Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Hoodia-Pure 1000 mg Ingredients & Drug Interactions

by Hi-Tech Pharmaceuticals

Hoodia-Pure 1000 mg label
See full label image
Tablet Or Pill Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Hoodia-Pure 1000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Hoodia-Pure 1000 mg is a dietary supplement by Hi-Tech Pharmaceuticals with 2 active ingredients. Its ingredients are commonly taken for appetite suppression, weight loss, reducing food cravings.Based on those ingredients, 262 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Hoodia gordonii 20:1 extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Hoodia-Pure 1000 mg by Hi-Tech Pharmaceuticals

Ask about any prescription or over-the-counter medication and we check it for interactions with Hoodia-Pure 1000 mg by Hi-Tech Pharmaceuticals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Hoodia-Pure 1000 mg by Hi-Tech Pharmaceuticals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (1,000 mg) without saying how much of each component you get.

Hoodia-Pure 1000 mg contains 2 active ingredients: a proprietary blend and two forms of hoodia gordonii — a 20:1 extract and powder. Hoodia is a succulent plant traditionally used in appetite control formulations.

The product also contains inactive ingredients (microcrystalline cellulose, dextrose, sodium starch glycolate, magnesium stearate, stearic acid, and silica) that serve as fillers and binders in the tablet.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Hoodia's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: appetite suppressant.
  • We looked for evidence on: Obesity, Weight management, Food cravings, Satiety.
  • The closest evidence on file: Hoodia is rated "Insufficient Reliable Evidence To Rate" for Obesity (Natural Medicines).

The evidence for hoodia in obesity is insufficient to rate reliably, according to our data. This means we don't have enough solid clinical research to say whether it actually works for weight management.

Before deciding whether to try it, talk it over with your doctor.

The evidence, ingredient by ingredient Hoodia

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Hoodia has limited safety data and quality concerns have been reported. Minor side effects reported in trials include skin sensation changes, headache, dizziness, lightheadedness, nausea, and a potential increase in blood pressure and heart rate.

There isn't enough safety information to recommend use during pregnancy or breastfeeding — the data advises against it in both cases. If you're pregnant, planning pregnancy, or nursing, avoid this product and talk with your healthcare provider about alternatives.

Side effects, ingredient by ingredient Hoodia

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Hoodia.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 262 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check with your doctor or pharmacist before taking Hoodia-Pure if you're on blood pressure medications (antihypertensives), beta-blockers, diabetes drugs, or insulin. Hoodia may weaken blood pressure control and could lower your blood sugar too much.

All of these are Moderate-severity interactions that need monitoring.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Hoodia-Pure might appeal to someone looking for appetite support, but the evidence that it works isn't established. More importantly, it carries Moderate interaction risks with blood pressure, diabetes, and heart medications.

If you take any of those drugs, or if you're pregnant or breastfeeding, talk with your doctor or pharmacist before starting — this one needs clearance from your own healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 25, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Hoodia-Pure 1000 mg, straight from the product label.

Brand Hi-Tech Pharmaceuticals
Barcode (UPC) 857084000118
Net contents 60 Tablet(s); 1000 mg
Market status On market
Date entered into DSLD Aug 25, 2015
DSLD ID 48158
Product type Botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Hoodia-Pure 1000 mg by Hi-Tech Pharmaceuticals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
60
UPC/BARCODE
857084000118
IngredientAmount% DV
Proprietary Blend1000 mg--
Hoodia gordonii 20:1 extract0 NP--
Hoodia gordonii powder0 NP--

Other ingredients: Microcrystalline Cellulose, Dextrose, Sodium Starch Glycolate, Magnesium Stearate, Stearic Acid, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

HTP HI-TECH PHARMACEUTICALS

FDA Statement of Identity

Dietary Supplement

General Statements

- The world's strongest hoodia product! - The only HPLC standardized hoodia product on the market

Hi-Tech standardizes its Hoodia Extract to guarantee the active constituents (steroidal saponins 15% and pregnane glycosides 25%) are available for maximum effectiveness.

Suggested/Recommended/Usage/Directions

DIRECTIONS: As a dietary supplement take 1 tablet twice a day.

Brand IP Statement(s)

Hoodia-Pure(TM) is the only HPLC standardized Hoodia Gordonii product on the market.

Each batch is certified to contain these active constituents in order to make Hoodia-Pure(TM) "The world's strongest appitite suppressant." All studies showing the effectiveness of Hoodia Gordonii have been standardized like Hi-Tech's Hoodia-Pure(TM). Hoodia-Pure(TM) is a revolutionary appetite suppressant that will be the "Gold Standard" by which all Hoodia products will soon be judged.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Hoodia-Pure 1000 mg by Hi-Tech Pharmaceuticals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Hoodia-Pure 1000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Hoodia-Pure 1000 mg by Hi-Tech Pharmaceuticals

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

1000 mg per serving

Other (inactive) ingredients: Microcrystalline Cellulose, Dextrose, Sodium Starch Glycolate, Magnesium Stearate, Stearic Acid, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Hoodia-Pure 1000 mg by Hi-Tech Pharmaceuticals Drug Interactions

Want to check YOUR meds against Hoodia-Pure 1000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
262Drugs
262 Moderate

Ingredients driving the most interactions

Hoodia gordonii 20:1 extract 262

Individual Drug Interactions

The ingredients in Hoodia-Pure 1000 mg interact with 262 drugs. Click any drug to see the details.

1 of the 2 ingredients in Hoodia-Pure 1000 mg interact with drugs. Each result below shows which ingredient is responsible. Hoodia gordonii 20:1 extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Hoodia-Pure 1000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Hoodia gordonii 20:1 extract4 drug types · 262 drugs

Antidiabetes Drugs

Animal research shows that a steroid glycoside of hoodia, gordonoside F, increases glucose-stimulated insulin secretion by activating GPR119. This effect enhances glucose disposal. Theoretically, concomitant use of hoodia with antidiabetes medications may enhance blood glucose-lowering effects and increase the risk of hypoglycemia. Some antidiabetes medications include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.

Likelihood Possible Evidence D
Antihypertensive Drugs

Clinical research shows that hoodia can increase blood pressure. Theoretically, concomitant use of hoodia with antihypertensive drugs might decrease the effectiveness of the antihypertensive drugs and increase the risk of hypertension. Some antihypertensive drugs include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), Amlodipine (Norvasc), hydrochlorothiazide (HydroDiuril), furosemide (Lasix), and many others.

Likelihood Possible Evidence D
Beta-Blockers

Evidence from in vitro research shows that hoodia may stimulate beta-adrenergic receptors. Also, clinical research shows that hoodia can increase blood pressure and heart rate. Theoretically, using hoodia with beta-blockers might decrease the effects of these medications. Some beta-blocker drugs include atenolol (Tenormin), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), and propranolol (Inderal).

Likelihood Possible Evidence D
Insulin

Animal research shows that a steroid glycoside of hoodia, gordonoside F, increases glucose-stimulated insulin secretion by activating GPR119. Theoretically, concomitant use of hoodia with insulin may enhance the blood glucose-lowering effects of insulin. Blood glucose levels should be monitored.

Likelihood Possible Evidence D
Hoodia gordonii 20:1 extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Hoodia-Pure 1000 mg, from the product label.

Hi-Tech Pharmaceuticals

See all Hi-Tech Pharmaceuticals products
Name
Hi-Tech Pharmaceuticals, Inc.
Street Address
6015-B Unity Drive
City
Norcross
State
GA
ZipCode
30071
Phone Number
1-888-855-7919
Pharmacist Counseling Corner

Hoodia-Pure 1000 mg by Hi-Tech Pharmaceuticals: Common Questions

Does Hoodia-Pure 1000 mg by Hi-Tech Pharmaceuticals interact with any medications?
Yes. Based on its ingredients, Hoodia-Pure 1000 mg has a known interaction with 262 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Hoodia-Pure 1000 mg contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will Hoodia-Pure actually help me lose weight?
The evidence isn't solid enough to say. Our data shows insufficient reliable evidence to rate hoodia for obesity, which means there hasn't been enough strong clinical research to prove it works. Talk with your doctor about what's proven for weight management.
Can I take this while I'm pregnant or nursing?
No. There isn't enough safety information available, so the data advises against use during pregnancy and while breastfeeding. If you're in either situation, skip this product and talk with your doctor about safe options.
What side effects might I get?
Hoodia has caused minor side effects in some people: headache, dizziness, lightheadedness, nausea, and skin sensation changes. There's also concern it may raise blood pressure and heart rate. If you notice these or feel your blood pressure climbing, stop and call your healthcare provider.
Is this safe if I take blood pressure medication?
That's a conversation for your doctor. Hoodia may increase blood pressure and could reduce how well your blood pressure medication works. Your provider will need to know you're considering it and may want to monitor you.
What's a 20:1 extract versus powder, and why are both in here?
A 20:1 extract is a concentrated form made by processing hoodia — it's more potent per dose than the powder. This product includes both forms to deliver the ingredient in different ways, but both carry the same interaction and safety concerns.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Hoodia-Pure 1000 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Hoodia-Pure 1000 mg label
Go deeper

The Full Monographs Behind Hoodia-Pure 1000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Hoodia

Interacts with 262 drugs

Hoodia is a succulent plant from southern Africa that is marketed as an appetite suppressant for weight loss, but solid human evidence that it actually works is lacking. The few quality stud...

Read the full Hoodia monograph →
Sources

Sources & How We Checked

Hoodia-Pure 1000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Hoodia 3 references
  1. Blom WAM, Abrahamse SL, Bradford R, et al. Effects of 15-d repeated consumption of Hoodia gordonii purified extract on safety, ad libitum energy intake, and body weight in healthy, overweight women: a randomized controlled trial. Am J Clin Nutr 2011;94(5) PubMed
  2. Roza O, Lovász N, Zupkó I, Hohmann J, Csupor D. Sympathomimetic activity of a Hoodia gordonii product: a possible mechanism of cardiovascular side effects. Biomed Res Int. 2013;2013:171059.
  3. Zhang S, Ma Y, Li J, et al. Molecular matchmaking between the popular weight-loss herb Hoodia gordonii and GPR119, a potential drug target for metabolic disorder. Proc Natl Acad Sci U S A. 2014;111(40):14571-6.

See these in context on the Hoodia monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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