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Dietary supplement

Holy Basil Holixer 250 mg Ingredients & Drug Interactions

by Double Wood Supplements

Holy Basil Holixer 250 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Holy Basil Holixer 250 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Holy Basil Holixer 250 mg is a dietary supplement by Double Wood Supplements with 1 active ingredient. Its ingredients are commonly taken for stress and anxiety, blood sugar support, respiratory complaints.Based on those ingredients, 212 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Holixer. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Holy Basil Holixer 250 mg by Double Wood Supplements

Ask about any prescription or over-the-counter medication and we check it for interactions with Holy Basil Holixer 250 mg by Double Wood Supplements — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Holy Basil Holixer 250 mg by Double Wood Supplements

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Holy Basil Holixer contains one active ingredient: Holixer, a form of holy basil, at 250 mg per capsule. The capsule also contains inactive ingredients — hypromellose (a plant-based capsule material), rice flour, and microcrystalline cellulose (a binder) — that help hold the capsule together.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Stress and anxiety support.
  • We looked for evidence on: Generalized anxiety disorder (GAD), Stress, Insomnia, Adaptogenic support, Nervous system health.
  • The closest evidence on file: Holy Basil is rated "Insufficient Reliable Evidence To Rate" for Generalized anxiety disorder (GAD) (Natural Medicines).
  • Also on file: Holy Basil is rated "Insufficient Reliable Evidence To Rate" for Insomnia, Stress.

The evidence we hold shows insufficient reliable data to rate holy basil for the conditions it's traditionally used for — generalized anxiety disorder, asthma, headache, respiratory tract infections, dental plaque, and diabetes. That doesn't mean it won't work for you; it means the research backing these uses hasn't yet met a standard we can confidently recommend on.

The evidence, ingredient by ingredient Holy Basil

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Holy Basil Holixer is generally well tolerated in short-term use in adults, though long-term safety data are limited. The most common side effects reported are loose stools and nausea — in one clinical trial, two out of 24 people taking holy basil capsules experienced these.

You should avoid this product during pregnancy and breastfeeding. Animal data raise safety concerns in pregnancy, and there isn't enough reliable information on its use while breastfeeding for us to say it's okay.

Side effects, ingredient by ingredient Holy Basil

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Holy Basil.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 212 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Holy Basil Holixer, double-check with us if you take blood thinners or antiplatelet drugs (Moderate risk of increased bleeding), diabetes medications (Moderate risk of low blood sugar), or pentobarbital/Nembutal (Moderate risk of increased sedation). These are the medication types with documented interactions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you're looking to try holy basil for anxiety or another condition, this single-ingredient product is worth a conversation with your pharmacist — especially if you take blood thinners, diabetes medications, or sedatives. Ask us to check your specific drugs against this supplement before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Holy Basil Holixer 250 mg, straight from the product label.

Brand Double Wood Supplements
Barcode (UPC) 850033272390
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Sep 25, 2024
DSLD ID 315648
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Holy Basil Holixer 250 mg by Double Wood Supplements, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
850033272390
IngredientAmount% DV
Holixer250 mg--

Other ingredients: Hypromellose, Rice Flour, Microcrystalline Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Product info: Holixer Holy Basil is a patented and clinically studied Holy Basil extract. Holixer is standardized to contain greater than or equal to 5% Ocimum bioactive complex consists of Rabdosiin, Rosmarinic acid, Luteolin-7-o-beta-glucuronide, Ociglycosides 1 and Apigenin-7-o-betaglucuronide.

Holy Basil Holixer 250 mg per serving Clinically studied Holy Basil

Suggested/Recommended/Usage/Directions

Suggested use: Take 1 capsule once or twice daily.

Storage

Storage: Store in a cool, dark place. Do not freeze or expose to moisture or heat above room temperature.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Proudly Manufactured in the USA Made with Non-GMO Ingredients

Formulation

Made with non-GMO ingredients Gluten free

Patented standardization

FDA Statement of Identity

Dietary Supplement

Precautions

Warning: Consult your physician before use if you are taking any medications, are pregnant, nursing, or under 18 years of age.

Warning: Consult your physician before use if you are taking any medications, are pregnant, nursing, or under 18 years of age.

Discontinue use and consult your doctor immediately if any adverse reactions occur. Do not use Holixer Holy Basil and operate heavy machinery until you know how it affects you. Do not exceed 4 capsules per day.

Keep out of reach of children.

Brand IP Statement(s)

Holixer is a registered trademark of Natural Remedies distributed exclusively by AIDP In.

Product info: Holixer Holy Basil is a patented and clinically studied Holy Basil extract.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Holy Basil Holixer 250 mg by Double Wood Supplements label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Holy Basil Holixer 250 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Holy Basil Holixer 250 mg by Double Wood Supplements

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Holixer

Interacts with
212 drugs
250 mg per serving Form: Apigenin-7-O-betaglucuronide, Holy Basil Aerial Parts, Leaf Extract, Luteolin-7-O-glucuronide, Ociglycoside-I, Rabdosiin, Rosmarinic Acid

Holy basil (tulsi) is a traditional Ayurvedic herb most often used today for stress and general wellness, but the human evidence is mostly small and p...

Holixer monograph & interactions

Other (inactive) ingredients: Hypromellose, Rice Flour, Microcrystalline Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Holy Basil Holixer 250 mg by Double Wood Supplements Drug Interactions

Want to check YOUR meds against Holy Basil Holixer 250 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
212Drugs
212 Moderate

Ingredients driving the most interactions

Holixer 212

Individual Drug Interactions

The ingredients in Holy Basil Holixer 250 mg interact with 212 drugs. Click any drug to see the details.

1 of the 1 ingredient in Holy Basil Holixer 250 mg interact with drugs. Each result below shows which ingredient is responsible. Holixer

Each ingredient & the kinds of drugs it affects

For each ingredient in Holy Basil Holixer 250 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Holixer3 drug types · 212 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, holy basil seed oil might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Animal research shows that holy basil seed oil can prolong bleeding time, possibly due to inhibition of platelet aggregation. However, it is not known if this occurs in humans.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, holy basil might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Small clinical studies show that taking holy basil can decrease fasting blood glucose and other measures of glycemic control in patients with type 2 diabetes.

Likelihood Possible Evidence B
Pentobarbital (Nembutal)

Theoretically, holy basil seed oil might increase the sedative effects of pentobarbital.
Animal research shows that holy basil seed oil increases pentobarbitone-induced sleeping time. However, it is not known if this occurs in humans or if this applies to other barbiturates or sedatives.

Likelihood Possible Evidence D
Holixer full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Holy Basil Holixer 250 mg, from the product label.

Double Wood Supplements

See all Double Wood Supplements products
Name
Double Wood LLC
Street Address
3510 Scotts Ln Ste 219
City
Philadelphia
State
PA
ZipCode
19129-1573
Web Address
www.doublewoodsupplements.com
Pharmacist Counseling Corner

Holy Basil Holixer 250 mg by Double Wood Supplements: Common Questions

Does Holy Basil Holixer 250 mg by Double Wood Supplements interact with any medications?
Yes. Based on its ingredients, Holy Basil Holixer 250 mg has a known interaction with 212 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Holy Basil Holixer 250 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
No. The safety data advise against use during pregnancy because of animal study concerns, and there isn't enough reliable information to use it while breastfeeding either. Talk with your doctor or pharmacist about safer options.
What's Holixer, exactly?
Holixer is a form of holy basil, an herb used traditionally for stress and wellness. This product gives you 250 mg per capsule.
What side effects might I notice?
The most common ones reported are loose stools and nausea — but they're uncommon overall. A small number of people in trials experienced these. Holy basil is generally well tolerated short-term.
Does this really work for anxiety or diabetes?
The evidence we hold shows insufficient reliable data to say for sure. Holy basil is used traditionally for these conditions, but we don't have high-quality research backing those uses yet.
Are there any fillers or junk in here?
The capsule contains hypromellose (a plant-based capsule material), rice flour, and microcrystalline cellulose — these are inactive ingredients that help form and hold the capsule together, not the active holy basil itself.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Holy Basil Holixer 250 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Holy Basil Holixer 250 mg label
Go deeper

The Full Monographs Behind Holy Basil Holixer 250 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Holy Basil

Interacts with 212 drugs

Holy basil (tulsi) is a traditional Ayurvedic herb most often used today for stress and general wellness, but the human evidence is mostly small and preliminary. It is generally well tolerat...

Read the full Holy Basil monograph →
Sources

Sources & How We Checked

Holy Basil Holixer 250 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Holy Basil 8 references
  1. Agrawal P, Rai V, Singh RB. Randomized placebo-controlled, single blind trial of holy basil leaves in patients with noninsulin-dependent diabetes mellitus. Int J Clin Pharmacol Ther 1996;34:406-9.
  2. Sakina MR, Dandiya PC, Hamdard ME, Hameed A. Preliminary psychopharmacological evaluation of Ocimum sanctum leaf extract. J Ethnopharmacol 1990;28:143-50. PubMed
  3. Singh S, Rehan HM, Majumdar DK. Effect of Ocimum sanctum fixed oil on blood pressure, blood clotting time and pentobarbitone-induced sleeping time. J Ethnopharmacol 2001;78:139-43. PubMed
  4. Mondal, S., Varma, S., Bamola, V. D., Naik, S. N., Mirdha, B. R., Padhi, M. M., Mehta, N., and Mahapatra, S. C. Double-blinded randomized controlled trial for immunomodulatory effects of Tulsi (Ocimum sanctum Linn.) leaf extract on healthy volunteers. J PubMed
  5. Agarwal, P. and Nagesh, L. Comparative evaluation of efficacy of 0.2% Chlorhexidine, Listerine and Tulsi extract mouth rinses on salivary Streptococcus mutans count of high school children--RCT. Contemp.Clin Trials 2011;32(6):802-808. PubMed
  6. Vohora, S. B., Garg, S. K., and Chaudhury, R. R. Antifertility screening of plants. 3. Effect of six indigenous plants on early pregnancy in albino rats. Indian J Med Res 1969;57(5):893-899.
  7. Khanna S, Gupta SR, Grover JK. Effect of long term feeding of tulsi (Ocimum sanctum Linn) on reproductive performance of adult albino rats. Indian J Exp Biol 1986;24(5):302-4.
  8. Somasundaram G, Manimekalai K, Salwe KJ, Pandiamunian J. Evaluation of the antidiabetic effect of Ocimum sanctum in type 2 diabetes patients. Int J Life Sci Pharma Res 2012;2(3):75-81.

See these in context on the Holy Basil monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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