Interactions on record — worth a quick check against your medications. Based on 3 of 5 ingredients. Check your meds →
Dietary supplement

Gypsy Cold Care Ingredients & Drug Interactions

by Traditional Medicinals

Other (e.g. Tea Bag) Category: Botanical
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Gypsy Cold Care is a dietary supplement by Traditional Medicinals with 5 active ingredients. Its ingredients are commonly taken for irritable bowel syndrome (ibs), indigestion and gas, nausea.Based on those ingredients, 1,330 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic Peppermint, Organic yarrow flower. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Gypsy Cold Care by Traditional Medicinals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 4 of its 10 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (560 mg) without saying how much of each component you get.
  • “All Herbal Ingredients” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Gypsy Cold Care contains 10 ingredients, including a proprietary blend of organic herbs and an all-herbal blend. The active botanical ingredients are organic cinnamon, organic peppermint, organic ginger rhizome, organic elder flower, organic yarrow flower, organic hyssop herb, organic rose hip, safflower petal, organic clove flower bud, and organic licorice root dry aqueous extract.

There are no inactive other ingredients listed.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: support during cold and cough.
  • We looked for evidence on: Common cold, Cough, sore throat, congestion, fever.
  • The closest evidence on file: Clove is rated "Insufficient Reliable Evidence To Rate" for Cough (Natural Medicines).
  • Also on file: Hyssop is rated "Insufficient Reliable Evidence To Rate" for Cough, Sore throat.
  • Also on file: Peppermint is rated "Insufficient Reliable Evidence To Rate" for Common cold.

The evidence for most of these ingredients in treating colds is limited. Peppermint is likely effective for irritable bowel syndrome and possibly effective for indigestion and nausea.

Ginger is possibly effective for pregnancy-related nausea, period pain, and osteoarthritis, though it's possibly ineffective for muscle soreness. Cinnamon, yarrow, hyssop, rose hip, safflower, clove, and licorice have insufficient evidence or no established data to rate their use for cold symptoms.

Overall, the research does not firmly establish that this blend helps with the common cold.

The evidence, ingredient by ingredient Peppermint Yarrow Hyssop

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 7 of the 8 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 8 of 8.
  • General safety write-ups exist for 8 of 8.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

The ingredients are generally well tolerated at the tea and food-amount levels typical in this product. Cinnamon in large doses raises liver concerns because it contains coumarin, which can cause liver damage over time; this product's dose is unclear from the label.

Peppermint is well tolerated orally, though concentrated oil can cause abdominal pain, heartburn, nausea, or burning in the mouth and throat. Ginger doses above 5 grams daily increase the risk of side effects, and the most common are abdominal discomfort, burping, diarrhea, and heartburn.

Yarrow may cause allergic skin reactions and has traditionally been avoided in pregnancy due to concerns it may affect the uterus—the safety data advise against it in pregnancy. Hyssop's essential oil can be toxic and cause seizures, and the herb itself is traditionally avoided in pregnancy and while breastfeeding.

Safflower flower has been traditionally used to bring on menstruation and should be avoided in medicinal amounts during pregnancy. Licorice's active component glycyrrhizin can raise blood pressure, cause fluid retention, and lower potassium; the safety data advise against licorice in pregnancy and breastfeeding.

Clove is safe as a food spice but toxic in concentrated doses, especially in children.

Side effects, ingredient by ingredient Peppermint Yarrow Hyssop

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 7 of the 8 matched ingredients can interact with medications — Safflower, Yarrow, Clove, Peppermint, Licorice, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; heart-rhythm medications; lithium.
  • For scale: 1,331 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before using this product if you take blood thinners (warfarin, other anticoagulants, or antiplatelet drugs), diabetes medications, heart drugs (especially digoxin, nifedipine, or any calcium channel blocker), loop diuretics, lithium, or any medication metabolized by liver enzymes. Several of these interactions are moderate in severity and could raise blood levels of your medication or reduce its effectiveness.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a multi-herb tea blend with modest evidence for cold relief and a significant interaction profile, especially with blood thinners, diabetes drugs, and heart medications. If you take any prescriptions—particularly for blood clotting, blood sugar, heart function, or lithium—talk with your own doctor or pharmacist before using this product.

Peppermint and ginger content may help some cold symptoms, but the overall benefit for colds is not well established.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 8 of 10 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Gypsy Cold Care, straight from the product label.

Brand Traditional Medicinals
Net contents 16 Wrapped Tea Bag(s); 0.99 oz.; 28 g
Market status On market
Date entered into DSLD Feb 25, 2013
DSLD ID 18723
Product type Botanical
Supplement form Other (e.g. Tea Bag)
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Gypsy Cold Care by Traditional Medicinals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Cup Brewed Tea
Maximum serving Sizes:
1 Cup Brewed Tea
Servings per container
16
IngredientAmount% DV
Calories2 {Calories}--
Proprietary Blend560 mg--
organic Cinnamon0 NP--
All Herbal Ingredients0 NP--
organic Peppermint350 mg--
Organic ginger rhizome0 NP--
Organic elder flower350 mg--
Organic yarrow flower350 mg--
Organic hyssop herb140 mg--
Organic rose hip0 NP--
Safflower petal0 NP--
Organic clove flower bud0 NP--
Organic licorice root dry aqueous extract0 NP--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Gypsy Cold Care(R) Gypsy Cold Care(R) is a complex and aromatic blend of herbal tastes–pungent, slightly bitter, minty and sweet.

General Statements

You Deserve Only The Best We use pharmacopoeial grade herbs in this tea. That means that these herbs meet the highest standards set for quality, purity, strength, identity and composition. While it is accepted to use food grade herbs in herbal tea products, we choose instead to use the higher pharmacopoeial grade for its enhanced quality. What is a Pharmacopoeia Many countries in the world, including the United States, have a Pharmacopoeia. A country’s pharmacopoeia is an official guide of quality standards for ingredients used in dietary supplements, as well as over-the-counter and prescription medications.

Tea for Kids? See Inside Flap

Pharmacopoeial Quality Herb, Tested for Strength & Purity

Herbal Tea

** Quality standards. See definitions inside.

Formula

Made with Organic Elder

Formulation

Caffeine Free

Certified by the California Certified Organic Farmers (CCOF). 92% organic ingredients.

FDA Statement of Identity

HERBAL DIETARY SUPPLEMENT

Seals/Symbols

K

Certified Organic Farmers California CCOF

Precautions

Cautions: Consult a health care provider prior to use if you have gallstones, gallbladder or bile-duct obstruction, hiatal hernia, or acid reflux.

Contraindications: Do not use if you have known allergies to plants of the Asteraceae (daisy) family such as blessed thistle, calendula, chamomile, echinacea, safflower or yarrow.

Do not use if pregnant or breast-feeding unless directed otherwise by your doctor.

See for yourself

Gypsy Cold Care by Traditional Medicinals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Gypsy Cold Care by Traditional Medicinals

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Cup Brewed Tea Dosage formOther (e.g. Tea Bag) Servings per container16 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

All Herbal Ingredients

0 NP per serving
Interaction report

Gypsy Cold Care by Traditional Medicinals Drug Interactions

Want to check YOUR meds against Gypsy Cold Care?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
1,330Drugs
1,329 Moderate 1 Minor

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Gypsy Cold Care with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

organic Peppermint5 drug types · 796 drugs

Cyclosporine (Neoral, Sandimmune)

Theoretically, peppermint oil might increase the levels and adverse effects of cyclosporine.
In animal research, peppermint oil inhibits cyclosporine metabolism and increases cyclosporine levels. Inhibition of cytochrome P450 3A4 (CYP3A4) may be partially responsible for this interaction. An interaction between peppermint oil and cyclosporine has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, peppermint might increase the levels of CYP2C19 substrates.
In vitro research shows that peppermint oil inhibits CYP2C19. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, peppermint might increase the levels of CYP2C9 substrates.
In vitro research shows that peppermint oil inhibits CYP2C9. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Clinical research in healthy volunteers shows that a single dose of peppermint oil 600 mg inhibits CYP3A4 enzymes and increases the AUC of felodipine, a CYP3A4 substrate. However, in vitro research suggests that peppermint oil only inhibits CYP3A4 at very high concentrations.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, peppermint might increase the levels of CYP1A2 substrates.
In vitro and animal research shows that peppermint oil and peppermint leaf inhibit CYP1A2. However, in clinical research, peppermint tea did not significantly affect the metabolism of caffeine, a CYP1A2 substrate. It is possible that the 6-day duration of treatment may have been too short to identify a difference.

Likelihood Possible Evidence B

Organic yarrow flower1 drug type · 1 drug

Lithium

Theoretically, taking yarrow with lithium might increase the levels and adverse effects of lithium.
Animal research shows that yarrow has diuretic activity. Theoretically, due to these potential diuretic effects, yarrow might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
The maker

Brand information

Manufacturer and brand details for Gypsy Cold Care, from the product label.

Pharmacist Counseling Corner

Gypsy Cold Care by Traditional Medicinals: Common Questions

Does Gypsy Cold Care by Traditional Medicinals interact with any medications?
Yes. Based on its ingredients, Gypsy Cold Care has a known interaction with 1,330 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Gypsy Cold Care contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this tea really help a cold?
The evidence isn't strong. Peppermint and ginger—both in this blend—have some research backing for nausea and stomach upset, but cinnamon, yarrow, hyssop, and the other herbs lack solid proof they treat cold symptoms. This blend may feel soothing, but it's not proven to shorten a cold or ease most cold symptoms.
Is peppermint safe to drink every day?
Peppermint tea in normal amounts is generally well tolerated. However, concentrated peppermint oil can cause abdominal pain, heartburn, and nausea. Stick to tea form and moderate amounts, and if you develop stomach upset or burning, cut back or stop.
I'm pregnant—is this tea safe?
Several ingredients raise concerns in pregnancy. Yarrow is traditionally avoided because it may affect the uterus. Hyssop is also traditionally avoided. Licorice's safety data advise against it in pregnancy due to potential harmful effects from its active compound. Cinnamon and ginger are likely safe in food amounts, but licorice extract in medicinal doses is not. Talk with your doctor or pharmacist before taking this blend while pregnant.
Can I take this with warfarin or other blood thinners?
No, not without checking first with your doctor. Licorice in this blend may reduce warfarin's effectiveness, raising your clotting risk. Ginger and safflower may increase bleeding risk. Your doctor needs to assess the specific risks for you.
What's in the 'proprietary blend' and 'all herbal blend'?
The product lists 10 ingredients total: cinnamon, peppermint, ginger, elder flower, yarrow, hyssop, rose hip, safflower, clove, and licorice. Some are grouped under 'proprietary blend' or 'all herbal blend' on the label, but they're all named here in the ingredient list. The exact amount of each isn't disclosed separately.
Will this interfere with my diabetes medication?
Possibly. Cinnamon, ginger, safflower, and clove all have evidence suggesting they may lower blood sugar. If you take insulin or oral diabetes drugs, combining them with this tea could raise your low-blood-sugar (hypoglycemia) risk. Talk to your doctor before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Gypsy Cold Care is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Gypsy Cold Care label
Sources

Sources & How We Checked

Gypsy Cold Care's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 266 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Cassia Cinnamon 20 references
  1. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  2. Khan A, Safdar M, Ali Khan M, et al. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care 2003;26:3215-8. PubMed
  3. De Benito V, Alzaga R. Occupational allergic contact dermatitis from cassia (Chinese cinnamon) as a flavouring agent in coffee. Contact Dermatitis 1999;40:165. PubMed
  4. Drake TE, Maibach HI. Allergic contact dermatitis and stomatitis caused by a cinnamic aldehyde-flavored toothpaste. Arch Dermatol 1976;112:202-3.
  5. Press release. Cinnamon capsules to reduce blood sugar are medicinal products! Efficacy has not been scientifically proven - some products contain high levels of coumarin. Federal Institute of Risk Assessment (BfM), Germany, November 11, 2006. Available a
  6. Felter SP, Vassallo JD, Carlton BD, Daston GP. A safety assessment of coumarin taking into account species-specificity of toxicokinetics. Food Chem Toxicol 2006;44:462-75. PubMed
  7. Crawford P. Effectiveness of cinnamon for lowering hemoglobin A1C in patients with type 2 diabetes: a randomized, controlled trial. J Am Board Fam Med 2009;22:507-12. PubMed
  8. Akilen, R., Tsiami, A., Devendra, D., and Robinson, N. Glycated haemoglobin and blood pressure-lowering effect of cinnamon in multi-ethnic Type 2 diabetic patients in the UK: a randomized, placebo-controlled, double-blind clinical trial. Diabet.Med. 2010; PubMed
  9. Lu T, Sheng H Wu J Cheng Y Zhu J Chen Y. Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes. Nutr Res. 2012;32(6):408-412. PubMed
  10. Choi, J., Lee, K. T., Ka, H., Jung, W. T., Jung, H. J., and Park, H. J. Constituents of the essential oil of the Cinnamomum cassia stem bark and the biological properties. Arch Pharm Res 2001;24(5):418-423.
  11. Altschuler JA, Casella SJ, MacKenzie TA, Curtis KM. The effect of cinnamon on A1C among adolescents with type 1 diabetes. Diabetes Care 2007;30(4):813-6. PubMed
  12. Stoecker BR, Zhan Z, Luo R, et al. Cinnamon extract lowers blood glucose in hyperglycemic subjects. FASEB J. 2010;22:722.1 (Abstract only). DOI
  13. Admani S, Hill H, Jacob SE. Cinnamon Sugar Scrub Dermatitis: "Natural" Is Not Always Best. Pediatr Dermatol. 2017;34(1):e42-e43. PubMed
  14. Isaac-Renton M, Li MK, Parsons LM. Cinnamon spice and everything not nice: many features of intraoral allergy to cinnamic aldehyde. Dermatitis. 2015;26(3):116-21. PubMed
  15. Vandersall A, Katta R. Eyelid dermatitis as a manifestation of systemic contact dermatitis to cinnamon. Dermatitis. 2015 Jul-Aug;26(4):189. PubMed
  16. Wickenberg J, Lindstedt S, Nilsson J, Hlebowicz J. Cassia cinnamon does not change the insulin sensitivity or the liver enzymes in subjects with impaired glucose tolerance. Nutr J 2014 Sep 24;13:96. PubMed
  17. Brancheau D, Patel B, Zughaib M. Do cinnamon supplements cause acute hepatitis? Am J Case Rep 2015;16:250-4. PubMed
  18. Shekarchizadeh-Esfahani P, Heydarpour F, Izadi F, Jalili C. The effect of cinnamon supplementation on liver enzymes in adults: A systematic review and meta-analysis of randomized controlled trials. Complement Ther Med 2021;58:102699. PubMed
  19. Bernaola J, Valverde-Monge M, Otal-Buesa M, Cullen D, Heras-Mendaza F. Cinnamon allergic contact cheilitis. Contact Dermatitis 2023;88(5):418-419. PubMed
  20. Patel K, Howard M, Tate B. Cheilitis caused by allergic contact dermatitis to cinnamon in chai tea: A case report. Contact Dermatitis 2023;88(3):239-240. PubMed

See these in context on the Cassia Cinnamon monograph →

Peppermint 41 references
  1. Liu JH, Chen GH, Yeh HZ, et al. Enteric-coated peppermint-oil capsules in the treatment of irritable bowel syndrome: a prospective, randomized trial. J Gastroenterol 1997;32:765-8. PubMed
  2. Pittler MH, Ernst E. Peppermint oil for irritable bowel syndrome: a critical review and metaanalysis. Am J Gastroenterol 1998;93:1131-5. PubMed
  3. Kline RM, Kline JJ, Di Palma J, Barbero GJ. Enteric-coated, pH-dependent peppermint oil capsules for the treatment of irritable bowel syndrome in children. J Pediatr 2001;138:125-8. PubMed
  4. Madisch A, Heydenreich CJ, Wieland V, et al. Treatment of functional dyspepsia with a fixed peppermint oil and caraway oil combination preparation as compared to cisapride. A multicenter, reference-controlled, double-blind equivalence study. Arzneimittel
  5. May B, Kuntz HD, Kieser M, Kohler S. Efficacy of a fixed peppermint oil/caraway oil combination in non-ulcer dyspepsia. Arzneimittelforschung 1996;46:1149-53.
  6. Micklefield GH, Greving I, May B. Effects of peppermint oil and caraway oil on gastroduodenal motility. Phytother Res 2000;14:20-3. DOI
  7. Morton CA, Garioch J, Todd P, et al. Contact sensitivity to menthol and peppermint in patients with intra-oral symptoms. Contact Dermatitis 1995;32:281-4. PubMed
  8. May B, Kohler S, Schneider B. Efficacy and tolerability of a fixed combination of peppermint oil and caraway oil in patients suffering from functional dyspepsia. Aliment Pharmacol Ther 2000;14:1671-7. PubMed
  9. Nash P, Gould SR, Bernardo DE. Peppermint oil does not relieve the pain of irritable bowel syndrome. Br J Clin Pract 1986;40:292-3. DOI
  10. Rees WD, Evans BK, Rhodes J. Treating irritable bowel syndrome with peppermint oil. Br Med J 1979;2:835-6. PubMed
  11. Davies SJ, Harding LM, Baranowski AP. A novel treatment of postherpetic neuralgia using peppermint oil. Clin J Pain 2002;18:200-2. PubMed
  12. Weston CF. Anal burning and peppermint oil. Postgrad Med J 1987;63:717. PubMed
  13. Dresser GK, Wacher V, Wong S, et al. Evaluation of peppermint oil and ascorbyl palmitate as inhibitors of cytochrome P4503A4 activity in vitro and in vivo. Clin Pharmacol Ther 2002;72:247-55. PubMed
  14. Wacher VJ, Wong S, Wong HT. Peppermint oil enhances cyclosporine oral bioavailability in rats: comparison with D-alpha-tocopheryl poly(ethylene glycol 1000) succinate (TPGS) and ketoconazole. J Pharm Sci 2002;91:77-90.
  15. Lawson MJ, Knight RE, Tran K, et al. Failure of enteric-coated peppermint oil in the irritable bowel syndrome: a randomized double-blind crossover study. J Gastroenterol Hepatol 1988;3:235-8. DOI
  16. Unger M, Frank A. Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. Rapid Commun Mass Spectrom 2004;1 PubMed
  17. Maliakal PP, Wanwimolruk S. Effect of herbal teas on hepatic drug metabolizing enzymes in rats. J Pharm Pharmacol 2001;53:1323-9. PubMed
  18. Rogers SN, Pahor AL. A form of stomatitis induced by excessive peppermint consumption. Dent Update 1995;22:36-7.
  19. Cappello G, Spezzaferro M, Grossi L, et al. Peppermint oil (Mintoil) in the treatment of irritable bowel syndrome: a prospective double blind placebo-controlled randomized trial. Dig Liver Dis 2007;39:530-6. PubMed
  20. Moghadam BK, Gier R, and Thurlow T. Extensive oral mucosal ulcerations caused by misuse of a commercial mouthwash. Cutis 1999;64:131-134.
  21. Andersen, K. E. Contact allergy to toothpaste flavors. Contact Dermatitis 1978;4(4):195-198. PubMed
  22. Barnard, D. R. Repellency of essential oils to mosquitoes (Diptera: Culicidae). J Med Entomol. 1999;36(5):625-629. PubMed
  23. Tamir, S., Davidovich, Z., Attal, P., and Eliashar, R. Peppermint oil chemical burn. Otolaryngol.Head Neck Surg. 2005;133(5):801-802. PubMed
  24. Kalavala, M., Hughes, T. M., Goodwin, R. G., Anstey, A. V., and Stone, N. M. Allergic contact dermatitis to peppermint foot spray. Contact Dermatitis 2007;57(1):57-58. PubMed
  25. Vermaat, H., van Meurs, T., Rustemeyer, T., Bruynzeel, D. P., and Kirtschig, G. Vulval allergic contact dermatitis due to peppermint oil in herbal tea. Contact Dermatitis 2008;58(6):364-365. PubMed
  26. Merat, S., Khalili, S., Mostajabi, P., Ghorbani, A., Ansari, R., and Malekzadeh, R. The effect of enteric-coated, delayed-release peppermint oil on irritable bowel syndrome. Dig.Dis.Sci. 2010;55(5):1385-1390. PubMed
  27. Tran, A., Pratt, M., and DeKoven, J. Acute allergic contact dermatitis of the lips from peppermint oil in a lip balm. Dermatitis 2010;21(2):111-115. DOI
  28. Hitz, Lindenmuller, I and Lambrecht, J. T. Oral care. Curr Probl.Dermatol 2011;40:107-115.
  29. Shavakhi, A., Ardestani, S. K., Taki, M., Goli, M., and Keshteli, A. H. Premedication with peppermint oil capsules in colonoscopy: a double blind placebo-controlled randomized trial study. Acta Gastroenterol Belg 2012;75(3):349-353.
  30. Lech, Y., Olesen, K. M., Hey, H., Rask-Pedersen, E., Vilien, M., and Ostergaard, O. [Treatment of irritable bowel syndrome with peppermint oil. A double- blind study with a placebo]. Ugeskr.Laeger 10-3-1988;150(40):2388-2389.
  31. Parys, B. T. Chemical burns resulting from contact with peppermint oil mar: a case report. Burns Incl.Therm.Inj. 1983;9(5):374-375. PubMed
  32. Bayat R, Borici-Mazi R. A case of anaphylaxis to peppermint. Allergy Asthma Clin Immunol. 2014;10(1):6. PubMed
  33. Rich G, Shah A, Koloski N, et al. A randomized placebo-controlled trial on the effects of Menthacarin, a proprietary peppermint- and caraway-oil-preparation, on symptoms and quality of life in patients with functional dyspepsia. Neurogastroenterol Motil 2 PubMed
  34. Douros A, Bronder E, Andersohn F, et al. Herb-Induced Liver Injury in the Berlin Case-Control Surveillance Study. Int J Mol Sci 2016;17(1). PubMed
  35. Begas E, Tsioutsiouliti A, Kouvaras E, et al. Effects of peppermint tea consumption on the activities of CYP1A2, CYP2A6, Xanthine Oxidase, N-acetyltranferase-2 and UDP-glucuronosyltransferases-1A1/1A6 in healthy volunteers. Food Chem Toxicol 2017;100:80-9 PubMed
  36. Cash BD, Epstein MS, Shah SM. A Novel Delivery System of Peppermint Oil Is an Effective Therapy for Irritable Bowel Syndrome Symptoms. Dig Dis Sci 2016;61(2):560-71. PubMed
  37. Elsaie LT, El Mohsen AM, Ibrahim IM, Mohey-Eddin MH, Elsaie ML. Effectiveness of topical peppermint oil on symptomatic treatment of chronic pruritus. Clin Cosmet Investig Dermatol 2016;9:333-8. PubMed
  38. Wu J, Xu R, Zhan R, et al. Effective symptomatic treatment for severe and intractable pruritus associated with severe burn-induced hypertrophic scars: A prospective, multicenter, controlled trial. Burns 2016;42(5):1059-66. PubMed
  39. Weerts ZZRM, Masclee AAM, Witteman BJM, et al. Efficacy and safety of peppermint oil in a randomized, double-blind trial of patients with irritable bowel syndrome. Gastroenterology. 2020;158(1):123-136. PubMed
  40. Nee J, Ballou S, Kelley JM, et al. Peppermint Oil Treatment for Irritable Bowel Syndrome: A Randomized Placebo-Controlled Trial. Am J Gastroenterol 2021;116(11):2279-2285. PubMed
  41. Ingrosso MR, Ianiro G, Nee J, et al. Systematic review and meta-analysis: efficacy of peppermint oil in irritable bowel syndrome. Aliment Pharmacol Ther 2022;56(6):932-41. PubMed

See these in context on the Peppermint monograph →

Ginger 64 references
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Yarrow 8 references
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Hyssop 1 reference
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Safflower 14 references
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Clove 26 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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