus terrestris3 drug types · 259 drugs

Antidiabetes Drugs

Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that Tribulus can lower blood glucose levels in adults with type 2 diabetes who are taking antidiabetes medications.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that tribulus can lower blood pressure by inhibiting angiotensin-converting enzyme (ACE). Tribulus has also demonstrated hypotensive effects in pre-hypertensive adults.

Likelihood Possible Evidence D
Lithium

Theoretically, tribulus might increase the levels and clinical effects of lithium.
Tribulus is thought to have diuretic properties. Due to these potential diuretic effects, tribulus might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Tribulus terrestris full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Full Spectrum Tribulus Fruit 500 mg, from the product label.

Swanson

See all Swanson products
Name
Swanson Health Products
City
Fargo
State
ND
ZipCode
58104
Phone Number
1-800-437-4148
Web Address
swanson.com
Pharmacist Counseling Corner

Full Spectrum Tribulus Fruit 500 mg by Swanson: Common Questions

Does Full Spectrum Tribulus Fruit 500 mg by Swanson interact with any medications?
Yes. Based on its ingredients, Full Spectrum Tribulus Fruit 500 mg has a known interaction with 259 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Full Spectrum Tribulus Fruit 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
No — avoid it during pregnancy because tribulus may affect hormones and safety isn't established, and the data advises against use while breastfeeding due to lack of reliable safety information. If you're pregnant, planning pregnancy, or nursing, talk with your doctor or pharmacist before considering any supplement.
Does tribulus actually help with sexual function?
The evidence we hold rates tribulus as possibly effective for sexual dysfunction, which means there's some clinical support but it's not definitive. Individual results vary, and it's worth discussing with your doctor what results you might realistically expect.
What are the most common side effects?
Stomach discomfort, nausea, and changes in bowel habits can occur, though in trials these complaints happened about as often in people taking placebo. Serious side effects like liver or kidney injury are rare but have been reported.
How long does it take to work?
The product facts we have don't specify a timeframe for when you might notice effects. It's something to discuss with your doctor or pharmacist based on the clinical trial data for the condition you're addressing.
Is this product tested for quality and purity?
The data we hold note that quality and long-term safety data are limited. Tribulus products vary in their manufacturing standards, so you might ask the manufacturer or retailer about third-party testing if that's important to you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Full Spectrum Tribulus Fruit 500 mg is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Full Spectrum Tribulus Fruit 500 mg label
Go deeper

The Full Monographs Behind Full Spectrum Tribulus Fruit 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Tribulus

Interacts with 259 drugs

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims is weak and inconsistent. It is general...

Read the full Tribulus monograph →
Sources

Sources & How We Checked

Full Spectrum Tribulus Fruit 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 10 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tribulus 10 references
  1. Sharifi AM, Darabi R, Akbarloo N. Study of antihypertensive mechanism of Tribulus terrestris in 2K1C hypertensive rats: role of tissue ACE activity. Life Sci 2003;73:2963-71. PubMed
  2. Walker D, Bird A, Flora T, O'Sullivan B. Some effects of feeding Tribulus terrestris, Ipomoea lonchophylla and the seed of Abelmoschus ficulneus on fetal development and the outcome of pregnancy in sheep. Reprod Fertil Dev 1992;4:135-44. PubMed
  3. Al-Ali M, Wahbi S, Twaij H, Al-Badr A. Tribulus terrestris: preliminary study of its diuretic and contractile effects and comparison with Zea mays. J Ethnopharmacol 2003;85:257-60. PubMed
  4. Tabakova, P., Dimitrov, M., Ognyanov, K., and et al. Clinical study of Tribestan in females with endocrine sterility. Documentation for Registration (unpublished) 1999.
  5. Akhtari E, Raisi F, Keshavarz M, et al. Tribulus terrestris for treatment of sexual dysfunction in women: randomized double-blind placebo-controlled study. Daru 2014;22:40. PubMed
  6. Ryan M, Lazar I, Nadasdy GM, et al. Acute kidney injury and hyperbilirubinemia in a young male after ingestion of Tribulus terrestris. Clin Nephrol 2015;83(3):177-83. PubMed
  7. Postigo S, Lima SM, Yamada SS, et al. Assessment of the effects of Tribulus terrestris on sexual function of menopausal women. Rev Bras Ginecol Obstet 2016;38(3):140-6. PubMed
  8. Talasaz AH, Abbasi MR, Abkhiz S, Dashti-Khavidaki S. Tribulus terrestris-induced severe nephrotoxicity in a young healthy male. Nephrol Dial Tranplant 2010;25(11):3792-3. PubMed
  9. Samani NB, Jokar A, Soveid M, Heydari M, Mosavat SH. Efficacy of the hydroalcoholic extract of Tribulus terrestris on the serum glucose and lipid profile of women with diabetes mellitus: a double-blind randomized placebo-controlled clinical trial. J Evid
  10. Siddiqui MA, Itrat M, Mobeen A, Khan MI. Efficacy of khar-i-khasak (Tribulus terrestris Linn.) in prehypertension: a randomized, double-blind, placebo-controlled trial. J Complement Integr Med. 2021.

See these in context on the Tribulus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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