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Dietary supplement

HydroxoCobalamin 1 mg Cherry Flavored Ingredients & Drug Interactions

by Source Naturals

HydroxoCobalamin 1 mg Cherry Flavored label
See full label image
Tablet Or Pill Category: Vitamin
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking HydroxoCobalamin 1 mg Cherry Flavored against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

HydroxoCobalamin 1 mg Cherry Flavored is a dietary supplement by Source Naturals with 1 active ingredient. Its ingredients are commonly taken for treating or preventing b12 deficiency, pernicious anemia, low energy and fatigue.Based on those ingredients, 20 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Hydroxocobalamin Hydrochloride. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against HydroxoCobalamin 1 mg Cherry Flavored by Source Naturals

Ask about any prescription or over-the-counter medication and we check it for interactions with HydroxoCobalamin 1 mg Cherry Flavored by Source Naturals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of HydroxoCobalamin 1 mg Cherry Flavored by Source Naturals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 1 active ingredient: hydroxocobalamin hydrochloride, a form of vitamin B12. B12 is an essential vitamin your body needs for nerve function, red blood cell formation, and DNA synthesis.

The tablet also contains several inactive ingredients—sorbitol, mannitol, natural cherry flavor, stearic acid, and magnesium stearate—which are excipients that help form and flavor the tablet.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Vitamin B-12 supplementation.
  • We looked for evidence on: Vitamin B12 deficiency, Peripheral neuropathy, Diabetic neuropathy, Chemotherapy-induced peripheral neuropathy, Hyperhomocysteinemia, Imerslund-Grasbeck disease — and 3 related terms.
  • The strongest evidence on file: Vitamin B12 is rated "Effective" for Imerslund-Grasbeck disease (Natural Medicines).
  • Also on file: Vitamin B12 is rated "Effective" for Vitamin B12 deficiency.
  • Also on file: Vitamin B12 is rated "Possibly Effective" for Hyperhomocysteinemia.

Hydroxocobalamin is Effective for treating Imerslund-Grasbeck disease (a rare genetic condition affecting B12 absorption) and for correcting vitamin B12 deficiency. It is Likely Effective for cyanide poisoning, where B12 binds to cyanide and helps remove it from the body.

For canker sores and postherpetic neuralgia (nerve pain after shingles), the evidence is Possibly Effective—meaning there is some support but it is not conclusive.

The evidence, ingredient by ingredient Vitamin B12

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin B12 is generally very well tolerated by mouth, and your body removes any excess through your urine, so there is no established upper safe limit. Allergic reactions like rash or itching are rare but can occur, and in very rare cases may be linked to a cobalt allergy.

B12 is safe and needed during pregnancy and breastfeeding at recommended amounts—follow your provider's guidance on dosing.

Side effects, ingredient by ingredient Vitamin B12

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Vitamin B12.
  • The most serious interaction on file is rated Minor.
  • For scale: 20 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take metformin (Glucophage) for diabetes, metformin can lower your B12 levels, and this supplement is meant to address that. Before taking this product, check with your doctor or pharmacist about any other medications you're on, since we have data on interactions with 20 individual medications overall.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

This supplement is a good option if your doctor has diagnosed you with B12 deficiency or a condition that prevents you from absorbing B12 normally. If you take metformin for diabetes, your doctor may recommend checking your B12 level periodically and using a supplement like this one.

Talk with your doctor or pharmacist before starting it, especially if you take other medications or have a history of cobalt allergies.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about HydroxoCobalamin 1 mg Cherry Flavored, straight from the product label.

Brand Source Naturals
Barcode (UPC) 021078026563
Net contents 240 Tablet(s)
Market status On market
Date entered into DSLD Nov 22, 2022
DSLD ID 274673
Product type Vitamin
Supplement form Tablet Or Pill
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Seniors/Mature (>50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for HydroxoCobalamin 1 mg Cherry Flavored by Source Naturals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
240
UPC/BARCODE
021078026563
IngredientAmount% DV
Hydroxocobalamin Hydrochloride1 mg16667%

Other ingredients: Sorbitol, Mannitol, natural Cherry flavor, Stearic Acid, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

Formula

Vitamin B-12

Source Naturals HydroxoCobalamin supports brain health and energy levels with a meaningful dose of B-12 in a convenient lozenge form.

This is especially helpful for adults 50 years and older who may need assistance meeting their RDA requirements.

Hydroxocobalamin is the form of B-12 that is transported in the blood, before it is converted into the coenzyme forms of methylcobalamin or adenosylcobalamin inside the cell. Vitamin B-12 helps support normal homocysteine levels, healthy brain cells and nerve tissues, and the production of red blood cells that carry oxygen to the cells and tissues.

Suggested/Recommended/Usage/Directions

Suggested Use: 1 tablet daily. Place tablet under the tongue and allow to dissolve slowly, altering the position of the tablet to avoid prolonged contact with the same area.

Precautions

Note: If you are pregnant, may become pregnant, or breastfeeding, consult your health care professional before using this product.

Do not use if either tamper-evident seal is broken or missing.

Keep out of the reach of children.

Storage

Store in a cool, dry place.

Formulation

Suitable for vegans and vegetarians.

Contains no yeast, dairy, egg, gluten, soy or wheat. Contains no sugar, starch, salt, preservatives, or artificial color, flavor or fragrance.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

Copyright SOURCE NATURALS, INC.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

HydroxoCobalamin 1 mg Cherry Flavored by Source Naturals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

HydroxoCobalamin 1 mg Cherry Flavored label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in HydroxoCobalamin 1 mg Cherry Flavored by Source Naturals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container240 Amounts shown are per serving.

Hydroxocobalamin Hydrochloride

Interacts with
20 drugs
1 mg per serving

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Hydroxocobalamin Hydrochloride monograph & interactions

Other (inactive) ingredients: Sorbitol, Mannitol, Natural Cherry flavor, Stearic Acid, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

HydroxoCobalamin 1 mg Cherry Flavored by Source Naturals Drug Interactions

Want to check YOUR meds against HydroxoCobalamin 1 mg Cherry Flavored?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
20Drugs
20 Minor

Ingredients driving the most interactions

Hydroxocobalamin Hydrochloride 20

Individual Drug Interactions

The ingredients in HydroxoCobalamin 1 mg Cherry Flavored interact with 20 drugs. Click any drug to see the details.

1 of the 1 ingredient in HydroxoCobalamin 1 mg Cherry Flavored interact with drugs. Each result below shows which ingredient is responsible. Hydroxocobalamin Hydrochloride

Each ingredient & the kinds of drugs it affects

For each ingredient in HydroxoCobalamin 1 mg Cherry Flavored with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Hydroxocobalamin Hydrochloride1 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Hydroxocobalamin Hydrochloride full monograph & interactions
The maker

Brand information

Manufacturer and brand details for HydroxoCobalamin 1 mg Cherry Flavored, from the product label.

Source Naturals

Name
Source Naturals, Inc.
Street Address
P. O. Box 2118
City
Santa Cruz
State
CA
ZipCode
95062
Web Address
www.sourcenaturals.com
Pharmacist Counseling Corner

HydroxoCobalamin 1 mg Cherry Flavored by Source Naturals: Common Questions

Does HydroxoCobalamin 1 mg Cherry Flavored by Source Naturals interact with any medications?
Yes. Based on its ingredients, HydroxoCobalamin 1 mg Cherry Flavored has a known interaction with 20 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
HydroxoCobalamin 1 mg Cherry Flavored contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is hydroxocobalamin, and why is it different from other B12 forms?
Hydroxocobalamin is one form of vitamin B12, the active ingredient in this product. It is used by your body for nerve function, red blood cells, and DNA. This particular form is especially useful for treating B12 deficiency and has been studied for cyanide poisoning because it binds to and helps remove cyanide from the body.
Is this supplement safe if I'm pregnant or breastfeeding?
Yes, vitamin B12 is Likely Safe during pregnancy and breastfeeding at recommended amounts, and it is actually needed during both periods. Follow your provider's advice on dosing and whether you need a supplement.
I take metformin for type 2 diabetes. Should I take this supplement?
Metformin can lower your B12 levels over time by interfering with how your body absorbs it. Talk with your doctor about checking your B12 level and whether this supplement is right for you, since it could help restore what metformin may reduce.
Can I take too much vitamin B12?
No—B12 has no established upper safe limit because your body removes any excess through your urine. It is generally very safe even at higher doses.
Are there any side effects I should watch for?
B12 is generally well tolerated by mouth. Allergic reactions like rash or itching are rare, and severe side effects are extremely uncommon. If you have a known cobalt allergy, mention it to your doctor or pharmacist before taking this supplement.
Does this supplement work for canker sores or nerve pain?
For canker sores and postherpetic neuralgia (nerve pain after shingles), the evidence is Possibly Effective—meaning there is some support but it is not conclusive. Talk with your doctor about whether it might help with your specific condition.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

HydroxoCobalamin 1 mg Cherry Flavored label
Go deeper

The Full Monographs Behind HydroxoCobalamin 1 mg Cherry Flavored’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph →
Sources

Sources & How We Checked

HydroxoCobalamin 1 mg Cherry Flavored's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 30 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B12 30 references
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  2. Hartman TJ, Woodson K, Stolzenberg-Solomon R, et al. Association of the B-vitamins pyridoxal 5'-phosphate (B6), B12, and folate with lung cancer risk in older men. Am J Epidemiol 2001;153:688-94.. DOI
  3. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  4. Lange H, Suryapranata H, De Luca G, et al. Folate therapy and in-stent restenosis after coronary stenting. N Engl J Med 2004;350:2673-81. PubMed
  5. Collin, S. M., Metcalfe, C., Refsum, H., Lewis, S. J., Zuccolo, L., Smith, G. D., Chen, L., Harris, R., Davis, M., Marsden, G., Johnston, C., Lane, J. A., Ebbing, M., Bonaa, K. H., Nygard, O., Ueland, P. M., Grau, M. V., Baron, J. A., Donovan, J. L., Nea
  6. Geissbuhler, P., Mermillod, B., and Rapin, C. H. Elevated serum vitamin B12 levels associated with CRP as a predictive factor of mortality in palliative care cancer patients: a prospective study over five years. J.Pain Symptom.Manage. 2000;20(2):93-103. PubMed
  7. Salles, N., Herrmann, F., Sakbani, K., Rapin, C. H., and Sieber, C. High vitamin B12 level: a strong predictor of mortality in elderly inpatients. J Am Geriatr.Soc 2005;53(5):917-918.
  8. Looker, H. C., Fagot-Campagna, A., Gunter, E. W., Pfeiffer, C. M., Sievers, M. L., Bennett, P. H., Nelson, R. G., Hanson, R. L., and Knowler, W. C. Homocysteine and vitamin B(12) concentrations and mortality rates in type 2 diabetes. Diabetes Metab Res R
  9. Uhl, W., Nolting, A., Golor, G., Rost, K. L., and Kovar, A. Safety of hydroxocobalamin in healthy volunteers in a randomized, placebo-controlled study. Clin Toxicol (Phila) 2006;44 Suppl 1:17-28. PubMed
  10. Borron, S. W., Baud, F. J., Barriot, P., Imbert, M., and Bismuth, C. Prospective study of hydroxocobalamin for acute cyanide poisoning in smoke inhalation. Ann Emerg.Med 2007;49(6):794-801, 801. PubMed
  11. Borron, S. W., Baud, F. J., Megarbane, B., and Bismuth, C. Hydroxocobalamin for severe acute cyanide poisoning by ingestion or inhalation. Am J Emerg.Med 2007;25(5):551-558. PubMed
  12. Lewis, J. G. Gout, Steatorrhoea, and Megaloblastic Anaemia. Ann Rheum.Dis 1962;21(3):284-286. PubMed
  13. Tal, S., Shavit, Y., Stern, F., and Malnick, S. Association between vitamin B12 levels and mortality in hospitalized older adults. J Am Geriatr.Soc 2010;58(3):523-526. PubMed
  14. Baztan, J. J., Gavidia, J. J., Gomez-Pavon, J., Esteve, A., and Ruiperez, I. High vitamin B12 levels and in-hospital mortality. J Am Geriatr.Soc 2010;58(11):2237-2238. PubMed
  15. Omboni, E., Checchini, M., and Longoni, F. [Hypopotassemia and megaloblastic anemia. Presentation of a case]. Minerva Med 8-31-1987;78(16):1255-1257.
  16. Aalfs As, Scholvinck LH, Horvath B. Acneiform eruption in a 5-year old due to vitamin B12 supplementation. Eur J Dermatol 2013;23(5):726-7. PubMed
  17. Balta I, Ozuguz P. Vitamin B12-induced acneiform eruption. Cutan Ocul Toxicol 2014;33(2):94-5. PubMed
  18. Carman KB, Belgemen T, Yis U. Involuntary movements misdiagnosed as seizure during vitamin B12 treatment. Pediatr Emerg Care 2013;29(11):1223-4. PubMed
  19. Djuric V, Bogic M, Popadic AP, et al. Anaphylactic reaction to hydroxycobalamin with tolerance to cyanocobalamin. Ann Allergy Asthma Immunol 2012;108(3):207-8. PubMed
  20. Kartel O, Gulec M, Demirel F, et al. Vitamin B12 allergy and successful desensitization with cyanocobalamin: A case report. Allergol Immunopath (Madr) 2012;40(5):324-5.
  21. Patiroglu T, Unal E, Yildirim S. Infantile tremor syndrome associated with cobalamin therapy: A case report. Clin Neurol Neurosurg 2013;115(9):1903-5. PubMed
  22. Schulte S, Barkema LW, Kardaun SH. Long-lasting atypical acneiform eruption with prominent comedones induced by hydroxocobalamin (vitamin B12). J Dtsch Dermatol Ges 2014;12(6):502-3.
  23. Zanus C, Alberini E, Costa P, et al. Involuntary movements after correction of vitamin B12 deficiency: A video-case report. Epileptic Disord 2012;14(2):174-80. PubMed
  24. Fanidi A, Carreras-Torres R, Larose TL, et al. Is high vitamin B12 status a cause of lung cancer? Int J Cancer. 2019 Sep 15;145(6):1499-1503. PubMed
  25. Fujita Y, Mizukami T, Maya Y, et al. Vitamin B12 allergy manifesting as lymphomatoid contact dermatitis. Eur J Dermatol. 2020;30(3):304-305. PubMed
  26. Dépret F, Hoffmann C, Daoud L, et al. Association between hydroxocobalamin administration and acute kidney injury after smoke inhalation: a multicenter retrospective study. Crit Care. 2019;23(1):421. PubMed
  27. Khairan P, Sobue T, Eshak ES, et al. Association of dietary intakes of vitamin B12, vitamin B6, folate, and methionine with the risk of esophageal cancer: the Japan Public Health Center-based (JPHC) prospective study. BMC Cancer 2021;21(1):982. PubMed
  28. Evans J, Pandya A, Ding Y, Qunibi WY. Hydroxocobalamin-Induced Oxalate Nephropathy in a Patient With Smoke Inhalation. Kidney Int Rep 2021;6(8):2228-2231. PubMed
  29. Lacombe V, Chabrun F, Lacout C, et al. Persistent elevation of plasma vitamin B12 is strongly associated with solid cancer. Sci Rep 2021;11(1):13361. PubMed
  30. Pegalajar-García MD, Cebolla-Verdugo M, Prados-Carmona Á, Llamas-Segura C, Navarro-Triviño FJ. Systemic allergic dermatitis to cobalt present in cyanocobalamin supplementation. Contact Dermatitis 2023;89(3):203-205. PubMed

See these in context on the Vitamin B12 monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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