Interactions on record — worth a quick check against your medications. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

Immune Senescene Protection Formula Ingredients & Drug Interactions

by Life Extension

Immune Senescene Protection Formula label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Immune Senescene Protection Formula against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Immune Senescene Protection Formula is a dietary supplement by Life Extension with 3 active ingredients. Its ingredients are commonly taken for immune support, fatigue and general well-being, stress and sleep.Based on those ingredients, 375 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Reishi Mushroom (Ganoderma lucidum) extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Immune Senescene Protection Formula by Life Extension

Ask about any prescription or over-the-counter medication and we check it for interactions with Immune Senescene Protection Formula by Life Extension — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Immune Senescene Protection Formula by Life Extension

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This formula has 3 active ingredients. The two reishi mushroom forms—a standard extract and a shell-broken extract—are the core actives; they're derived from a fungus traditionally used in herbal medicine.

The third active ingredient is Cistanche tubulosa extract, though we hold no interaction data for it. The inactive ingredients are vegetable cellulose (the capsule), rice flour, starch, L-leucine, and silica—standard capsule fillers and flow agents.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Reishi Mushroom's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: support for the aging immune system.
  • We looked for evidence on: Aging, immune function, immunosenescence, age-related immune decline.
  • The closest evidence on file: Reishi Mushroom is rated "Insufficient Reliable Evidence To Rate" for Aging (Natural Medicines).

The evidence we hold doesn't support reishi mushroom for lowering cholesterol (hyperlipidemia)—it's rated possibly ineffective for that purpose. For altitude sickness, Alzheimer disease, and athletic performance, the evidence is too thin to rate either way.

We have no effectiveness data on file for Cistanche tubulosa extract.

The evidence, ingredient by ingredient Reishi Mushroom

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Reishi mushroom is generally well tolerated in the short term, but long-term safety hasn't been well studied, so use caution if you plan to take it regularly. The most common side effects are dizziness, dry mouth, itching, nausea, rash, and stomach upset.

A small number of people may experience respiratory allergy to reishi spores, with sore throat and runny nose. Rare symptoms include insomnia and headache.

Not enough safety data exists for use during pregnancy or while breastfeeding—the data advises against both. We hold no pregnancy or breastfeeding safety information for Cistanche tubulosa extract.

Side effects, ingredient by ingredient Reishi Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Reishi Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 375 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before taking this product if you're on any blood pressure medications, blood thinners (including aspirin), or diabetes drugs. All three interactions with reishi are Moderate severity.

No interactions are documented for Cistanche tubulosa extract, since we hold no data for it.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product is built on reishi mushroom, which has a long history of traditional use but limited proven benefit for most conditions. If you take blood pressure meds, blood thinners, or diabetes drugs, you'll need to check your specific medications against the interaction tool on this page before starting.

Talk it over with your doctor or pharmacist—especially if you're pregnant, breastfeeding, or plan to use it long-term.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Immune Senescene Protection Formula, straight from the product label.

Brand Life Extension
Barcode (UPC) 737870190561
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jun 24, 2016
DSLD ID 60843
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Immune Senescene Protection Formula by Life Extension, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Vegetarian Capsule(s)
Maximum serving Sizes:
2 Vegetarian Capsule(s)
Servings per container
30
UPC/BARCODE
737870190561
IngredientAmount% DV
Reishi Mushroom (Ganoderma lucidum) extract980 mg--
shell-broken Reishi Mushroom150 mg--
Cistanche tubulosa extract210 mg--

Other ingredients: Vegetable Cellulose, Rice Flour, Starch, L-Leucine, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula

Standardized Cistanche and Reishi

General Statements

Support for the Aging Immune System*

To report a serious adverse event or obtain product information, contact 1-866-280-2852.

Scan for product info

FDA Statement of Identity

Dietary Supplement

Formulation

Non-GMO

Precautions

WARNINGS: ~ KEEP OUT OF REACH OF CHILDREN.

~ DO NOT EXCEED RECOMMENDED DOSE. ~ Do not purchase if outer seal is broken or damaged.

~ When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

General

Q01905B

Suggested/Recommended/Usage/Directions

Read the entire label and follow the directions carefully prior to use. DIRECTIONS: Take two (2) capsules daily with food, or as recommended by a healthcare practitioner.

Storage

Store tightly closed in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Immune Senescene Protection Formula by Life Extension label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Immune Senescene Protection Formula label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Immune Senescene Protection Formula by Life Extension

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Vegetarian Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Reishi Mushroom (Ganoderma lucidum) extract

Interacts with
375 drugs
980 mg per serving Form: Polysaccharides, Triterpenes

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits...

Reishi Mushroom (Ganoderma lucidum) extract monograph & interactions

Shell-broken Reishi Mushroom

Interacts with
375 drugs
150 mg per serving

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits...

Shell-broken Reishi Mushroom monograph & interactions

Cistanche tubulosa extract

210 mg per serving Form: Echinacosides

Other (inactive) ingredients: Vegetable Cellulose, Rice Flour, Starch, L-Leucine, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Immune Senescene Protection Formula by Life Extension Drug Interactions

Want to check YOUR meds against Immune Senescene Protection Formula?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
375Drugs
375 Moderate

Ingredients driving the most interactions

Reishi Mushroom (Ganoderma lucidum) extract 375

Individual Drug Interactions

The ingredients in Immune Senescene Protection Formula interact with 375 drugs. Click any drug to see the details.

1 of the 3 ingredients in Immune Senescene Protection Formula interact with drugs. Each result below shows which ingredient is responsible. Reishi Mushroom (Ganoderma lucidum) extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Immune Senescene Protection Formula with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Reishi Mushroom (Ganoderma lucidum) extract3 drug types · 375 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
A dose of 1.5 grams daily of reishi mushroom does not seem to decrease platelet aggregation, but a higher dose of 3 grams daily does.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Animal research suggests that reishi mushroom decreases blood sugar. However, in patients with type 2 diabetes, taking reishi mushroom does not reduce fasting glucose levels, and its effects on glycated hemoglobin are inconsistent.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Reishi mushroom has shown hypotensive activity in animal research. Clinical evidence suggests that reishi mushroom reduces blood pressure in some, but not all, patients with hypertension.

Likelihood Possible Evidence D
Reishi Mushroom (Ganoderma lucidum) extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Immune Senescene Protection Formula, from the product label.

Life Extension

See all Life Extension products
Name
Quality Supplements and Vitamins, Inc.
City
Ft. Lauderdale
State
FL
ZipCode
33309
Phone Number
1-866-280-2852
Web Address
LifeExtension.com
Pharmacist Counseling Corner

Immune Senescene Protection Formula by Life Extension: Common Questions

Does Immune Senescene Protection Formula by Life Extension interact with any medications?
Yes. Based on its ingredients, Immune Senescene Protection Formula has a known interaction with 375 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Immune Senescene Protection Formula contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant or breastfeeding?
The safety data advises against it. Not enough information exists to know if reishi mushroom is safe during pregnancy or while breastfeeding. Talk to your doctor or pharmacist about whether this product is right for you during these times.
What are the most common side effects?
Dizziness, dry mouth, itching, nausea, rash, and stomach upset are the most frequently reported. Some people have also had sore throat, runny nose, insomnia, or headache, though these are less common.
Will this help my cholesterol?
No. Reishi mushroom is rated possibly ineffective for lowering cholesterol, so it's not a good choice for that goal.
Is it safe to take long-term?
The short-term safety looks okay, but long-term safety hasn't been well studied. Use caution if you plan to take it regularly, and discuss it with your pharmacist or doctor.
What's the difference between the two reishi forms in this formula?
One is a standard extract and the other is shell-broken, which may improve absorption. Both come from the same mushroom (Ganoderma lucidum) and have the same interactions and side effects.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Immune Senescene Protection Formula is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Immune Senescene Protection Formula label
Go deeper

The Full Monographs Behind Immune Senescene Protection Formula’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Reishi Mushroom

Interacts with 375 drugs

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits is limited or low-quality, so it should...

Read the full Reishi Mushroom monograph →
Sources

Sources & How We Checked

Immune Senescene Protection Formula's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 17 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Reishi Mushroom 17 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Tao J, Feng KY. Experimental and clinical studies on inhibitory effect of ganoderma lucidum on platelet aggregation. J Tongji Med Univ 1990;10:240-3. PubMed
  3. Singh AB, Gupta SK, Pereira BM, Prakash D. Sensitization to Ganoderma lucidum in patients with respiratory allergy in India. Clin Exp Allergy 1995;25:440-7.
  4. Lee SY, Rhee HM. Cardiovascular effects of mycelium extract of Ganoderma lucidum: inhibition of sympathetic outflow as a mechanism of its hypotensive action. Chem Pharm Bull (Tokyo) 1990;38:1359-64. PubMed
  5. Kwok Y, Ng KFJ, Li, CCF, et al. A prospective, randomized, double-blind, placebo-controlled study of the platelet and global hemostatic effects of Ganoderma lucidum (Ling-Zhi) in healthy volunteers. Anesth Analg 2005;101:423-6. PubMed
  6. Wanmuang, H., Leopairut, J., Kositchaiwat, C., Wananukul, W., and Bunyaratvej, S. Fatal fulminant hepatitis associated with Ganoderma lucidum (Lingzhi) mushroom powder. J Med Assoc Thai. 2007;90(1):179-181.
  7. Seto, S. W., Lam, T. Y., Tam, H. L., Au, A. L., Chan, S. W., Wu, J. H., Yu, P. H., Leung, G. P., Ngai, S. M., Yeung, J. H., Leung, P. S., Lee, S. M., and Kwan, Y. W. Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db
  8. Chu, T. T., Benzie, I. F., Lam, C. W., Fok, B. S., Lee, K. K., and Tomlinson, B. Study of potential cardioprotective effects of Ganoderma lucidum (Lingzhi): results of a controlled human intervention trial. Br.J.Nutr. 2012;107(7):1017-1027.
  9. Jin, X., Ruiz, Beguerie J., Sze, D. M., and Chan, G. C. Ganoderma lucidum (Reishi mushroom) for cancer treatment. Cochrane.Database.Syst.Rev. 2012;6:CD007731.
  10. Kabir, Y., Kimura, S., and Tamura, T. Dietary effect of Ganoderma lucidum mushroom on blood pressure and lipid levels in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol.(Tokyo) 1988;34(4):433-438. PubMed
  11. Kanmatsuse, K., Kajiwara, N., Hayashi, K., Shimogaichi, S., Fukinbara, I., Ishikawa, H., and Tamura, T. [Studies on Ganoderma lucidum. I. Efficacy against hypertension and side effects]. Yakugaku Zasshi 1985;105(10):942-947. PubMed
  12. Gao, Y., Lan, J., Dai, X., Ye, J., and Zhou, S. A Phase I/II Study of Ling Zhi Mushroom Ganoderma lucidum(W.Curt: Fr.) Lloyd (Aphyllophoromycetideae) Extract in Patients with Type II Diabetes Mellitus. International Journal of Medicinal Mushrooms 2004;6. DOI
  13. Jin H, Zhang G, Cao X, and et al. Treatment of hypertension by linzhi combined with hypotensor and its effects on arterial, arteriolar and capillary pressure and microcirculation. In: Niimi H, Xiu RJ, Sawada T, and et al. Microcirculatory Approach to Asi
  14. Klupp NL, Chang D, Hawke F, Kiat H, Cao H, Grant SJ, Bensoussan A. Ganoderma lucidum mushroom for the treatment of cardiovascular risk factors. Cochrane Database Syst Rev. 2015 Feb 17;2:CD007259. PubMed
  15. Zhao H, Zhang Q, Zhao L, Huang X, Wang J, Kang X. Spore Powder of Ganoderma lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial. Evid Based Complement Alternat Med. 2012;2012:809614.
  16. Pazzi F, Adsuar JC, Domínguez-Muñoz FJ, García-Gordillo MA, Gusi N, Collado-Mateo D. Ganoderma lucidum effects on mood and health-related quality of life in women with fibromyalgia. Healthcare (Basel) 2020;8(4):520. PubMed
  17. Kogure T, Koiwai A, Fukushi D, et al. Hypereosinophilia with hepatic nodule formation caused by Ganoderma lucidum. Intern Med 2021;60(24):3897-3903.

See these in context on the Reishi Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team