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Dietary supplement

Grapefruit Pectin 1000 mg Ingredients & Drug Interactions

by The Vitamin Shoppe

Grapefruit Pectin 1000 mg label
See full label image
Tablet Or Pill Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Grapefruit Pectin 1000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Grapefruit Pectin 1000 mg is a dietary supplement by The Vitamin Shoppe with 1 active ingredient. Its ingredients are commonly taken for diarrhea relief, constipation and digestive health, cholesterol support.Based on those ingredients, 23 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Grapefruit Pectin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Grapefruit Pectin 1000 mg by The Vitamin Shoppe

Ask about any prescription or over-the-counter medication and we check it for interactions with Grapefruit Pectin 1000 mg by The Vitamin Shoppe — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Grapefruit Pectin 1000 mg by The Vitamin Shoppe

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: grapefruit pectin at 1000 mg per tablet. Pectin is a soluble fiber naturally found in citrus fruits and other plants.

The tablet also contains several inactive ingredients—microcrystalline cellulose, stearic acid, magnesium stearate, purified water, hydroxypropyl methylcellulose, and polyethylene glycol—which are common binders, lubricants, and capsule materials.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Pectin's overall clinical evidence instead.

Moderate

Some clinical evidence supports Pectin for:

Why this rating?
  • The label markets general wellness (“digestive health”), not a specific health condition, so there is no single claim to grade against clinical-evidence data.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Hypercholesterolemia — rated "Possibly Effective" (Natural Medicines).

Pectin is rated possibly effective for high cholesterol (hypercholesterolemia). For impaired glucose tolerance (prediabetes) and radiation exposure, the evidence isn't established enough to rate — we simply don't have reliable data on whether it works for those uses yet.

The evidence, ingredient by ingredient Pectin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pectin from food and typical supplement doses is generally well tolerated; most people don't report problems. The most common side effects are mild — diarrhea, gas, loose stools, and mild stomach cramps.

Rarely, sensitive individuals may have allergic reactions, including anaphylaxis. If you have a history of oral allergy syndrome or citrus sensitivity, be cautious.

For pregnancy and breastfeeding, pectin from food is considered likely safe, but concentrated supplement safety during pregnancy and lactation hasn't been well studied. Talk with your doctor or pharmacist about whether it's right for you in those situations.

Side effects, ingredient by ingredient Pectin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pectin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: heart-rhythm medications.
  • For scale: 23 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, check with your doctor or pharmacist if you take lovastatin, tetracycline antibiotics (like doxycycline or minocycline), or digoxin. All three may have reduced effectiveness when taken with pectin.

These interactions are Moderate in severity, so timing or dosing adjustments may be needed.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This supplement may help with cholesterol levels, though the evidence is modest. If you take lovastatin, tetracycline antibiotics, or digoxin, you'll want to check with your doctor or pharmacist first — pectin might reduce how well these drugs work.

For most other people without those medications, it's generally well tolerated, though gas and loose stools are possible.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Grapefruit Pectin 1000 mg, straight from the product label.

Brand The Vitamin Shoppe
Barcode (UPC) 766536016013
Net contents 300 Tablet(s)
Market status On market
Date entered into DSLD Apr 25, 2014
DSLD ID 32457
Product type Botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Grapefruit Pectin 1000 mg by The Vitamin Shoppe, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
3 Tablet(s)
UPC/BARCODE
766536016013
IngredientAmount% DV
Grapefruit Pectin1000 mg--

Other ingredients: Microcrystalline Cellulose, Stearic Acid, Magnesium Stearate, purified Water, Hydroxypropyl Methylcellulose, Polyethylene Glycol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Visit www.vitaminshoppe.com or call 1-800-223-1216 for more information and to reorder.

{QRC} learn more at vsquality.net

specialty

a natural source of soluble fiber

digestive health

{tablet} actual size

General

Item No. VS-1601 1054754 AO 1

FDA Statement of Identity

dietary supplement

Formulation

gluten free dairy free soy free nut free

Does not contain: Yeast, Corn, Wheat, Gluten, Sugar, Salt, Soy, Starch, Dairy, Fish, Animal Derivatives, Preservatives, Artificial Colors or Flavors.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

V SUITABLE FOR MOST VEGETARIANS

Suggested/Recommended/Usage/Directions

DIRECTIONS: As a dietary supplement, take one (1) to three (3) tablets daily, preferably with meals, and with an 8 oz. glass of water.

Precautions

WARNING: Consult your healthcare provider prior to use if you are pregnant, nursing, taking any medication or have any medical conditions.

KEEP OUT OF REACH OF CHILDREN.

TAMPER EVIDENT Do not use if outer seal is broken or missing.

Storage

STORE IN A COOL, DRY PLACE.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Grapefruit Pectin 1000 mg by The Vitamin Shoppe label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Grapefruit Pectin 1000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Grapefruit Pectin 1000 mg by The Vitamin Shoppe

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Grapefruit Pectin

Interacts with
23 drugs
1000 mg per serving

Pectin is a natural soluble fiber found in fruits like apples and citrus, and it is widely used in foods and as a fiber supplement. It may modestly he...

Grapefruit Pectin monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Stearic Acid, Magnesium Stearate, Purified Water, Hydroxypropyl Methylcellulose, Polyethylene Glycol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Grapefruit Pectin 1000 mg by The Vitamin Shoppe Drug Interactions

Want to check YOUR meds against Grapefruit Pectin 1000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
23Drugs
23 Moderate

Ingredients driving the most interactions

Grapefruit Pectin 23

Individual Drug Interactions

The ingredients in Grapefruit Pectin 1000 mg interact with 23 drugs. Click any drug to see the details.

1 of the 1 ingredient in Grapefruit Pectin 1000 mg interact with drugs. Each result below shows which ingredient is responsible. Grapefruit Pectin

Each ingredient & the kinds of drugs it affects

For each ingredient in Grapefruit Pectin 1000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Grapefruit Pectin3 drug types · 23 drugs

Digoxin (Lanoxin)

Theoretically, pectin might reduce the absorption of digoxin, potentially decreasing its effectiveness.
A small clinical study shows that taking digoxin with a kaolin-pectin suspension reduces the absorption of digoxin by about 62%. It is unclear if these effects are due to pectin, kaolin, or the combination.

Likelihood Possible Evidence B
Lovastatin (Mevacor)

Theoretically, pectin might reduce the absorption of lovastatin, potentially decreasing its effectiveness.
Case reports suggest that concomitant use of pectin and lovastatin might reduce the cholesterol-lowering effect of lovastatin, possibly due to reduced intestinal absorption of lovastatin.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, pectin might reduce the absorption of tetracycline antibiotics, potentially decreasing their effectiveness.
A small clinical study shows that taking tetracycline with bismuth subsalicylate in a kaolin-pectin suspension reduces the absorption of tetracycline by about 34%. It is unclear if these effects are due to pectin, kaolin, bismuth subsalicylate, or the combination.

Likelihood Possible Evidence B
Grapefruit Pectin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Grapefruit Pectin 1000 mg, from the product label.

The Vitamin Shoppe

See all The Vitamin Shoppe products
Name
Vitamin Shoppe, Inc.
City
Secaucus
State
NJ
ZipCode
07094
Phone Number
1-800-223-1216
Web Address
www.vitaminshoppe.com
Pharmacist Counseling Corner

Grapefruit Pectin 1000 mg by The Vitamin Shoppe: Common Questions

Does Grapefruit Pectin 1000 mg by The Vitamin Shoppe interact with any medications?
Yes. Based on its ingredients, Grapefruit Pectin 1000 mg has a known interaction with 23 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Grapefruit Pectin 1000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this supplement actually lower my cholesterol?
Pectin is rated possibly effective for high cholesterol, which means the evidence supports it may help, but it's not a strong guarantee. It works best alongside diet and exercise. If you're on a cholesterol medication like lovastatin, talk to your doctor before adding this — pectin might interfere with how well your medication works.
What side effects should I watch for?
Most people tolerate it fine. The most common issues are diarrhea, gas, loose stools, and mild stomach cramps. Rarely, people with citrus allergies or oral allergy syndrome may have a more serious allergic reaction, including anaphylaxis. If you have those sensitivities, skip this product.
Can I take this while pregnant or breastfeeding?
Pectin from food is considered likely safe in pregnancy, and the supplement is rated possibly safe, but concentrated doses haven't been well studied in either situation. Talk with your doctor or pharmacist about whether it's right for you during pregnancy or while breastfeeding.
Is this just powdered grapefruit, or is there anything else in it?
It's grapefruit pectin — a fiber from the fruit — at 1000 mg per tablet. The other ingredients are inactive: cellulose, stearic acid, magnesium stearate, water, and some capsule materials. None of those are active ingredients.
Can it help with prediabetes or blood sugar control?
The evidence isn't there yet to say either way — we don't have reliable data on whether pectin works for impaired glucose tolerance or blood sugar issues. If that's a concern of yours, talk to your doctor about what's proven to help.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Grapefruit Pectin 1000 mg is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Grapefruit Pectin 1000 mg label
Go deeper

The Full Monographs Behind Grapefruit Pectin 1000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pectin

Interacts with 23 drugs

Pectin is a natural soluble fiber found in fruits like apples and citrus, and it is widely used in foods and as a fiber supplement. It may modestly help with cholesterol, blood sugar, and di...

Read the full Pectin monograph →
Sources

Sources & How We Checked

Grapefruit Pectin 1000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pectin 11 references
  1. Jaakkola MS, et al. Asthma caused by occupational exposure to pectin. J Allergy Clin Immunol 1997;100:575-6. PubMed
  2. Westphal W, et al. [Exogenous allergic asthma following pectin exposure-a new occupational allergen]. Pneumologie 1990;44(Suppl 1):337-8.
  3. Baldwin JL, et al. Pectin-induced occupational asthma. Chest 1993;104:1936-7. PubMed
  4. Cohen AJ, Forse MS, Tarlo SM. Occupational asthma caused by pectin inhalation during the manufacture of jam. Chest 1993;103:309-11.
  5. Kraut A, et al. Christmas candy maker's asthma. IgG4-mediated pectin allergy. Chest 1992;102:1605-7. PubMed
  6. Richter WO, Jacob BG, Schwandt P. Interaction between fibre and lovastatin. Lancet 1991;338:706.
  7. Albert KS, Ayres JW, DiSanto AR, et al. Influence of kaolin-pectin suspension on digoxin bioavailability. J Pharm Sci 1978;67:1582-6. PubMed
  8. Albert KS, Welch RD, DeSante KA, et al. Decreased tetracycline bioavailability caused by a bismuth subsalicylate antidiarrheal mixture. J Pharm Sci 1979;68:586-8. PubMed
  9. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  10. Federal Register April 17,2003. Anti-Diarrheal Products for over-the-counter human use; final monograph. Available at: http://www.fda.gov/OHRMS/DOCKETS/98fr/03-9380.pdf (Accessed 27 December 2004).
  11. Washio K, Nakamura M, Sato N, et al. Anaphylaxis in a pectin- and cashew nut-allergic child caused by a citrus bath. Allergol Int 2022;71(1):155-157. PubMed

See these in context on the Pectin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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