Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Immune Bac Pro Ingredients & Drug Interactions

by Redd Remedies

Capsule Category: Botanical
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Immune Bac Pro is a dietary supplement by Redd Remedies with 5 active ingredients. Its ingredients are commonly taken for skin conditions like acne and eczema, digestive support, diuretic ('detox') and blood purifier.Based on those ingredients, 966 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Coptis Root Extract, Andrographis Leaf Extract, Forsythia fruit extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Immune Bac Pro by Redd Remedies

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 2 of its 5 active ingredients.
  • “Bac Pro Herbal Blend” is a proprietary blend — the label gives one combined amount (150 mg) without saying how much of each component you get.

Immune Bac Pro contains five active ingredients: Burdock Root Extract, Andrographis Leaf Extract, Forsythia Fruit Extract, Japanese Honeysuckle Flower Extract, and Coptis Root Extract. The product also includes a proprietary blend labeled Bac Pro Herbal Blend—its specific components are covered by the individual extracts listed above.

These are wrapped in a capsule made from hypromellose and filled with inactive ingredients including microcrystalline cellulose, rice extract, gum arabic, and others to stabilize and deliver the formula.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Rapid response immune support with adaptogenic formula.
  • We looked for evidence on: Common cold, Influenza, Upper respiratory tract infection (URTI), Acute bronchitis, Rhinosinusitis, Tonsillopharyngitis — and 4 related terms.
  • The strongest evidence on file: Andrographis is rated "Possibly Effective" for Tonsillopharyngitis (Natural Medicines).
  • Also on file: Burdock is rated "Insufficient Reliable Evidence To Rate" for Common cold.
  • Also on file: Honeysuckle is rated "Insufficient Reliable Evidence To Rate" for Respiratory tract infections.

The evidence for most uses in this product is still being established. Andrographis shows the strongest data—it's rated possibly effective for tonsillopharyngitis, ulcerative colitis, and osteoarthritis.

For the other ingredients and most conditions they're traditionally used for—acne, eczema, common cold, respiratory tract infections, and diabetes—the evidence isn't reliable enough to rate in our data. That doesn't mean they don't work; it means we don't yet have high-quality research to confirm it.

The evidence, ingredient by ingredient Burdock Andrographis Forsythia Honeysuckle Goldthread

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Burdock, Andrographis, Forsythia, and Honeysuckle are generally well tolerated when used short-term, though full safety profiles in humans are limited. Andrographis carries the most documented side effects: at higher doses or over longer periods (exceeding 14 days), users have reported headache, fatigue, nausea, rash, and rarely severe allergic reactions.

Burdock and Honeysuckle can cause allergic skin reactions and contact dermatitis, especially with prolonged use. A rare case of liver damage was reported with burdock in a herbal blend, though it's unclear if burdock alone was responsible.

Coptis Root Extract should be avoided in pregnancy (berberine may harm the fetus) and while breastfeeding (berberine can pass to infants). Andrographis is rated possibly unsafe in pregnancy.

Burdock, Forsythia, and Honeysuckle lack enough safety data in pregnancy and lactation—the facts advise against medicinal use during both.

Side effects, ingredient by ingredient Burdock Andrographis Forsythia Honeysuckle Goldthread

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Burdock, Goldthread, Honeysuckle, Andrographis, Forsythia.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs.
  • For scale: 967 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Immune Bac Pro, check with your doctor or pharmacist if you're on any anticoagulants or antiplatelets (like warfarin, aspirin, or clopidogrel)—multiple ingredients may raise bleeding risk. Also confirm any blood pressure medications, immunosuppressants (especially cyclosporine), or drugs processed by the liver enzyme CYP3A4, which includes certain cholesterol, heart, and cancer medications.

Minor interactions are also possible with azithromycin, celecoxib, etoricoxib, and glipizide.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and some safety-information gaps remain.

Immune Bac Pro is built on traditional herbal ingredients with limited high-quality evidence for most immune or cold-related uses—Andrographis has the strongest data for throat and gut inflammation. If you take blood thinners, blood pressure drugs, immunosuppressants like cyclosporine, or drugs metabolized by your liver's CYP3A4 enzyme, you need to check this product with your doctor or pharmacist before starting.

Pregnant or breastfeeding people should talk with their healthcare provider first, especially because several ingredients carry safety cautions for these times.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Immune Bac Pro, straight from the product label.

Brand Redd Remedies
Barcode (UPC) 855735001668
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Nov 22, 2023
DSLD ID 299920
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Immune Bac Pro by Redd Remedies, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
855735001668
IngredientAmount% DV
Burdock Root Extract75 mg--
Andrographis Leaf Extract200 mg--
Forsythia fruit extract0 NP--
Japanese Honeysuckle flower extract0 NP--
Bac Pro Herbal Blend150 mg--
Coptis Root Extract0 NP--

Other ingredients: Hypromellose, Water, Microcrystalline Cellulose, Silicon Dioxide, Rice extract, Rice Husk, Gum Arabic, Sunflower Oil

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Rapid response

Made without: sugar, yeast, wheat, gluten, artificial flavoring or coloring, or preservatives.

Every natural health solution from Redd Remedies is produced with 4-point quality control We verify 1 Every raw material vendor 2 Every raw material used 3 Every step of the manufacturing and packaging processes 4 Every product specification for every batch including testing by industry-leading, independent laboratories

GF Gluten free Non GMO

V Vegetarian

Lab tested

We do not use ingredients that were produced using biotechnology.

Formula

Advanced adaptogen formula with berberine

Coptis root, a source of berberine, supports digestive health. Andrographis, an adaptogen herb, supports healthy immune function and supports stress reduction. Japanese honeysuckle and Forsythia tonify Qi. Burdock root, an alternative herb, supports a healthy lymphatic system.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: 2 capsules up to twice daily without food.

Precautions

Warning: Do not use if pregnant or nursing. If taking any medication or if you have a medical condition, consult your healthcare practitioner before use.

Keep out of reach of children.

General Statements

Questions 888-453-5058 [email protected]

Actual size

Storage

Store in a dry place at room temperature.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

See for yourself

Immune Bac Pro by Redd Remedies label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Immune Bac Pro by Redd Remedies

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Burdock Root Extract

Interacts with
122 drugs
75 mg per serving Form: Arctium lappa Root Extract

Burdock is a traditional herb most often used for skin problems and as a so-called 'blood purifier,' but high-quality human studies are lacking and mo...

Burdock Root Extract monograph & interactions

Andrographis Leaf Extract

Interacts with
413 drugs
200 mg per serving Form: Andrographis paniculata Leaf Extract

Andrographis is a bitter Asian herb traditionally used for colds, flu, and infections, and some studies suggest it may ease cold symptoms and shorten...

Andrographis Leaf Extract monograph & interactions

Bac Pro Herbal Blend

150 mg per serving

Other (inactive) ingredients: Hypromellose, Water, Microcrystalline Cellulose, Silicon Dioxide, Rice extract, Rice Husk, Gum Arabic, Sunflower Oil. These complete the product’s ingredient list but are not active constituents.

Interaction report

Immune Bac Pro by Redd Remedies Drug Interactions

Want to check YOUR meds against Immune Bac Pro?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
966Drugs
962 Moderate 4 Minor

Each ingredient & the kinds of drugs it affects

For each ingredient in Immune Bac Pro with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Coptis Root Extract2 drug types · 643 drugs

Cyclosporine (Neoral, Sandimmune)

Berberine, a constituent of goldthread, can reduce metabolism of cyclosporine and increase serum levels. It might inhibit cytochrome P450 3A4 (CYP3A4), which metabolizes cyclosporine.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

There's very preliminary evidence that berberine, a constituent of goldthread, might inhibit cytochrome P450 3A4 (CYP3A4) enzyme. So far, this interaction has not been reported in humans. However, watch for an increase in the levels of drugs metabolized by CYP3A4 in patients taking goldthread. Some drugs metabolized by CYP3A4 include lovastatin (Mevacor), clarithromycin (Biaxin), indinavir (Crixivan), sildenafil (Viagra), triazolam (Halcion), and numerous others. Use goldthread cautiously or avoid in patients taking these drugs.

Likelihood Possible Evidence D

Andrographis Leaf Extract6 drug types · 413 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, andrographis might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Animal and laboratory studies suggest that andrographis has antiplatelet effects.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, andrographis might increase the risk of hypotension when used with antihypertensive drugs.
Animal research suggests that andrographis has hypotensive effects.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, andrographis might interfere with the effects of immunosuppressive drugs.
Laboratory research suggests that andrographolide has immunostimulant activity.

Likelihood Possible Evidence D
Celecoxib (Celebrex)

Theoretically, andrographis extract might increase the maximum concentration and time to peak concentration of celecoxib. The clinical significance of these changes is unclear.
Animal research suggests that andrographis extract taken orally increases the maximum concentration and time to peak concentration of celecoxib but does not appear to impact the area under the curve.

Likelihood Possible Evidence D
Etoricoxib (Arcoxia)

Theoretically, andrographis might decrease the absorption of etoricoxib, although the clinical significance is unclear.
Animal research shows that andrographis extract, or the constituent andrographolide, taken orally with etoricoxib decreases the bioavailability of etoricoxib. However, this reduced bioavailability is not correlated with a reduction in the anti-inflammatory effects of etoricoxib in arthritic mice models. The clinical significance of this interaction is unclear.

Likelihood Possible Evidence D
Glipizide (Glucotrol)

Theoretically, andrographis extract might increase the maximum concentration and area under the curve of glipizide; however, opposite effects are seen with the constituent, andrographolide. The clinical significance of this interaction is unclear.
Animal research suggests that andrographis extract taken orally with glipizide in diabetes-induced rats increases the maximum concentration and area under the curve of glipizide. However, the opposite effect is seen with the constituent, andrographolide, in which the maximum concentration and area under the curve are decreased when taken with glipizide.

Likelihood Possible Evidence D

Forsythia fruit extract2 drug types · 123 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking forsythia with anticoagulant or antiplatelet drugs might increase the risk of bleeding due to decreased platelet aggregation. Forsythia might reduce platelet aggregation by inhibiting platelet activating factor. Some of these drugs include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.

Likelihood Unlikely Evidence D
Azithromycin (Zithromax)

Theoretically, taking forsythia with azithromycin might increase the risk of adverse effects. Animal research in rats shows that taking a single dose of forsythia with azithromycin decreases the clearance and increases the area under the curve of both forsythiaside, a constituent of forsythia, and azithromycin. The mechanism of this interaction is not well understood.

Likelihood Unlikely Evidence D

Burdock Root Extract1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking burdock with anticoagulant or antiplatelet drugs might increase the risk of bleeding.

In vitro research shows that lignans from burdock reduce rabbit platelet aggregation by inhibiting platelet activating factor. This interaction has not been reported in humans.

Likelihood Possible Evidence D

Japanese Honeysuckle flower extract1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, honeysuckle might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that polyphenols extracted from honeysuckle can inhibit platelet aggregation.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Immune Bac Pro, from the product label.

Redd Remedies

See all Redd Remedies products
Name
Redd Remedies
City
Bradley
State
IL
ZipCode
60915
Phone Number
888-453-5058
Web Address
www.reddremedies.com
Pharmacist Counseling Corner

Immune Bac Pro by Redd Remedies: Common Questions

Does Immune Bac Pro by Redd Remedies interact with any medications?
Yes. Based on its ingredients, Immune Bac Pro has a known interaction with 966 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Immune Bac Pro contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is it safe to take Immune Bac Pro while I'm pregnant?
No, not based on the safety data we hold. Coptis Root Extract (which contains berberine) is rated likely unsafe in pregnancy because it may harm the fetus. Andrographis is rated possibly unsafe. Burdock, Forsythia, and Honeysuckle lack enough data, but the facts advise against medicinal use in pregnancy. Talk with your doctor or pharmacist before taking this product if you're pregnant or planning to become pregnant.
Can I breastfeed while taking Immune Bac Pro?
The safety data advise against it. Coptis Root Extract is rated likely unsafe—berberine passes into breast milk and may harm your infant. Andrographis, Burdock, Forsythia, and Honeysuckle all lack enough safety information. Check with your doctor or pharmacist for personalized guidance if you're breastfeeding.
What does Andrographis in this product actually do?
Andrographis has the best evidence in this formula. It's rated possibly effective for tonsillopharyngitis (sore throat), ulcerative colitis (inflammatory bowel condition), and osteoarthritis. For other uses, the evidence isn't established yet. It's been used in traditional medicine for immune and digestive support.
Are there any common side effects from taking this?
Andrographis is the ingredient most likely to cause side effects, especially at higher doses or over longer periods. Users have reported headache, fatigue, nausea, diarrhea, and rash. Burdock and Honeysuckle can cause allergic skin reactions in some people. Most people tolerate the ingredients short-term without problems, but individual responses vary.
Why does this product interact with so many medications?
Coptis Root Extract alone accounts for most of them—its active compound, berberine, affects a broad liver enzyme (CYP3A4) that processes hundreds of drugs used for cholesterol, heart, cancer, and many other conditions. The other four ingredients each carry their own interactions with blood thinners, blood pressure drugs, and immune drugs. That's why checking your specific medications is essential before starting.
Does this product contain any fillers or inactive ingredients I should know about?
Yes. Beyond the five active extracts, the capsule contains hypromellose, microcrystalline cellulose, silicon dioxide, rice extract, rice husk, gum arabic, sunflower oil, and water as inactive ingredients. These are typical capsule binders and stabilizers. If you have sensitivities to any of these, review the full list with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Immune Bac Pro is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Immune Bac Pro label
Go deeper

The Full Monographs Behind Immune Bac Pro’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

Immune Bac Pro's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 46 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Burdock 11 references
  1. Iwakami S, Wu JB, Ebizuka Y, Sankawa U. Platelet activating factor (PAF) antagonists contained in medicinal plants: lignans and sesquiterpenes. Chem Pharm Bull (Tokyo) 1992;40:1196-8. PubMed
  2. Sasaki Y, Kimura Y, Tsunoda T, Tagami H. Anaphylaxis due to burdock. Int J Dermatol 2003;42:472-3. PubMed
  3. Rhoads PM, Tong TG, Banner W Jr, Anderson R. Anticholinergic poisonings associated with commercial burdock root tea. J Toxicol Clin Toxicol 1984-85;22:581-4. PubMed
  4. Rodriguez P, Blanco J, Juste S, et al. Allergic contact dermatitis due to burdock (Arctium lappa). Contact Dermatitis 1995;33:134-5.
  5. Kassler, W. J., Blanc, P., and Greenblatt, R. The use of medicinal herbs by human immunodeficiency virus-infected patients. Arch Intern Med 1991;151(11):2281-2288. DOI
  6. Chan, Y. S., Cheng, L. N., Wu, J. H., Chan, E., Kwan, Y. W., Lee, S. M., Leung, G. P., Yu, P. H., and Chan, S. W. A review of the pharmacological effects of Arctium lappa (burdock). Inflammopharmacology. 2011;19(5):245-254. PubMed
  7. Breed, F. B. and Kuwabara, T. Burdock ophthalmia. Arch Ophthalmol 1966;75(1):16-20.
  8. Bryson, P. D., Watanabe, A. S., Rumack, B. H., and Murphy, R. C. Burdock root tea poisoning. Case report involving a commercial preparation. JAMA 5-19-1978;239(20):2157. DOI
  9. <p>Fletcher GF<span>, </span>Cantwell JD. Burdock root tea poisoning. JAMA <span>1978 Oct 6;240(15):1586.</span></p> DOI
  10. Latif A, Fichadiya H, Abid F, Capo G. Herbal Teas and Thrombocytopenia: A Curious Case of Yellow Dock and Burdock-Induced Thrombocytopenia. Eur J Case Rep Intern Med 2022;9(3):003247. PubMed
  11. Niazi B, Ahmed K, Ahmed M, Ali S, Song K, Elias S. Drug-Induced Liver Injury from Herbal Liver Detoxification Tea. Case Rep Gastroenterol 2022;16(3):612-617. PubMed

See these in context on the Burdock monograph →

Andrographis 26 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Thamlikitkul V, Dechatiwongse T, Theerapong S, et al. Efficacy of Andrographis paniculata, Nees for pharyngotonsillitis in adults. J Med Assoc Thai 1991;74:437-42.
  3. Zhang CY, Tan BK. Mechanisms of cardiovascular activity of Andrographis paniculata in the anaesthetized rat. J Ethnopharmacol 1997;56:97-101. PubMed
  4. Zhao HY, Fang WY. Antithrombotic effects of Andrographis paniculata nees in preventing myocardial infarction. Chin Med J (Engl) 1991;104:770-5.
  5. Amroyan E, Gabrielian E, Panossian A, et al. Inhibitory effect of andrographolide from Andrographis paniculata on PAF-induced platelet aggregation. Phytomedicine 1999;6:27-31. PubMed
  6. Zhang C, Kuroyangi M, Tan BK. Cardiovascular activity of 14-deoxy-11,12-didehydroandrographolide in the anaesthetised rat and isolated right atria. Pharmacol Res 1998;38:413-7. PubMed
  7. Puri A, Saxena R, Saxena RP, et al. Immunostimulant agents from Andrographis paniculata. J Nat Prod 1993;56:995-9. PubMed
  8. Melchoir J, Spasov AA, Ostrovskij OV, et al. Double-blind, placebo-controlled pilot and phase III study of activity of standardized Andrographis paniculata Herba Nees extract fixed combination (Kan Jang) in the treatment of uncomplicated upper-respirator
  9. Calabrese C, Berman SH, Babish JG, et al. A phase I trial of andrographolide in HIV positive patients and normal volunteers. Phytother Res 2000;14:333-8. PubMed
  10. Gabrielian ES, Shukarian AK, Goukasova GI, et al. A double blind, placebo-controlled study of Andrographis paniculata fixed combination Kan Jang in the treatment of acute upper respiratory tract infections including sinusitis. Phytomedicine 2002;9:589-97 PubMed
  11. Poolsup N, Suthisisang C, Prathanturarug S, et al. Andrographis paniculata in the symptomatic treatment of uncomplicated upper respiratory tract infection: systematic review of randomized controlled trials. J Clin Pharm Ther 2004;29:37-45. PubMed
  12. Coon JT, Ernst E. Andrographis paniculata in the treatment of upper respiratory tract infections: a systematic review of safety and efficacy. Planta Med 2004;70:293-8.
  13. Kligler, B., Ulbricht, C., Basch, E., Kirkwood, C. D., Abrams, T. R., Miranda, M., Singh Khalsa, K. P., Giles, M., Boon, H., and Woods, J. Andrographis paniculata for the treatment of upper respiratory infection: a systematic review by the natural standa
  14. Burgos, R. A., Hancke, J. L., Bertoglio, J. C., Aguirre, V., Arriagada, S., Calvo, M., and Caceres, D. D. Efficacy of an Andrographis paniculata composition for the relief of rheumatoid arthritis symptoms: a prospective randomized placebo-controlled tria
  15. Saxena, R. C., Singh, R., Kumar, P., Yadav, S. C., Negi, M. P., Saxena, V. S., Joshua, A. J., Vijayabalaji, V., Goudar, K. S., Venkateshwarlu, K., and Amit, A. A randomized double blind placebo controlled clinical evaluation of extract of Andrographis pa
  16. Tang, T., Targan, S. R., Li, Z. S., Xu, C., Byers, V. S., and Sandborn, W. J. Randomised clinical trial: herbal extract HMPL-004 in active ulcerative colitis - a double-blind comparison with sustained release mesalazine. Aliment.Pharmacol Ther 2011;33(2) PubMed
  17. Sandborn, W. J., Targan, S. R., Byers, V. S., Rutty, D. A., Mu, H., Zhang, X., and Tang, T. Andrographis paniculata extract (HMPL-004) for active ulcerative colitis. Am J Gastroenterol. 2013;108(1):90-98. PubMed
  18. Melchior, J., Palm, S., and Wikman, G. Controlled clinical study of standardized Andrographis paniculata extract in common cold - a pilot trial. Phytomedicine. 1997;3(4):315-318. PubMed
  19. Balap A, Atre B, Lohidasan S, et al. Pharmacokinetic and pharmacodynamic herb-drug interaction of Andrographis paniculata (Nees) extract and andrographolide with etoricoxib after oral administration in rats. J Ethnopharmacol. 2016 May 13;183:9-17. PubMed
  20. Bertoglio JC, Baumgartner M, Palma R, et al. Andrographis paniculata decreases fatigue in patients with relapsing-remitting multiple sclerosis: a 12-month double-blind placebo-controlled pilot study. BMC Neurol. 2016; 16(1):77. PubMed
  21. Suwankesawong W, Saokaew S, Permsuwan U, et al. Characterization of hypersensitivity reactions reported among Andrographis paniculata users in Thailand using Health Product Vigilance Center (HPVC) database. BMC Complement Altern Med. 2014; 14:515. PubMed
  22. Ciampi E, Uribe-San-Martin R, Cárcamo C, et al. Efficacy of andrographolide in not active progressive multiple sclerosis: a prospective exploratory double-blind, parallel-group, randomized, placebo-controlled trial. BMC Neurol 2020;20(1):173. PubMed
  23. Worakunphanich W, Thavorncharoensap M, Youngkong S, Thadanipon K, Thakkinstian A. Safety of Andrographis paniculata: A systematic review and meta-analysis. Pharmacoepidemiol Drug Saf 2021;30(6):727-739.
  24. More SJ, Tandulwadkar SS, Balap AR, Lohidasan S, Sinnathambi A, Mahadik KR. Effect of Andrographis paniculata extract and Andrographolide on the pharmacokinetics of Aceclofenac and Celecoxib in rats. Futur J Pharm Sci. 2023;9(1):1. PubMed
  25. Sundhani E, Nugroho AE, Nurrochmad A, Puspitasari I, Amalia Prihati D, Lukitaningsih E. Pharmacokinetic Herb-Drug Interactions of Glipizide with Andrographis paniculata (Burm. f.) and Andrographolide in Normal and Diabetic Rats by Validated HPLC Method. M PubMed
  26. Shang YX, Shen C, Stub T, et al. Adverse Effects of Andrographolide Derivative Medications Compared to the Safe use of Herbal Preparations of Andrographis paniculata: Results of a Systematic Review and Meta-Analysis of Clinical Studies. Front Pharmacol 20 PubMed

See these in context on the Andrographis monograph →

Forsythia 3 references
  1. Kong XT, Fang HT, Jiang GQ, et al. Treatment of acute bronchiolitis with Chinese herbs. Arch Dis Child 1993;68:468-71. PubMed
  2. Iwakami S, Wu JB, Ebizuka Y, Sankawa U. Platelet activating factor (PAF) antagonists contained in medicinal plants: lignans and sesquiterpenes. Chem Pharm Bull (Tokyo) 1992;40:1196-8. PubMed
  3. Li XG, Ni J, Shen S, Wang XP, Tian JC. Pharmacokinetic interaction of Forsythia suspensa extract and azithromycin injection after single and co-intravenous administration in rats. Chin J Nat Med 2020;18(3):234-240. PubMed

See these in context on the Forsythia monograph →

Honeysuckle 3 references
  1. Chang WC, Hsu FL. Inhibition of platelet activation and endothelial cell injury by polyphenolic compounds isolated from Lonicera japonica Thunb. Prostaglandins Leukot Essent Fatty Acids 1992;45:307-12. PubMed
  2. Webster RM. Honeysuckle contact dermatitis. Cutis 1993;51:424.
  3. Zhou LF, Lu R. Compound-honeysuckle-induced drug eruption with special manifestations: A case report. World J Clin Cases 2022;10(22):8018-8024. PubMed

See these in context on the Honeysuckle monograph →

Goldthread 3 references
  1. Chan E. Displacement of bilirubin from albumin by berberine. Biol Neonate 1993;63:201-8. PubMed
  2. Wu X, Li Q, Xin H, Yu A, Zhong M. Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study. Eur J Clin Pharmacol 2005;61:567-72. PubMed
  3. Chuang CH, Doyle P, Wang JD, et al. Herbal medicines used during the first trimester and major congenital malformations: an analysis of data from a pregnancy cohort study. Drug Saf 2006;29:537-48. PubMed

See these in context on the Goldthread monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring