ImmPowerD3 Ingredients & Drug Interactions
What is this page for?
First and foremost: checking ImmPowerD3 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
ImmPowerD3 is a dietary supplement by American BioSciences with 5 active ingredients. Its ingredients are commonly taken for bone health and osteoporosis, correcting vitamin d deficiency, immune system support.Based on those ingredients, 715 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin D3. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against ImmPowerD3 by American BioSciences
Ask about any prescription or over-the-counter medication and we check it for interactions with ImmPowerD3 by American BioSciences — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of ImmPowerD3 by American BioSciences
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
ImmPowerD3 contains 5 active ingredients. Vitamin D3 is the primary active ingredient — it's a form of vitamin D your body uses to regulate calcium and support bone health.
The product also contains an AHCC proprietary blend, which is a group of ingredients listed separately. The remaining actives — dextrin and alpha-cyclodextrin — are there as well.
Vegetable cellulose is included as an inactive ingredient (the capsule material).
Does it work?
Moderate evidence
Vitamin D3 is effective for treating familial hypophosphatemia, osteomalacia (soft bones from vitamin D deficiency), renal osteodystrophy (bone disease from kidney problems), rickets (childhood bone disease), and hypoparathyroidism (low parathyroid hormone). The evidence we hold does not establish effectiveness ratings for the AHCC proprietary blend, dextrin, or alpha-cyclodextrin.
How safe is it?
Well-documented data
Vitamin D3 is generally well tolerated at recommended doses, though very high doses taken over time can build up and cause toxicity — symptoms include high blood calcium (hypercalcemia), kidney problems (azotemia), and anemia. Additional symptoms of vitamin D toxicity include bone loss in adults, slowed growth in children, eye inflammation (calcific conjunctivitis), and light sensitivity (photophobia).
The safety data notes that vitamin D is often used during pregnancy at recommended amounts, but only under your doctor's guidance, and is generally acceptable while breastfeeding at recommended doses — check with your doctor before taking higher amounts.
Meds to double-check
Moderate interaction found
Before taking ImmPowerD3, check with your doctor or pharmacist if you take digoxin, thiazide diuretics, verapamil, diltiazem, atorvastatin, any aluminum-containing antacids, calcipotriene, or other CYP3A4 substrates — all carry documented interactions. The main concern is that high-dose vitamin D can raise your blood calcium too high, which is risky with heart medications and diuretics.
Stay within the recommended upper limit of 4000 IU daily for adults unless your doctor advises otherwise.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
ImmPowerD3 is worth considering if you have a vitamin D deficiency or a condition like rickets, osteomalacia, or hypoparathyroidism — but it interacts with several common medications, especially heart drugs and blood pressure pills. If you take digoxin, a thiazide diuretic, verapamil, diltiazem, atorvastatin, or any aluminum-containing product, talk with your doctor or pharmacist before starting this supplement.
High doses matter: staying within recommended limits cuts your risk of calcium buildup and related side effects.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 22, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about ImmPowerD3, straight from the product label.
| Brand | American BioSciences |
|---|---|
| Barcode (UPC) | 678226034309 |
| Net contents | 30 Vegetarian Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jan 22, 2021 |
| DSLD ID | 241162 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for ImmPowerD3 by American BioSciences, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 5 Calorie(s) | -- |
| Vitamin D3 | 37.5 mcg | 188% |
| Carnauba Wax | 0 NP | -- |
| AHCC Proprietary Blend | 500 Gram(s) | -- |
| Dextrin | 0 NP | -- |
| Alpha-Cyclodextrin | 0 NP | -- |
| AHCC | 0 NP | -- |
Other ingredients: Vegetable Cellulose
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
AHCC plus vitamin D3
ImmPower D3 contains two of the most well-researched immune supplements, AHCC and Vitamin D3. AHCC is a powerful Japanese mushroom extract that maintains peak natural killer cell function, one of the most important aspects of immune system performance and Vitamin D3, known as the "Sunshine Vitamin" plays a role in overall immune health.
AHCC plus vitamin D3 for daily immune support
Suggested/Recommended/Usage/Directions
Suggested Use: As a dietary supplement for adults, take one (1) capsule twice per day for general maintenance. For maximum benefit, take up to 6 capsules per day.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Brand IP Statement(s)
AHCC is a registered trademark of the Amino Up Co., Ltd., and is a product of Japan. Vcaps is a registered trademark of Capsugel.
General Statements
The leader in immune defense since 1999
Formulation
Intense immune protection Clinically proven Works fast
Gluten free
FDA Statement of Identity
Dietary Supplement
Precautions
Keep out of reach of children.
Consult a healthcare professional first if you are pregnant or nursing.
Call 888-884-7770 with questions, comments or to report a serious adverse event.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
ImmPowerD3 by American BioSciences label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in ImmPowerD3 by American BioSciences
These are the 5 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container15 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Vitamin D3
Interacts with715 drugs
Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people,...
Vitamin D3 monograph & interactionsAHCC Proprietary Blend
- › Carnauba Wax
- › Dextrin
- › Alpha-Cyclodextrin
- › AHCC
Other (inactive) ingredients: Vegetable Cellulose. These complete the product’s ingredient list but are not active constituents.
ImmPowerD3 by American BioSciences Drug Interactions
HelloPharmacist Interaction Report
ImmPowerD3 by American BioSciences contains vitamin D3, which interacts with a number of medications — most notably thiazide diuretics, verapamil, atorvastatin, aluminum-containing products, digoxin, diltiazem, calcipotriene, and CYP3A4 substrates.
The most serious concern is with digoxin: high-dose vitamin D can raise calcium levels in your blood (hypercalcemia), which increases the risk of dangerous heart rhythm problems when combined with this heart medication.
Read the full breakdown — every affected drug type, severity by severity
Thiazide diuretics, verapamil, and diltiazem all carry Moderate risk. Thiazide diuretics lower how much calcium your kidneys excrete, which combined with vitamin D can push calcium levels too high.
Verapamil and diltiazem are used for abnormal heart rhythms, and hypercalcemia from high-dose vitamin D can make them less effective. Atorvastatin absorption may be reduced by vitamin D — one small study showed levels dropped as much as 55% — though cholesterol numbers in that study didn't shift noticeably.
Aluminum-containing antacids pose a Moderate risk: vitamin D can increase how much aluminum your body absorbs, though this risk is mainly a concern if you have kidney problems. Calcipotriene, a vitamin D-like topical medication for psoriasis, carries the same Moderate hypercalcemia risk.
CYP3A4 substrates — a broad category of medications — may have reduced effectiveness if vitamin D induces these liver enzymes, though the evidence here is preliminary (Minor severity).
We could not check interactions for carnauba wax, dextrin, alpha-cyclodextrin, or AHCC itself — we hold no data for these ingredients. Before starting this product, run your exact medications through the search tool on this page.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against ImmPowerD3?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in ImmPowerD3 interact with 715 drugs. Click any drug to see the details.
1 of the 5 ingredients in ImmPowerD3 interact with drugs. Each result below shows which ingredient is responsible. Vitamin D3
Hydrochlorothiazide, ReserpineHydropres, Serpasil-Esidrix, Serpasil-Esidrix #1, Serpasil-Esidrix #2
How Hydrochlorothiazide, Reserpine interacts with ImmPowerD3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Hydrochlorothiazide, Reserpine interactionHydrochlorothiazide, SpironolactoneAldactazide, Aldactide 25, Aldactide 50, Spirozine
How Hydrochlorothiazide, Spironolactone interacts with ImmPowerD3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Hydrochlorothiazide, Spironolactone interactionHydrochlorothiazide, TimololTimolide
How Hydrochlorothiazide, Timolol interacts with ImmPowerD3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Hydrochlorothiazide, Timolol interactionHydrochlorothiazide, TriamtereneDyazide, Maxzide, Maxzide-25, Triamzide, Triazide
How Hydrochlorothiazide, Triamterene interacts with ImmPowerD3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Hydrochlorothiazide, Triamterene interactionHydrochlorothiazide, ValsartanDiovan HCT
How Hydrochlorothiazide, Valsartan interacts with ImmPowerD3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Hydrochlorothiazide, Valsartan interactionHydroflumethiazideSaluron
How Hydroflumethiazide interacts with ImmPowerD3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Hydroflumethiazide interactionHydroflumethiazide, ReserpineSalutensin, Salutensin-Demi
How Hydroflumethiazide, Reserpine interacts with ImmPowerD3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Hydroflumethiazide, Reserpine interactionIndapamideLozide, Lozol
How Indapamide interacts with ImmPowerD3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Indapamide interactionIrbesartan, HydrochlorothiazideCoAprovel
How Irbesartan, Hydrochlorothiazide interacts with ImmPowerD3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Irbesartan, Hydrochlorothiazide interactionMethyclothiazideAquatensen, Enduron
How Methyclothiazide interacts with ImmPowerD3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Methyclothiazide interactionMethyclothiazide, PargylineEutron
How Methyclothiazide, Pargyline interacts with ImmPowerD3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Methyclothiazide, Pargyline interactionMethyclothiazide, ReserpineDiutensen-R
How Methyclothiazide, Reserpine interacts with ImmPowerD3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Methyclothiazide, Reserpine interactionMetolazoneDiulo, Mykrox, Zaroxolyn
How Metolazone interacts with ImmPowerD3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Metolazone interactionPolythiazideRenese
How Polythiazide interacts with ImmPowerD3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Polythiazide interactionPolythiazide, PrazosinMinizide
How Polythiazide, Prazosin interacts with ImmPowerD3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Polythiazide, Prazosin interactionPolythiazide, ReserpineRenese R
How Polythiazide, Reserpine interacts with ImmPowerD3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Polythiazide, Reserpine interactionReserpine, TrichlormethiazideMetatensin #2, Metatensin #4, Naquival
How Reserpine, Trichlormethiazide interacts with ImmPowerD3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Reserpine, Trichlormethiazide interactionTrandolapril, VerapamilTarka
How Trandolapril, Verapamil interacts with ImmPowerD3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Cytochrome P450 3a4 (cyp3a4) Substrates, Verapamil (calan, Others) Moderate
Interaction Summary
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D3 + Trandolapril, Verapamil interactionTrichlormethiazideAq 4B Aquazide, Marazide II, Metahydrin, Naqua
How Trichlormethiazide interacts with ImmPowerD3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Trichlormethiazide interactionVerapamilCalan, Calan SR, Covera HS, Isoptin, Isoptin SR, Veramil +3 more
How Verapamil interacts with ImmPowerD3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Verapamil (calan, Others), Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of verapamil for arrhythmia.
Read the full Vitamin D3 + Verapamil interactionAdo-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with ImmPowerD3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D3 + Ado-trastuzumab Emtansine interactionAbemaciclibVerzenio
How Abemaciclib interacts with ImmPowerD3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D3 + Abemaciclib interactionAbiraterone
How Abiraterone interacts with ImmPowerD3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D3 + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with ImmPowerD3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D3 + Abiraterone Acetate interactionAcalabrutinibCalquence
How Acalabrutinib interacts with ImmPowerD3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D3 + Acalabrutinib interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with ImmPowerD3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D3 + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with ImmPowerD3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D3 + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with ImmPowerD3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D3 + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with ImmPowerD3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D3 + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with ImmPowerD3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D3 + Acetaminophen, Caffeine, Codeine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in ImmPowerD3 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Vitamin D3
Aluminum
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
The protein that transports calcium across the intestinal wall can also bind and transport aluminum. This protein is stimulated by vitamin D, which may therefore increase aluminum absorption. This mechanism may contribute to increased aluminum levels and toxicity in people with renal failure, when they take vitamin D and aluminum-containing phosphate binders chronically.
Atorvastatin (Lipitor)
Vitamin D might reduce absorption of atorvastatin.
A small, low-quality clinical study shows that taking vitamin D reduces levels of atorvastatin and its active metabolites by up to 55%. However, while atorvastatin levels decreased, total cholesterol, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol levels did not substantially change. Atorvastatin is metabolized in the gut by CYP3A4 enzymes, and researchers theorized that vitamin D might induce CYP3A4, causing reduced levels of atorvastatin. However, this proposed mechanism was not specifically studied.
Calcipotriene (Dovonex)
Taking calcipotriene with vitamin D increases the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with vitamin D supplements might increase the risk of hypercalcemia.
Digoxin (Lanoxin)
Theoretically, hypercalcemia induced by high-dose vitamin D can increase the risk of arrhythmia from digoxin.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and digoxin concurrently.
Diltiazem (Cardizem, Others)
Theoretically, hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of diltiazem for arrhythmia.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically this could also occur with diltiazem. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and diltiazem concurrently.
Thiazide Diuretics
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Thiazide diuretics decrease urinary calcium excretion, which could lead to hypercalcemia if vitamin D supplements are taken concurrently. This has been reported in people being treated with vitamin D for hypoparathyroidism, and also in elderly people with normal parathyroid function who were taking a thiazide, vitamin D, and calcium-containing antacids daily.
Verapamil (Calan, Others)
Hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of verapamil for arrhythmia.
Hypercalcemia due to high doses of vitamin D can reduce the effectiveness of verapamil in atrial fibrillation. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and verapamil concurrently.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
There is some concern that vitamin D might induce CYP3A4. In vitro research suggests that vitamin D induces CYP3A4 transcription. Additionally, observational research has found that increased UV light exposure and serum vitamin D levels are associated with decreased serum levels of CYP3A4 substrates such as tacrolimus and sirolimus, while no association between UV light exposure or vitamin D levels and levels of mycophenolic acid, a non-CYP3A4 substrate, was found. A small, low-quality clinical study shows that taking vitamin D reduces levels of the CYP3A4 substrate atorvastatin and its active metabolites by up to 55%; however, the clinical effects of atorvastatin were not reduced. While researchers theorized that vitamin D might induce CYP3A4, this proposed mechanism was not specifically studied.
Brand information
Manufacturer and brand details for ImmPowerD3, from the product label.
American BioSciences
See all American BioSciences products- Name
- American BioSciences, Inc.
- City
- Blauvelt
- State
- NY
- ZipCode
- 10913
- Phone Number
- 888-884-7770
- Web Address
- www.americanbiosciences.com
ImmPowerD3 by American BioSciences: Common Questions
Does ImmPowerD3 by American BioSciences interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is ImmPowerD3 safe to take while I'm pregnant or breastfeeding?
Can I take this if I'm on a blood pressure medication?
What are the side effects of vitamin D3?
Will this help my osteomalacia?
Does this product have fillers?
Can I take this with my cholesterol medication?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if ImmPowerD3 is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind ImmPowerD3’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
ImmPowerD3's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 26 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Vitamin D 26 references
- McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
- Tatro DS, ed. Drug Interactions Facts. Facts and Comparisons Inc., St. Louis, MO. 1999.
- Koutkia P, Chen TC, Holick MF. Vitamin D intoxication associated with an over-the-counter supplement. N Engl J Med 2001;345:66-7. PubMed
- Bar-Or D, Yoel G. Calcium and calciferol antagonize effect of verapamil in atrial fibrillation. Br Med J 1981;282:1585-6.
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