Gastrotene Ingredients & Drug Interactions
by Zycal Bioceuticals Healthcare
What is this page for?
First and foremost: checking Gastrotene against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Gastrotene is a dietary supplement by Zycal Bioceuticals Healthcare with 3 active ingredients. Its ingredients are commonly taken for muscle recovery and sports performance, gut health and 'leaky gut', recovery from severe illness or injury.Based on those ingredients, 2,080 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Slippery Elm extract, 2-Beta Coxatene, L-Glutamine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Gastrotene by Zycal Bioceuticals Healthcare
Ask about any prescription or over-the-counter medication and we check it for interactions with Gastrotene by Zycal Bioceuticals Healthcare — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Gastrotene by Zycal Bioceuticals Healthcare
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Gastrotene contains 3 active ingredients. L-Glutamine is an amino acid your body uses during recovery from illness or stress.
2-Beta Coxatene is a form of vitamin A, a nutrient important for vision, immune function, and skin health. Slippery Elm extract comes from the inner bark of the slippery elm tree and has traditionally been used for digestive comfort.
The capsule itself is made from gelatin, and the powder inside includes microcrystalline cellulose as an inactive filler.
Does it work?
Not established
The evidence for this product's ingredients is mixed. L-Glutamine is effective for sickle cell disease and possibly effective for HIV-related wasting and recovery from surgery or critical illness.
Vitamin A is effective for vitamin A deficiency and possibly effective for oral leukoplakia, aging skin, measles, ulcerative colitis, and bronchopulmonary dysplasia. Slippery elm extract, however, has insufficient reliable evidence in our data to rate it for constipation, cough, diarrhea, inflammatory bowel disease, or cancer.
If you're taking this product for one of those last conditions, the evidence doesn't yet support its use.
How safe is it?
Well-documented data
L-Glutamine is generally well tolerated, though people with kidney or liver disease should only use it under medical supervision. The most common side effects are gastrointestinal—belching, bloating, constipation, diarrhea, nausea, and vomiting—especially at higher doses.
Dizziness and headache have been reported, and rarely, mania in people with bipolar disorder. There isn't enough safety data to recommend it in pregnancy; talk with your doctor.
2-Beta Coxatene (vitamin A) is generally safe at recommended amounts but toxic in high doses because it builds up in your body. Serious effects from excess vitamin A include liver damage, pseudotumor cerebri, and in severe cases, coma.
Chronic overuse causes dry, cracking skin, hair loss, and nail brittleness. High doses in pregnancy can cause birth defects and should be avoided.
Slippery elm is generally well tolerated for short-term use, though long-term safety data are limited. It can cause contact dermatitis and allergic reactions.
Safety in pregnancy and breastfeeding isn't well established—talk with your pharmacist or doctor.
Meds to double-check
Major interaction found
Before taking Gastrotene, double-check with your pharmacist if you take retinoid drugs (like isotretinoin or tretinoin)—that's a Major interaction. Also check if you're on warfarin, tetracycline antibiotics, other potentially liver-damaging drugs, anticonvulsants, or any oral medications that need to be absorbed well, since slippery elm may slow that absorption.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.
Gastrotene may be worth considering if you're recovering from surgery or critical illness, or managing sickle cell disease, since glutamine has evidence for those uses. If you take retinoid drugs, warfarin, tetracycline antibiotics, or other hepatotoxic medications, or anticonvulsants, check your exact medications with the tool on this page before starting.
Talk with your pharmacist, especially if you have kidney or liver disease, take multiple medications, or are pregnant or breastfeeding.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 22, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Gastrotene, straight from the product label.
| Brand | Zycal Bioceuticals Healthcare |
|---|---|
| Net contents | 60 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Apr 22, 2021 |
| DSLD ID | 247887 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Gastrotene by Zycal Bioceuticals Healthcare, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| L-Glutamine | 275 mg | -- |
| 2-Beta Coxatene | 135 mg | -- |
| Slippery Elm extract | 100 mg | -- |
Other ingredients: Gelatin Capsules, Microcrystalline Cellulose
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Gastrotene is a breakthrough GI health product that contains 2-Beta Coxatene, a new class of nutritional ingredient. 2-Beta Coxatene is an all-natural protein & herbal blend providing the right balance and support for healthy immune signaling and stem cell activation to help support your body's ability to create new, healthy, epithelial lining for a healthy gut.
Powdered by 2-Beta Coxatene An immune reactive compound Glutamine Slippery Elm
Suggested/Recommended/Usage/Directions
Suggested dosage: As a dietary supplement, take one (1) to three (3) capsules per day.
Precautions
Warning: Consult a physician before using if pregnant, nursing or on medication.
Do not use if inner seal is missing or broken.
Keep out of the reach of children.
Storage
Store in a cool, dry place.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
FDA Statement of Identity
Dietary Supplement
General Statements
Innovators in Natural Health
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Gastrotene by Zycal Bioceuticals Healthcare label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Gastrotene by Zycal Bioceuticals Healthcare
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
L-Glutamine
Interacts with50 drugs
Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle c...
L-Glutamine monograph & interactions2-Beta Coxatene
Interacts with387 drugs
Vitamin A is an essential nutrient important for vision, skin, immune function, and growth. Most people get enough from a balanced diet, and supplemen...
2-Beta Coxatene monograph & interactionsSlippery Elm extract
Interacts with2,022 drugs
Slippery elm is a traditional herbal remedy made from the inner bark of a North American elm tree, used mainly to soothe sore throats and irritated di...
Slippery Elm extract monograph & interactionsOther (inactive) ingredients: Gelatin Capsules, Microcrystalline Cellulose. These complete the product’s ingredient list but are not active constituents.
Gastrotene by Zycal Bioceuticals Healthcare Drug Interactions
HelloPharmacist Interaction Report
Gastrotene by Zycal Bioceuticals Healthcare contains three active ingredients, and two of them do interact with medications.
The most serious concern is 2-Beta Coxatene (vitamin A), which can have a Major interaction with retinoid drugs—taking them together could push vitamin A to unsafe levels in your body. Vitamin A derivatives are already forms of vitamin A, so combining them amplifies the risk.
Read the full breakdown — every affected drug type, severity by severity
Vitamin A also carries Moderate interactions with several other drug types. High doses can thin your blood further if you're on warfarin, increase the risk of a specific type of brain swelling (pseudotumor cerebri) if you're taking tetracycline antibiotics, and theoretically add stress to your liver if you're on other drugs that can damage it.
L-Glutamine has a Moderate interaction with anticonvulsant medications—though it hasn't been seen in actual patients, glutamine can be converted to an excitatory brain chemical that might work against seizure drugs.
Slippery Elm extract may slow how your body absorbs oral medications generally, a Moderate concern. Altogether, these interactions span 2,057 individual medications.
We couldn't find interaction data for slippery elm beyond that broad effect on drug absorption. Run your exact medications through the checker on this page before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Gastrotene?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Gastrotene interact with 2,080 drugs. Click any drug to see the details.
3 of the 3 ingredients in Gastrotene interact with drugs. Each result below shows which ingredient is responsible. Slippery Elm extract 2-Beta Coxatene L-Glutamine
AcitretinSoriatane
How Acitretin interacts with Gastrotene — through 2 ingredients. Tap an ingredient for the detail:
2-beta CoxateneRetinoids Major
Interaction Summary
Concomitant use of retinoids with vitamin A supplements might produce supratherapeutic vitamin A levels.
Read the full 2-beta Coxatene + Acitretin interactionSlippery Elm ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Extract + Acitretin interactionAlitretinoinPanretin
How Alitretinoin interacts with Gastrotene — through 2 ingredients. Tap an ingredient for the detail:
2-beta CoxateneRetinoids Major
Interaction Summary
Concomitant use of retinoids with vitamin A supplements might produce supratherapeutic vitamin A levels.
Read the full 2-beta Coxatene + Alitretinoin interactionSlippery Elm ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Extract + Alitretinoin interactionBexaroteneTargretin
How Bexarotene interacts with Gastrotene — through 2 ingredients. Tap an ingredient for the detail:
2-beta CoxateneRetinoids Major
Interaction Summary
Concomitant use of retinoids with vitamin A supplements might produce supratherapeutic vitamin A levels.
Read the full 2-beta Coxatene + Bexarotene interactionSlippery Elm ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Extract + Bexarotene interactionHalobetasol Propionate,tazaroteneDuobrii
How Halobetasol Propionate,tazarotene interacts with Gastrotene — through 1 ingredient. Tap an ingredient for the detail:
2-beta CoxateneRetinoids Major
Interaction Summary
Concomitant use of retinoids with vitamin A supplements might produce supratherapeutic vitamin A levels.
Read the full 2-beta Coxatene + Halobetasol Propionate,tazarotene interactionIsotretinoinAbsorica, Accutane, Amnesteem, Claravis, Roaccutane, Sotret
How Isotretinoin interacts with Gastrotene — through 2 ingredients. Tap an ingredient for the detail:
2-beta CoxateneRetinoids Major
Interaction Summary
Concomitant use of retinoids with vitamin A supplements might produce supratherapeutic vitamin A levels.
Read the full 2-beta Coxatene + Isotretinoin interactionSlippery Elm ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Extract + Isotretinoin interactionTazaroteneArazlo, Avage, Fabior, Tazorotene, Zorac
How Tazarotene interacts with Gastrotene — through 1 ingredient. Tap an ingredient for the detail:
2-beta CoxateneRetinoids Major
Interaction Summary
Concomitant use of retinoids with vitamin A supplements might produce supratherapeutic vitamin A levels.
Read the full 2-beta Coxatene + Tazarotene interactionTretinoinAltreno, Renova, Retin-A, Vesanoid
How Tretinoin interacts with Gastrotene — through 2 ingredients. Tap an ingredient for the detail:
2-beta CoxateneRetinoids Major
Interaction Summary
Concomitant use of retinoids with vitamin A supplements might produce supratherapeutic vitamin A levels.
Read the full 2-beta Coxatene + Tretinoin interactionSlippery Elm ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Extract + Tretinoin interactionTretinoin, Benzoyl PeroxideTwyneo
How Tretinoin, Benzoyl Peroxide interacts with Gastrotene — through 1 ingredient. Tap an ingredient for the detail:
2-beta CoxateneRetinoids Major
Interaction Summary
Concomitant use of retinoids with vitamin A supplements might produce supratherapeutic vitamin A levels.
Read the full 2-beta Coxatene + Tretinoin, Benzoyl Peroxide interactionEtretinateTegison
How Etretinate interacts with Gastrotene — through 2 ingredients. Tap an ingredient for the detail:
2-beta CoxateneRetinoids Major
Interaction Summary
Concomitant use of retinoids with vitamin A supplements might produce supratherapeutic vitamin A levels.
Read the full 2-beta Coxatene + Etretinate interactionSlippery Elm ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Extract + Etretinate interaction"phentolamineOraVerse, Rogitine, Ryzumvi
How "phentolamine interacts with Gastrotene — through 1 ingredient. Tap an ingredient for the detail:
Slippery Elm ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Extract + "phentolamine interaction6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Gastrotene — through 2 ingredients. Tap an ingredient for the detail:
Slippery Elm ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Extract + 6-mercaptopurine interaction2-beta CoxateneHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking high doses of vitamin A in combination with other potentially hepatotoxic drugs might increase the risk of liver disease.
Read the full 2-beta Coxatene + 6-mercaptopurine interactionAbacavirZiagen
How Abacavir interacts with Gastrotene — through 1 ingredient. Tap an ingredient for the detail:
Slippery Elm ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Extract + Abacavir interactionAbacavir Sulfate, Dolutegravir, LamivudineTriumeq
How Abacavir Sulfate, Dolutegravir, Lamivudine interacts with Gastrotene — through 2 ingredients. Tap an ingredient for the detail:
2-beta CoxateneHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking high doses of vitamin A in combination with other potentially hepatotoxic drugs might increase the risk of liver disease.
Read the full 2-beta Coxatene + Abacavir Sulfate, Dolutegravir, Lamivudine interactionSlippery Elm ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Extract + Abacavir Sulfate, Dolutegravir, Lamivudine interactionAbacavir, LamivudineEpzicom
How Abacavir, Lamivudine interacts with Gastrotene — through 2 ingredients. Tap an ingredient for the detail:
2-beta CoxateneHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking high doses of vitamin A in combination with other potentially hepatotoxic drugs might increase the risk of liver disease.
Read the full 2-beta Coxatene + Abacavir, Lamivudine interactionSlippery Elm ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Extract + Abacavir, Lamivudine interactionAbciximabReoPro
How Abciximab interacts with Gastrotene — through 1 ingredient. Tap an ingredient for the detail:
Slippery Elm ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Extract + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Gastrotene — through 1 ingredient. Tap an ingredient for the detail:
Slippery Elm ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Extract + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Gastrotene — through 2 ingredients. Tap an ingredient for the detail:
Slippery Elm ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Extract + Abiraterone interaction2-beta CoxateneHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking high doses of vitamin A in combination with other potentially hepatotoxic drugs might increase the risk of liver disease.
Read the full 2-beta Coxatene + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Gastrotene — through 2 ingredients. Tap an ingredient for the detail:
2-beta CoxateneHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking high doses of vitamin A in combination with other potentially hepatotoxic drugs might increase the risk of liver disease.
Read the full 2-beta Coxatene + Abiraterone Acetate interactionSlippery Elm ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Extract + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Gastrotene — through 1 ingredient. Tap an ingredient for the detail:
Slippery Elm ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Extract + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Gastrotene — through 1 ingredient. Tap an ingredient for the detail:
Slippery Elm ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Extract + Acalabrutinib interactionAcamprosateCampral
How Acamprosate interacts with Gastrotene — through 1 ingredient. Tap an ingredient for the detail:
Slippery Elm ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Extract + Acamprosate interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Gastrotene — through 2 ingredients. Tap an ingredient for the detail:
Slippery Elm ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Extract + Acarbose interaction2-beta CoxateneHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking high doses of vitamin A in combination with other potentially hepatotoxic drugs might increase the risk of liver disease.
Read the full 2-beta Coxatene + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Gastrotene — through 2 ingredients. Tap an ingredient for the detail:
2-beta CoxateneHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking high doses of vitamin A in combination with other potentially hepatotoxic drugs might increase the risk of liver disease.
Read the full 2-beta Coxatene + Acebutolol interactionSlippery Elm ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Extract + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Gastrotene — through 1 ingredient. Tap an ingredient for the detail:
Slippery Elm ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Extract + Acenocoumarol interactionAcepromazineAtravet
How Acepromazine interacts with Gastrotene — through 1 ingredient. Tap an ingredient for the detail:
Slippery Elm ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Extract + Acepromazine interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Gastrotene — through 2 ingredients. Tap an ingredient for the detail:
Slippery Elm ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Extract + Acetaminophen interaction2-beta CoxateneHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking high doses of vitamin A in combination with other potentially hepatotoxic drugs might increase the risk of liver disease.
Read the full 2-beta Coxatene + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Gastrotene — through 2 ingredients. Tap an ingredient for the detail:
2-beta CoxateneHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking high doses of vitamin A in combination with other potentially hepatotoxic drugs might increase the risk of liver disease.
Read the full 2-beta Coxatene + Acetaminophen, Aspirin interactionSlippery Elm ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Extract + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Gastrotene — through 2 ingredients. Tap an ingredient for the detail:
2-beta CoxateneHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking high doses of vitamin A in combination with other potentially hepatotoxic drugs might increase the risk of liver disease.
Read the full 2-beta Coxatene + Acetaminophen, Aspirin, Caffeine interactionSlippery Elm ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Extract + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Gastrotene — through 2 ingredients. Tap an ingredient for the detail:
Slippery Elm ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Extract + Acetaminophen, Brompheniramine, Phenylpropanolamine interaction2-beta CoxateneHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking high doses of vitamin A in combination with other potentially hepatotoxic drugs might increase the risk of liver disease.
Read the full 2-beta Coxatene + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Gastrotene — through 2 ingredients. Tap an ingredient for the detail:
2-beta CoxateneHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking high doses of vitamin A in combination with other potentially hepatotoxic drugs might increase the risk of liver disease.
Read the full 2-beta Coxatene + Acetaminophen, Butalbital interactionSlippery Elm ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Extract + Acetaminophen, Butalbital interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Gastrotene with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Slippery Elm extract
Oral Drugs
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Slippery elm inner bark contains mucilage, which may interfere with the absorption of orally administered drugs.
2-Beta Coxatene
Retinoids
Concomitant use of retinoids with vitamin A supplements might produce supratherapeutic vitamin A levels.
Retinoids, which are vitamin A derivatives, could have additive toxic effects when taken with vitamin A supplements.
Hepatotoxic Drugs
Theoretically, taking high doses of vitamin A in combination with other potentially hepatotoxic drugs might increase the risk of liver disease.
The tolerable upper intake level (UL) is the highest level of intake that is likely to pose no risk of adverse effects. Doses of vitamin A above the UL can cause hepatotoxicity, ranging from elevated liver enzymes to liver failure.
Tetracycline Antibiotics
Theoretically, taking tetracycline antibiotics with high doses of vitamin A can increase the risk of pseudotumor cerebri.
Benign intracranial hypertension (pseudotumor cerebri) can occur with tetracyclines and with acute or chronic vitamin A toxicity. Case reports suggest that taking tetracyclines and vitamin A concurrently can increase the risk of this condition. Avoid high doses of vitamin A in people taking tetracyclines chronically.
Warfarin (Coumadin)
Theoretically, high doses of vitamin A could increase the risk of bleeding with warfarin.
Vitamin A toxicity is associated with hemorrhage and hypoprothrombinemia, possibly due to vitamin K antagonism. Advise patients taking warfarin to avoid doses of vitamin A above the tolerable upper intake level of 10,000 IU/day for adults.
L-Glutamine
Anticonvulsants
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.
Brand information
Manufacturer and brand details for Gastrotene, from the product label.
Zycal Bioceuticals Healthcare
- Name
- ZyCal Bioceuticals Healthcare Co.
- Street Address
- 5 Executive Dr, Ste A
- City
- Toms River
- State
- NJ
- ZipCode
- 08755
- Phone Number
- 1-888-779-9225
- Web Address
- Ostinol.com
Gastrotene by Zycal Bioceuticals Healthcare: Common Questions
Does Gastrotene by Zycal Bioceuticals Healthcare interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is glutamine safe if I have kidney or liver problems?
Can I take this if I'm pregnant or breastfeeding?
What are the most common side effects?
Will this help my inflammatory bowel disease or constipation?
Does vitamin A in this product build up in my body?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Gastrotene is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Gastrotene’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Glutamine
Interacts with 50 drugsGlutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...
Read the full Glutamine monograph → Herb & supplement monographVitamin A
Interacts with 387 drugsVitamin A is an essential nutrient important for vision, skin, immune function, and growth. Most people get enough from a balanced diet, and supplements are mainly useful for correcting a tr...
Read the full Vitamin A monograph → Herb & supplement monographSlippery Elm
Interacts with 2,022 drugsSlippery elm is a traditional herbal remedy made from the inner bark of a North American elm tree, used mainly to soothe sore throats and irritated digestive tracts. Its mucilage can coat an...
Read the full Slippery Elm monograph →Sources & How We Checked
Gastrotene's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 45 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Glutamine 11 references
- Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
- Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
- Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
- Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
- Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
- Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
- Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
- Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
- Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
- Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
- Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed
Vitamin A 31 references
- McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
- Griffiths JK. The vitamin A paradox. J Pediatr 2000;137:604-7.. PubMed
- Hardman JG, Limbird LL, Molinoff PB, eds. Goodman and Gillman's The Pharmacological Basis of Therapeutics, 9th ed. New York, NY: McGraw-Hill, 1996.
- Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
- FDA Talk Paper. Vitamin A and birth defects (T95-56). Food and Drug Administration, U.S. Department of Health and Human Services, Rockville, MD. October 6, 1995.
- Russell RM. The vitamin A spectrum: from deficiency to toxicity. Am J Clin Nutr 2000;71:878-84. PubMed
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
- Feskanich D, Singh V, Willett WC, Colditz GA. Vitamin A intake and hip fractures among postmenopausal women. JAMA 2002;287:47-54. PubMed
- Melhus H, Michaelsson K, Kindmark A, et al. Excessive dietary intake of vitamin A is associated with reduced bone mineral density and increased risk for hip fracture. Ann Intern Med 1998;129:770-8. PubMed
- Michaelsson K, Lithell H, Vessby B, Melhus H. Serum retinol levels and the risk of fracture. N Engl J Med 2003;348:287-94.. PubMed
- Botterweck AA, van den Brandt PA, Goldbohm RA. Vitamins, carotenoids, dietary fiber, and the risk of gastric carcinoma: results from a prospective study after 6.3 years of follow-up. Cancer 2000;88:737-48.. DOI
- Meyskens FL Jr, Graham V, Chvapil M, et al. A phase I trial of beta-all-trans-retinoic acid delivered via a collagen sponge and a cervical cap for mild or moderate intraepithelial cervical neoplasia. J Natl Cancer Inst 1983;71:921-5..
- Hathcock JN, Hattan DG, Jenkins MY, et al. Evaluation of vitamin A toxicity. Am J Clin Nutr 1990;52:183-202.. PubMed
- Walters BN, Gubbay SS. Tetracycline and benign intracranial hypertension: report of five cases. Br Med J 1981;282:19-20.. PubMed
- Pearson MG, Littlewood SM, Bowden AN. Tetracycline and benign intracranial hypertension (letter). Br Med J 1981;282:568-9.. PubMed
- Azais-Braesco V, Pascal G. Vitamin A in pregnancy: requirements and safety limits. Am J Clin Nutr 2000;71:1325S-33S. PubMed
- Smedts HP, de Vries JH, Rakhshandehroo M, et al. High maternal vitamin E intake by diet or supplements is associated with congenital heart defects in the offspring. BJOG 2009;116:416-23. PubMed
- Grotto, I., Mimouni, M., Gdalevich, M., and Mimouni, D. Vitamin A supplementation and childhood morbidity from diarrhea and respiratory infections: a meta-analysis. J Pediatr 2003;142(3):297-304. PubMed
- Mahalanabis, D., Lahiri, M., Paul, D., Gupta, S., Gupta, A., Wahed, M. A., and Khaled, M. A. Randomized, double-blind, placebo-controlled clinical trial of the efficacy of treatment with zinc or vitamin A in infants and young children with severe acute l
- Long, K. Z., Montoya, Y., Hertzmark, E., Santos, J. I., and Rosado, J. L. A double-blind, randomized, clinical trial of the effect of vitamin A and zinc supplementation on diarrheal disease and respiratory tract infections in children in Mexico City, Mex
- Fritz, H., Kennedy, D., Fergusson, D., Fernandes, R., Doucette, S., Cooley, K., Seely, A., Sagar, S., Wong, R., and Seely, D. Vitamin A and retinoid derivatives for lung cancer: a systematic review and meta analysis. PLoS.One. 2011;6(6):e21107. PubMed
- Mayo-Wilson, E., Imdad, A., Herzer, K., Yakoob, M. Y., and Bhutta, Z. A. Vitamin A supplements for preventing mortality, illness, and blindness in children aged under 5: systematic review and meta-analysis. BMJ 2011;343:d5094. PubMed
- Mazumder S, Taneja S, Bhatia K, Yoshida S, Kaur J, Dube B, Toteja GS, Bahl R, Fontaine O, Martines J, Bhandari N; Neovita India Study Group. Efficacy of early neonatal supplementation with vitamin A to reduce mortality in infancy in Haryana, India (Neovit
- Baineni R, Gulati R, Delhi CK. Vitamin A toxicity presenting as bone pain. Arch Dis Child. 2017;102(6):556-8. PubMed
- Darlow BA, Graham PJ, Rojas-Reyes MX. Vitamin A supplementation to prevent mortality and short- and long-term morbidity in very low birth weight infants. Cochrane Database Syst Rev. 2016;(8):CD000501. PubMed
- Haider BA, Sharma R, Bhutta ZA. Neonatal vitamin A supplementation for the prevention of mortality and morbidity in term neonates in low and middle income countries. Cochrane Database Syst Rev. 2017;2:CD006980. PubMed
- Mohammad YM, Raslan IR, Al-Hussain FA. Idiopathic Intracranial Hypertension Induced by Topical Application of Vitamin A. J Neuroophthalmol. 2016;36(4):412-3. PubMed
- Masnadi Shirazi K, Nikniaz Z, Masnadi Shirazi A, Rohani M. Vitamin A supplementation decreases disease activity index in patients with ulcerative colitis: A randomized controlled clinical trial. Complement Ther Med. 2018 Dec;41:215-219. PubMed
- Ding Y, Hu P, Yang Y, et al. Impact of maternal daily oral low-dose vitamin A supplementation on the mother-infant pair: a randomised placebo-controlled trial in China. Nutrients 2021;13(7):2370. PubMed
- Knapik JJ, Hoedebecke SS. Vitamin A and bone fractures: systematic review and meta-analysis. J Spec Oper Med 2021;21(2):100-7. PubMed
- Imdad A, Mayo-Wilson E, Haykal MR, et al. Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age. Cochrane Database Syst Rev 2022;3(3):CD008524. PubMed
Slippery Elm 3 references
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Czarnecki D, Nixon R, Bekhor P, and et al. Delayed prolonged contact urticaria from the elm tree. Contact Dermatitis 1993;28:196-197. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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