Interactions on record — worth a quick check against your medications. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

Gutsy Berry Burst Ingredients & Drug Interactions

by SimplyBiotix

Powder Category: Other Combinations
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Gutsy Berry Burst is a dietary supplement by SimplyBiotix with 3 active ingredients. Its ingredients are commonly taken for bone health and osteoporosis, correcting vitamin d deficiency, immune system support.Based on those ingredients, 715 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin D. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Gutsy Berry Burst by SimplyBiotix

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 3 active ingredients.
  • “Gutsy Probiotic Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

Gutsy Berry Burst contains 3 active ingredients: vitamin D (which helps your body absorb calcium and supports bone health and immune function), Lactobacillus rhamnosus GG (a probiotic strain), and Bifidobacterium lactis Bl-04 (another probiotic strain). The powder also includes inactive ingredients — erythritol and xylitol (sweeteners), emulsifier, magnesium oxide, strawberry and raspberry flavors, sodium carboxymethylcellulose (a thickener), and silica.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Vitamin D's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: digestive health and immune health.
  • We looked for evidence on: Crohn disease, Irritable bowel syndrome (IBS), gut microbiome, dysbiosis, intestinal permeability.
  • The closest evidence on file: Vitamin D is rated "Insufficient Reliable Evidence To Rate" for Crohn disease (Natural Medicines).
  • Also on file: Vitamin D is rated "Insufficient Reliable Evidence To Rate" for Irritable bowel syndrome (IBS).

Vitamin D in this product is established as effective for treating familial hypophosphatemia, osteomalacia (soft bones from vitamin D deficiency), renal osteodystrophy (bone disease from kidney failure), rickets (childhood bone disease), and hypoparathyroidism (low parathyroid hormone). The effectiveness data we hold does not cover the probiotic strains in this product.

The evidence, ingredient by ingredient Vitamin D

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin D is generally well tolerated at recommended doses. At very high doses over time, it can cause toxicity — symptoms include high blood calcium (hypercalcemia), weak bones, or vision problems.

Vitamin D is often used during pregnancy at recommended amounts, though you should do so only under your doctor's guidance. For breastfeeding, recommended doses are generally considered acceptable; check with your doctor before taking higher amounts.

We do not hold safety data for the probiotic strains.

Side effects, ingredient by ingredient Vitamin D

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Vitamin D.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: heart-rhythm medications.
  • For scale: 716 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Gutsy Berry Burst, double-check with your doctor or pharmacist if you take thiazide diuretics (water pills), calcium channel blockers like verapamil or diltiazem, digoxin, atorvastatin, calcipotriene cream, or aluminum-containing antacids — all have Moderate interactions with the vitamin D in this product. Also mention any medications cleared by CYP3A4 enzymes (a large group that includes many drugs); vitamin D may reduce their effectiveness at Minor severity.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product is designed for people who need vitamin D and probiotics, especially those with bone-health concerns. If you take any heart medication, blood-pressure drug, cholesterol medicine, or psoriasis cream, check with your pharmacist or doctor before starting — vitamin D can interact with several of these.

Stick to recommended doses and mention this product to your doctor or pharmacist, particularly if you're pregnant, breastfeeding, or have kidney disease.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 28, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Gutsy Berry Burst, straight from the product label.

Brand SimplyBiotix
Barcode (UPC) X001BX1THJ
Net contents 30 FastMelt Probiotic Sticks
Market status On market
Date entered into DSLD May 28, 2019
DSLD ID 201999
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Gutsy Berry Burst by SimplyBiotix, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Stick(s)
Maximum serving Sizes:
1 Stick(s)
Servings per container
30
UPC/BARCODE
X001BX1THJ
IngredientAmount% DV
Vitamin D7.5 mg38%
Lactobacillus rhamnosus GG0 NP--
Bifidobacterium lactis Bl-040 NP--
Gutsy Probiotic Blend0 NP--

Other ingredients: Erythritol, Xylitol, Mono- and Diglyceride Emulsifier, Magnesium Oxide, natural Strawberry flavor, natural Raspberry flavor, Sodium Carboxymethylcellulose, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Gutsy, to make life easy! A convenient, portable, tasty probiotic stick. Melts in seconds! For those who hate swallowing supplement pills, are always on the go, have kids, or simply want to take something that tastes good. Go Gutsy - right dose, anytime, anywhere.

The Formula: Designed for guaranteed purity and labeled potency through the end of shelf life.

Product of Denmark

This Product Supports: Digestive Health Immune Health Healthy Digestive Tract

Tasty. Portable. Simple.

Natural Flavors Digestive & Immune Health

Storage

Store sticks in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

This Product is Free From: No Soy No Gluten No GMOs No Peanuts/Tree Nuts No Eggs No Dairy No Sugar

Sugar Free

Seals/Symbols

No Gluten

Formula

On-the-Go Probiotic & Great for Kids

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: Adults and Children over 4 years: Open 1 stick, pour directly on tongue, and swallow. Dissolves rapidly, no water required.

Precautions

Keep out of reach of children.

General

SKU: GUT 02 P11000, 2017 R-1

See for yourself

Gutsy Berry Burst by SimplyBiotix label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Gutsy Berry Burst by SimplyBiotix

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Stick(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin D

Interacts with
715 drugs
7.5 mg per serving Form: Cholecalciferol

Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people,...

Vitamin D monograph & interactions

Gutsy Probiotic Blend

0 NP per serving
  • › Lactobacillus rhamnosus GG
  • › Bifidobacterium lactis Bl-04

Other (inactive) ingredients: Erythritol, Xylitol, Mono- and Diglyceride Emulsifier, Magnesium Oxide, Natural Strawberry flavor, Natural Raspberry flavor, Sodium Carboxymethylcellulose, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Gutsy Berry Burst by SimplyBiotix Drug Interactions

Want to check YOUR meds against Gutsy Berry Burst?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
715Drugs
80 Moderate 635 Minor

Ingredients driving the most interactions

Vitamin D 715

Each ingredient & the kinds of drugs it affects

For each ingredient in Gutsy Berry Burst with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin D8 drug types · 715 drugs

Aluminum

Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
The protein that transports calcium across the intestinal wall can also bind and transport aluminum. This protein is stimulated by vitamin D, which may therefore increase aluminum absorption. This mechanism may contribute to increased aluminum levels and toxicity in people with renal failure, when they take vitamin D and aluminum-containing phosphate binders chronically.

Likelihood Probable Evidence B
Atorvastatin (Lipitor)

Vitamin D might reduce absorption of atorvastatin.
A small, low-quality clinical study shows that taking vitamin D reduces levels of atorvastatin and its active metabolites by up to 55%. However, while atorvastatin levels decreased, total cholesterol, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol levels did not substantially change. Atorvastatin is metabolized in the gut by CYP3A4 enzymes, and researchers theorized that vitamin D might induce CYP3A4, causing reduced levels of atorvastatin. However, this proposed mechanism was not specifically studied.

Likelihood Probable Evidence B
Calcipotriene (Dovonex)

Taking calcipotriene with vitamin D increases the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with vitamin D supplements might increase the risk of hypercalcemia.

Likelihood Probable Evidence D
Digoxin (Lanoxin)

Theoretically, hypercalcemia induced by high-dose vitamin D can increase the risk of arrhythmia from digoxin.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and digoxin concurrently.

Likelihood Possible Evidence D
Diltiazem (Cardizem, Others)

Theoretically, hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of diltiazem for arrhythmia.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically this could also occur with diltiazem. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and diltiazem concurrently.

Likelihood Probable Evidence B
Thiazide Diuretics

Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Thiazide diuretics decrease urinary calcium excretion, which could lead to hypercalcemia if vitamin D supplements are taken concurrently. This has been reported in people being treated with vitamin D for hypoparathyroidism, and also in elderly people with normal parathyroid function who were taking a thiazide, vitamin D, and calcium-containing antacids daily.

Likelihood Probable Evidence D
Verapamil (Calan, Others)

Hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of verapamil for arrhythmia.
Hypercalcemia due to high doses of vitamin D can reduce the effectiveness of verapamil in atrial fibrillation. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and verapamil concurrently.

Likelihood Probable Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
There is some concern that vitamin D might induce CYP3A4. In vitro research suggests that vitamin D induces CYP3A4 transcription. Additionally, observational research has found that increased UV light exposure and serum vitamin D levels are associated with decreased serum levels of CYP3A4 substrates such as tacrolimus and sirolimus, while no association between UV light exposure or vitamin D levels and levels of mycophenolic acid, a non-CYP3A4 substrate, was found. A small, low-quality clinical study shows that taking vitamin D reduces levels of the CYP3A4 substrate atorvastatin and its active metabolites by up to 55%; however, the clinical effects of atorvastatin were not reduced. While researchers theorized that vitamin D might induce CYP3A4, this proposed mechanism was not specifically studied.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Gutsy Berry Burst, from the product label.

SimplyBiotix

See all SimplyBiotix products
Name
Healthy Directions
City
Bethesda
State
MD
ZipCode
20817
Phone Number
(800) 618-1810
Web Address
SimplyBiotix.com
Pharmacist Counseling Corner

Gutsy Berry Burst by SimplyBiotix: Common Questions

Does Gutsy Berry Burst by SimplyBiotix interact with any medications?
Yes. Based on its ingredients, Gutsy Berry Burst has a known interaction with 715 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Gutsy Berry Burst contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is it safe to take this during pregnancy?
Vitamin D is often used during pregnancy at recommended doses, though the data also notes possibly unsafe concerns — you'll want personalized guidance. Talk with your doctor before taking this product if you're pregnant; they know your full health picture and can advise whether this product is right for you.
Can I take this if I'm breastfeeding?
Vitamin D at recommended doses is generally considered acceptable while breastfeeding. That said, check with your doctor before taking higher amounts, and mention this product so your doctor can confirm it fits your situation.
What does vitamin D actually do?
Vitamin D helps your body absorb calcium, which is essential for strong bones and teeth. It also supports immune function and is used to treat bone disorders like rickets, osteomalacia (soft bones), and conditions related to kidney disease or low parathyroid hormone.
What are the probiotics in this powder for?
The product contains two probiotic strains — Lactobacillus rhamnosus GG and Bifidobacterium lactis Bl-04. Probiotics are beneficial bacteria that support gut health, but we don't hold effectiveness data for these specific strains in our records.
Can I take too much vitamin D from this?
Yes. Very high doses of vitamin D over time can cause toxicity, with symptoms like high blood calcium, weak bones, or vision problems. Stick to recommended doses and mention this product to your doctor, especially if you take heart or blood-pressure medications.
Is this a powder I mix into water or food?
Yes, Gutsy Berry Burst is a powder. The exact instructions for how to mix it should be on the package label — follow those directions for best results.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Gutsy Berry Burst label
Sources

Sources & How We Checked

Gutsy Berry Burst's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 26 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin D 26 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Tatro DS, ed. Drug Interactions Facts. Facts and Comparisons Inc., St. Louis, MO. 1999.
  3. Koutkia P, Chen TC, Holick MF. Vitamin D intoxication associated with an over-the-counter supplement. N Engl J Med 2001;345:66-7. PubMed
  4. Bar-Or D, Yoel G. Calcium and calciferol antagonize effect of verapamil in atrial fibrillation. Br Med J 1981;282:1585-6.
  5. Demontis R, Leflon A, Fournier A, et al. 1 alpha(OH) vitamin D3 increases plasma aluminum in hemodialyzed patients taking AI(OH)3. Clin Nephrol 1986;26:146-9.
  6. Crowe M, Wollner L, Griffiths RA. Hypercalcemia following vitamin D and thiazide therapy in the elderly. Practitioner 1984;228:312-3.
  7. Parfitt AM. Thiazide-induced hypercalcemia in vitamin D-treated hypoparathyroidism. Ann Intern Med 1972;77:557-63. PubMed
  8. Thiazide diuretics and the risk of osteoporosis. Pharmacist's Letter/Prescriber's Letter 2003;19(11):191105.
  9. Moon J. The role of vitamin D in toxic metal absorption. J Am Coll Nutr 1994;13:559-64.
  10. Demontis R, Reissi D, Noel C, et al. Indirect clinical evidence that 1alphaOH vitamin D<SUB>3</SUB> increases the intestinal absorption of aluminum. Clin Nephrol 1989;31:123-7.
  11. Adler AJ, Berlyne GM. Duodenal aluminum absorption in the rat: effect of vitamin D. Am J Physiol 1985;249:G209-13. PubMed
  12. Schwartz JB. Effects of vitamin D supplementation in atorvastatin-treated patients: A new drug interaction with an unexpected consequence. Clin Pharmacol Ther 2009;85:198-203. PubMed
  13. Dietary reference intakes for calcium and vitamin D. Institute of Medicine, November 30, 2010. Available at: http://www.iom.edu/~/media/Files/Report%20Files/2010/Dietary-Reference-Intakes-for-Calcium-and-Vitamin-D/Vitamin%20D%20and%20Calcium%202010%20Repo
  14. Cox KA, Dunn MA. Aluminum toxicity alters the regulation of calbindin-D28k protein and mRNA expression in chick intestine. J Nutr 2001;131:2007-13. PubMed
  15. Escribano, J., Balaguer, A., Pagone, F., Feliu, A., and Roque, I. Figuls. Pharmacological interventions for preventing complications in idiopathic hypercalciuria. Cochrane.Database.Syst.Rev. 2009;(1):CD004754. PubMed
  16. Carlton, S., Clopton, D., and Cappuzzo, K. A. Vitamin D deficiency: appropriate replenishment therapies and the effects of vitamin D toxicity. Consult Pharm 2010;25(3):171-177. PubMed
  17. Wang, H., Xia, N., Yang, Y., and Peng, D. Q. Influence of vitamin D supplementation on plasma lipid profiles: a meta-analysis of randomized controlled trials. Lipids Health Dis. 2012;11:42. PubMed
  18. Turner AN, Carr Reese P, Fields KS, Anderson J, Ervin M, Davis JA, Fichorova RN, Roberts MW, Klebanoff MA, Jackson RD. A blinded, randomized controlled trial of high-dose vitamin D supplementation to reduce recurrence of bacterial vaginosis. Am J Obstet G PubMed
  19. Weiner M, Epstein FH. Signs and symptoms of electrolyte disorders. Yale J Biol Med. 1970;43(2):76-109.
  20. Lappe J, Watson P, Travers-Gustafson D, Recker R, Garland C, Gorham E, Baggerly K, McDonnell SL. Effect of Vitamin D and Calcium Supplementation on Cancer Incidence in Older Women: A Randomized Clinical Trial. JAMA. 2017 Mar 28;317(12):1234-1243. PubMed
  21. Roth DE, Leung M, Mesfin E, Qamar H, Watterworth J, Papp E. Vitamin D supplementation during pregnancy: state of the evidence from a systematic review of randomised trials. BMJ. 2017;359:j5237. PubMed
  22. Murai IH, Fernandes AL, Sales LP, et al. Effect of a single high dose of vitamin D3 on hospital length of stay in patients with moderate to severe COVID-19: A randomized clinical trial. JAMA. 2021.
  23. Wang Z, Schuetz EG, Xu Y, Thummel KE. Interplay between vitamin D and the drug metabolizing enzyme CYP3A4. J Steroid Biochem Mol Biol 2013;136:54-8. PubMed
  24. Doyle D, Browne U, Brickley A, Murphy D. Vitamin D-induced hypercalcaemia and acute kidney injury in sarcoidosis. BMJ Case Rep 2023;16(1):e250580. PubMed
  25. Williamson A, Martineau AR, Sheikh A, Jolliffe D, Griffiths CJ. Vitamin D for the management of asthma. Cochrane Database Syst Rev 2023;2(2):CD011511. PubMed
  26. Kinesya E, Santoso D, Gde Arya N, et al. Vitamin D as adjuvant therapy for diabetic foot ulcers: Systematic review and meta-analysis approach. Clin Nutr ESPEN 2023;54:137-143. PubMed

See these in context on the Vitamin D monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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