Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Green Papaya Powder Ingredients & Drug Interactions

by Maui Medicinal

Green Papaya Powder label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Green Papaya Powder against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Green Papaya Powder is a dietary supplement by Maui Medicinal with 1 active ingredient. Its ingredients are commonly taken for digestive upset and indigestion, constipation, wound and skin care (topical).Based on those ingredients, 92 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Green Papaya powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Green Papaya Powder by Maui Medicinal

Ask about any prescription or over-the-counter medication and we check it for interactions with Green Papaya Powder by Maui Medicinal — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Green Papaya Powder by Maui Medicinal

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Green Papaya Powder contains a single active ingredient: green papaya powder. This form is the dried, ground fruit of the unripe papaya plant.

The product has no other inactive ingredients listed.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: herbal nutrient support.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The evidence for green papaya powder isn't established for any of the conditions studied so far. Claims around aging skin, hair loss, colorectal cancer, and diabetes all have insufficient reliable evidence to rate in our data.

That doesn't mean it doesn't work—it means good-quality human studies haven't proven it yet.

The evidence, ingredient by ingredient Papaya

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Ripe papaya fruit eaten as food is generally well tolerated, but this product is a concentrated supplement made from unripe (green) papaya, which is less well studied. The safety data advises caution with supplement amounts.

Nausea and vomiting have been reported with papaya leaf extract in clinical research. Rare allergic reactions are possible, especially in people with latex allergies, since papaya contains similar proteins.

Green papaya and papaya latex should be avoided in pregnancy; ripe fruit is considered likely safe during pregnancy and lactation, but concentrated green papaya supplements are not.

Side effects, ingredient by ingredient Papaya

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Papaya.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 92 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check this product with your doctor or pharmacist if you take blood thinners like warfarin, diabetes medications, amiodarone for heart rhythm, or levothyroxine for thyroid. All carry documented moderate-severity interactions with papaya.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Green Papaya Powder carries moderate interaction risks with blood thinners, diabetes drugs, amiodarone, and thyroid medication—making it a product to clear with your doctor or pharmacist before starting, especially if you take any of those. The evidence for its health claims isn't established yet.

Talk it over with your own healthcare provider to decide if it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Green Papaya Powder, straight from the product label.

Brand Maui Medicinal
Barcode (UPC) 673125716066
Net contents 6 Ounce(s); 170 Gram(s)
Market status On market
Date entered into DSLD Nov 21, 2020
DSLD ID 235660
Product type Botanical
Supplement form Powder
Dietary claims / uses Nutrient, All Other
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Green Papaya Powder by Maui Medicinal, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.25 tsp
Maximum serving Sizes:
0.25 tsp
Servings per container
212
UPC/BARCODE
673125716066
IngredientAmount% DV
Green Papaya powder0.8 Gram(s)--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Fruit Powder

Formulation

Gluten free GMO free

Vegan

Makes 8 fl. oz

Suggested/Recommended/Usage/Directions

Suggested use: As herbal nutrient support, take one serving, once daily, or as directed. Dispense in water, juice, yogurt, smoothie or sprinkle on food.

FDA Statement of Identity

herbal nutrient support

Precautions

Keep out of reach of children

General Statements

800.936.6532

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Green Papaya Powder by Maui Medicinal label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Green Papaya Powder label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Green Papaya Powder by Maui Medicinal

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.25 tsp Dosage formPowder Servings per container212 Amounts shown are per serving.

Green Papaya powder

Interacts with
92 drugs
0.8 Gram(s) per serving

Papaya is a tropical fruit that is nutritious and generally safe to eat as food, and it contains an enzyme called papain used as a digestive aid and m...

Green Papaya powder monograph & interactions
Interaction report

Green Papaya Powder by Maui Medicinal Drug Interactions

Want to check YOUR meds against Green Papaya Powder?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
92Drugs
92 Moderate

Ingredients driving the most interactions

Green Papaya powder 92

Individual Drug Interactions

The ingredients in Green Papaya Powder interact with 92 drugs. Click any drug to see the details.

1 of the 1 ingredient in Green Papaya Powder interact with drugs. Each result below shows which ingredient is responsible. Green Papaya powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Green Papaya Powder with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Green Papaya powder4 drug types · 92 drugs

Amiodarone (Cordarone)

Theoretically, papaya extract may increase the levels and clinical effects of amiodarone.
Animal research in rats shows that a single oral dose of papaya extract, as well as multiple doses of papaya extract daily over 14 days, prior to a single dose of amiodarone delays the time to maximum amiodarone concentration. However, only the 14-day papaya extract regimen increases systemic amiodarone exposure by 60% to 70%. This interaction has not been reported in humans.

Likelihood Probable Evidence D
Antidiabetes Drugs

Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects. It is unclear if other forms of papaya have the same effect.
A small low-quality clinical study in patients with type 2 diabetes who are taking glibenclamide shows that taking a fermented papaya preparation 3 grams daily for 2 months decreases fasting and postprandial blood glucose levels when compared to baseline. Additionally, of the 25 patients in the study, 9 required a reduction in glibenclamide dose.

Likelihood Probable Evidence B
Levothyroxine (Synthroid, Others)

Theoretically, consuming large quantities of papaya fruit can reduce the clinical effects of levothyroxine.
In one case-report, a 37-year-old male with a history of thyroidectomy who was stabilized on levothyroxine for 5 years presented with hypothyroidism after consuming 5-6 papaya fruits daily for 14 days during vacation. In a controlled re-challenge test involving 5-6 papayas daily, the patient remained euthyroid for 7 days, but developed mild hypothyroidism after 14 days. Both times, thyroid levels normalized 40-45 days after discontinuing papaya.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, concomitant use of warfarin with papain-containing papaya extract might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Green Papaya powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Green Papaya Powder, from the product label.

Maui Medicinal

See all Maui Medicinal products
Name
Maui Medicinal
Street Address
62 N Market St.
City
Wailuku
State
HI
ZipCode
96793
Phone Number
808.572.9331
Web Address
Mauimedicinal.com
Pharmacist Counseling Corner

Green Papaya Powder by Maui Medicinal: Common Questions

Does Green Papaya Powder by Maui Medicinal interact with any medications?
Yes. Based on its ingredients, Green Papaya Powder has a known interaction with 92 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Green Papaya Powder contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this product safe during pregnancy?
The safety data is mixed: ripe papaya fruit is considered likely safe in pregnancy, but green papaya and papaya latex should be avoided. Since this is a concentrated green papaya supplement, the safety data advises against it during pregnancy. Talk with your doctor or pharmacist for personalized advice.
What are the side effects?
When eaten as ripe fruit, papaya is generally well tolerated. With this concentrated supplement made from green papaya, nausea and vomiting have been reported in clinical research. Allergic reactions are rare but possible, especially in people with latex allergies.
Does it actually work for anti-aging or diabetes?
The evidence isn't established in our data. Claims around aging skin and diabetes all have insufficient reliable evidence. That means good-quality human studies haven't proven it yet, not that it doesn't work.
Why is this a powder instead of the fruit?
The product facts don't explain the choice. What we do know is that concentrated supplements like this powder are less well studied than eating the ripe fruit itself, so moderation and caution are advised.
Can I take this with my blood pressure or heart medications?
Documented moderate interactions exist with amiodarone (a heart drug). There's also a theoretical risk with blood thinners like warfarin. Check with your doctor or pharmacist about your specific medications before starting this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Green Papaya Powder is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Green Papaya Powder label
Go deeper

The Full Monographs Behind Green Papaya Powder’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Papaya

Interacts with 92 drugs

Papaya is a tropical fruit that is nutritious and generally safe to eat as food, and it contains an enzyme called papain used as a digestive aid and meat tenderizer. Papaya leaf extract is b...

Read the full Papaya monograph →
Sources

Sources & How We Checked

Green Papaya Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Papaya 14 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Blanco C, Diaz-Perales A, Collada C, et al. Class I chitinases as potential panallergens involved in the latex-fruit syndrome. J Allergy Clin Immunol 1999;103(3 Pt 1):507-13. PubMed
  6. Diaz-Perales A, Collada C, Blanco C, et al. Cross-reactions in the latex-fruit syndrome: A relevant role of chitinases but not of complex asparagine-linked glycans. J Allergy Clin Immunol 1999;104:681-7. PubMed
  7. Castillo, R., Delgado, J., Quiralte, J., Blanco, C., and Carrillo, T. Food hypersensitivity among adult patients: epidemiological and clinical aspects. Allergol.Immunopathol.(Madr.) 1996;24(3):93-97.
  8. Oderinde, O., Noronha, C., Oremosu, A., Kusemiju, T., and Okanlawon, O. A. Abortifacient properties of aqueous extract of Carica papaya (Linn) seeds on female Sprague-Dawley rats. Niger.Postgrad.Med J 2002;9(2):95-98. DOI
  9. Danese, C., Esposito, D., D'Alfonso, V., Cirene, M., Ambrosino, M., and Colotto, M. Plasma glucose level decreases as collateral effect of fermented papaya preparation use. Clin Ter. 2006;157(3):195-198.
  10. Iliev, D. and Elsner, P. Generalized drug reaction due to papaya juice in throat lozenges. Dermatology 1997;194(4):364-366. PubMed
  11. Andersen HA, Bernatz PE, Grindlay JH. Perforation of the esophagus after use of a digestant agent: report of case and experimental study. Ann Otol Rhinol Laryngol 1959;68:890-6. PubMed
  12. Deiana L, Marini S, Mariotti S. Ingestion of large amounts of papaya fruit and impaired effectiveness of levothyroxine therapy. Endocr Pract 2012;18(1):98-100. PubMed
  13. Rodrigues M, Alves G, Francisco J, Fortuna A, Falcão A. Herb-drug pharmacokinetic interaction between Carica papaya extract and amiodarone in rats. J Pharm Pharm Sci 2014;17(3):302-15. PubMed
  14. Rajapakse S, de Silva NL, Weeratunga P, Rodrigo C, Sigera C, Fernando SD. Carica papaya extract in dengue: a systematic review and meta-analysis. BMC Complement Altern Med. 2019;19(1):265. PubMed

See these in context on the Papaya monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team