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Dietary supplement

Gynostemma Extract Ingredients & Drug Interactions

by BulkSupplements.com

Gynostemma Extract label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Gynostemma Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Gynostemma Extract is a dietary supplement by BulkSupplements.com with 1 active ingredient. Its ingredients are commonly taken for fatigue and stress (adaptogen), blood sugar support, high blood pressure.Based on those ingredients, 327 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Gynostemma extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Gynostemma Extract by BulkSupplements.com

Ask about any prescription or over-the-counter medication and we check it for interactions with Gynostemma Extract by BulkSupplements.com — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Gynostemma Extract by BulkSupplements.com

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product is just one active ingredient: gynostemma extract (also called jiaogulan), a plant used in traditional medicine. It comes as a powder you can mix into water or add to food.

There are no other active ingredients, and no inactive fillers are listed.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Jiaogulan's overall clinical evidence instead.

Moderate

Some clinical evidence supports Jiaogulan for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Diabetes — rated "Possibly Effective" (Natural Medicines).

Gynostemma shows possibly effective evidence for diabetes — clinical research suggests it can lower blood glucose levels. For athletic performance, cancer, heart disease, fatty liver disease, and respiratory infections, the evidence we hold is insufficient to rate whether it works.

If you're considering this for one of those other uses, talk it over with your doctor, since the research isn't yet clear.

The evidence, ingredient by ingredient Jiaogulan

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Gynostemma is generally well tolerated when used as a tea or supplement for short periods (up to 4 months in studies), but we don't have solid data on what happens with long-term use. The most common side effects are diarrhea and nausea; some people also report dry mouth, dizziness, or trouble sleeping.

Avoid this product during pregnancy — safety hasn't been established and it may affect the developing baby. Also avoid it while breastfeeding, since there isn't enough safety information.

Side effects, ingredient by ingredient Jiaogulan

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Jiaogulan.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 327 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check your medications with your doctor or pharmacist if you're on blood thinners or antiplatelet drugs (the risk of bleeding is moderate), immune-suppressing medications (gynostemma may reduce their effectiveness), or diabetes drugs (it may increase low-blood-sugar risk).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Gynostemma may be worth considering if you have diabetes and want to explore blood-sugar support, but it's not for everyone. If you take blood thinners, immune-suppressing drugs, or diabetes medications, you need to check with your doctor or pharmacist before starting — it could change how those drugs work or raise your risk of bleeding or low blood sugar.

Pregnant and breastfeeding folks should skip it. Talk it over with your own healthcare provider before you add it to your routine.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Gynostemma Extract, straight from the product label.

Brand BulkSupplements.com
Barcode (UPC) X001N0DS3D
Net contents 250 Gram(s); 8.8 Ounce(s)
Market status On market
Date entered into DSLD Aug 23, 2021
DSLD ID 253816
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Gynostemma Extract by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
500 mg
Maximum serving Sizes:
500 mg
Servings per container
500
UPC/BARCODE
X001N0DS3D
IngredientAmount% DV
Gynostemma extract500 mg--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Clean & pure bulk supplements

New - BulkSupplements Gynostemma Extract Powder (250 Grams)

FDA Disclaimer Statement

Warning: This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Always consult a physician before taking any dietary supplement.

Keep out of reach of children.

Formulation

Free of: Added sugar, soy, dairy, yeast, gluten, additives

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 500 mg (about 1/5 tsp) once daily, or as directed by a physician.

Storage

Store in a dry, cool place

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Gynostemma Extract by BulkSupplements.com label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Gynostemma Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Gynostemma Extract by BulkSupplements.com

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size500 mg Dosage formPowder Servings per container500 Amounts shown are per serving.

Gynostemma extract

Interacts with
327 drugs
500 mg per serving

Jiaogulan is a climbing vine used in traditional Chinese medicine as an adaptogen and for heart, blood sugar, and cholesterol support. Early human and...

Gynostemma extract monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

Gynostemma Extract by BulkSupplements.com Drug Interactions

Want to check YOUR meds against Gynostemma Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
327Drugs
327 Moderate

Ingredients driving the most interactions

Gynostemma extract 327

Individual Drug Interactions

The ingredients in Gynostemma Extract interact with 327 drugs. Click any drug to see the details.

1 of the 1 ingredient in Gynostemma Extract interact with drugs. Each result below shows which ingredient is responsible. Gynostemma extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Gynostemma Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Gynostemma extract3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, jiaogulan might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research suggests that jiaogulan has antiplatelet effects.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, jiaogulan might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Clinical research shows that jiaogulan can lower blood glucose levels.

Likelihood Possible Evidence B
Immunosuppressants

Theoretically, jiaogulan might decrease the effectiveness of immunosuppressive therapy.
Clinical and animal studies suggest that jiaogulan can stimulate the immune system.

Likelihood Possible Evidence D
Gynostemma extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Gynostemma Extract, from the product label.

BulkSupplements.com

See all BulkSupplements.com products
Name
BulkSupplements.com
Street Address
7511 Eastgate Rd
City
Henderson
State
NV
ZipCode
89011
Web Address
BulkSupplements.com
Pharmacist Counseling Corner

Gynostemma Extract by BulkSupplements.com: Common Questions

Does Gynostemma Extract by BulkSupplements.com interact with any medications?
Yes. Based on its ingredients, Gynostemma Extract has a known interaction with 327 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Gynostemma Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
No. The data we have rates gynostemma as possibly unsafe in pregnancy because its safety hasn't been established and it may affect the developing baby. While breastfeeding, there isn't enough safety information, so it's best to avoid it then too. Talk with your doctor or pharmacist before using it if you're planning pregnancy or nursing.
What are the most common side effects?
Diarrhea and nausea are the most common. Some people also report dry mouth, dizziness, or insomnia. Most of these seem mild, but if they bother you or don't go away, let your pharmacist know.
How long is it safe to take this?
Studies show it's well tolerated for up to 4 months. We don't have good data on long-term safety, so if you're thinking about using it beyond that, ask your doctor or pharmacist whether it's right for your situation.
Does gynostemma actually work for diabetes?
Clinical research shows gynostemma can lower blood glucose, which is why it rates as possibly effective for diabetes. That said, it shouldn't replace your diabetes medication — talk with your doctor about how to use it safely alongside your current treatment.
What is gynostemma (jiaogulan)?
It's a plant used in traditional medicine, sometimes called the 'herb of immortality' in Asia. This product is a concentrated extract of that plant, sold as a powder.
Does this product have any fillers or other ingredients?
No — it's just the gynostemma extract powder, with no inactive ingredients listed.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Gynostemma Extract is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Gynostemma Extract label
Go deeper

The Full Monographs Behind Gynostemma Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Jiaogulan

Interacts with 327 drugs

Jiaogulan is a climbing vine used in traditional Chinese medicine as an adaptogen and for heart, blood sugar, and cholesterol support. Early human and animal studies are promising for some u...

Read the full Jiaogulan monograph →
Sources

Sources & How We Checked

Gynostemma Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Jiaogulan 8 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Tan H, Liu ZL, Liu MJ. [Antithrombotic effect of Gynostemma pentaphyllum]. Zhingguo Zhong Xi Yi Jie He Za Zhi 1993;13:278-80.
  3. Chan LY, Chiu PY, Lau TK. An in-vitro study of ginsenoside Rb(1)-induced teratogenicity using a whole rat embryo culture model. Hum Reprod 2003;18:2166-8..
  4. Huyen VT, Phan DV, Thang P, Hoa NK, Ostenson CG. Gynostemma pentaphyllum Tea Improves Insulin Sensitivity in Type 2 Diabetic Patients. J Nutr Metab. 2013;2013:765383. doi: 10.1155/2013/765383.
  5. Li Y, Lin W, Huang J, Xie Y, Ma W. Anti-cancer effects of Gynostemma pentaphyllum (Thunb.) Makino (Jiaogulan). Chin Med. 2016 Sep 27;11:43. Review. PubMed
  6. Huyen VT, Phan DV, Thang P, Ky PT, Hoa NK, Ostenson CG. Antidiabetic effect of add-on Gynostemma pentaphyllum extract therapy with sulfonylureas in type 2 diabetic patients. Evid Based Complement Alternat Med 2012; 452313.
  7. Huyen VT, Phan DV, Thang P, Hoa NK, Ostenson CG. Antidiabetic effect of Gynostemma pentaphyllum tea in randomly assigned type 2 diabetic patients. Horm Metab Res. 2010;42(5):353-7.
  8. Rao A, Clayton P, Briskey D. The effect of an orally-dosed Gynostemma pentaphyllum extract (ActivAMP®) on body composition in overweight, adult men and women: a double-blind, randomised, placebo-controlled study. J Hum Nutr Diet 2021.

See these in context on the Jiaogulan monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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