Interactions on record — worth a quick check against your medications. Based on 3 of 4 ingredients. Check your meds →
Dietary supplement

Intensive Bowel Support Ingredients & Drug Interactions

by Schiff Digestive Advantage

Intensive Bowel Support label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Intensive Bowel Support against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Intensive Bowel Support is a dietary supplement by Schiff Digestive Advantage with 4 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are BC30 Bacillus coagulans GBI-30, 6086. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Intensive Bowel Support by Schiff Digestive Advantage

Ask about any prescription or over-the-counter medication and we check it for interactions with Intensive Bowel Support by Schiff Digestive Advantage — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Intensive Bowel Support by Schiff Digestive Advantage

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 4 active ingredients.

Intensive Bowel Support has four active ingredients, each an enzyme or organism that supports digestion. Protease and Lipase are digestive enzymes — they break down proteins and fats, respectively.

Amylase breaks down carbohydrates. BC30 Bacillus coagulans is a live probiotic (beneficial bacterium) included to support gut health.

The rest of the capsule is made up of inactive ingredients like microcrystalline cellulose, maltodextrin, and hypromellose — the fillers and binders that hold it together.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: digestive health and occasional digestive discomfort.
  • We looked for evidence on: Constipation, Diarrhea, Dyspepsia, Flatulence, Irritable bowel syndrome (IBS), Antibiotic-associated diarrhea — and 4 related terms.
  • The strongest evidence on file: Bacillus Coagulans is rated "Possibly Effective" for Constipation (Natural Medicines).
  • Also on file: Bacillus Coagulans is rated "Possibly Effective" for Irritable bowel syndrome (IBS).
  • Also on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia.

The evidence for this product's ingredients is mixed. BC30 Bacillus coagulans is possibly effective for constipation and irritable bowel syndrome (IBS) based on the data we hold.

For the other conditions listed — antibiotic-associated diarrhea, athletic performance, cancer, and nonalcoholic fatty liver disease — the evidence isn't established. Protease and Lipase both show insufficient reliable evidence for the digestive conditions we evaluated them for, including inflammatory bowel disease and dyspepsia (indigestion).

We couldn't check Amylase.

The evidence, ingredient by ingredient Proteolytic Enzymes (proteases) Lipase Bacillus Coagulans

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

The enzymes in this product — Protease and Lipase — are generally well tolerated in adults, though some people report digestive upset or allergic reactions. Protease specifically has rarely caused allergic reactions in people with occupational exposure to similar enzymes, and those with airborne exposure have reported allergic rhinoconjunctivitis or asthma.

BC30 Bacillus coagulans is generally well tolerated in healthy adults, but there's a theoretical concern: if you're severely ill, have a weakened immune system, or have central lines (catheters), live probiotics could potentially cause serious infection. This is rare in healthy people with intact immune systems.

For pregnancy and breastfeeding, safety data is limited for all three checked ingredients — talk to your doctor or pharmacist before using if you're pregnant or nursing.

Side effects, ingredient by ingredient Proteolytic Enzymes (proteases) Lipase Bacillus Coagulans

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 3 matched ingredients can interact with medications — Bacillus Coagulans.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

The main thing to watch for is antibiotics (Moderate severity) — they can reduce how well the probiotic in this product works, so separate your doses by several hours. For the other ingredients we checked, no interactions are documented in our data.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help with constipation or IBS if BC30 Bacillus coagulans is the active ingredient doing the work — the other enzymes lack strong evidence. If you take antibiotics, space them several hours away from this supplement.

If you're pregnant, nursing, severely ill, or immunocompromised, check with your pharmacist first. Run your medications through the checker on this page before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Intensive Bowel Support, straight from the product label.

Brand Schiff Digestive Advantage
Barcode (UPC) 815066001164
Net contents 32 Capsule(s)
Market status On market
Date entered into DSLD Jul 25, 2016
DSLD ID 62644
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Intensive Bowel Support by Schiff Digestive Advantage, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
815066001164
IngredientAmount% DV
Amylase0 NP--
Protease0 NP--
Lipase0 NP--
BC30 Bacillus coagulans GBI-30, 60860 NP--

Other ingredients: Maltodextrin, Hypromellose, Microcrystalline Cellulose, Stearic Acid, Water, Dextrin, Titanium Dioxide, Silicon Dioxide, Magnesium Stearate, Caramel color

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Studies show that BC30 probiotics and digestive enzymes break down proteins, carbohydrates and fats to aid the digestive process. Probiotics are beneficial bacteria that live in your digestive tract and promote digestive and immune health. Other probiotics don't survive the harsh acidic stomach environment.

Actual size

Enjoy the benefits Helps defend against gas, bloating and occasional diarrhea Relieves occasional abdominal discomfort Promotes long-term digestive health with continued use

Survives 10x better

For information call: 1-800-526-6251 (8am-5pm MST M-F)

New look / Improved formula Now with a blend of enzymes to help break down foods and promote healthy digestion.

GUARANTEED for purity, freshness and labeled potency.

Survivability and delivery of probiotic cells to the small & large intestines is one of several factors influencing overall product effect.

New look improved formula with enzymes

Since 1936

The probiotic that survies Improved Formula

Helps defend against occasional gas, bloating & abdominal discomfort

Brand IP Statement(s)

Because Digestive Advantage Intensive Bowel Support reaches your intestines alive, it is able to provide digestive and immune health benefits where you need them.

U.S. patents 6,461,607 & 6,849,256. International patents pending.

Schiff Digestive Advantage targets your specific digestive health needs and, with continued use, gives you long-term digestive support.

Digestive Advantage Intensive Bowel Support defends against occasional gas, bloating, abdominal discomfort and diarrhea.

Studies reveal that the single strain of probiotic used in Schiff Digestive Advantage survives 10x better than other probiotics and yogurt to deliver good bacteria where you need it.

Based on median % survivability of Digestive Advantage vs. probiotic supplements and 20 probiotic yogurts in simulated gastric pH for 2 hours.

POWERED BY Ganeden BC30 Probiotic Digestive & Immune health

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General

18116 46018116.8

Formula

Ganeden BC30 Probiotic

Contains wheat and soy.

That's because Digestive Advantage contains BC30, a natural probiotic that survives 10x better than yogurt to deliver good bacteria where you need it.

Suggested/Recommended/Usage/Directions

Directions Adults: Take one capsule daily with water. Some adults may benefit from taking two or more capsules daily. Children 8 years & over: For children it is recommended that one capsule be opened and contents mixed into food or drink. Upon initial use, it may take 7 to 14 days for you to feel the product working. Consistent, daily use is needed to maintain results.

Just one capsule daily

Storage

No refrigeration necessary.

Store in a cool, dry place.

Precautions

Contains wheat and soy.

Always consult your pediatrician before giving your child dietary supplements.

Note: If pregnant, lactating or on prescribed medication, consult your physician before using.

Keep out of reach of children.

Seals/Symbols

Schiff Quality Guarantee

Formulation

GUARANTEED: No added sugar (sucrose, fructose, lactose), salt (sodium chloride) or yeast. No preservatives or artificial flavors.

FDA Statement of Identity

Dietary Suppelment

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Intensive Bowel Support by Schiff Digestive Advantage label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Intensive Bowel Support label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Intensive Bowel Support by Schiff Digestive Advantage

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Amylase

0 NP per serving Form: Aspergillus oryzae

Protease

No known
interactions
0 NP per serving Form: Aspergillus oryzae

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Protease monograph & interactions

Lipase

No known
interactions
0 NP per serving Form: Rhizopus oryzae

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy fo...

Lipase monograph & interactions

BC30 Bacillus coagulans GBI-30, 6086

Interacts with
182 drugs
0 NP per serving

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, a...

BC30 Bacillus coagulans GBI-30, 6086 monograph & interactions

Other (inactive) ingredients: Maltodextrin, Hypromellose, Microcrystalline Cellulose, Stearic Acid, Water, Dextrin, Titanium Dioxide, Silicon Dioxide, Magnesium Stearate, Caramel color. These complete the product’s ingredient list but are not active constituents.

Interaction report

Intensive Bowel Support by Schiff Digestive Advantage Drug Interactions

Want to check YOUR meds against Intensive Bowel Support?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

BC30 Bacillus coagulans GBI-30, 6086 182

Individual Drug Interactions

The ingredients in Intensive Bowel Support interact with 182 drugs. Click any drug to see the details.

1 of the 4 ingredients in Intensive Bowel Support interact with drugs. Each result below shows which ingredient is responsible. BC30 Bacillus coagulans GBI-30, 6086

Each ingredient & the kinds of drugs it affects

For each ingredient in Intensive Bowel Support with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

BC30 Bacillus coagulans GBI-30, 60861 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B. coagulans.
B. coagulans preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. coagulans preparations by at least two hours.

Likelihood Probable Evidence D
BC30 Bacillus coagulans GBI-30, 6086 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Intensive Bowel Support, from the product label.

Schiff Digestive Advantage

See all Schiff Digestive Advantage products
Name
Schiff Nutrition Group, Inc.
City
Salt Lake City
State
UT
ZipCode
84104
Phone Number
1-800-526-6251
Web Address
www.DigestiveAdvantage.com
Pharmacist Counseling Corner

Intensive Bowel Support by Schiff Digestive Advantage: Common Questions

Does Intensive Bowel Support by Schiff Digestive Advantage interact with any medications?
Yes. Based on its ingredients, Intensive Bowel Support has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Intensive Bowel Support contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my IBS or constipation?
BC30 Bacillus coagulans, the probiotic in this product, is possibly effective for both. The enzymes Protease and Lipase don't have enough evidence yet to say whether they help with these conditions. Your results may vary.
Can I take this if I'm on antibiotics?
You can, but space them out. Antibiotics can kill the live organisms in this supplement, making it less effective. Take your antibiotic and this supplement several hours apart — ask your pharmacist for timing that works with your specific antibiotic.
Is this safe during pregnancy?
The safety data for these ingredients during pregnancy is limited. Talk to your doctor or pharmacist for personalized advice before using it while pregnant.
Can I breastfeed while taking this?
There isn't enough safety data on these ingredients during breastfeeding. Check with your healthcare provider first before using it while nursing.
What are the active ingredients doing in here?
Protease, Lipase, and Amylase are digestive enzymes that break down proteins, fats, and carbohydrates in your food. BC30 Bacillus coagulans is a live probiotic bacterium meant to support your gut health.
Does it have fillers?
Yes — like most capsules, it contains inactive ingredients like microcrystalline cellulose, maltodextrin, and magnesium stearate to hold the capsule together and keep the product stable.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Intensive Bowel Support is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Intensive Bowel Support label
Go deeper

The Full Monographs Behind Intensive Bowel Support’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph → Herb & supplement monograph

Bacillus Coagulans

Interacts with 182 drugs

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, and certain types of diarrhea. The eviden...

Read the full Bacillus Coagulans monograph →
Sources

Sources & How We Checked

Intensive Bowel Support's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 24 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Bacillus Coagulans 20 references
  1. Saxelin M, Chuang NH, Chassy B, et al. Lactobacilli and bacteremia in southern Finland 1989-1992. Clin Infect Dis 1996;22:564-6. PubMed
  2. Tynkkynen S, Singh KV, Varmanen P. Vancomycin resistance factor of Lactobacillus rhamnosus GG in relation to enterococcal vancomycin resistance (van) genes. Int J Food Microbiol 1998;41:195-204. PubMed
  3. Klein G, Zill E, Schindler R, et al. Peritonitis associated with vancomycin-resistant Lactobacillus rhamnosus in a continuous ambulatory peritoneal dialysis patient; organism identification, antibiotic therapy, and case report. J Clin Microbiol 1998;36:
  4. Kalima P, Masterton RG, Roddie PH, et al. Lactobacillus rhamnosus infection in a child following bone marrow transplant. J Infect 1996;32:165-7. PubMed
  5. Goldin BR. Health Benefits of probiotics. Br J Nutr 1998;80:S203-7. DOI
  6. Rautio M, Jousimies-Somer H, Kauma H, et al. Liver abscess due to Lactobacillus rhamnosus strain indistinguishable from L. rhamnosus strain GG. Clin Infect Dis 1999;28:1159-60.
  7. MacGregor G, Smith AJ, Thakker B, Kinsella J. Yoghurt biotherapy: contraindicated in immunosuppressed patients? Postgrad Med J 2002;78:366-7. PubMed
  8. Land MH, Rouster-Stevens K, Woods CR, et al. Lactobacillus sepsis associated with probiotic therapy. Pediatrics 2005;115:178-81.
  9. De Groote MA, Frank DN, Dowell E, et al. Lactobacillus rhamnosus GG bacteremia associated with probiotic use in a child with short gut syndrome. Pediatr Infect Dis J 2005;24:278-80. PubMed
  10. Vahabnezhad E, Mochon AB, Wozniak LJ, Ziring DA. Lactobacillus bacteremia associated with probiotic use in a pediatric patient with ulcerative colitis. J Clin Gastroenterol. 2013;47(5):437-9. PubMed
  11. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  12. Sendil S, Shrimanker I, Mansoora Q, Goldman J, Nookala VK. Lactobacillus rhamnosus bacteremia in an immunocompromised renal transplant patient. Cureus. 2020;12(2):e6887. PubMed
  13. Albarillo FS, Shah U, Joyce C, Slade D. Lactobacillus rhamnosus Infection: A single-center 4-year descriptive analysis. J Glob Infect Dis. 2020;12(3):119-123. PubMed
  14. Pasala S, Singer L, Arshad T, Roach K. Lactobacillus endocarditis in a healthy patient with probiotic use. IDCases. 2020;22:e00915. PubMed
  15. Agrawal S, Tuchman ES, Bruce MJ, Theodorou ME. Fatal Lactobacillus endocarditis in a patient with transcatheter aortic valve replacement. BMJ Case Rep. 2020;13(11):e236835.
  16. Antoun M, Hattab Y, Akhrass FA, Hamilton LD. Uncommon pathogen, Lactobacillus, causing infective endocarditis: Case report and review. Case Rep Infect Dis. 2020;2020:8833948. PubMed
  17. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  18. Franko B, Vaillant M, Recule C, Vautrin E, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics. Med Mal Infect. 2013;43(4):171-3. PubMed
  19. Campbell RE, Miller A, Afroze A. Native valve endocarditis secondary to Lactobacillus paracasei bacteremia. Consultant. 2020;60(9):27-8. DOI
  20. Kato K, Funabashi N, Takaoka H, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics with advanced and severe bicuspid aortic valve stenosis complicated with diffuse left ventricular mid-layer fibrosis. Int J Cardiol. 2016;224:157-161. PubMed

See these in context on the Bacillus Coagulans monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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