Gan Di Huang Ingredients & Drug Interactions
by Hawaii Pharm
What is this page for?
First and foremost: checking Gan Di Huang against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Gan Di Huang is a dietary supplement by Hawaii Pharm with 1 active ingredient. Its ingredients are commonly taken for kidney and adrenal support, anemia and blood building (traditional), inflammatory conditions.Based on those ingredients, 258 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Gan Di Huang extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Gan Di Huang by Hawaii Pharm
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AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Gan Di Huang by Hawaii Pharm
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Gan Di Huang is a liquid extract containing one active ingredient: Gan Di Huang (rehmannia extract). The formula also includes vegetable palm glycerin and alcohol as inactive ingredients that help preserve and deliver the extract.
Does it work?
Moderate evidence
The evidence we have is limited. Rehmannia is possibly effective for chronic kidney disease (CKD).
For other uses — aplastic anemia, atopic disease, osteoporosis, diabetes, and diabetic nephropathy — there isn't enough reliable evidence yet to know whether it works.
How safe is it?
Some data gaps
Rehmannia is used in traditional medicine, but human safety data are sparse and product quality varies. There isn't enough safety information to recommend it during pregnancy or while breastfeeding — the safety data advise against use in both.
No adverse effects are listed in our data, though the limited research means side effects may not be fully documented.
Meds to double-check
Moderate interaction found
Check your blood pressure medications and diabetes medications with your doctor or pharmacist before starting this product. Rehmannia may increase the risk of low blood pressure or low blood sugar when combined with either category.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and some safety-information gaps remain.
If you have chronic kidney disease and want to explore rehmannia, it's worth a conversation with your doctor or pharmacist. Anyone taking blood pressure or diabetes medication should not start this product without checking with their own healthcare provider first.
Pregnant people and those breastfeeding should avoid it. Talk it over with your doctor or pharmacist before you begin.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Gan Di Huang, straight from the product label.
| Brand | Hawaii Pharm |
|---|---|
| Barcode (UPC) | 617503480040 |
| Net contents | 4 Fluid Ounce(s); 120 mL |
| Market status | On market |
| Date entered into DSLD | Nov 21, 2020 |
| DSLD ID | 237337 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Gan Di Huang by Hawaii Pharm, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Gan Di Huang extract | 970 mg | -- |
Other ingredients: Vegetable Palm Glycerin, Alcohol
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Hawaii Pharm Herbal Extract Highest quality since 2008
Made with Aloha!
Formulation
Contains no GMO, gluten, artificial colors, heavy metals, preservatives, pesticides, fertilizers.
Super concentrated liquid herbal extract. Dry herb/menstruum ratio: 1:3.
Manufactured in an FDA registered facility.
Non GMO Gluten free
Made in USA, Hawaii
Suggested/Recommended/Usage/Directions
Directions for use: Shake well before using. Take about 20-30 drops (0.7-1 ml, one full squeeze of the dropper bulb) to 2-4 oz of juice or water up to 4 times per day.
Precautions
Warning: Keep out of the reach of children.
We recommend to seek expert medical advice before taking. May have contraindications.
Do not use if you are allergic to any ingredients.
Consult your physician before giving to children under 18, during pregnancy, if nursing or taking any medications.
Consult your physician before giving to children under 18, during pregnancy, if nursing or taking any medications.
Do not use if seal is broken or missing.
Storage
Store in a cool dry place.
Formula
(Rehmannia glutinosa)
FDA Statement of Identity
Herbal Dietary Supplement
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Seals/Symbols
FDA Registered Facility Made in United States of America USA
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Gan Di Huang by Hawaii Pharm label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Gan Di Huang by Hawaii Pharm
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size0.7 mL Dosage formLiquid Servings per container120 Amounts shown are per serving.
Gan Di Huang extract
Interacts with258 drugs
Rehmannia is a root used for centuries in Traditional Chinese Medicine, often to 'tonify' the kidneys and support energy or blood health. Human eviden...
Gan Di Huang extract monograph & interactionsOther (inactive) ingredients: Vegetable Palm Glycerin, Alcohol. These complete the product’s ingredient list but are not active constituents.
Gan Di Huang by Hawaii Pharm Drug Interactions
HelloPharmacist Interaction Report
Gan Di Huang by Hawaii Pharm contains rehmannia extract, which interacts with two major drug categories.
The most serious concern is with blood pressure medications (antihypertensive drugs) — rehmannia may theoretically increase the risk of low blood pressure (hypotension) when combined with them. Animal research suggests rehmannia can lower blood pressure, and lab work shows it may inhibit an enzyme involved in blood pressure regulation.
Read the full breakdown — every affected drug type, severity by severity
Rehmannia also carries a Moderate interaction risk with diabetes medications (antidiabetes drugs). It may theoretically raise the risk of low blood sugar (hypoglycemia) when used together, since animal studies indicate rehmannia may lower blood sugar on its own.
Altogether, these interactions span 258 individual medications. Before you start this product, check your exact medications with the tool on this page — especially if you take any prescription for high blood pressure or diabetes.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Gan Di Huang?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Gan Di Huang interact with 258 drugs. Click any drug to see the details.
1 of the 1 ingredient in Gan Di Huang interact with drugs. Each result below shows which ingredient is responsible. Gan Di Huang extract
Bendroflumethiazide, Rauwolfia SerpentinaRauzide
How Bendroflumethiazide, Rauwolfia Serpentina interacts with Gan Di Huang — through 1 ingredient. Tap an ingredient for the detail:
Gan Di Huang ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, rehmannia might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Gan Di Huang Extract + Bendroflumethiazide, Rauwolfia Serpentina interactionBenzthiazideExna
How Benzthiazide interacts with Gan Di Huang — through 1 ingredient. Tap an ingredient for the detail:
Gan Di Huang ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, rehmannia might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Gan Di Huang Extract + Benzthiazide interactionBetaxololBetoptic, Kerlone
How Betaxolol interacts with Gan Di Huang — through 1 ingredient. Tap an ingredient for the detail:
Gan Di Huang ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, rehmannia might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Gan Di Huang Extract + Betaxolol interactionBisoprololZebeta
How Bisoprolol interacts with Gan Di Huang — through 1 ingredient. Tap an ingredient for the detail:
Gan Di Huang ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, rehmannia might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Gan Di Huang Extract + Bisoprolol interactionBisoprolol, HydrochlorothiazideZiac
How Bisoprolol, Hydrochlorothiazide interacts with Gan Di Huang — through 1 ingredient. Tap an ingredient for the detail:
Gan Di Huang ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, rehmannia might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Gan Di Huang Extract + Bisoprolol, Hydrochlorothiazide interactionBosentanTracleer
How Bosentan interacts with Gan Di Huang — through 1 ingredient. Tap an ingredient for the detail:
Gan Di Huang ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, rehmannia might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Gan Di Huang Extract + Bosentan interactionBumetanideBurinex
How Bumetanide interacts with Gan Di Huang — through 1 ingredient. Tap an ingredient for the detail:
Gan Di Huang ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, rehmannia might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Gan Di Huang Extract + Bumetanide interactionBumetanide (iv)Bumex
How Bumetanide (iv) interacts with Gan Di Huang — through 1 ingredient. Tap an ingredient for the detail:
Gan Di Huang ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, rehmannia might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Gan Di Huang Extract + Bumetanide (iv) interactionBumetanide (oral)Bumex
How Bumetanide (oral) interacts with Gan Di Huang — through 1 ingredient. Tap an ingredient for the detail:
Gan Di Huang ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, rehmannia might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Gan Di Huang Extract + Bumetanide (oral) interactionCanagliflozinInvokana
How Canagliflozin interacts with Gan Di Huang — through 1 ingredient. Tap an ingredient for the detail:
Gan Di Huang ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, rehmannia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Gan Di Huang Extract + Canagliflozin interactionCanagliflozin, MetforminInvokamet
How Canagliflozin, Metformin interacts with Gan Di Huang — through 1 ingredient. Tap an ingredient for the detail:
Gan Di Huang ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, rehmannia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Gan Di Huang Extract + Canagliflozin, Metformin interactionCanagliflozin, Metformin HydrochlorideInvokamet XR
How Canagliflozin, Metformin Hydrochloride interacts with Gan Di Huang — through 1 ingredient. Tap an ingredient for the detail:
Gan Di Huang ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, rehmannia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Gan Di Huang Extract + Canagliflozin, Metformin Hydrochloride interactionCandesartan CilexetilAmias, Atacand
How Candesartan Cilexetil interacts with Gan Di Huang — through 1 ingredient. Tap an ingredient for the detail:
Gan Di Huang ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, rehmannia might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Gan Di Huang Extract + Candesartan Cilexetil interactionCandesartan Cilexetil, HydrochlorothiazideAtacand HCT
How Candesartan Cilexetil, Hydrochlorothiazide interacts with Gan Di Huang — through 1 ingredient. Tap an ingredient for the detail:
Gan Di Huang ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, rehmannia might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Gan Di Huang Extract + Candesartan Cilexetil, Hydrochlorothiazide interactionCaptoprilAcepril, Capoten
How Captopril interacts with Gan Di Huang — through 1 ingredient. Tap an ingredient for the detail:
Gan Di Huang ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, rehmannia might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Gan Di Huang Extract + Captopril interactionCaptopril, HydrochlorothiazideAcezide, Capozide
How Captopril, Hydrochlorothiazide interacts with Gan Di Huang — through 1 ingredient. Tap an ingredient for the detail:
Gan Di Huang ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, rehmannia might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Gan Di Huang Extract + Captopril, Hydrochlorothiazide interactionCarteololCartrol, Ocupress
How Carteolol interacts with Gan Di Huang — through 1 ingredient. Tap an ingredient for the detail:
Gan Di Huang ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, rehmannia might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Gan Di Huang Extract + Carteolol interactionCarvedilolCoreg, Coreg CR
How Carvedilol interacts with Gan Di Huang — through 1 ingredient. Tap an ingredient for the detail:
Gan Di Huang ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, rehmannia might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Gan Di Huang Extract + Carvedilol interactionCeliprololCelicard
How Celiprolol interacts with Gan Di Huang — through 1 ingredient. Tap an ingredient for the detail:
Gan Di Huang ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, rehmannia might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Gan Di Huang Extract + Celiprolol interactionChlorothiazideDiuril
How Chlorothiazide interacts with Gan Di Huang — through 1 ingredient. Tap an ingredient for the detail:
Gan Di Huang ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, rehmannia might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Gan Di Huang Extract + Chlorothiazide interactionChlorothiazide, MethyldopaAldochlor, Aldoclor 150, Aldoclor 250
How Chlorothiazide, Methyldopa interacts with Gan Di Huang — through 1 ingredient. Tap an ingredient for the detail:
Gan Di Huang ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, rehmannia might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Gan Di Huang Extract + Chlorothiazide, Methyldopa interactionChlorothiazide, ReserpineDiupres
How Chlorothiazide, Reserpine interacts with Gan Di Huang — through 1 ingredient. Tap an ingredient for the detail:
Gan Di Huang ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, rehmannia might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Gan Di Huang Extract + Chlorothiazide, Reserpine interactionChlorpropamideChlorpropam, Diabinese
How Chlorpropamide interacts with Gan Di Huang — through 1 ingredient. Tap an ingredient for the detail:
Gan Di Huang ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, rehmannia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Gan Di Huang Extract + Chlorpropamide interactionChlorthalidoneHygroton, Thalitone
How Chlorthalidone interacts with Gan Di Huang — through 1 ingredient. Tap an ingredient for the detail:
Gan Di Huang ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, rehmannia might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Gan Di Huang Extract + Chlorthalidone interactionChlorthalidone, ClonidineClorpres, Combipres
How Chlorthalidone, Clonidine interacts with Gan Di Huang — through 1 ingredient. Tap an ingredient for the detail:
Gan Di Huang ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, rehmannia might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Gan Di Huang Extract + Chlorthalidone, Clonidine interactionCilazaprilInhibace
How Cilazapril interacts with Gan Di Huang — through 1 ingredient. Tap an ingredient for the detail:
Gan Di Huang ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, rehmannia might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Gan Di Huang Extract + Cilazapril interactionClevidipineCleviprex
How Clevidipine interacts with Gan Di Huang — through 1 ingredient. Tap an ingredient for the detail:
Gan Di Huang ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, rehmannia might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Gan Di Huang Extract + Clevidipine interactionClonidineCatapres
How Clonidine interacts with Gan Di Huang — through 1 ingredient. Tap an ingredient for the detail:
Gan Di Huang ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, rehmannia might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Gan Di Huang Extract + Clonidine interactionCryptenamine, MethyclothiazideDiutensen
How Cryptenamine, Methyclothiazide interacts with Gan Di Huang — through 1 ingredient. Tap an ingredient for the detail:
Gan Di Huang ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, rehmannia might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Gan Di Huang Extract + Cryptenamine, Methyclothiazide interactionCyclothiazideAnhydron, Fluidil
How Cyclothiazide interacts with Gan Di Huang — through 1 ingredient. Tap an ingredient for the detail:
Gan Di Huang ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, rehmannia might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Gan Di Huang Extract + Cyclothiazide interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Gan Di Huang with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Gan Di Huang extract
Antidiabetes Drugs
Theoretically, rehmannia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research shows that rehmannia may have hypoglycemic effects.
Antihypertensive Drugs
Theoretically, rehmannia might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research shows that rehmannia may have hypotensive effects. Laboratory research shows that formulations of dried and processed rehmannia root inhibit angiotensin-converting enzyme (ACE).
Brand information
Manufacturer and brand details for Gan Di Huang, from the product label.
Hawaii Pharm
See all Hawaii Pharm products- Name
- Hawaii Pharm LLC
- City
- Honolulu
- State
- HI
- ZipCode
- 96815
- Web Address
- www.hawaiipharm.com
Gan Di Huang by Hawaii Pharm: Common Questions
Does Gan Di Huang by Hawaii Pharm interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take Gan Di Huang if I'm pregnant or breastfeeding?
What is Gan Di Huang used for?
What are the side effects?
Does this product have fillers?
Why does the safety data say to avoid it in pregnancy and breastfeeding?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Gan Di Huang is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Gan Di Huang’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Gan Di Huang's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 3 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Rehmannia 3 references
- Zhang R, Zhou J, Jia Z, et al. Hypoglycemic effect of Rehmannia glutinosa oligosaccharide in hyperglycemic and alloxan-induced diabetic rats and its mechanism. J Ethnopharmacol 2004;90:39-43. PubMed
- Zhang RX, Li MX, Jia ZP. Rehmannia glutinosa: review of botany, chemistry and pharmacology. J Ethnopharmacol 2008;117(2):199-214. PubMed
- Chao CH, Hsu JL, Chen MF, et al. Anti-hypertensive effects of Radix Rehmanniae and its active ingredients. Nat Prod Res. 2020;34(11):1547-1552.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC