Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Intesta Cleanse Ingredients & Drug Interactions

by Marco Pharma Int'l

Intesta Cleanse label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Intesta Cleanse against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Intesta Cleanse is a dietary supplement by Marco Pharma Int'l with 2 active ingredients. Its ingredients are commonly taken for constipation, irritable bowel syndrome (ibs), diarrhea.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bacillus coagulans. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Intesta Cleanse by Marco Pharma Int'l

Ask about any prescription or over-the-counter medication and we check it for interactions with Intesta Cleanse by Marco Pharma Int'l — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Intesta Cleanse by Marco Pharma Int'l

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Intesta Cleanse has 2 active ingredients. The main one is Bacillus coagulans, a live probiotic organism — a friendly bacteria strain that's meant to support gut health.

The product also includes a proprietary blend, a combination of other ingredients the manufacturer doesn't break down individually on the label. The capsules also contain inactive ingredients: cellulose, magnesium stearate, and silicon dioxide — these are fillers and binders that help hold the capsule together.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: digestive and bowel health support.
  • We looked for evidence on: Constipation, Irritable bowel syndrome (IBS), Flatulence, Dyspepsia, Bowel regularity, Gastrointestinal comfort.
  • The strongest evidence on file: Bacillus Coagulans is rated "Possibly Effective" for Constipation (Natural Medicines).
  • Also on file: Bacillus Coagulans is rated "Possibly Effective" for Irritable bowel syndrome (IBS).
  • Also on file: Bacillus Coagulans is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia, Flatulence.

Bacillus coagulans shows some promise for constipation and irritable bowel syndrome (IBS); the evidence rates it as possibly effective for both. For antibiotic-related diarrhea, athletic performance, cancer, and fatty liver disease, the evidence we have isn't strong enough to rate it yet.

The evidence, ingredient by ingredient Bacillus Coagulans

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bacillus coagulans is generally well tolerated in healthy adults, though the quality and safety data for probiotic products vary widely. There is a theoretical concern: live probiotics can occasionally cause serious bloodstream infections (bacteremia) or infection throughout the body (sepsis) in people with central lines or catheters, severely ill patients, or those with weakened immune systems — including very premature infants.

Healthy people with intact immune systems aren't at the same risk, but talk to your doctor or pharmacist before starting this product, especially if you have a catheter, are severely ill, or have a weakened immune system. We don't have reliable safety data for pregnancy or breastfeeding.

If you're pregnant or breastfeeding, check with your doctor or pharmacist before using.

Side effects, ingredient by ingredient Bacillus Coagulans

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Bacillus Coagulans.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antibiotics, separate your dose from Intesta Cleanse by a few hours so the live organisms don't get killed off. Check with your doctor or pharmacist about your exact antibiotic and any other medications before you start.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Intesta Cleanse may help with constipation or IBS if the live organisms survive and take hold. The catch is that antibiotics will kill them, so you'll need to time the doses carefully — separate them by a few hours.

Before you start, especially if you're on antibiotics, have a weakened immune system, or have a central line, talk it over with your doctor or pharmacist to make sure it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Intesta Cleanse, straight from the product label.

Brand Marco Pharma Int'l
Net contents 60 Veggie Capsule(s)
Market status On market
Date entered into DSLD Sep 25, 2013
DSLD ID 25282
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Children (All)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Intesta Cleanse by Marco Pharma Int'l, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veggie Capsule(s)
Maximum serving Sizes:
1 Veggie Capsule(s)
Servings per container
60
IngredientAmount% DV
Bacillus coagulans300000000 CFU--
Proprietary Blend630 mg--

Other ingredients: Cellulose, Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols

MPI

Suggested/Recommended/Usage/Directions

Suggested Use: Adults begin with 1 capsule after dinner. Can be increased to 1 capsule after breakfast and 1 capsule after dinner. For children under age 12, consult a healthcare professional.

Read and follow directions carefully.

Precautions

Keep out of reach of children.

Do not use if you have or develop diarrhea, loose stools, or abdominal pain because senna may worsen these conditions and be harmful to your health.

Consult your physician if you have frequent diarrhea or if you are pregnant or nursing, taking medication, or have a medical condition.

Tamper Evident: Do not use if shrink wrap with MPI logo is broken or missing.

Warnings: If pregnant or breast-feeding, consult a health professional before use.

FDA Statement of Identity

Herbal Dietary Supplement

Formula

Notice: This product contains senna.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Intesta Cleanse by Marco Pharma Int'l label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Intesta Cleanse label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Intesta Cleanse by Marco Pharma Int'l

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Veggie Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Bacillus coagulans

Interacts with
182 drugs
300000000 CFU per serving

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, a...

Bacillus coagulans monograph & interactions

Proprietary Blend

630 mg per serving Form: Acacia, Barberry, Buckthorn, Cascara Sagrada bark extract, Fennel, Fenugreek, Ginger, Papaya, Peppermint, Psyllium, Senna, Triphala

Other (inactive) ingredients: Cellulose, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Intesta Cleanse by Marco Pharma Int'l Drug Interactions

Want to check YOUR meds against Intesta Cleanse?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Bacillus coagulans 182

Individual Drug Interactions

The ingredients in Intesta Cleanse interact with 182 drugs. Click any drug to see the details.

1 of the 2 ingredients in Intesta Cleanse interact with drugs. Each result below shows which ingredient is responsible. Bacillus coagulans

Each ingredient & the kinds of drugs it affects

For each ingredient in Intesta Cleanse with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Bacillus coagulans1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B. coagulans.
B. coagulans preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. coagulans preparations by at least two hours.

Likelihood Probable Evidence D
Bacillus coagulans full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Intesta Cleanse, from the product label.

Marco Pharma Int'l

See all Marco Pharma Int'l products
Name
Marco Pharma Int'l
City
Roseburg
State
OR
ZipCode
97470
Pharmacist Counseling Corner

Intesta Cleanse by Marco Pharma Int'l: Common Questions

Does Intesta Cleanse by Marco Pharma Int'l interact with any medications?
Yes. Based on its ingredients, Intesta Cleanse has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Intesta Cleanse contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will antibiotics stop this product from working?
Yes. Antibiotics can kill the live organisms in Bacillus coagulans, which is how the supplement works. That's why you should take your antibiotic and Intesta Cleanse a few hours apart — not at the same time — so the probiotic has a chance to survive.
Is this safe if I'm immunocompromised or have a central line?
Live probiotics carry a small risk of serious infection in people with weakened immune systems or indwelling catheters. If this applies to you, talk to your doctor before starting.
Can I take this if I'm pregnant or breastfeeding?
We don't have enough safety data to say either way. Talk to your doctor or pharmacist for personalized advice before using it during pregnancy or while breastfeeding.
Does this actually work for IBS?
The evidence suggests Bacillus coagulans is possibly effective for IBS — meaning there's some promising research, but it's not definitive. Results vary from person to person.
What's in the proprietary blend?
The label doesn't list the individual ingredients in the proprietary blend, so we can't tell you exactly what's in it or check how those ingredients might interact with your medications.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Intesta Cleanse is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Intesta Cleanse label
Go deeper

The Full Monographs Behind Intesta Cleanse’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bacillus Coagulans

Interacts with 182 drugs

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, and certain types of diarrhea. The eviden...

Read the full Bacillus Coagulans monograph →
Sources

Sources & How We Checked

Intesta Cleanse's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 20 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bacillus Coagulans 20 references
  1. Saxelin M, Chuang NH, Chassy B, et al. Lactobacilli and bacteremia in southern Finland 1989-1992. Clin Infect Dis 1996;22:564-6. PubMed
  2. Tynkkynen S, Singh KV, Varmanen P. Vancomycin resistance factor of Lactobacillus rhamnosus GG in relation to enterococcal vancomycin resistance (van) genes. Int J Food Microbiol 1998;41:195-204. PubMed
  3. Klein G, Zill E, Schindler R, et al. Peritonitis associated with vancomycin-resistant Lactobacillus rhamnosus in a continuous ambulatory peritoneal dialysis patient; organism identification, antibiotic therapy, and case report. J Clin Microbiol 1998;36:
  4. Kalima P, Masterton RG, Roddie PH, et al. Lactobacillus rhamnosus infection in a child following bone marrow transplant. J Infect 1996;32:165-7. PubMed
  5. Goldin BR. Health Benefits of probiotics. Br J Nutr 1998;80:S203-7. DOI
  6. Rautio M, Jousimies-Somer H, Kauma H, et al. Liver abscess due to Lactobacillus rhamnosus strain indistinguishable from L. rhamnosus strain GG. Clin Infect Dis 1999;28:1159-60.
  7. MacGregor G, Smith AJ, Thakker B, Kinsella J. Yoghurt biotherapy: contraindicated in immunosuppressed patients? Postgrad Med J 2002;78:366-7. PubMed
  8. Land MH, Rouster-Stevens K, Woods CR, et al. Lactobacillus sepsis associated with probiotic therapy. Pediatrics 2005;115:178-81.
  9. De Groote MA, Frank DN, Dowell E, et al. Lactobacillus rhamnosus GG bacteremia associated with probiotic use in a child with short gut syndrome. Pediatr Infect Dis J 2005;24:278-80. PubMed
  10. Vahabnezhad E, Mochon AB, Wozniak LJ, Ziring DA. Lactobacillus bacteremia associated with probiotic use in a pediatric patient with ulcerative colitis. J Clin Gastroenterol. 2013;47(5):437-9. PubMed
  11. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  12. Sendil S, Shrimanker I, Mansoora Q, Goldman J, Nookala VK. Lactobacillus rhamnosus bacteremia in an immunocompromised renal transplant patient. Cureus. 2020;12(2):e6887. PubMed
  13. Albarillo FS, Shah U, Joyce C, Slade D. Lactobacillus rhamnosus Infection: A single-center 4-year descriptive analysis. J Glob Infect Dis. 2020;12(3):119-123. PubMed
  14. Pasala S, Singer L, Arshad T, Roach K. Lactobacillus endocarditis in a healthy patient with probiotic use. IDCases. 2020;22:e00915. PubMed
  15. Agrawal S, Tuchman ES, Bruce MJ, Theodorou ME. Fatal Lactobacillus endocarditis in a patient with transcatheter aortic valve replacement. BMJ Case Rep. 2020;13(11):e236835.
  16. Antoun M, Hattab Y, Akhrass FA, Hamilton LD. Uncommon pathogen, Lactobacillus, causing infective endocarditis: Case report and review. Case Rep Infect Dis. 2020;2020:8833948. PubMed
  17. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  18. Franko B, Vaillant M, Recule C, Vautrin E, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics. Med Mal Infect. 2013;43(4):171-3. PubMed
  19. Campbell RE, Miller A, Afroze A. Native valve endocarditis secondary to Lactobacillus paracasei bacteremia. Consultant. 2020;60(9):27-8. DOI
  20. Kato K, Funabashi N, Takaoka H, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics with advanced and severe bicuspid aortic valve stenosis complicated with diffuse left ventricular mid-layer fibrosis. Int J Cardiol. 2016;224:157-161. PubMed

See these in context on the Bacillus Coagulans monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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