Hypo-Selenium 200 mcg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Hypo-Selenium 200 mcg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Hypo-Selenium 200 mcg is a dietary supplement by Douglas Laboratories with 1 active ingredient. Its ingredients are commonly taken for thyroid health support, antioxidant support, immune support.Based on those ingredients, 321 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Selenium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Hypo-Selenium 200 mcg by Douglas Laboratories
Ask about any prescription or over-the-counter medication and we check it for interactions with Hypo-Selenium 200 mcg by Douglas Laboratories — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Hypo-Selenium 200 mcg by Douglas Laboratories
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Hypo-Selenium 200 mcg contains one active ingredient: selenium, a mineral your body needs for thyroid function, immune health, and protection against oxidative stress. The 200 mcg dose is at the upper limit of what's considered safe to take daily (the tolerable upper intake level is 400 mcg).
The tablet also contains inactive ingredients — cellulose, vegetable stearate, silica, and selenium krebs/chelate — which are binders and fillers that hold the tablet together.
Does it work?
Strong evidence
Selenium is likely effective for treating selenium deficiency. For other conditions, the evidence is more limited: it's possibly effective for Kashin-Beck disease (a joint disease), pre-eclampsia (high blood pressure in pregnancy), and autoimmune thyroiditis (inflammation of the thyroid).
For dyslipidemia (high cholesterol), the evidence suggests it's possibly ineffective. If you're taking this for a specific health reason, talk with your doctor about whether the evidence supports that use.
How safe is it?
Well-documented data
Selenium at doses up to 400 mcg daily is generally well-tolerated. However, this product is at the upper edge of that safe range, and excess selenium can be toxic.
The most common side effects at normal doses are gastric discomfort, headache, and rash. At higher doses, selenium can cause hair loss, nail changes, fatigue, nausea, and vomiting.
Rarely, very high amounts have caused serious organ damage. There's also research suggesting that long-term exposure to selenium at high levels may increase the risk of motor neuron damage and amyotrophic lateral sclerosis (ALS).
For pregnancy, the data is mixed — selenium appears possibly safe but possibly unsafe depending on the study — so talk with your doctor or midwife before taking it while pregnant. For breastfeeding, it's possibly safe.
Meds to double-check
Moderate interaction found
Check with your doctor or pharmacist before taking this supplement if you use blood thinners or antiplatelet drugs (like warfarin or aspirin) — selenium may increase bleeding risk. Also flag it if you take immune suppressants, barbiturates, or niacin-based cholesterol drugs.
These are the medication types with documented interactions in our data.
The bottom line
Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
This supplement is a good fit if you're deficient in selenium and your doctor recommends it, or if you want to cover your selenium needs at a reasonably high dose. Be cautious if you take blood thinners, immune suppressants, sedatives, or cholesterol medications — check with your doctor or pharmacist first.
Don't exceed 400 mcg daily from all sources. If you're pregnant or breastfeeding, talk it over with your healthcare provider before starting.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 23, 2012.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Hypo-Selenium 200 mcg, straight from the product label.
| Brand | Douglas Laboratories |
|---|---|
| Barcode (UPC) | 310539074497 |
| Net contents | 100 Tablet(s) |
| Market status | On market |
| Date entered into DSLD | Mar 23, 2012 |
| DSLD ID | 8707 |
| Product type | Mineral |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years), Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Hypo-Selenium 200 mcg by Douglas Laboratories, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Selenium | 200 mcg | 286% |
Other ingredients: Selenium krebs/chelate, Cellulose, Vegetable Stearate, Silica
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity
A Dietary Supplement
Suggested/Recommended/Usage/Directions
Suggested Usage: As a dietary supplement, adults take 1 tablet daily or as directed by your healthcare professional.
Precautions
KEEP OUT OF REACH OF CHILDREN.
Tamper resistant package, do not use if outer seal is missing.
Storage
For optimal storage conditions, store in a cool, dry place. (59(0)-77(0)F/15(0)-25(0)C) (35-65% relative humidity)
General
Formula #7449
Formulation
This product contains NO yeast, wheat gluten, soy protein, milk/dairy, corn, sodium, sugar, starch, artificial color-ing, preservatives or flavoring.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Hypo-Selenium 200 mcg by Douglas Laboratories label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Hypo-Selenium 200 mcg by Douglas Laboratories
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.
Selenium
Interacts with321 drugs
Selenium is an essential trace mineral your body needs in small amounts for thyroid function, antioxidant defense, and immune health. Most people who...
Selenium monograph & interactionsOther (inactive) ingredients: Selenium krebs/chelate, Cellulose, Vegetable Stearate, Silica. These complete the product’s ingredient list but are not active constituents.
Hypo-Selenium 200 mcg by Douglas Laboratories Drug Interactions
HelloPharmacist Interaction Report
Hypo-Selenium 200 mcg by Douglas Laboratories contains selenium, which interacts with several medication types.
The most serious concern is with blood thinners and antiplatelet drugs (like warfarin and aspirin): selenium may increase bleeding risk or interfere with how warfarin works by displacing it from its binding sites in your blood or slowing its breakdown in your liver.
Read the full breakdown — every affected drug type, severity by severity
Selenium may also reduce how well immune-suppressing medications work by stimulating your immune system. It can prolong the sedating effects of barbiturates (older sedative drugs) by slowing how your body breaks them down.
Additionally, birth control pills might increase your selenium levels, though we're not sure if this matters clinically. There's also a minor concern that selenium might reduce niacin's beneficial effects on HDL cholesterol.
Altogether, these interactions span 321 individual medications. Before you start this supplement, run your exact medications through the search tool on this page or check with your doctor or pharmacist — especially if you take any blood thinners, immune suppressants, sedatives, or cholesterol drugs.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Hypo-Selenium 200 mcg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Hypo-Selenium 200 mcg interact with 321 drugs. Click any drug to see the details.
1 of the 1 ingredient in Hypo-Selenium 200 mcg interact with drugs. Each result below shows which ingredient is responsible. Selenium
Etanercept-ykroEticovo
How Etanercept-ykro interacts with Hypo-Selenium 200 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumImmunosuppressants Moderate
Interaction Summary
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
Read the full Selenium + Etanercept-ykro interactionEtrasimodVelsipity
How Etrasimod interacts with Hypo-Selenium 200 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumImmunosuppressants Moderate
Interaction Summary
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
Read the full Selenium + Etrasimod interactionFamotidine, IbuprofenDuexis
How Famotidine, Ibuprofen interacts with Hypo-Selenium 200 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Selenium + Famotidine, Ibuprofen interactionFingolimodGilenya, Tascenso ODT
How Fingolimod interacts with Hypo-Selenium 200 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumImmunosuppressants Moderate
Interaction Summary
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
Read the full Selenium + Fingolimod interactionFish Oil TriglyceridesOmegaven
How Fish Oil Triglycerides interacts with Hypo-Selenium 200 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Selenium + Fish Oil Triglycerides interactionFludrocortisoneFlorinef Acetate
How Fludrocortisone interacts with Hypo-Selenium 200 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumImmunosuppressants Moderate
Interaction Summary
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
Read the full Selenium + Fludrocortisone interactionFluorouracil (iv)Fluorouracil
How Fluorouracil (iv) interacts with Hypo-Selenium 200 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumImmunosuppressants Moderate
Interaction Summary
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
Read the full Selenium + Fluorouracil (iv) interactionFlupenthixolFluanxol
How Flupenthixol interacts with Hypo-Selenium 200 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumImmunosuppressants Moderate
Interaction Summary
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
Read the full Selenium + Flupenthixol interactionFondaparinuxArixtra
How Fondaparinux interacts with Hypo-Selenium 200 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Selenium + Fondaparinux interactionFostamatinibTavalisse
How Fostamatinib interacts with Hypo-Selenium 200 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumImmunosuppressants Moderate
Interaction Summary
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
Read the full Selenium + Fostamatinib interactionGlatiramer AcetateCopaxone
How Glatiramer Acetate interacts with Hypo-Selenium 200 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumImmunosuppressants Moderate
Interaction Summary
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
Read the full Selenium + Glatiramer Acetate interactionGlofitamab-gxbmColumvi
How Glofitamab-gxbm interacts with Hypo-Selenium 200 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumImmunosuppressants Moderate
Interaction Summary
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
Read the full Selenium + Glofitamab-gxbm interactionGolimumabSimponi Aria
How Golimumab interacts with Hypo-Selenium 200 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumImmunosuppressants Moderate
Interaction Summary
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
Read the full Selenium + Golimumab interactionGuselkumabTremfya
How Guselkumab interacts with Hypo-Selenium 200 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumImmunosuppressants Moderate
Interaction Summary
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
Read the full Selenium + Guselkumab interactionHeparinHeparin
How Heparin interacts with Hypo-Selenium 200 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Selenium + Heparin interactionHexobarbitalHexobarbital, Sombulex
How Hexobarbital interacts with Hypo-Selenium 200 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumBarbiturates Moderate
Interaction Summary
Theoretically, selenium might prolong the sedating effects of barbiturates.
Read the full Selenium + Hexobarbital interactionHexobarbitoneCyclonal, Evipan
How Hexobarbitone interacts with Hypo-Selenium 200 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumBarbiturates Moderate
Interaction Summary
Theoretically, selenium might prolong the sedating effects of barbiturates.
Read the full Selenium + Hexobarbitone interactionHyaluronidase, RituximabRituxan Hycela
How Hyaluronidase, Rituximab interacts with Hypo-Selenium 200 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumImmunosuppressants Moderate
Interaction Summary
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
Read the full Selenium + Hyaluronidase, Rituximab interactionHydrocodone, IbuprofenVicoprofen
How Hydrocodone, Ibuprofen interacts with Hypo-Selenium 200 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Selenium + Hydrocodone, Ibuprofen interactionHydrocortisoneAlkindi Sprinkle, Alphaderm, Calmurid HC, Carmol HC cream, Cortef, Dioderm +8 more
How Hydrocortisone interacts with Hypo-Selenium 200 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumImmunosuppressants Moderate
Interaction Summary
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
Read the full Selenium + Hydrocortisone interactionHyoscyamine, PhenobarbitalLevsin Pb, Levsinex Pb Timecaps
How Hyoscyamine, Phenobarbital interacts with Hypo-Selenium 200 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumBarbiturates Moderate
Interaction Summary
Theoretically, selenium might prolong the sedating effects of barbiturates.
Read the full Selenium + Hyoscyamine, Phenobarbital interactionIbrutinibImbruvica
How Ibrutinib interacts with Hypo-Selenium 200 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Selenium + Ibrutinib interactionIbuprofenAdvil, Arthrofen, Brufen, Brufen Retard, Calodor, Calprofen +14 more
How Ibuprofen interacts with Hypo-Selenium 200 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Selenium + Ibuprofen interactionIbuprofen LysineNeoProfen
How Ibuprofen Lysine interacts with Hypo-Selenium 200 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Selenium + Ibuprofen Lysine interactionIbuprofen, AcetaminophenAdvil Dual Action
How Ibuprofen, Acetaminophen interacts with Hypo-Selenium 200 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Selenium + Ibuprofen, Acetaminophen interactionIbuprofen, HydrocodoneIbucodone
How Ibuprofen, Hydrocodone interacts with Hypo-Selenium 200 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Selenium + Ibuprofen, Hydrocodone interactionIbuprofen, OxycodoneCombunox
How Ibuprofen, Oxycodone interacts with Hypo-Selenium 200 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Selenium + Ibuprofen, Oxycodone interactionIbuprofen, PseudoephedrineDristan
How Ibuprofen, Pseudoephedrine interacts with Hypo-Selenium 200 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Selenium + Ibuprofen, Pseudoephedrine interactionIcosapent Ethyl (prescription Drug)Vascepa
How Icosapent Ethyl (prescription Drug) interacts with Hypo-Selenium 200 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Selenium + Icosapent Ethyl (prescription Drug) interactionIloprostAurlumyn, Ventavis
How Iloprost interacts with Hypo-Selenium 200 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Selenium + Iloprost interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Hypo-Selenium 200 mcg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Selenium
Anticoagulant/Antiplatelet Drugs
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Clinical research suggests that taking selenium 10 mcg/kg/day can increase bleeding times by increasing prostacyclin production, which inhibits platelet activity. Other clinical research suggests that taking selenium 75 mcg daily, in combination with ascorbic acid 600 mg, alpha-tocopherol 300 mg, and beta-carotene 27 mg, reduces platelet aggregation.
Barbiturates
Theoretically, selenium might prolong the sedating effects of barbiturates.
Laboratory research suggests that selenium can inhibit the hepatic metabolism of barbiturates. Selenium seems to prolong the sedative effect of pentobarbital in animal models.
Immunosuppressants
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
In vitro research and preliminary clinical evidence suggests that selenium may stimulate the immune system.
Warfarin (Coumadin)
Theoretically, selenium might interfere with warfarin activity.
Animal research suggests that selenium can increase warfarin activity. Selenium might interact with warfarin by displacing it from albumin binding sites, reducing its metabolism in the liver, or by decreasing production of vitamin K-dependent clotting factors. Selenium can also prolong bleeding times in humans by increasing prostacyclin production, which inhibits platelet activity.
Contraceptive Drugs
Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.
Some research suggests that oral contraceptives increase serum selenium levels in women taking oral contraceptives; however, other research shows no change in selenium levels. It is suggested that an increase could be due to increased carrier proteins, indicating a redistribution of selenium rather than a change in total body selenium.
Niacin
Selenium might reduce the beneficial effects of niacin on high-density lipoprotein (HDL) levels.
A combination of niacin and simvastatin (Zocor) effectively raises HDL cholesterol levels in patients with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50% in patients with coronary disease. It is not known whether this adverse effect is due to a single antioxidant such as selenium, or to the combination. It also is not known whether it will occur in other patient populations.
Brand information
Manufacturer and brand details for Hypo-Selenium 200 mcg, from the product label.
Douglas Laboratories
See all Douglas Laboratories products- Name
- Douglas Laboratories
- Street Address
- 600 Boyce Road
- City
- Pittsburgh
- State
- PA
- ZipCode
- 15205
- Web Address
- www.douglaslabs.com
Hypo-Selenium 200 mcg by Douglas Laboratories: Common Questions
Does Hypo-Selenium 200 mcg by Douglas Laboratories interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is 200 mcg selenium safe to take every day?
What are the side effects of selenium?
Will this help my thyroid?
Can I take this while pregnant?
Will this help prevent cancer?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Hypo-Selenium 200 mcg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Hypo-Selenium 200 mcg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Hypo-Selenium 200 mcg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 36 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Selenium 36 references
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: National Academy Press, 2000. Available at: http://www.nap.edu/books/0309069351/html/.
- Brown BG, Zhao XQ, Chait A, et al. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med 2001;345:1583-93. DOI
- Trafikowska U, Zachara BA, Wiacek M, et al. Selenium supply and glutathione peroxidase activity in breastfed Polish infants. Acta Paediatr 1996;85:1143-5. PubMed
- Duffield-Lillico AJ, Slate EH, Reid ME, et al. Selenium supplementation and secondary prevention of nonmelanoma skin cancer in a randomized trial. J Natl Cancer Inst 2003;95:1477-81.. PubMed
- Cheung MC, Zhao XQ, Chait A, et al. Antioxidant supplements block the response of HDL to simvastatin-niacin therapy in patients with coronary artery disease and low HDL. Arterioscler Thromb Vasc Biol 2001;21:1320-6. PubMed
- Schiavon R, Freeman GE, Guidi GC, et al. Selenium enhances prostacyclin production by cultured endothelial cells: possible explanation for increased bleeding times in volunteers taking selenium as a dietary supplement. Thromb Res 1984;34:389-96. PubMed
- Davila JC, Edds GT, Osuna O, Simpson CF. Modification of the effects of aflatoxin B1 and warfarin in young pigs given selenium. Am J Vet Res 1983;44:1877-83. DOI
- Heese HD, Lawrence MA, Dempster WS, Pocock F. Reference concentrations of serum selenium and manganese in healthy nulliparas. S Afr Med J 1988;73:163-5.
- Lloyd B, Lloyd RS, Clayton BE. Effect of smoking, alcohol and other factors on the selenium status of a healthy population. J Epidemiol Commun Health 1983;37:213-7. PubMed
- Capel ID, Jenner M, Williams DC, et al. The effect of prolonged oral contraceptive steroid use on erythrocyte glutathione peroxidase activity. J Steroid Biochem 1981;14:729-32. PubMed
- Contempre B, Dumont JE, Ngo B, et al. Effect of selenium supplementation in hypothyroid subjects of an iodine and selenium deficient area: the possible danger of indiscriminate supplementation of iodine-deficient subjects with selenium. J Clin Endocrinol PubMed
- Hofbauer LC, Spitzweg C, Magerstadt RA, Heufelder AE. Selenium-induced thyroid dysfunction. Postgrad Med J 1997;73:103-4. PubMed
- Debski B, Milner JA. Dietary selenium supplementation prolongs pentobarbital induced hypnosis. J Nutr Biochem 2004;15:548-53. PubMed
- Ishikawa M, Sasaki M, Koiwai K, et al. Inhibition of hepatic mixed-function oxidase enzymes in mice by acute and chronic treatment with selenium. J Pharmacobiodyn 1992;15:377-85. PubMed
- Lippmann SM, Klein EA, Goodman PJ, et al. Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the selenium and vitamin E cancer prevention trial (SELECT). JAMA 2009;301:39-51. DOI
- Reid SM, Middleton P, Cossich MC, Crowther CA. Interventions for clinical and subclinical hypothyroidism in pregnancy. Cochrane Database Syst Rev 2010;(7):CD007752. PubMed
- Vinceti, M., Wei, E. T., Malagoli, C., Bergomi, M., and Vivoli, G. Adverse health effects of selenium in humans. Rev.Environ.Health 2001;16(4):233-251. PubMed
- Abrams, C. K., Siram, S. M., Galsim, C., Johnson-Hamilton, H., Munford, F. L., and Mezghebe, H. Selenium deficiency in long-term total parenteral nutrition. Nutr Clin Pract 1992;7(4):175-178. PubMed
- Spiller, H. A. and Pfiefer, E. Two fatal cases of selenium toxicity. Forensic Sci Int 8-24-2007;171(1):67-72. PubMed
- Negro, R., Greco, G., Mangieri, T., Pezzarossa, A., Dazzi, D., and Hassan, H. The influence of selenium supplementation on postpartum thyroid status in pregnant women with thyroid peroxidase autoantibodies. J Clin Endocrinol.Metab 2007;92(4):1263-1268. PubMed
- Alexander, J. Selenium. Novartis.Found.Symp 2007;282:143-149.
- Salonen, J. T., Salonen, R., Seppanen, K., Rinta-Kiikka, S., Kuukka, M., Korpela, H., Alfthan, G., Kantola, M., and Schalch, W. Effects of antioxidant supplementation on platelet function: a randomized pair-matched, placebo-controlled, double-blind trial
- Kupka, R., Mugusi, F., Aboud, S., Msamanga, G. I., Finkelstein, J. L., Spiegelman, D., and Fawzi, W. W. Randomized, double-blind, placebo-controlled trial of selenium supplements among HIV-infected pregnant women in Tanzania: effects on maternal and chil
- Kamble, P., Mohsin, N., Jha, A., Date, A., Upadhaya, A., Mohammad, E., Khalil, M., Pakkyara, A., and Budruddin, M. Selenium intoxication with selenite broth resulting in acute renal failure and severe gastritis. Saudi.J Kidney Dis.Transpl. 2009;20(1):106
- Peretz, A., Neve, J., Desmedt, J., Duchateau, J., Dramaix, M., and Famaey, J. P. Lymphocyte response is enhanced by supplementation of elderly subjects with selenium-enriched yeast. Am.J Clin.Nutr. 1991;53(5):1323-1328. PubMed
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