Immuno-Resp Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Immuno-Resp against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Immuno-Resp is a dietary supplement by Physician's Strength with 5 active ingredients. Its ingredients are commonly taken for cough and sore throat, wound and burn care, soothing minor skin irritation.Based on those ingredients, 1,278 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Black Seed Oil, Honey, Raw, Mediterranean Oregano Essence, Wild. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Immuno-Resp by Physician's Strength
Ask about any prescription or over-the-counter medication and we check it for interactions with Immuno-Resp by Physician's Strength — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Immuno-Resp by Physician's Strength
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Immuno-Resp is a 5-ingredient liquid formula. Its active ingredients are raw honey, black seed oil, Mediterranean oregano essence, wild Mediterranean oregano oil, and wild juniper oil, delivered in a proprietary blend.
There are no inactive ingredients listed for this product.
Does it work?
Moderate evidence
The evidence for this product's ingredients is mixed and incomplete. Honey is possibly effective for cold sores, cough, mouth sores (oral mucositis), burns, and dry eye.
Black seed oil is possibly effective for acne, hay fever (allergic rhinitis), asthma, and Helicobacter pylori infection. For oregano essence and oregano oil, the evidence isn't established in our data—we don't have reliable ratings for acne, bronchitis, asthma, headache, or upper respiratory tract infections.
Juniper oil also lacks established evidence for the conditions listed in our records.
How safe is it?
Well-documented data
Raw honey is generally well tolerated and is considered safe for adults and children over 1 year of age as a food. However, if you're using it medicinally in supplement form, check with your doctor first.
Honey can cause nausea, stomach pain, or vomiting orally, and burning or stinging when applied to skin or eyes. Rare serious reactions include allergic responses and anaphylaxis.
Black seed oil is generally well tolerated but may cause constipation, stomach burning, nausea, or vomiting; in rare cases, menstrual bleeding and severe gastrointestinal complaints have occurred. Oregano is well tolerated in food amounts but may cause stomach upset, skin irritation, or rarely allergic reactions including anaphylaxis at medicinal doses.
Juniper is generally tolerated short-term in low doses but may cause skin allergies or irritation topically. Juniper should not be used long-term due to potential kidney irritation.
Meds to double-check
Moderate interaction found
Before taking Immuno-Resp, double-check with your doctor or pharmacist if you're on any blood thinner or antiplatelet drug (like warfarin, apixaban, aspirin, or clopidogrel)—the product may increase bleeding risk. If you take diabetes medications, this product may lower your blood sugar further.
Also check if you're on sedatives or CNS depressants, antidepressants or other serotonergic drugs, blood pressure medications, immunosuppressants, diuretics, lithium, or cyclosporine.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Immuno-Resp is best for someone not taking medications that affect blood sugar, blood pressure, or bleeding—or who's already discussed this product with their doctor. Black seed oil and oregano interact with blood thinners and diabetes drugs, and black seed also interacts with sedatives and antidepressants.
If you're on any prescription medication, talk with your own doctor or pharmacist before starting, and bring the label or this page to that conversation.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 5 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Immuno-Resp, straight from the product label.
| Brand | Physician's Strength |
|---|---|
| Barcode (UPC) | 850032454735 |
| Net contents | 2 Fluid Ounce(s); 60 mL |
| Market status | On market |
| Date entered into DSLD | Sep 25, 2023 |
| DSLD ID | 296826 |
| Product type | Other Combinations |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Immuno-Resp by Physician's Strength, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Blend | 0 NP | -- |
| Honey, Raw | 0 NP | -- |
| Black Seed Oil | 0 NP | -- |
| Mediterranean Oregano Essence, Wild | 0 NP | -- |
| Wild Mediterranean Oregano Oil | 0 NP | -- |
| Juniper Oil, Wild | 0 NP | -- |
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Directions: Take two dropperful daily. Makes a tasty addition to salad dressings or smoothies.
Formula
Immuno-Resp is a combination of Mediterranean black seed plus wild oregano P73 oil and essence for bronchial and lung support and mycellized for optimal absorption. It also contains wild juniper for immune and respiratory support. With raw honey it is a traditional way to support the immune system and bronchial tract.
Black Seed-Wild Oregano
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Formulation
Respiratory & Immune Support
Doctor's Formula
Chemical-Free
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Immuno-Resp by Physician's Strength label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Immuno-Resp by Physician's Strength
These are the 5 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Droppersful Dosage formLiquid Servings per container39 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Blend
Immuno-Resp by Physician's Strength Drug Interactions
HelloPharmacist Interaction Report
Physician's Strength Immuno-Resp interacts with medications through its honey, black seed oil, oregano essence, oregano oil, and juniper oil content.
The most serious documented interaction is a Moderate risk: honey may theoretically increase phenytoin (Dilantin) levels based on animal studies, though this hasn't been reported in humans.
Read the full breakdown — every affected drug type, severity by severity
Black seed oil carries several Moderate-severity interactions. It may add to the sedative effects of CNS depressants (sedating drugs), increase serotonin-related side effects with serotonergic drugs (including antidepressants), raise bleeding risk with blood thinners (anticoagulants) and antiplatelet drugs, and theoretically lower blood sugar more than intended with diabetes medications.
Black seed may also reduce blood pressure further with antihypertensive drugs, interfere with immunosuppressants, increase potassium loss with diuretics, and reduce cyclosporine levels.
Oregano essence and oregano oil both carry Moderate interactions: they may increase bleeding risk with blood thinners and antiplatelet drugs, and raise the risk of low blood sugar (hypoglycemia) with diabetes medications. Honey also has a Minor interaction with blood thinners and antiplatelet drugs.
Juniper oil carries a Moderate interaction with diabetes drugs and Minor interactions with diuretics and lithium.
Altogether, these interactions span 1,279 individual medications. Use the medication checker on this page to look up your exact prescriptions before starting.
Check your own medications below · Editorial policy · How we use AI
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Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Immuno-Resp interact with 1,278 drugs. Click any drug to see the details.
4 of the 5 ingredients in Immuno-Resp interact with drugs. Each result below shows which ingredient is responsible. Black Seed Oil Honey, Raw Mediterranean Oregano Essence, Wild Juniper Oil, Wild
Adalimumab-afzbAbrilada
How Adalimumab-afzb interacts with Immuno-Resp — through 1 ingredient. Tap an ingredient for the detail:
Black Seed OilImmunosuppressants Moderate
Interaction Summary
Theoretically, black seed might interfere with immunosuppressive therapy.
Read the full Black Seed Oil + Adalimumab-afzb interactionAdalimumab-attoAmjevita
How Adalimumab-atto interacts with Immuno-Resp — through 1 ingredient. Tap an ingredient for the detail:
Black Seed OilImmunosuppressants Moderate
Interaction Summary
Theoretically, black seed might interfere with immunosuppressive therapy.
Read the full Black Seed Oil + Adalimumab-atto interactionAdalimumab-bwwdHadlima
How Adalimumab-bwwd interacts with Immuno-Resp — through 1 ingredient. Tap an ingredient for the detail:
Black Seed OilImmunosuppressants Moderate
Interaction Summary
Theoretically, black seed might interfere with immunosuppressive therapy.
Read the full Black Seed Oil + Adalimumab-bwwd interactionAdalimumab-fkjpHulio
How Adalimumab-fkjp interacts with Immuno-Resp — through 1 ingredient. Tap an ingredient for the detail:
Black Seed OilImmunosuppressants Moderate
Interaction Summary
Theoretically, black seed might interfere with immunosuppressive therapy.
Read the full Black Seed Oil + Adalimumab-fkjp interactionAerosphere Budesonide, Formoterol Fumarate, GlycopyrrolateBreztri
How Aerosphere Budesonide, Formoterol Fumarate, Glycopyrrolate interacts with Immuno-Resp — through 1 ingredient. Tap an ingredient for the detail:
Black Seed OilCytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, black seed might increase levels of drugs metabolized by CYP2C9.
Read the full Black Seed Oil + Aerosphere Budesonide, Formoterol Fumarate, Glycopyrrolate interactionAgomelatineValdoxan
How Agomelatine interacts with Immuno-Resp — through 1 ingredient. Tap an ingredient for the detail:
Black Seed OilCytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, black seed might increase levels of drugs metabolized by CYP2C9.
Read the full Black Seed Oil + Agomelatine interactionAlbiglutideTanzeum
How Albiglutide interacts with Immuno-Resp — through 3 ingredients. Tap an ingredient for the detail:
Black Seed OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking black seed with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Black Seed Oil + Albiglutide interactionWild Mediterranean Oregano OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oregano might increase the risk for hypoglycemia when taken with antidiabetes drugs.
Read the full Wild Mediterranean Oregano Oil + Albiglutide interactionJuniper Oil, WildAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking juniper berry with antidiabetes medications might cause additive hypoglycemia.
Read the full Juniper Oil, Wild + Albiglutide interactionAlefaceptAmevive
How Alefacept interacts with Immuno-Resp — through 1 ingredient. Tap an ingredient for the detail:
Black Seed OilImmunosuppressants Moderate
Interaction Summary
Theoretically, black seed might interfere with immunosuppressive therapy.
Read the full Black Seed Oil + Alefacept interactionAlemtuzumabCampath
How Alemtuzumab interacts with Immuno-Resp — through 1 ingredient. Tap an ingredient for the detail:
Black Seed OilImmunosuppressants Moderate
Interaction Summary
Theoretically, black seed might interfere with immunosuppressive therapy.
Read the full Black Seed Oil + Alemtuzumab interactionAlfentanilAlfenta
How Alfentanil interacts with Immuno-Resp — through 2 ingredients. Tap an ingredient for the detail:
Black Seed OilCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.
Read the full Black Seed Oil + Alfentanil interactionHoney, RawCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Read the full Honey, Raw + Alfentanil interactionAliskirenTekturna
How Aliskiren interacts with Immuno-Resp — through 2 ingredients. Tap an ingredient for the detail:
Black Seed OilAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking black seed with antihypertensive drugs might increase the risk of hypotension.
Read the full Black Seed Oil + Aliskiren interactionHoney, RawCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Read the full Honey, Raw + Aliskiren interactionAlmotriptanAlmogran, Axert
How Almotriptan interacts with Immuno-Resp — through 2 ingredients. Tap an ingredient for the detail:
Black Seed OilSerotonergic Drugs Moderate
Interaction Summary
Theoretically, combining serotonergic drugs with black seed might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders.
Read the full Black Seed Oil + Almotriptan interactionHoney, RawCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Read the full Honey, Raw + Almotriptan interactionAlogliptinNesina
How Alogliptin interacts with Immuno-Resp — through 4 ingredients. Tap an ingredient for the detail:
Black Seed OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking black seed with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Black Seed Oil + Alogliptin interactionJuniper Oil, WildAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking juniper berry with antidiabetes medications might cause additive hypoglycemia.
Read the full Juniper Oil, Wild + Alogliptin interactionWild Mediterranean Oregano OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oregano might increase the risk for hypoglycemia when taken with antidiabetes drugs.
Read the full Wild Mediterranean Oregano Oil + Alogliptin interactionHoney, RawCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Read the full Honey, Raw + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Immuno-Resp — through 3 ingredients. Tap an ingredient for the detail:
Wild Mediterranean Oregano OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oregano might increase the risk for hypoglycemia when taken with antidiabetes drugs.
Read the full Wild Mediterranean Oregano Oil + Alogliptin, Metformin interactionJuniper Oil, WildAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking juniper berry with antidiabetes medications might cause additive hypoglycemia.
Read the full Juniper Oil, Wild + Alogliptin, Metformin interactionBlack Seed OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking black seed with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Black Seed Oil + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Immuno-Resp — through 4 ingredients. Tap an ingredient for the detail:
Black Seed OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking black seed with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Black Seed Oil + Alogliptin, Pioglitazone interactionJuniper Oil, WildAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking juniper berry with antidiabetes medications might cause additive hypoglycemia.
Read the full Juniper Oil, Wild + Alogliptin, Pioglitazone interactionWild Mediterranean Oregano OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oregano might increase the risk for hypoglycemia when taken with antidiabetes drugs.
Read the full Wild Mediterranean Oregano Oil + Alogliptin, Pioglitazone interactionHoney, RawCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Read the full Honey, Raw + Alogliptin, Pioglitazone interactionAlosetronLotronex
How Alosetron interacts with Immuno-Resp — through 1 ingredient. Tap an ingredient for the detail:
Black Seed OilSerotonergic Drugs Moderate
Interaction Summary
Theoretically, combining serotonergic drugs with black seed might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders.
Read the full Black Seed Oil + Alosetron interactionAlprazolamNiravam, Xanax
How Alprazolam interacts with Immuno-Resp — through 2 ingredients. Tap an ingredient for the detail:
Black Seed OilCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.
Read the full Black Seed Oil + Alprazolam interactionHoney, RawCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Read the full Honey, Raw + Alprazolam interactionAlteplase, TpaActilyse, Activase
How Alteplase, Tpa interacts with Immuno-Resp — through 3 ingredients. Tap an ingredient for the detail:
Wild Mediterranean Oregano OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, oregano might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Wild Mediterranean Oregano Oil + Alteplase, Tpa interactionBlack Seed OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, black seed may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Black Seed Oil + Alteplase, Tpa interactionHoney, RawAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Theoretically, honey may increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Honey, Raw + Alteplase, Tpa interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Immuno-Resp — through 3 ingredients. Tap an ingredient for the detail:
Wild Mediterranean Oregano OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, oregano might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Wild Mediterranean Oregano Oil + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionBlack Seed OilCns Depressants, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.
Read the full Black Seed Oil + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionHoney, RawAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Theoretically, honey may increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Honey, Raw + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with Immuno-Resp — through 3 ingredients. Tap an ingredient for the detail:
Black Seed OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, black seed may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Black Seed Oil + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionWild Mediterranean Oregano OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, oregano might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Wild Mediterranean Oregano Oil + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionHoney, RawAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Theoretically, honey may increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Honey, Raw + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with Immuno-Resp — through 2 ingredients. Tap an ingredient for the detail:
Black Seed OilAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking black seed with antihypertensive drugs might increase the risk of hypotension.
Read the full Black Seed Oil + Ambrisentan interactionHoney, RawCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Read the full Honey, Raw + Ambrisentan interactionAmilorideAmilamont, Midamor
How Amiloride interacts with Immuno-Resp — through 1 ingredient. Tap an ingredient for the detail:
Black Seed OilAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking black seed with antihypertensive drugs might increase the risk of hypotension.
Read the full Black Seed Oil + Amiloride interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with Immuno-Resp — through 2 ingredients. Tap an ingredient for the detail:
Black Seed OilAntihypertensive Drugs, Diuretic Drugs Moderate
Interaction Summary
Theoretically, taking black seed with antihypertensive drugs might increase the risk of hypotension.
Read the full Black Seed Oil + Amiloride, Hydrochlorothiazide interactionJuniper Oil, WildDiuretic Drugs Minor
Interaction Summary
Theoretically, juniper berry might increase the risk of adverse effects from diuretic drugs.
Read the full Juniper Oil, Wild + Amiloride, Hydrochlorothiazide interactionAminoglutethimideCytadren
How Aminoglutethimide interacts with Immuno-Resp — through 1 ingredient. Tap an ingredient for the detail:
Black Seed OilCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.
Read the full Black Seed Oil + Aminoglutethimide interactionAminophylline, Amobarbital, EphedrineAmesec
How Aminophylline, Amobarbital, Ephedrine interacts with Immuno-Resp — through 1 ingredient. Tap an ingredient for the detail:
Black Seed OilCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.
Read the full Black Seed Oil + Aminophylline, Amobarbital, Ephedrine interactionAmitriptylineElavil
How Amitriptyline interacts with Immuno-Resp — through 2 ingredients. Tap an ingredient for the detail:
Black Seed OilSerotonergic Drugs, Cns Depressants +1 Moderate
Interaction Summary
Theoretically, combining serotonergic drugs with black seed might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders.
Read the full Black Seed Oil + Amitriptyline interactionHoney, RawCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Read the full Honey, Raw + Amitriptyline interactionAmitriptyline, ChlordiazepoxideLimbitrol DS
How Amitriptyline, Chlordiazepoxide interacts with Immuno-Resp — through 2 ingredients. Tap an ingredient for the detail:
Black Seed OilCytochrome P450 2c9 (cyp2c9) Substrates, Cns Depressants +1 Moderate
Interaction Summary
Theoretically, black seed might increase levels of drugs metabolized by CYP2C9.
Read the full Black Seed Oil + Amitriptyline, Chlordiazepoxide interactionHoney, RawCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Read the full Honey, Raw + Amitriptyline, Chlordiazepoxide interactionAmitriptyline, PerphenazineEtrafon, Etrafon-A, Etrafon-Forte, Triavil
How Amitriptyline, Perphenazine interacts with Immuno-Resp — through 2 ingredients. Tap an ingredient for the detail:
Black Seed OilSerotonergic Drugs, Cytochrome P450 2c9 (cyp2c9) Substrates +1 Moderate
Interaction Summary
Theoretically, combining serotonergic drugs with black seed might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders.
Read the full Black Seed Oil + Amitriptyline, Perphenazine interactionHoney, RawCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Read the full Honey, Raw + Amitriptyline, Perphenazine interactionAmlodipineNorliqva
How Amlodipine interacts with Immuno-Resp — through 2 ingredients. Tap an ingredient for the detail:
Black Seed OilAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking black seed with antihypertensive drugs might increase the risk of hypotension.
Read the full Black Seed Oil + Amlodipine interactionHoney, RawCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Read the full Honey, Raw + Amlodipine interactionAmlodipine BenzoateKaterzia
How Amlodipine Benzoate interacts with Immuno-Resp — through 2 ingredients. Tap an ingredient for the detail:
Black Seed OilAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking black seed with antihypertensive drugs might increase the risk of hypotension.
Read the full Black Seed Oil + Amlodipine Benzoate interactionHoney, RawCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Read the full Honey, Raw + Amlodipine Benzoate interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Immuno-Resp with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Black Seed Oil
Anticoagulant/Antiplatelet Drugs
Theoretically, black seed may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research suggests that black seed extract can inhibit platelet aggregation and clotting, and increase bleeding time. In addition, decreased platelet counts have occurred in a human case report and in animal research.
Antidiabetes Drugs
Theoretically, taking black seed with antidiabetes drugs might increase the risk of hypoglycemia.
Some clinical research and numerous animal studies suggest that black seed, especially its constituent thymoquinone, can have hypoglycemic effects.
Antihypertensive Drugs
Theoretically, taking black seed with antihypertensive drugs might increase the risk of hypotension.
Clinical research suggests that black seed powder and oil might reduce blood pressure by 2-3 mmHg. In animal research, black seed modestly reduces blood pressure and concomitant use of black seed and amlodipine (Norvasc) or metoprolol (Lopressor) increased the blood pressure lowering effects of these drugs.
Clopidogrel (Plavix)
Theoretically, black seed may increase the risk of bleeding if used with clopidogrel.
Animal research shows that taking black seed extract daily for 2 weeks prior to a single dose of clopidogrel increases maximum concentrations of clopidogrel by approximately 31% and modestly decreases oral clearance. Furthermore, bleeding time was increased by 12%. This has not been shown in humans.
Cns Depressants
Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.
Animal research suggests that black seed may have CNS depressant effects.
Cyclosporine (Neoral, Sandimmune)
Theoretically taking black seed might reduce the levels and clinical effects of cyclosporine.
In animal research, black seed extract decreased the maximal levels of cyclosporine in the blood by 35.5%. This has not been shown in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, black seed might increase levels of drugs metabolized by CYP2C9.
In vitro research suggests that thymoquinone, a constituent of black seed, can decrease the metabolism of phenytoin by a mechanism possibly related to the inhibition of CYP2C9. The effect of black seed on CYP2C9 is unclear. This has not been shown in humans.
Diuretic Drugs
Theoretically, taking black seed with diuretic drugs might increase potassium loss and the risk of hypokalemia.
Black seed extract has shown diuretic effects in animals, which could theoretically increase potassium loss. This has not been shown in humans.
Immunosuppressants
Theoretically, black seed might interfere with immunosuppressive therapy.
Animal and in vitro studies suggest that black seed might stimulate immune function. However, other animal studies suggest that black seed may suppress immune function.
Phenytoin (Dilantin)
Theoretically, black seed might increase or decrease levels and effects of phenytoin.
In vitro research suggests that thymoquinone, a constituent of black seed, can decrease the metabolism of phenytoin. This effect may be due to inhibition of cytochrome P450 2C9 (CYP2C9). However, animal research shows that black seed decreases the maximum concentration of and total systemic exposure to phenytoin by 57% and 87%, respectively. This seems to be related to increased clearance and steady state volume of distribution. This interaction has not been shown in humans.
Serotonergic Drugs
Theoretically, combining serotonergic drugs with black seed might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders.
Animal research suggests that black seed can increase brain serotonin levels. In one case report, a 35-year-old man undergoing endoscopic surgery experienced immediate postoperative serotonin syndrome that was likely associated with the use of black seed oil 600 mg daily starting 4 days before surgery, and precipitated by the use of serotonergic pain medications, including fentanyl and oxycodone. Monitor patients for signs of serotonin syndrome and other serotonergic side effects if using black seed with serotonergic drugs.
Sildenafil (Viagra)
Theoretically, black seed might reduce plasma levels and the therapeutic effects of sildenafil.
Animal research shows that black seed reduces the total systemic exposure to sildenafil by 43%. So far, this interaction has not been reported in humans.
Warfarin (Coumadin)
Theoretically, black seed might increase levels of warfarin and increase the risk of bleeding.
In vitro research suggests that thymoquinone, a constituent of black seed, can decrease the metabolism of warfarin. This effect may be due to inhibition of cytochrome P450 2C9 (CYP2C9). The effect of black seed on warfarin metabolism is unclear. This has not been shown in humans.
Prednisolone
Theoretically black seed might reduce plasma levels and therapeutic effects of prednisolone.
In animal research, oral administration of a single dose of black seed oil 15 minutes prior to oral prednisolone decreases the prednisolone maximum plasma concentration by 65% and area under the curve by 25%. This has not been shown in humans.
Honey, Raw
Phenytoin (Dilantin)
Theoretically, honey might increase levels of phenytoin.
In an animal model, the rate and extent of absorption of phenytoin was increased by honey. This effect has not been reported in humans.
Anticoagulant/Antiplatelet Drugs
Theoretically, honey may increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
In vitro, honey inhibits platelet aggregation and increases the time to clotting. Furthermore, animal research suggests that feeding mice large doses of honey for 12 days increases bleeding time when compared with no intervention. However, these effects have not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Some clinical research shows that honey induces CYP3A4. However, other clinical studies found no effect on CYP3A4 activity. Different honey preparations may have different effects on CYP3A4.
Mediterranean Oregano Essence, Wild
Anticoagulant/Antiplatelet Drugs
Theoretically, oregano might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that aristolochic acid isolated from oregano leaves has antithrombin activity. It has also been reported that oregano oil inhibits arachidonic acid-induced, and ADP-induced, platelet aggregation.
Antidiabetes Drugs
Theoretically, oregano might increase the risk for hypoglycemia when taken with antidiabetes drugs.
In vitro and animal research shows that oregano extracts might lower blood glucose levels.
Juniper Oil, Wild
Antidiabetes Drugs
Theoretically, taking juniper berry with antidiabetes medications might cause additive hypoglycemia.
Animal research shows that juniper berry can lower blood glucose.
Diuretic Drugs
Theoretically, juniper berry might increase the risk of adverse effects from diuretic drugs.
Juniper berry is thought to have mild diuretic effects.
Lithium
Theoretically, juniper berry might reduce lithium excretion and increase serum levels of lithium.
Juniper berry is thought to have mild diuretic effects.
Brand information
Manufacturer and brand details for Immuno-Resp, from the product label.
Physician's Strength
See all Physician's Strength products- Name
- Physician's Strength
- Street Address
- 13900 W. Polo Trail Drive
- City
- Lake Forest
- State
- IL
- ZipCode
- 60045
- Web Address
- www.physicians-strength.com
Immuno-Resp by Physician's Strength: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Immuno-Resp’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Honey
Interacts with 736 drugsHoney is a natural food with some real, modest evidence for easing coughs and helping certain wounds, especially when special medical-grade or Manuka honey is used. It is generally safe for...
Read the full Honey monograph → Herb & supplement monographBlack Seed
Interacts with 912 drugsBlack seed (Nigella sativa) is a traditional spice and remedy that has been studied for asthma, blood sugar, cholesterol, and blood pressure, with early research showing some promise but no...
Read the full Black Seed monograph → Herb & supplement monographOregano
Interacts with 208 drugsOregano is a common Mediterranean cooking herb that is also sold as a concentrated oil or supplement, often standardized for a compound called carvacrol. While lab studies suggest it may hav...
Read the full Oregano monograph → Herb & supplement monographJuniper
Interacts with 162 drugsJuniper berry is a traditional herb best known for flavoring gin and for its folk use as a diuretic and digestive aid. Solid human evidence for its health benefits is limited, and it can irr...
Read the full Juniper monograph →Sources & How We Checked
Immuno-Resp's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 119 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Honey 40 references
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
- Bose B. Honey or sugar in treatment of infected wounds? Lancet 1982;1:963. PubMed
- Ozhan H, Akdemir R, Yazici M, et al. Cardiac emergencies caused by honey ingestion: a single centre experience. Emerg Med J 2004;21:742-4. PubMed
- Centers for Disease Control. Botulism in the Unites Sates, 1899-1996. Handbook for epidemiologists, clinicians, and laboratory workers, 1998. Available online: http://www.cdc.gov/ncidod/dbmd/diseaseinfo/botulism.PDF.
- Simon A, Traynor K, Santos K, et al. Medical honey for wound care - still the 'latest resort'? Evid Based Complement Alternat Med 2009;6:165-73. PubMed
- Gethin G, Cowman S. Case series of use of Manuka honey in leg ulceration. Int Wound J 2005;2:10-15. PubMed
- Ingle R, Levin J, Polinder K. Wound healing with honey - a randomised controlled trial. S Afr Med J 2006;96:831-5.
- Johnson DW, van Eps C, Mudge DW, et al. Randomized, controlled trial of topical exit-site application of honey (Medihoney) versus mupirocin for the prevention of catheter-associated infections in hemodialysis patients. J Am Soc Nephrol 2005;16:1456-62. PubMed
- Sukriti and Garg, S. K. Influence of honey on the pharmacokinetics of phenytoin in rabbits. Ind J Pharmacol 2002;34(147).
- Jung, A. and Ottosson, J. [Infantile botulism caused by honey]. Ugeskr Laeger 2001;163(2):169.
- Gunduz, A., Turedi, S., Uzun, H., and Topbas, M. Mad honey poisoning. Am J Emerg.Med 2006;24(5):595-598.
- van der Vorst, M. M., Jamal, W., Rotimi, V. O., and Moosa, A. Infant botulism due to consumption of contaminated commercially prepared honey. First report from the Arabian Gulf States. Med Princ.Pract. 2006;15(6):456-458. PubMed
- Tushar, T., Vinod, T., Rajan, S., Shashindran, C., and Adithan, C. Effect of honey on CYP3A4, CYP2D6 and CYP2C19 enzyme activity in healthy human volunteers. Basic Clin Pharmacol Toxicol 2007;100(4):269-272. PubMed
- Nilforoushzadeh, M. A., Jaffary, F., Moradi, S., Derakhshan, R., and Haftbaradaran, E. Effect of topical honey application along with intralesional injection of glucantime in the treatment of cutaneous leishmaniasis. BMC Complement Altern Med 2007;7:13. PubMed
- Koca, I. and Koca, A. F. Poisoning by mad honey: a brief review. Food Chem Toxicol 2007;45(8):1315-1318. PubMed
- Akinci, S., Arslan, U., Karakurt, K., and Cengel, A. An unusual presentation of mad honey poisoning: acute myocardial infarction. Int J Cardiol 2008;129(2):e56-e58. PubMed
- Yildirim, N., Aydin, M., Cam, F., and Celik, O. Clinical presentation of non-ST-segment elevation myocardial infarction in the course of intoxication with mad honey. Am J Emerg Med 2008;26(1):108.e-2. PubMed
- Shrestha, P., Vaidya, R., and Sherpa, K. Mad honey poisoning: a rare case report of seven cases. Nepal Med Coll J 2009;11(3):212-213.
- Fetzner, L., Burhenne, J., Weiss, J., Völker, M., Unger, M., Mikus, G., and Haefeli, W. E. Daily honey consumption does not change CYP3A activity in humans. J Clin Pharmacol 2011;51(8):1223-1232. PubMed
- Thamboo, A., Thamboo, A., Philpott, C., Javer, A., and Clark, A. Single-blind study of manuka honey in allergic fungal rhinosinusitis. J Otolaryngol Head Neck Surg 2011;40(3):238-243.
- Ahmed, A., Khan, R. A., Azim, M. K., Saeed, S. A., Mesaik, M. A., Ahmed, S., and Imran, I. Effect of natural honey on human platelets and blood coagulation proteins. Pak.J Pharm Sci 2011;24(3):389-397.
- Yarlioglues, M., Akpek, M., Ardic, I., Elcik, D., Sahin, O., and Kaya, M. G. Mad-honey sexual activity and acute inferior myocardial infarctions in a married couple. Tex.Heart Inst.J 2011;38(5):577-580.
- Biberoglu, S., Biberoglu, K., and Komsuoglu, B. Mad honey. JAMA 4-1-1988;259(13):1943.
- Biberoglu, K., Biberoglu, S., and Komsuoglu, B. Transient Wolff-Parkinson-White syndrome during honey intoxication. Isr.J.Med.Sci. 1988;24(4-5):253-254.
- Gössinger, H., Hruby, K., Pohl, A., Davogg, S., Sutterlütti, G., and Mathis, G. [Poisoning with andromedotoxin-containing honey]. Dtsch Med Wochenschr 1983;108(41):1555-1558.
- Fenicia, L., Ferrini, A. M., Aureli, P., and Pocecco, M. A case of infant botulism associated with honey feeding in Italy. Eur J Epidemiol 1993;9(6):671-673. PubMed
- Sutlupinar, N., Mat, A., and Satganoglu, Y. Poisoning by toxic honey in Turkey. Arch.Toxicol. 1993;67(2):148-150. PubMed
- von Malottki, K. and Wiechmann, H. W. [Acute life-threatening bradycardia: food poisoning by Turkish wild honey]. Dtsch.Med.Wochenschr. 7-26-1996;121(30):936-938.
- Abdulla CO, Ayubi A, Zulfiquer F, Santhanam G, Ahmed MA, Deeb J. Infant botulism following honey ingestion. BMJ Case Rep. 2012 Sep 7;2012.
- Johnson DW, Badve SV, Pascoe EM, Beller E, Cass A, Clark C, de Zoysa J, Isbel NM, McTaggart S, Morrish AT, Playford EG, Scaria A, Snelling P, Vergara LA, Hawley CM; HONEYPOT Study Collaborative Group. Antibacterial honey for the prevention of peritoneal-d
- Matos D, Serrano P, Menezes Brandão F. A case of allergic contact dermatitis caused by propolis-enriched honey. Contact Dermatitis. 2015 Jan;72(1):59-60. PubMed
- Oduwole O, Meremikwu MM, Oyo-Ita A, Udoh EE. Honey for acute cough in children. Cochrane Database Syst Rev. 2014 Dec 23;12:CD007094. PubMed
- Vezir E, Kaya A, Toyran M, Azkur D, Dibek Misirlioglu E, Kocabas CN. Anaphylaxis/angioedema caused by honey ingestion. Allergy Asthma Proc. 2014 Jan-Feb;35(1):71-4. PubMed
- Wang YT, Qi Y, Tang FY, et al. The effect of cupping therapy for low back pain: A meta-analysis based on existing randomized controlled trials. J Back Musculoskelet Rehabil. 2017;30(6):1187-1195. PubMed
- Oduwole O, Udoh EE, Oyo-Ita A, Meremikwu MM. Honey for acute cough in children. Cochrane Database Syst Rev. 2018;4:CD007094. PubMed
- Wong D, Albietz JM, Tran H, et al. Treatment of contact lens related dry eye with antibacterial honey. Cont Lens Anterior Eye. 2017;40(6):389-393. PubMed
- Martina SJ, Ramar LAP, Silaban MRI, Luthfi M, Govindan PAP. Antiplatelet Effectivity between Aspirin with Honey on Cardiovascular Disease Based on Bleeding Time Taken on Mice. Open Access Maced J Med Sci. 2019 Oct 14;7(20):3416-3420. PubMed
- Jhawar N, Gonzalez-Estrada A. Honey-induced anaphylaxis in an adult. QJM 2022;115(5):325-326. PubMed
- Di Costanzo M, De Paulis N, Peveri S, Montagni M, Berni Canani R, Biasucci G. Anaphylaxis caused by artisanal honey in a child: a case report. J Med Case Rep 2021;15(1):235. PubMed
Black Seed 60 references
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Aqel M, Shaheen R. Effects of the volatile oil of black seed seeds on the uterine smooth muscle of rat and guinea pig. J Ethnopharmacol 1996;52:23-6.
- Keshri G, Singh MM, Lakshmi V, Kamboj VP. Post-coital contraceptive efficacy of the seeds of Black seed in rats. Indian J Physiol Pharmacol 1995;39:59-62.
- Tennekoon KH, Jeevathayaparan S, Kurukulasooriya AP, Karunanayake EH. Possible hepatotoxicity of Nigella sativa seeds and Dregea volubilis leaves. J Ethnopharmacol 1991;31:283-9. PubMed
- Dehkordi FR, Kamkhah AF. Antihypertensive effect of Nigella sativa seed extract in patients with mild hypertension. Fundam Clin Pharmacol 2008;22:447-52.
- Zaoui, A., Cherrah, Y., Lacaille-Dubois, M. A., Settaf, A., Amarouch, H., and Hassar, M. [Diuretic and hypotensive effects of Nigella sativa in the spontaneously hypertensive rat]. Therapie 2000;55(3):379-382.
- Enomoto, S., Asano, R., Iwahori, Y., Narui, T., Okada, Y., Singab, A. N., and Okuyama, T. Hematological studies on black cumin oil from the seeds of Nigella sativa L. Biol.Pharm.Bull 2001;24(3):307-310. PubMed
- Meral, I., Yener, Z., Kahraman, T., and Mert, N. Effect of Nigella sativa on glucose concentration, lipid peroxidation, anti-oxidant defence system and liver damage in experimentally-induced diabetic rabbits. J Vet.Med A Physiol Pathol.Clin Med 2001;48(1
- Al Jishi, S. A. and Abuo, Hozaifa B. Effect of Nigella sativa on blood hemostatic function in rats. J Ethnopharmacol. 2003;85(1):7-14. PubMed
- Ali, B. H. and Blunden, G. Pharmacological and toxicological properties of Nigella sativa. Phytother.Res. 2003;17(4):299-305.
- Al Naggar, T. B., Gomez-Serranillos, M. P., Carretero, M. E., and Villar, A. M. Neuropharmacological activity of Nigella sativa L. extracts. J Ethnopharmacol. 2003;88(1):63-68. PubMed
- Kalus, U., Pruss, A., Bystron, J., Jurecka, M., Smekalova, A., Lichius, J. J., and Kiesewetter, H. Effect of Nigella sativa (black seed) on subjective feeling in patients with allergic diseases. Phytother.Res. 2003;17(10):1209-1214.
- Islam, S. N., Begum, P., Ahsan, T., Huque, S., and Ahsan, M. Immunosuppressive and cytotoxic properties of Nigella sativa. Phytother.Res. 2004;18(5):395-398.
- Fararh, K. M., Atoji, Y., Shimizu, Y., Shiina, T., Nikami, H., and Takewaki, T. Mechanisms of the hypoglycaemic and immunopotentiating effects of Nigella sativa L. oil in streptozotocin-induced diabetic hamsters. Res Vet.Sci 2004;77(2):123-129. PubMed
- Awad, E. M. and Binder, B. R. In vitro induction of endothelial cell fibrinolytic alterations by Nigella sativa. Phytomedicine 2005;12(3):194-202. PubMed
- El Obeid, A., Al Harbi, S., Al Jomah, N., and Hassib, A. Herbal melanin modulates tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6) and vascular endothelial growth factor (VEGF) production. Phytomedicine. 2006;13(5):324-333.
- Abbas, A. T., Abdel-Aziz, M. M., Zalata, K. R., and Tel, Abd Al-Galel. Effect of dexamethasone and Nigella sativa on peripheral blood eosinophil count, IgG1 and IgG2a, cytokine profiles and lung inflammation in murine model of allergic asthma. Egypt J Im
- Kaleem, M., Kirmani, D., Asif, M., Ahmed, Q., and Bano, B. Biochemical effects of Nigella sativa L seeds in diabetic rats. Indian J Exp.Biol. 2006;44(9):745-748.
- Hawsawi, Z. A., Ali, B. A., and Bamosa, A. O. Effect of Nigella sativa (Black Seed) and thymoquinone on blood glucose in albino rats. Ann.Saudi Med 2001;21(3-4):242-244.
- Massadeh, A. M., Al Safi, S. A., Momani, I. F., Al Mahmoud, M., and Alkofahi, A. S. Analysis of cadmium and lead in mice organs: effect of Nigella sativa L. (Black Cumin) on the distribution and immunosuppressive effect of cadmium-lead mixture in mice. B PubMed
- Akhondian, J., Parsa, A., and Rakhshande, H. The effect of Nigella sativa L. (black cumin seed) on intractable pediatric seizures. Med Sci Monit. 2007;13(12):CR555-CR559.
- Meddah, B., Ducroc, R., El Abbes, Faouzi M., Eto, B., Mahraoui, L., Benhaddou-Andaloussi, A., Martineau, L. C., Cherrah, Y., and Haddad, P. S. Nigella sativa inhibits intestinal glucose absorption and improves glucose tolerance in rats. J Ethnopharmacol. PubMed
- Najmi, A., Nasiruddin, M., Khan, R. A., and Haque, S. F. Effect of Nigella sativa oil on various clinical and biochemical parameters of insulin resistance syndrome. Int J Diabetes Dev.Ctries. 2008;28(1):11-14.
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- Al-Jenoobi FI, Al-Suwayeh SA, Muzaffar I, et al. Effects of Nigella sativa and Lepidium sativum on cyclosporine pharmacokinetics. Biomed Res Int 2013;2013:953520.
- Arslan E, Sayin S, Demirbas S, et al. A case study report of acute renal failure associated with Nigella sativa in a diabetic patient. J Integr Med 2013;11:64-6. PubMed
- Bamosa AO, Kaatabi H, Lebdaa FM, et al. Effect of Nigella sativa seeds on the glycemic control of patients with type 2 diabetes mellitus. Indian J Physiol Pharmacol 2010;54:344-54.
- Bonhomme A, Poreaux C, Jouen F, et al. Bullous drug eruption to Nigella sativa oil: Consideration of the use of a herbal medicine - clinical report and review of the literature. J Eur Acad Dermatol Venereol 2017;31:e217-e219.
- Farhangi MA, Dehghan P, Tajmiri S, Abbasi MM. The effects of Nigella sativa on thyroid function, serum Vascular Endothelial Growth Factor (VEGF) - 1, Nesfatin-1 and anthropometric features in patients with Hashimoto's thyroiditis: a randomized controlled
- Kaatabi H, Bamosa AO, Badar A, et al. Nigella sativa improves glycemic control and ameliorates oxidative stress in patients with type 2 diabetes mellitus: placebo controlled participant blinded clinical trial. PLoS One 2015;10:e0113486. PubMed
- Mohtashami R, Huseini HF, Heydari M, et al. Efficacy and safety of honey based formulation of Nigella sativa seed oil in functional dyspepsia: A double blind randomized controlled clinical trial. J Ethnopharmacol 2015;175:147-52. PubMed
- Perveen T, Haider S, Zuberi NA, et al. Increased 5-HT levels following repeated administration of Nigella sativa L. (Black Seed) oil produce antidepressant effects in rats. Sci Pharm 2013;82:161-70. PubMed
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- Dehavay F, Kolivras A, Scheers C. Local and systemic adverse skin reactions following the use of herbal products believed to contain Nigella sativa seeds and oil. Contact Dermatitis. 2019 Mar;80(3):176-177.
- Kooshki A, Tofighiyan T, Rastgoo N, Rakhshani MH, Miri M. Effect of Nigella sativa oil supplement on risk factors for cardiovascular diseases in patients with type 2 diabetes mellitus. Phytother Res. 2020.
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- Alam MA, Bin Jardan YA, Raish M, Al-Mohizea AM, Ahad A, Al-Jenoobi FBI. Effect of Nigella sativa and fenugreek on the pharmacokinetics and pharmacodynamics of amlodipine in hypertensive rats. Curr Drug Metab. 2020;21(4):318-325. PubMed
- Moustafa HAM, El Wakeel LM, Halawa MR, Sabri NA, El-Bahy AZ, Singab AN. Effect of Nigella sativa oil versus metformin on glycemic control and biochemical parameters of newly diagnosed type 2 diabetes mellitus patients. Endocrine 2019;65(2):286-94. PubMed
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- Wang X, Jiang A, Batra V. Severe thrombocytopenia associated with black seed oil and evening primrose oil. Cureus. 2020;12(6):e8390. PubMed
- Alkharfy K, Jan B, Alotaibi K, et al. Clopidogrel-herb Interactions: A Pharmacokinetic and Pharmacodynamic Assessment in a Rat Model. Curr Drug Metab 2021;22(12):969-977. PubMed
- Bin Jardan YA, Ahad A, Raish M, Alam MA, Al-Mohizea AM, Al-Jenoobi FI. Effects of garden cress, fenugreek and black seed on the pharmacodynamics of metoprolol: an herb-drug interaction study in rats with hypertension. Pharm Biol 2021;59(1):1088-1097. PubMed
- Thomas JV, Mohan ME, Prabhakaran P, Das S S, Maliakel B, I M K. A phase I clinical trial to evaluate the safety of thymoquinone-rich black cumin oil (BlaQmax®) on healthy subjects: Randomized, double-blinded, placebo-controlled prospective study. Toxicol PubMed
- Assier H, Kouby F, Ingen-Housz-Oro S, Roux C. Severe allergic contact connubial dermatitis to Nigella Sativa Seed Oil due to repeated contacts to beard cosmetics. Contact Dermatitis 2022. PubMed
- Koshak AE, Koshak EA, Mobeireek AF, et al. Nigella sativa for the treatment of COVID-19: An open-label randomized controlled clinical trial. Complement Ther Med 2021;61:102769. PubMed
- Hadi S, Daryabeygi-Khotbehsara R, Mirmiran P, et al. Effect of Nigella sativa oil extract on cardiometabolic risk factors in type 2 diabetes: A randomized, double-blind, placebo-controlled clinical trial. Phytother Res 2021;35(7):3747-3755.
- Ali SM, Chen P, Sheikh S, et al. Thymoquinone with metformin decreases fasting, post prandial glucose, and HbA1c in type 2 diabetic patients. Drug Res (Stuttg) 2021;71(6):302-306. PubMed
- Tavakoli-Rouzbehani OM, Abbasnezhad M, Kheirouri S, Alizadeh M. Effects of Nigella sativa oil supplementation on selected metabolic parameters and anthropometric indices in patients with coronary artery disease: A randomized, double-blind, placebo-control
- Fargeas M, Calugareanu A, Ben-Said B. Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome after topical use of Nigella sativa (black cumin) oil. Contact Dermatitis 2022;87(2):203-204.
- Wang Z, Wang Z, Wang X, et al. Potential food-drug interaction risk of thymoquinone with warfarin. Chem Biol Interact. 2022;365:110070. PubMed
- Wang Z, Wang X, Wang Z, et al. Potential herb-drug interaction risk of thymoquinone and phenytoin. Chem Biol Interact. 2022;353:109801. PubMed
- Al-Mohizea AM, Ahad A, El-Maghraby GM, et al. Effects of Nigella sativa, Lepidium sativum and Trigonella foenum-graecum on sildenafil disposition in beagle dogs. Eur J Drug Metab Pharmacokinet. 2015;40(2):219-24. PubMed
- Alkharfy KM, Al-Jenoobi FI, Al-Mohizea AM, et al. Effects of Lepidium sativum, Nigella sativa and Trigonella foenum-graceum on phenytoin pharmacokinetics in beagle dogs. Phytother Res. 2013;27(12):1800-4.
- Abutaima R, Al-Ebini Y, Alkofahi A, et al. In vivo assessment of black seed oil single dose on prednisolone pharmacokinetics. J Pharm Pharmacol 2024;76(1):57-63.
- Sener K, Cakir A, Yesiloglu O, Altug E, Guven R, Korkut S. Rhabdomyolysis and acute kidney injury after consumption of black seed oil. Toxicon 2024;245:107787. PubMed
Oregano 12 references
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