Interactions on record — worth a quick check against your medications. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

Ostinol Insta Joint Ingredients & Drug Interactions

by ZyCal Bioceuticals Healthcare

Ostinol Insta Joint label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Ostinol Insta Joint against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Ostinol Insta Joint is a dietary supplement by ZyCal Bioceuticals Healthcare with 3 active ingredients. Its ingredients are commonly taken for osteoarthritis joint pain, rheumatoid arthritis, inflammation.Based on those ingredients, 952 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are ApresFlex. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Ostinol Insta Joint by ZyCal Bioceuticals Healthcare

Ask about any prescription or over-the-counter medication and we check it for interactions with Ostinol Insta Joint by ZyCal Bioceuticals Healthcare — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Ostinol Insta Joint by ZyCal Bioceuticals Healthcare

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Ostinol Insta Joint contains 3 active ingredients. ApresFlex is a standardized Boswellia serrata extract, used for joint and inflammatory support.

The other two actives — Cyplexinol and 3-O-Acetyl-11-Keto Beta-Boswellic Acid — are also plant-derived compounds aimed at joint health. The capsule also contains inactive ingredients (microcrystalline cellulose, stearic acid, magnesium stearate, and gelatin) that serve as fillers and binders.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: bone and cartilage formation and joint support.
  • We looked for evidence on: Osteoarthritis, Rheumatoid arthritis (RA), Knee pain, Joint inflammation, Cartilage degradation, Bone health.
  • The strongest evidence on file: Boswellia Serrata is rated "Possibly Effective" for Osteoarthritis (Natural Medicines).
  • Also on file: Boswellia Serrata is rated "Insufficient Reliable Evidence To Rate" for Rheumatoid arthritis (RA), Knee pain.

Boswellia serrata (ApresFlex) is rated possibly effective for osteoarthritis — meaning there's some clinical support, though the evidence isn't definitive yet. For other uses listed in our data — hay fever, Alzheimer's disease, asthma, and cluster headache — the evidence we hold is insufficient to rate it either way.

We have no effectiveness data on file for the other two active ingredients in this product.

The evidence, ingredient by ingredient Boswellia Serrata

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Boswellia serrata is generally well tolerated short-term when taken by mouth. The most common side effects are mild: abdominal pain, diarrhea, headache, heartburn, itching, and nausea.

Some people also report dizziness or vertigo; in one study, about 11% reported headache. Rarely, large amounts can cause a bezoar (a mass in the stomach).

Do not use this product during pregnancy — there isn't enough safety data. Avoid it while breastfeeding as well, since safety is unknown.

We hold no safety data on the other two active ingredients.

Side effects, ingredient by ingredient Boswellia Serrata

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Boswellia Serrata.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs.
  • For scale: 953 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist if you take any drugs processed by your liver's CYP2D6, CYP2C19, CYP1A2, CYP2C9, or CYP3A4 enzymes (including antidepressants, blood thinners, blood pressure drugs, and many pain relievers), or immunosuppressants. Use the medication checker below to search your exact prescriptions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you take medications that depend on your liver's CYP450 enzymes — especially blood thinners, heart drugs, antidepressants, or pain relievers — talk to your pharmacist before starting Ostinol Insta Joint. Boswellia may slow how your body clears these drugs.

It's generally well tolerated, but side effects like stomach upset and headache do happen. Not for pregnancy or breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Ostinol Insta Joint, straight from the product label.

Brand ZyCal Bioceuticals Healthcare
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Aug 22, 2024
DSLD ID 316024
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Ostinol Insta Joint by ZyCal Bioceuticals Healthcare, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
IngredientAmount% DV
ApresFlex50 mg--
Cyplexinol200 mg--
3-0-Acetyl-11-Keto Beta-Boswellic Acid150 mg--

Other ingredients: Microcrystalline Cellulose, Stearic Acid, Magnesium Stearate, Gelatin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Ostinol InstaJoint contains Cyplexinol Std, a natural protein complex functionally involved in the formation of bone and cartilage tissue. Additionally, Ostinol InstaJoint contains boswellic acid (AKBA), enriched to 65% and AprèsFlex supporting 5 pathways for the ultimate in joint comfort in a few as 5 days.

AprèsFlex Powered by Cyplexinol Standard grade Std Nature's BMP - Complex

Suggested/Recommended/Usage/Directions

Suggested Use: As a supplement take one (1) to two (2) Ostinol InstaJoint capsules two (2) times per day or as needed.

Precautions

Warning: Consult a physician before using if pregnant, nursing or on medication.

Do not use if inner seal is missing or broken.

Keep out of the reach of children.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

New & Improved!

Formulation

Starts working 5 days 5 Pathways supported

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Patent Nos. 9,011,930 and 9,173,905 AprèsFlex is a registered trademark of PLT Health Solutions-Laila Nutraceuticals LLC. ZyCal Bioceuticals Healthcare Co. Innovators in Natural Health

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Ostinol Insta Joint by ZyCal Bioceuticals Healthcare label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Ostinol Insta Joint label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Ostinol Insta Joint by ZyCal Bioceuticals Healthcare

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

ApresFlex

Interacts with
952 drugs
50 mg per serving Form: Boswellia serrata gum resin extract

Boswellia serrata is a tree resin used in traditional medicine, mainly for joint pain and inflammation. Some studies suggest it may help with osteoart...

ApresFlex monograph & interactions

Cyplexinol

200 mg per serving Form: Bone Morphogenetic Proteins

3-0-Acetyl-11-Keto Beta-Boswellic Acid

150 mg per serving Form: Boswellia serrata Concentrate

Other (inactive) ingredients: Microcrystalline Cellulose, Stearic Acid, Magnesium Stearate, Gelatin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Ostinol Insta Joint by ZyCal Bioceuticals Healthcare Drug Interactions

Want to check YOUR meds against Ostinol Insta Joint?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
952Drugs
952 Moderate

Ingredients driving the most interactions

ApresFlex 952

Individual Drug Interactions

The ingredients in Ostinol Insta Joint interact with 952 drugs. Click any drug to see the details.

1 of the 3 ingredients in Ostinol Insta Joint interact with drugs. Each result below shows which ingredient is responsible. ApresFlex

Each ingredient & the kinds of drugs it affects

For each ingredient in Ostinol Insta Joint with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

ApresFlex6 drug types · 952 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP2C19 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2C19 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP2C9 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2C9 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP2D6 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2D6 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP3A4 enzymes. Other in vitro research shows that Boswellia serrata extract inhibits CYP3A4 enzymes at most concentrations, although it may modestly induce enzyme activity at low concentrations.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, Boswellia serrata might alter the effects of immunosuppressive drugs.
Some in vitro research suggests that Boswellia serrata extracts might inhibit mediators of autoimmune disorders such as leukotrienes and reduce production of antibodies and cell-mediated immunity. However, other in vitro research suggests that, when coupled with calcium ions, boswellic acids containing the keto group have immunostimulant properties within specific cell signaling pathways.

Likelihood Possible Evidence D
ApresFlex full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Ostinol Insta Joint, from the product label.

ZyCal Bioceuticals Healthcare

See all ZyCal Bioceuticals Healthcare products
Name
ZyCal Bioceuticals Healthcare Co.
Street Address
5 Executive Drive, Suite A
City
Toms River
State
NJ
ZipCode
08755
Phone Number
888.779.9225
Web Address
RTS.Ostinol.com
Pharmacist Counseling Corner

Ostinol Insta Joint by ZyCal Bioceuticals Healthcare: Common Questions

Does Ostinol Insta Joint by ZyCal Bioceuticals Healthcare interact with any medications?
Yes. Based on its ingredients, Ostinol Insta Joint has a known interaction with 952 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Ostinol Insta Joint contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is Boswellia actually effective for joint pain?
For osteoarthritis, Boswellia serrata is rated possibly effective — there's some clinical evidence supporting it, but the research isn't definitive yet. For other joint or inflammatory conditions, we don't have enough data to say either way. Talk to your pharmacist about whether it's right for you.
What are the most common side effects?
The most frequent ones are mild stomach issues — abdominal pain, diarrhea, heartburn, and nausea — plus headache, itching, and occasionally dizziness. These happened in people taking it short-term. If any of these bother you, mention it to your pharmacist.
Can I take this while pregnant or breastfeeding?
No — there isn't enough safety data during pregnancy, so it's best avoided. Safety during breastfeeding is also unknown, so skip it then too. Talk to your doctor or pharmacist about safer options during these times.
Why does this interact with so many medications?
The Boswellia in this product may slow down your liver's enzyme systems that break down many drugs. When those enzymes work slower, medications can build up in your blood. That's why your exact prescriptions need to be checked — not all drugs are affected the same way.
Is the quality consistent from bottle to bottle?
Not always — Boswellia products vary widely in quality and dose between brands, so potency can differ. That's why it's important to stick with the same brand if you find one that works for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Ostinol Insta Joint is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Ostinol Insta Joint label
Go deeper

The Full Monographs Behind Ostinol Insta Joint’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Boswellia Serrata

Interacts with 952 drugs

Boswellia serrata is a tree resin used in traditional medicine, mainly for joint pain and inflammation. Some studies suggest it may help with osteoarthritis symptoms, but the overall evidenc...

Read the full Boswellia Serrata monograph →
Sources

Sources & How We Checked

Ostinol Insta Joint's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Boswellia Serrata 16 references
  1. Gupta I, Gupta V, Parihar A, et al. Effects of Boswellia serrata gum resin in patients with bronchial asthma: results of a double-blind, placebo-controlled, 6-week clinical study. Eur J Med Res 1998;3:511-4.
  2. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  3. Kimmatkar N, Thawani V, Hingorani L, et al. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial. Phytomedicine 2003;10:3-7. PubMed
  4. Liu JJ, Nilsson A, Oredsson S, et al. Boswellic acids trigger apoptosis via a pathway dependent on caspase-8 activation but independent on Fas/Fas ligand interaction in colon cancer HT-29 cells. Carcinogenesis 2002;23:2087-93. PubMed
  5. Wildfeuer A, Neu IS, Safayhi H, et al. Effects of boswellic acids extracted from a herbal medicine on the biosynthesis of leukotrienes and the course of experimental autoimmune encephalomyelitis. Arzneimittelforschung 1998;48:668-74.
  6. Gupta I, Parihar A, Malhotra P, et al. Effects of gum resin of Boswellia serrata in patients with chronic colitis. Planta Med 2001;67:391-5. PubMed
  7. Sengupta K, Alluri KV, Satish AR, et al. A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin. Arthritis Res Ther 2008;10:R85.
  8. Sengupta K, Krishnaraju AV, Vishal AA, et al. Comparative efficacy and tolerability of 5-Loxin and Aflapin against osteoarthritis of the knee: a double blind, randomized, placebo controlled clinical study. Int J Med Sci 2010;7:366-77.
  9. Ernst E. Frankincense: systematic review. BMJ 2008;337:a2813. PubMed
  10. Kirste S, Treier M, Wehrle SJ, et al. Boswellia serratea extract acts on cerebral edema in patients irradiated for brain tumors: a prospective, randomized, placebo-controlled, double-blind pilot trial. Cancer 2011;117:3788-95.
  11. Frank A, Unger M. Analysis of frankincense from various Boswellia species with inhibitory activity on human drug metabolising cytochrome P450 enzymes using liquid chromatography mass spectrometry after automated on-line extraction. J Chromatogr A 2006;111 PubMed
  12. Altmann A, Poeckel D, Fischer L, et al. Coupling of boswellic acid-incuded Ca2+ mobilisation and MAPK activation to lipid metabolism and peroxide formation in human leucocytes. Br J Pharmacol 2004;141:223-32.
  13. El Fortia, M., Badi, H., Elalem, Kh, Kadiki, O., and Topov, Y. Olibanum bezoar: complication of a traditional popular medicine. East Mediterr.Health J 2006;12(6):927-929.
  14. Meshkat S, Mahmoodi Baram S, Rajaei S, et al. Boswellia serrata extract shows cognitive benefits in a double-blind, randomized, placebo-controlled pilot clinical trial in individuals who suffered traumatic brain injury. Brain Inj 2022;36(4):553-559. PubMed
  15. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
  16. Valente IVB, Garcia D, Abbott A, et al. The anti-proliferative effects of a frankincense extract in a window of opportunity phase ia clinical trial for patients with breast cancer. Breast Cancer Res Treat 2024;204(3):521-530. PubMed

See these in context on the Boswellia Serrata monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team