NAD+ Cell Regenerator Ingredients & Drug Interactions
What is this page for?
First and foremost: checking NAD+ Cell Regenerator against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
NAD+ Cell Regenerator is a dietary supplement by Life Extension with 1 active ingredient. Its ingredients are commonly taken for healthy aging, boosting cellular energy, supporting metabolism.Based on those ingredients, 172 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Niagen. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against NAD+ Cell Regenerator by Life Extension
Ask about any prescription or over-the-counter medication and we check it for interactions with NAD+ Cell Regenerator by Life Extension — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of NAD+ Cell Regenerator by Life Extension
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
NAD+ Cell Regenerator is a single-ingredient supplement containing nicotinamide riboside (sold as Niagen). Nicotinamide riboside is a form of vitamin B3 that your body converts into NAD+, a molecule involved in cellular energy and repair.
The capsule also contains inactive ingredients—microcrystalline cellulose, cellulose, silica, and stearate—which are standard fillers and binders.
Does it work?
Couldn't assess
The evidence for nicotinamide riboside isn't yet established for the purposes listed in our data. We hold insufficient reliable evidence to rate it for age-related macular degeneration, Alzheimer disease, athletic performance, nonalcoholic fatty liver disease, or heart failure.
More research is needed before we can say whether it works for these conditions.
How safe is it?
Well-documented data
Nicotinamide riboside appears generally well tolerated in short-term studies, though long-term safety isn't fully known. Common side effects in trials have included bloating, muscle pain, nausea, itching, sweating, and mild changes in stool.
A small number of trial participants reported leg cramps or muscle soreness. The safety data advises against use during pregnancy and while breastfeeding because there isn't enough information to know whether it's safe in those situations.
Meds to double-check
Minor interactions only
Check any blood pressure-lowering medications (antihypertensives) you take before starting this supplement. It may theoretically add to their effect and lower your blood pressure further.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Only minor medication interactions are documented, and safety information is well characterized.
If you're curious about NAD+ support and don't take blood pressure medication, this product is worth discussing with your pharmacist. If you take any medication for high blood pressure, check your specific drugs first—the interaction is documented but low-risk (Minor severity).
Pregnant or breastfeeding? Talk with your doctor or pharmacist before starting, since safety data is limited in those situations.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 24, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about NAD+ Cell Regenerator, straight from the product label.
| Brand | Life Extension |
|---|---|
| Net contents | 30 Vegetarian Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jul 24, 2025 |
| DSLD ID | 332696 |
| Product type | Vitamin |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for NAD+ Cell Regenerator by Life Extension, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Niagen | 300 mg | -- |
Other ingredients: Microcrystalline Cellulose, Cellulose, Silica, Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
NAD+ Cell Regenerator 300 mg
Formulation
Gluten free Non GMO LE Certified
Defense against cellular aging
Seals/Symbols
Non GMO LE Certified
FDA Statement of Identity
Dietary Supplement
Precautions
To report a serious adverse event or obtain product information, contact 1-866-280-2852.
Storage
Store tightly closed in a cool, dry place.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
NAD+ Cell Regenerator by Life Extension label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in NAD+ Cell Regenerator by Life Extension
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Vegetarian Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Niagen
Interacts with172 drugs
Nicotinamide riboside (NR) is a form of vitamin B3 that the body converts into NAD+, a molecule involved in cellular energy and repair. Early human st...
Niagen monograph & interactionsOther (inactive) ingredients: Microcrystalline Cellulose, Cellulose, Silica, Stearate. These complete the product’s ingredient list but are not active constituents.
NAD+ Cell Regenerator by Life Extension Drug Interactions
HelloPharmacist Interaction Report
NAD+ Cell Regenerator by Life Extension contains one active ingredient, nicotinamide riboside (Niagen), which has one documented interaction we need to flag.
It may have additive effects with blood pressure-lowering drugs (antihypertensives), potentially increasing the risk for low blood pressure (hypotension). One small study suggests nicotinamide riboside can modestly reduce blood pressure in people with high blood pressure, though other research hasn't found the same effect.
Read the full breakdown — every affected drug type, severity by severity
Altogether, these interactions span 170 individual medications. If you take any medication for high blood pressure, check your exact drugs with the search tool on this page before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against NAD+ Cell Regenerator?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in NAD+ Cell Regenerator interact with 172 drugs. Click any drug to see the details.
1 of the 1 ingredient in NAD+ Cell Regenerator interact with drugs. Each result below shows which ingredient is responsible. Niagen
AcebutololRhotral, Sectral
How Acebutolol interacts with NAD+ Cell Regenerator — through 1 ingredient. Tap an ingredient for the detail:
NiagenAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Niagen + Acebutolol interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with NAD+ Cell Regenerator — through 1 ingredient. Tap an ingredient for the detail:
NiagenAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Niagen + Acetazolamide interactionAliskirenTekturna
How Aliskiren interacts with NAD+ Cell Regenerator — through 1 ingredient. Tap an ingredient for the detail:
NiagenAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Niagen + Aliskiren interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with NAD+ Cell Regenerator — through 1 ingredient. Tap an ingredient for the detail:
NiagenAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Niagen + Ambrisentan interactionAmilorideAmilamont, Midamor
How Amiloride interacts with NAD+ Cell Regenerator — through 1 ingredient. Tap an ingredient for the detail:
NiagenAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Niagen + Amiloride interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with NAD+ Cell Regenerator — through 1 ingredient. Tap an ingredient for the detail:
NiagenAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Niagen + Amiloride, Hydrochlorothiazide interactionAmlodipineNorliqva
How Amlodipine interacts with NAD+ Cell Regenerator — through 1 ingredient. Tap an ingredient for the detail:
NiagenAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Niagen + Amlodipine interactionAmlodipine BenzoateKaterzia
How Amlodipine Benzoate interacts with NAD+ Cell Regenerator — through 1 ingredient. Tap an ingredient for the detail:
NiagenAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Niagen + Amlodipine Benzoate interactionAmlodipine BesilateIstin
How Amlodipine Besilate interacts with NAD+ Cell Regenerator — through 1 ingredient. Tap an ingredient for the detail:
NiagenAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Niagen + Amlodipine Besilate interactionAmlodipine BesylateNorvasc
How Amlodipine Besylate interacts with NAD+ Cell Regenerator — through 1 ingredient. Tap an ingredient for the detail:
NiagenAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Niagen + Amlodipine Besylate interactionAmlodipine Besylate, BenazeprilLotrel
How Amlodipine Besylate, Benazepril interacts with NAD+ Cell Regenerator — through 1 ingredient. Tap an ingredient for the detail:
NiagenAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Niagen + Amlodipine Besylate, Benazepril interactionAmlodipine, CelecoxibConsensi
How Amlodipine, Celecoxib interacts with NAD+ Cell Regenerator — through 1 ingredient. Tap an ingredient for the detail:
NiagenAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Niagen + Amlodipine, Celecoxib interactionAmmonium ChlorideAmmonium Chloride
How Ammonium Chloride interacts with NAD+ Cell Regenerator — through 1 ingredient. Tap an ingredient for the detail:
NiagenAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Niagen + Ammonium Chloride interactionAprocitentanTryvio
How Aprocitentan interacts with NAD+ Cell Regenerator — through 1 ingredient. Tap an ingredient for the detail:
NiagenAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Niagen + Aprocitentan interactionAtenololAtenix, Tenormin
How Atenolol interacts with NAD+ Cell Regenerator — through 1 ingredient. Tap an ingredient for the detail:
NiagenAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Niagen + Atenolol interactionAtenolol, ChlortalidoneAtenixCo, Tenoret 50, Totaretic
How Atenolol, Chlortalidone interacts with NAD+ Cell Regenerator — through 1 ingredient. Tap an ingredient for the detail:
NiagenAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Niagen + Atenolol, Chlortalidone interactionAtenolol, ChlorthalidoneTenoretic
How Atenolol, Chlorthalidone interacts with NAD+ Cell Regenerator — through 1 ingredient. Tap an ingredient for the detail:
NiagenAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Niagen + Atenolol, Chlorthalidone interactionAzilsartanEdarbi
How Azilsartan interacts with NAD+ Cell Regenerator — through 1 ingredient. Tap an ingredient for the detail:
NiagenAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Niagen + Azilsartan interactionAzilsartan, ChlorthalidoneEdarbyclor
How Azilsartan, Chlorthalidone interacts with NAD+ Cell Regenerator — through 1 ingredient. Tap an ingredient for the detail:
NiagenAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Niagen + Azilsartan, Chlorthalidone interactionBenazeprilLotensin
How Benazepril interacts with NAD+ Cell Regenerator — through 1 ingredient. Tap an ingredient for the detail:
NiagenAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Niagen + Benazepril interactionBenazepril, HydrochlorothiazideLotensin HCT
How Benazepril, Hydrochlorothiazide interacts with NAD+ Cell Regenerator — through 1 ingredient. Tap an ingredient for the detail:
NiagenAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Niagen + Benazepril, Hydrochlorothiazide interactionBendroflumethiazideAprinox, Naturetin, Neo-NaClex
How Bendroflumethiazide interacts with NAD+ Cell Regenerator — through 1 ingredient. Tap an ingredient for the detail:
NiagenAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Niagen + Bendroflumethiazide interactionBendroflumethiazide, NadololCorzide
How Bendroflumethiazide, Nadolol interacts with NAD+ Cell Regenerator — through 1 ingredient. Tap an ingredient for the detail:
NiagenAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Niagen + Bendroflumethiazide, Nadolol interactionBendroflumethiazide, Rauwolfia SerpentinaRauzide
How Bendroflumethiazide, Rauwolfia Serpentina interacts with NAD+ Cell Regenerator — through 1 ingredient. Tap an ingredient for the detail:
NiagenAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Niagen + Bendroflumethiazide, Rauwolfia Serpentina interactionBenzthiazideExna
How Benzthiazide interacts with NAD+ Cell Regenerator — through 1 ingredient. Tap an ingredient for the detail:
NiagenAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Niagen + Benzthiazide interactionBetaxololBetoptic, Kerlone
How Betaxolol interacts with NAD+ Cell Regenerator — through 1 ingredient. Tap an ingredient for the detail:
NiagenAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Niagen + Betaxolol interactionBisoprololZebeta
How Bisoprolol interacts with NAD+ Cell Regenerator — through 1 ingredient. Tap an ingredient for the detail:
NiagenAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Niagen + Bisoprolol interactionBisoprolol, HydrochlorothiazideZiac
How Bisoprolol, Hydrochlorothiazide interacts with NAD+ Cell Regenerator — through 1 ingredient. Tap an ingredient for the detail:
NiagenAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Niagen + Bisoprolol, Hydrochlorothiazide interactionBosentanTracleer
How Bosentan interacts with NAD+ Cell Regenerator — through 1 ingredient. Tap an ingredient for the detail:
NiagenAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Niagen + Bosentan interactionBumetanideBurinex
How Bumetanide interacts with NAD+ Cell Regenerator — through 1 ingredient. Tap an ingredient for the detail:
NiagenAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Niagen + Bumetanide interactionEach ingredient & the kinds of drugs it affects
For each ingredient in NAD+ Cell Regenerator with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Niagen
Antihypertensive Drugs
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
One small clinical study suggests that nicotinamide riboside can modestly reduce blood pressure in hypertensive patients. However, other clinical research did not find a reduction in blood pressure when compared with control.
Brand information
Manufacturer and brand details for NAD+ Cell Regenerator, from the product label.
Life Extension
See all Life Extension products- Name
- Quality Supplements and Vitamins, Inc.
- City
- Ft. Lauderdale
- State
- FL
- ZipCode
- 33309
- Phone Number
- 1-866-280-2852
- Web Address
- LifeExtension.com
NAD+ Cell Regenerator by Life Extension: Common Questions
Does NAD+ Cell Regenerator by Life Extension interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is nicotinamide riboside safe during pregnancy or while breastfeeding?
What are the most common side effects?
Does nicotinamide riboside actually work for anti-aging or brain health?
Is this supplement well tolerated overall?
What is Niagen, and why is it in this product?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if NAD+ Cell Regenerator is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind NAD+ Cell Regenerator’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
NAD+ Cell Regenerator's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 7 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Nicotinamide Riboside 7 references
- Martens CR, Denman BA, Mazzo MR, et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nat Commun 2018;9(1):1286. PubMed
- Dollerup OL, Christensen B, Svart M, et al. A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects. Am J Clin Nutr 2018;108(2):343-53. PubMed
- Dellinger RW, Santos SR, Morris M, et al. Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safety and sustainably: a randomized, double-blind, placebo-controlled study. NPJ J Aging Mech Dis 2017;3:17.
- Conze D, Brenner C, Kruger CL. Safety and metabolism of long-term administration of NIAGEN (nicotinamide riboside chloride) in a randomized, double-blind, placebo-controlled clinical trial of healthy overweight adults. Sci Rep 2019;9(1):9772. PubMed
- Remie CME, Roumans KHM, Moonen MPB, et al. Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans. Am J Clin Nutr. 2020;112(2):413-426. PubMed
- Turck D, Castenmiller J, de Henauw S, et al. Safety of nicotinamide riboside chloride as a novel food pursuant to Regulation (EU) 2015/2283 and bioavailability of nicotinamide from this source, in the context of Directive 2002/46/EC. EFSA J. 2019;17(8):e0
- EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Turck D, et al. Extension of use of nicotinamide riboside chloride as a novel food pursuant to Regulation (EU) 2015/2283. EFSA J 2021;19(11):e06843.
See these in context on the Nicotinamide Riboside monograph →
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC