Interactions on record — worth a quick check against your medications. Based on 4 of 6 ingredients. Check your meds →
Dietary supplement

Highest Lignan Content Flax Oil Ingredients & Drug Interactions

by Barlean's Organic Oils

Highest Lignan Content Flax Oil label
See full label image
Liquid Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Highest Lignan Content Flax Oil against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Highest Lignan Content Flax Oil is a dietary supplement by Barlean's Organic Oils with 6 active ingredients. Its ingredients are commonly taken for brain and cognitive health, eye and vision health, fetal and infant development.Based on those ingredients, 2,134 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Dietary Fiber, Lignans, Omega-3 Fatty Acids. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Highest Lignan Content Flax Oil by Barlean's Organic Oils

Ask about any prescription or over-the-counter medication and we check it for interactions with Highest Lignan Content Flax Oil by Barlean's Organic Oils — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Highest Lignan Content Flax Oil by Barlean's Organic Oils

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • “Monounsaturated Fat” is listed as a grouped ingredient — the label gives one combined amount (2 g) without saying how much of each component you get.
  • “Polyunsaturated Fat” is listed as a grouped ingredient — the label gives one combined amount (8 g) without saying how much of each component you get.

This product is a liquid flax oil containing 5 active ingredients: omega-3 fatty acids, omega-6 fatty acids, omega-9 fatty acids, lignans (plant compounds from flaxseed), and flaxseed particulate. The omega-3s and lignans are the main active components you're getting here — lignans are concentrated in the seed itself, so the particulate matter adds to the lignan content that makes this product distinctive.

The oil base is 100% unrefined, unfiltered organic flaxseed oil, with no other inactive ingredients added.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Constipation — rated "Effective" (Black Psyllium) (Natural Medicines).
  • On file: Coronary heart disease (CHD) — rated "Likely Effective" (Black Psyllium) (Natural Medicines).
  • On file: Hypercholesterolemia — rated "Possibly Effective" (Flaxseed) (Natural Medicines).
  • On file: Systemic lupus erythematosus (SLE) nephritis — rated "Possibly Effective" (Flaxseed) (Natural Medicines).
  • On file: Obesity — rated "Possibly Effective" (Flaxseed) (Natural Medicines).

Evidence for the omega-3 content shows it's possibly effective for raised cholesterol (hyperlipidemia) and preterm labor prevention, but possibly ineffective for cognitive function and ADHD. The flaxseed lignans show possibly effective evidence for high cholesterol, diabetes, breast pain (mastalgia), high blood pressure (hypertension), and constipation.

Omega-6 fatty acids, by contrast, show only possibly ineffective ratings across the conditions studied, including high cholesterol and cardiovascular disease.

The evidence, ingredient by ingredient Docosahexaenoic Acid (dha) Black Psyllium Omega-6 Fatty Acids Flaxseed

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Omega-3 fatty acids from fish oil (which this product contains) are generally well tolerated at typical doses up to 3 grams daily. Common side effects are belching, fishy aftertaste, loose stools, and nausea.

Flaxseed itself is usually well tolerated as a food, but supplement doses can cause bloating, diarrhea, and gas — starting small and drinking plenty of water helps. Serious allergic reactions to flaxseed are rare.

Because flaxseed has hormone-like effects, supplement doses should be used only under your doctor's guidance.

Side effects, ingredient by ingredient Docosahexaenoic Acid (dha) Black Psyllium Omega-6 Fatty Acids Flaxseed

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 4 matched ingredients can interact with medications — Black Psyllium, Docosahexaenoic Acid (dha), Flaxseed.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; heart-rhythm medications; lithium.
  • For scale: 2,135 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this product if you're on blood thinners or antiplatelet drugs (such as warfarin or aspirin) — this product may increase bleeding risk. Also double-check if you take blood pressure medications, diabetes drugs, estrogen-based hormones or birth control, or antibiotics.

All of these can interact with the omega-3s and flaxseed lignans in this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This flax oil is a solid choice if you're looking for omega-3s and lignans and don't take blood thinners, blood pressure drugs, diabetes medications, estrogen-based hormones, or antibiotics — or if you do, you've cleared it with your doctor. The most important thing to do before you start is check your exact medications against the tool on this page, then confirm with your own doctor or pharmacist that it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 26, 2011.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Highest Lignan Content Flax Oil, straight from the product label.

Brand Barlean's Organic Oils
Net contents 16 fl. Oz.; 473 mL
Market status On market
Date entered into DSLD Oct 26, 2011
DSLD ID 756
Product type Other Combinations
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Highest Lignan Content Flax Oil by Barlean's Organic Oils, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tbsp
Maximum serving Sizes:
1 Tbsp
Servings per container
31
IngredientAmount% DV
Calories110 {Calories}--
Calories from Fat110 {Calories}--
Omega-3 Fatty Acids6200 mg--
Dietary Fiber1 g4%
Saturated Fat1 g5%
Total Fat11 g19%
Monounsaturated Fat2 g--
Polyunsaturated Fat8 g--
Omega-6 Fatty Acids1810 mg--
Omega-9 Fatty Acids2040 mg--
Lignans53 mg--
Flaxseed Particulate2660 mg--

Other ingredients: 100% unrefined, unfiltered organic Flaxseed Oil, flaxseed particulate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

COLD PRESSED FRESH DAILY™

MAKER'S DIET™ APPROVED TMDiet.com

COLD PRESSED FRESH DAILY(TM)

MAKER'S DIET(TM) APPROVED TMDiet.com

FDA Statement of Identity

SUPPLEMENT

Formula

Only ”Freshness Dated” flax oil

Formulation

CERTIFIED ORGANIC

USDA ORGANIC

General Statements

#1 Best Selling Flax Oil*

*AC Nielson Syndicated Market Data

100% ORGANIC

100% SATISFACTION GUARANTEED

Air Delivery – Arriving within days

America's Best Selling OMEGA-3

Bruce Barlean

Freshest, Best Tasting & Most Nutritious – Naturally!

FROM OUR FAMILY TO YOURS

Gold Medal Taster‘s Choice Award

Gold Medal VITY Award Winner

Nurture and nourish your body with Barlean’s Organic Oils, fresh from our handcrafted press and abundant in essential Omega-3 and vital flax lignans. Each drop is pure and pristine, unrefined and unfiltered to bring you vibrant health and energy!

Pressed Fresh – Made To Order

PRODUCT OF U.S.A .

PURE & UNFILTERED

Pure, unfiltered, unrefined, capturing nature’s full bounty

QUALITY ASSURANCE INTERNATIONAL

THE 2005 VITY Award

Top 10 Best Selling Natural Products*

Up to 25% more lignans than other brands

Suggested/Recommended/Usage/Directions

SUGGESTED USE: 1-2 Tbsp. daily, can be used in salad dressings, mixed with yogurt, cottage cheese, oatmeal, blended beverages & protein drinks. Refrigerate. Freezing will extend shelf life up to one year.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Highest Lignan Content Flax Oil by Barlean's Organic Oils label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Highest Lignan Content Flax Oil label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Highest Lignan Content Flax Oil by Barlean's Organic Oils

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tbsp Dosage formLiquid Servings per container31 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Omega-3 Fatty Acids

Interacts with
375 drugs
6200 mg per serving

DHA is an omega-3 fatty acid found in fatty fish and algae that is a building block for the brain, nervous system, and eyes. It is widely used and gen...

Omega-3 Fatty Acids monograph & interactions

Dietary Fiber

Interacts with
2,025 drugs
1 g per serving

Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. I...

Dietary Fiber monograph & interactions

Omega-6 Fatty Acids

No known
interactions
1810 mg per serving

Omega-6 fatty acids are essential fats your body needs but cannot make on its own, and most people get plenty from everyday foods like vegetable oils,...

Omega-6 Fatty Acids monograph & interactions

Omega-9 Fatty Acids

2040 mg per serving

Lignans

Interacts with
597 drugs
53 mg per serving

Flaxseed is a nutritious food rich in fiber, omega-3 fats (ALA), and plant compounds called lignans. It is most reliably helpful for constipation and...

Lignans monograph & interactions

Flaxseed Particulate

Interacts with
597 drugs
2660 mg per serving

Flaxseed is a nutritious food rich in fiber, omega-3 fats (ALA), and plant compounds called lignans. It is most reliably helpful for constipation and...

Flaxseed Particulate monograph & interactions

Other (inactive) ingredients: 100% unrefined, unfiltered organic Flaxseed Oil, Flaxseed particulate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Highest Lignan Content Flax Oil by Barlean's Organic Oils Drug Interactions

Want to check YOUR meds against Highest Lignan Content Flax Oil?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,134Drugs
600 Moderate 1,534 Minor

Ingredients driving the most interactions

Dietary Fiber 2,025
Lignans 597
Omega-3 Fatty Acids 375

Individual Drug Interactions

The ingredients in Highest Lignan Content Flax Oil interact with 2,134 drugs. Click any drug to see the details.

3 of the 6 ingredients in Highest Lignan Content Flax Oil interact with drugs. Each result below shows which ingredient is responsible. Dietary Fiber Lignans Omega-3 Fatty Acids

Each ingredient & the kinds of drugs it affects

For each ingredient in Highest Lignan Content Flax Oil with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Dietary Fiber7 drug types · 2,025 drugs

Carbamazepine (Tegretol)

Theoretically, black psyllium might reduce the effects of carbamazepine and increase the risk for convulsions.
Theoretically, black psyllium might reduce carbamazepine absorption. A preliminary study using blond psyllium reported decreased carbamazepine bioavailability due to binding of the drug to psyllium, as well as reduction of available fluid in the gut for dissolution of the drug. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Lithium

Theoretically, taking black psyllium at the same time as lithium might reduce lithium absorption.
The fiber in black psyllium might reduce lithium absorption and plasma levels. Some case reports describe a reduction in plasma lithium levels with concomitant administration of blond psyllium. This was reversed when psyllium was stopped. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Metformin (Glucophage)

Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Animal research shows that concurrent consumption of blond psyllium with metformin slows and increases the absorption of metformin. This interaction may also occur with black psyllium. To avoid changes in absorption, take psyllium 30-60 minutes after metformin.

Likelihood Possible Evidence D
Olanzapine (Zyprexa)

Theoretically, taking black psyllium at the same time as olanzapine might reduce olanzapine absorption.
The fiber in black psyllium might decrease the absorption of olanzapine. A single case report describes a reduction in the effectiveness of olanzapine when it was concomitantly administered with an unspecified type of psyllium 3 grams orally twice daily. This effect was reversed when psyllium was stopped.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, taking black psyllium at the same time as digoxin might reduce digoxin absorption and decrease digoxin levels.
Psyllium might bind digoxin in the gut. However, some clinical evidence suggests that psyllium does not impact digoxin absorption.

Likelihood Unlikely Evidence B
Ethinyl Estradiol

Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Concurrent use of blond psyllium with ethinyl estradiol results in a slight increase in the extent of ethinyl estradiol absorption and a slower rate of absorption. This is unlikely to be clinically significant.

Likelihood Unlikely Evidence D
Oral Drugs

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Psyllium seems to have variable effects on drug absorption. To avoid changes in absorption, take psyllium 30-60 minutes after oral medications. Animal research shows that blond psyllium delays and increases the absorption of metformin and ethinyl estradiol. Case reports and animal research suggest that blond psyllium might reduce absorption of lithium, digoxin, olanzapine, and carbamazepine. Finally, some pharmacokinetic studies show that psyllium does not affect the absorption of levothyroxine or warfarin. Although many of these studies evaluated blond psyllium, the fiber content in black psyllium may have similar effects.

Likelihood Possible Evidence B
Dietary Fiber full monograph & interactions

Lignans5 drug types · 597 drugs

Antibiotic Drugs

Theoretically, antibiotics might interfere with the metabolism of flaxseed constituents, which could potentially alter the effects of flaxseed.
Some potential benefits of flaxseed are thought to be due to its lignan content. Secoisolariciresinol diglucoside (SDG), a major lignan precursor, is found in high concentrations in flaxseed. SDG is converted by bacteria in the colon to the lignans enterolactone and enterodiol. Antibiotics alter the flora of the colon, which could theoretically alter the metabolism of flaxseed.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, using flaxseed in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Some clinical evidence suggests that the oil contained in flaxseed can decrease platelet aggregation.

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, flaxseed might have additive effects when used with antidiabetes drugs and increase the risk for hypoglycemia.
Some clinical research suggests that flaxseed can lower blood glucose levels.

Likelihood Probable Evidence B
Antihypertensive Drugs

Theoretically, flaxseed might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Clinical research shows that daily flaxseed consumption, especially for longer than 12 weeks, modestly reduces blood pressure.

Likelihood Possible Evidence D
Estrogens

Theoretically, taking flaxseed might decrease the effects of estrogens.
Flaxseed contains lignans with mild estrogenic and possible antiestrogenic effects. The lignans seem to compete with circulating endogenous estrogen and might reduce estrogen binding to estrogen receptors, resulting in an anti-estrogen effect. It is unclear if this effect transfers to exogenously administered estrogens.

Likelihood Possible Evidence D
Lignans full monograph & interactions

Omega-3 Fatty Acids3 drug types · 375 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, DHA may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Although some clinical evidence suggests that DHA might reduce collagen-stimulated platelet aggregation and thromboxane release, most clinical evidence suggests that DHA alone does not affect blood clotting. However, theoretically, when given in combination with EPA as fish oil, concomitant use with anticoagulant or antiplatelet drugs (including aspirin) might increase risk of bleeding.

Likelihood Unlikely Evidence B
Antidiabetes Drugs

Theoretically, taking DHA with antidiabetes drugs might reduce the effects of these medications.
In people with type 2 diabetes, including those taking oral hypoglycemic medications, DHA seems to increase fasting blood glucose levels.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking DHA with antihypertensive drugs might increase the risk of hypotension.
Fish oils containing DHA can lower blood pressure and might have additive effects in patients treated with antihypertensives; use with caution.

Likelihood Probable Evidence B
Omega-3 Fatty Acids full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Highest Lignan Content Flax Oil, from the product label.

Barlean's Organic Oils

See all Barlean's Organic Oils products
Name
Barlean's Organic Oils
Street Address
4936 Lake Terrell Road
City
Ferndale
State
WA
ZipCode
98248
Phone Number
1-800-445-3529
Web Address
www.barleans.com
Pharmacist Counseling Corner

Highest Lignan Content Flax Oil by Barlean's Organic Oils: Common Questions

Does Highest Lignan Content Flax Oil by Barlean's Organic Oils interact with any medications?
Yes. Based on its ingredients, Highest Lignan Content Flax Oil has a known interaction with 2,134 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Highest Lignan Content Flax Oil contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant?
The omega-3s in this product are rated likely safe in pregnancy and are often recommended as part of prenatal care, but only under your doctor's guidance and from a purified, low-mercury source. The flaxseed lignans, however, are rated possibly unsafe in pregnancy. Talk with your doctor before starting — they can weigh the omega-3 benefits against the lignan concerns for your situation.
Is this safe while breastfeeding?
Omega-3s pass into breast milk and are generally considered acceptable, but check the dose and source with your doctor. Flaxseed lignans don't have enough reliable safety information for breastfeeding doses, so use caution and get your doctor's approval before taking this product while nursing.
What side effects might I notice?
The most common ones are fishy aftertaste, belching, loose stools, nausea, and bloating or gas. Starting with a small amount and drinking plenty of water can help reduce digestive upset. Serious side effects like severe allergic reactions are rare.
Will this help my cholesterol?
The omega-3s and flaxseed lignans are both rated possibly effective for high cholesterol. That means evidence supports benefit, but it's not a guaranteed cure — talk with your doctor about whether this fits your overall cholesterol plan.
Can this help with blood pressure?
The flaxseed lignans have possibly effective evidence for lowering blood pressure, especially with daily use for longer than 12 weeks. But because this product may add to the effects of blood pressure medications, check with your doctor before starting if you're already on those drugs.
What's the difference between omega-3, omega-6, and omega-9?
They're all fatty acids your body needs, but in the right balance. The omega-3s and lignans in this product have shown some health benefits. The omega-6 content here shows only possibly ineffective evidence for the conditions studied. Your doctor can advise on whether the ratio in this product matches your needs.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Highest Lignan Content Flax Oil is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Highest Lignan Content Flax Oil label
Go deeper

The Full Monographs Behind Highest Lignan Content Flax Oil’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Docosahexaenoic Acid (dha)

Interacts with 375 drugs

DHA is an omega-3 fatty acid found in fatty fish and algae that is a building block for the brain, nervous system, and eyes. It is widely used and generally well tolerated, with the stronges...

Read the full Docosahexaenoic Acid (dha) monograph → Herb & supplement monograph

Black Psyllium

Interacts with 2,025 drugs

Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. It is best known and most studied for rel...

Read the full Black Psyllium monograph → Herb & supplement monograph

Omega-6 Fatty Acids

Omega-6 fatty acids are essential fats your body needs but cannot make on its own, and most people get plenty from everyday foods like vegetable oils, nuts, and seeds. Supplements such as ev...

Read the full Omega-6 Fatty Acids monograph → Herb & supplement monograph

Flaxseed

Interacts with 597 drugs

Flaxseed is a nutritious food rich in fiber, omega-3 fats (ALA), and plant compounds called lignans. It is most reliably helpful for constipation and may modestly lower cholesterol, but evid...

Read the full Flaxseed monograph →
Sources

Sources & How We Checked

Highest Lignan Content Flax Oil's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 124 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Docosahexaenoic Acid (dha) 49 references
  1. Akedo I, Ishikawa H, Nakamura T, et al. Three cases with familial adenomatous polyposis diagnosed as having malignant lesions in the course of a long-term trial using docosahexanoic acid (DHA)-concentrated fish oil capsules (abstract). Jpn J Clin Oncol PubMed
  2. Prisco D, Paniccia R, Bandinelli B, et al. Effect of medium-term supplementation with a moderate dose of n-3 polyunsaturated fatty acids on blood pressure in mild hypertensive patients. Thromb Res 1998;1:105-12.
  3. Grimsgaard S, Bonaa KH, Hansen JB, Nordoy A. Highly purified eicosapentaenoic acid and docosahexaenoic acid in humans have similar triacylglycerol-lowering effects but divergent effects on serum fatty acids. Am J Clin Nutr 1997;66:649-59.
  4. Toft I, Bonaa KH, Ingebretsen OC, et al. Effects of n-3 polyunsaturated fatty acids on glucose homeostasis and blood pressure in essential hypertension. A randomized, controlled trial. Ann Intern Med 1995;123:911-8.
  5. Sacks FM, Hebert P, Appel LJ, et al. Short report: the effect of fish oil on blood pressure and high-density lipoprotein-cholesterol levels in phase I of the trials of hypertension prevention. J Hypertens 1994;12:209-13.
  6. Vandongen R, Mori TA, Burke V, et al. Effects on blood pressure of omega 3 fats in subjects at increased risk of cardiovascular disease. Hypertension 1993;22:371-9. PubMed
  7. FDA. Center for Food Safety and Applied Nutrition. Letter regarding dietary supplement health claim for omega-3 fatty acids and coronary heart disease. Available at: http://www.fda.gov/ohrms/dockets/dockets/95s0316/95s-0316-Rpt0272-38-Appendix-D-Reference
  8. Pedersen HS, Mulvad G, Seidelin KN, et al. N-3 fatty acids as a risk factor for haemorrhagic stroke. Lancet 1999;353:812-3. PubMed
  9. Ito Y, Suzuki K, Imai H, et al. Effects of polyunsaturated fatty acids on atrophic gastritis in a Japanese population. Cancer Lett 2001;163:171-8. PubMed
  10. Kris-Ehterton PM, Harris WS, Appel LJ, et al. Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation 2002;106:2747-57. PubMed
  11. Woodman RJ, Mori TA, Burke V, et al. Effects of purified eicosapentaenoic and docosahexaenoic acids on glycemic control, blood pressure, and serum lipids in type 2 diabetic patients with treated hypertension. Am J Clin Nutr 2002;76:1007-15.. PubMed
  12. Marangell LB, Martinez JM, Zboyan HA, et al. A double-blind, placebo-controlled study of the omega-3 fatty acid docosahexaenoic acid in the treatment of major depression. Am J Psychiatry 2003;160:996-8.. PubMed
  13. Leng GC, Smith FB, Fowkes FG, et al. Relationship between plasma essential fatty acids and smoking, serum lipids, blood pressure and haemostatic and rheological factors. Prostaglandins Leukot Essent Fatty Acids 1994;51:101-8. PubMed
  14. Nelson GJ, Schmidt PS, Bartolini GL, et al. The effect of dietary docosahexaenoic acid on platelet function, platelet fatty acid composition, and blood coagulation in humans. Lipids 1997;32:1129-36. PubMed
  15. Wheaton DH, Hoffman DR, Locke KG, et al. Biological safety assessment of docosahexaenoic acid supplementation in a randomized clinical trial for X-linked retinitis pigmentosa. Arch Ophthalmol 2003;121:1269-78. PubMed
  16. Malcolm CA, McCulloch DL, Montgomery C, et al. Maternal docosahexaenoic acid supplementation during pregnancy and visual evoked potential development in term infants: a double blind, prospective, randomised trial. Arch Dis Child Fetal Neonatal Ed 2003;88: DOI
  17. Sanjurjo P, Ruiz-Sanz JI, Jimeno P, et al. Supplementation with docosahexaenoic acid in the last trimester of pregnancy: maternal-fetal biochemical findings. J Perinat Med 2004;32:132-6.
  18. Montgomery C, Speake BK, Cameron A, et al. Maternal docosahexaenoic acid supplementation and fetal accretion. Br J Nutr 2003;90:135-45. DOI
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  20. Hawkes JS, Bryan DL, Makrides M, et al. A randomized trial of supplementation with docosahexaenoic acid-rich tuna oil and its effects on the human milk cytokines interleukin 1 beta, interleukin 6, and tumor necrosis factor alpha. Am J Clin Nutr 2002;75:75
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