Major interaction on record — check this product against your medications before combining. Based on 6 of 7 ingredients. Check your meds →
Dietary supplement

Intestinal Bowel Support Ingredients & Drug Interactions

by Renew Life

Intestinal Bowel Support label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Intestinal Bowel Support against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Intestinal Bowel Support is a dietary supplement by Renew Life with 7 active ingredients. Its ingredients are commonly taken for muscle recovery and sports performance, gut health and 'leaky gut', recovery from severe illness or injury.Based on those ingredients, 2,155 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Marshmallow, Ginger, Marigold extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Intestinal Bowel Support by Renew Life

Ask about any prescription or over-the-counter medication and we check it for interactions with Intestinal Bowel Support by Renew Life — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Intestinal Bowel Support by Renew Life

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 3 of its 7 active ingredients.
  • “Proprietary Herbal Blend” is a proprietary blend — the label gives one combined amount (10 mg) without saying how much of each component you get.

Intestinal Bowel Support contains 7 ingredients, including L-Glutamine, Gamma Oryzanol, Ginger, Marshmallow, N-Acetyl D-Glucosamine (glucosamine), Cranesbill, and Marigold extract. These are meant to support digestive and intestinal function.

The capsules themselves are made from vegetable cellulose—there are no other inactive ingredients listed.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: healthy intestinal lining support.
  • We looked for evidence on: Inflammatory bowel disease (IBD), Irritable bowel syndrome (IBS), Crohn disease, Diarrhea, Dyspepsia, leaky gut syndrome — and 3 related terms.
  • The closest evidence on file: Glutamine is rated "Possibly Ineffective" for Crohn disease (Natural Medicines).
  • Also on file: Glutamine is rated "Possibly Ineffective" for Radiation-induced diarrhea.
  • Also on file: Marshmallow is rated "Insufficient Reliable Evidence To Rate" for Diarrhea.

The evidence for this formula's core ingredients is mixed. L-Glutamine is effective for sickle cell disease and possibly effective for wound healing after surgery and for wasting in HIV/AIDS, but the data we hold don't establish its use for general intestinal support.

Ginger is possibly effective for nausea in pregnancy and for menstrual cramping and possibly ineffective for exercise soreness. Gamma Oryzanol and Marshmallow show insufficient reliable evidence for their rated uses.

N-Acetyl D-Glucosamine (glucosamine) is likely effective for osteoarthritis but insufficient evidence supports it for other conditions listed. Marigold extract and Cranesbill have insufficient evidence in our data.

Overall, we don't hold effectiveness evidence for this product's specific intestinal-support claim.

The evidence, ingredient by ingredient Glutamine Gamma-oryzanol Ginger Marshmallow Calendula Glucosamine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-Glutamine is generally well tolerated but should be used only under medical supervision if you have kidney or liver disease; there isn't enough safety data for pregnancy or breastfeeding supplementation, so talk with your doctor first. Common side effects include bloating, constipation, diarrhea, nausea, and headache.

Ginger is generally well tolerated at typical food and supplement amounts; doses above 5 grams daily raise the risk of side effects. Gamma Oryzanol is generally well tolerated in studies but long-term safety isn't established; it's best avoided in pregnancy and breastfeeding.

Marshmallow is generally well tolerated short-term but should be avoided in pregnancy and breastfeeding due to insufficient safety data. N-Acetyl D-Glucosamine is generally well tolerated, though rare allergic reactions (hives, rash, swelling, difficulty breathing, anaphylaxis) have been reported; avoid in pregnancy and breastfeeding.

Marigold extract can cause allergic reactions in people sensitive to ragweed and related plants; it's best avoided orally in pregnancy and used only with doctor approval while breastfeeding.

Side effects, ingredient by ingredient Glutamine Gamma-oryzanol Ginger Marshmallow Calendula Glucosamine

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 5 of the 6 matched ingredients can interact with medications — Calendula, Marshmallow, Glucosamine, Glutamine, Ginger.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; seizure medications; immunosuppressants / transplant drugs; diabetes medications; lithium.
  • For scale: 2,156 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (warfarin, nifedipine, aspirin—Major risk from glucosamine with warfarin), diabetes medications, anticonvulsants (seizure drugs), cancer drugs (especially topoisomerase inhibitors), lithium, any medications metabolized by CYP3A4 (many cancer and heart drugs), or P-glycoprotein substrates. Ginger poses the broadest concern.

If you're on oral medications, space this supplement 30–60 minutes away from them to avoid absorption problems.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

This product may appeal to people looking for herbal intestinal support, but the individual ingredients have mixed evidence for digestive health. If you take blood thinners (especially warfarin), diabetes drugs, seizure medications, or cancer treatments, you'll need to check with your doctor or pharmacist before starting—the interactions are real and can affect how your medications work.

People with allergies to ragweed or related plants should be cautious of the Marigold extract. Talk with your own doctor or pharmacist about whether this product fits your health picture and medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 25, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Intestinal Bowel Support, straight from the product label.

Brand Renew Life
Barcode (UPC) 631257534521
Net contents 60 Vegetable Capsule(s)
Market status On market
Date entered into DSLD Nov 25, 2014
DSLD ID 39179
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Intestinal Bowel Support by Renew Life, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
631257534521
IngredientAmount% DV
L-Glutamine835 mg--
Gamma Oryzanol20 mg--
Ginger0 NP--
Marshmallow0 NP--
Proprietary Herbal Blend10 mg--
N-Acetyl D-Glucosamine35 mg--
Cranesbill0 NP--
Marigold extract0 NP--

Other ingredients: Vegetable Capsules

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Intestinal Bowel Support(TM) 1 contains natural ingredients that help the body maintain a healthy intestinal lining.* They include: ~ L-glutamine ~ N-acetyl D-glucosamine ~ Gamma oryzanol ~ Ginger, marshmallow and cranesbill

This product contains an ingredient derived from crustacean shells (shrimp, lobster, crab).

Formulation

Contains no yeast, wheat, soy, salt, gluten, sugar, dairy, binders, fillers or artificial ingredients

Gluten Free

Precautions

KEEP OUT OF REACH OF CHILDREN.

TAMPER EVIDENT: DO NOT USE IF SAFETY SEAL IS BROKEN OR MISSING.

This product contains an ingredient derived from crustacean shells (shrimp, lobster, crab).

WARNING: Consult your physician before using this or any product if you are pregnant, nursing, trying to conceive, taking medication or have a medical condition.

General Statements

Quality and Purity Guaranteed

MADE IN USA Manufactured in a GMP and Kosher facility

Intestinal Lining Support

1 Morning Formula

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

RENEW LIFE(R) The Digestive Care Company

Suggested/Recommended/Usage/Directions

Directions: Take 2 capsules in the morning on an empty stomach.

General

0310

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Intestinal Bowel Support by Renew Life label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Intestinal Bowel Support label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Intestinal Bowel Support by Renew Life

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Glutamine

Interacts with
50 drugs
835 mg per serving

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle c...

L-Glutamine monograph & interactions

Gamma Oryzanol

No known
interactions
20 mg per serving

Gamma-oryzanol is a mix of plant compounds taken from rice bran oil, used mainly for cholesterol, menopause symptoms, and as a sports supplement. The...

Gamma Oryzanol monograph & interactions

Proprietary Herbal Blend

10 mg per serving

N-Acetyl D-Glucosamine

Interacts with
170 drugs
35 mg per serving

Glucosamine is a natural compound found in cartilage and joint fluid, and it is one of the most popular supplements for osteoarthritis, especially of...

N-Acetyl D-Glucosamine monograph & interactions

Other (inactive) ingredients: Vegetable Capsules. These complete the product’s ingredient list but are not active constituents.

Interaction report

Intestinal Bowel Support by Renew Life Drug Interactions

Want to check YOUR meds against Intestinal Bowel Support?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,155Drugs
2 Major 924 Moderate 1,229 Minor

Ingredients driving the most interactions

Marshmallow 2,040
Ginger 1,007
Marigold extract 248
N-Acetyl D-Glucosamine 170
L-Glutamine 50

Individual Drug Interactions

The ingredients in Intestinal Bowel Support interact with 2,155 drugs. Click any drug to see the details.

5 of the 7 ingredients in Intestinal Bowel Support interact with drugs. Each result below shows which ingredient is responsible. Marshmallow Ginger Marigold extract N-Acetyl D-Glucosamine L-Glutamine

Each ingredient & the kinds of drugs it affects

For each ingredient in Intestinal Bowel Support with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Marshmallow3 drug types · 2,040 drugs

Lithium

Theoretically, due to potential diuretic effects, marshmallow might reduce excretion and increase levels of lithium.
Marshmallow is thought to have diuretic properties. To avoid lithium toxicity, the dose of lithium might need to be decreased when used with marshmallow.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, marshmallow flower might have antiplatelet effects.
Animal research suggests that marshmallow flower extract has antiplatelet effects. However, the root and leaf of marshmallow, not the flower, are the plant parts most commonly found in dietary supplements. Theoretically, use of marshmallow flower with anticoagulant/antiplatelet drugs can have additive effects, and might increase the risk for bleeding in some patients.

Likelihood Unlikely Evidence D
Oral Drugs

Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Marshmallow contains mucilage which can affect oral drug absorption. To avoid changes in absorption, take marshmallow 30-60 minutes after oral medications.

Likelihood Possible Evidence D
Marshmallow full monograph & interactions

Ginger14 drug types · 1,007 drugs

Anticoagulant/Antiplatelet Drugs

Ginger may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs. However, research is conflicting.
Laboratory research suggests that ginger inhibits thromboxane synthetase and decreases platelet aggregation. However, this has not been demonstrated unequivocally in humans, with mixed results from clinical trials. Theoretically, excessive amounts of ginger might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, taking ginger with antidiabetes drugs might increase the risk of hypoglycemia.
Animal and human research suggests that ginger might increase insulin levels and/or decrease blood glucose levels.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Ginger might increase or decrease the levels of CYP3A4 substrates.
In vitro research and some case reports suggest that ginger inhibits CYP3A4 activity. Three case reports from the World Health Organization (WHO) adverse drug reaction database describe increased toxicity in patients taking ginger and cancer medications that are CYP3A4 substrates (imatinib, dabrafenib, and crizotinib). However, the causality of this interaction is unclear due to the presence of multiple interacting drugs and routes of administration.
Conversely, other in vitro research suggests that ginger induces CYP3A4 activity, leading to reduced levels of CYP3A4 substrates. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Losartan (Cozaar)

Theoretically, ginger might increase levels of losartan and the risk of hypotension.
In animal research, ginger increased the levels and hypotensive effects of a single dose of losartan. It is not clear if ginger alters the concentration or effects of losartan when taken continuously. Additionally, this interaction has not been shown in humans.

Likelihood Possible Evidence D
Nifedipine (Procardia)

Ginger may have antiplatelet effects and increase the risk of bleeding if used with nifedipine.
Clinical research shows that combined treatment with ginger 1 gram plus nifedipine 10 mg significantly inhibits platelet aggregation when compared to nifedipine or ginger alone.

Likelihood Possible Evidence B
P-Glycoprotein Substrates

Ginger might increase the absorption and blood levels of P-glycoprotein (P-gp) substrates.
In vitro research and case reports suggest that ginger inhibits drug efflux by P-gp, potentially increasing absorption and serum levels of P-gp substrates. Two case reports from the World Health Organization (WHO) adverse drug reaction database describe increased toxicity in patients taking ginger and cancer medications that are P-gp substrates (trametinib, crizotinib). However, the causality of this interaction is unclear due to the presence of multiple interacting drugs and routes of administration.

Likelihood Possible Evidence D
Phenprocoumon (Marcoumar, Others)

Ginger might increase the risk of bleeding with phenprocoumon.
Phenprocoumon, a warfarin-related anticoagulant, might increase the international normalized ratio (INR) when taken with ginger. There is one case report of a 76-year-old woman with a stable INR on phenprocoumon that increased to greater than 10 when she began consuming dried ginger and ginger tea.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Ginger might increase the risk of bleeding with warfarin.
Laboratory research suggests that ginger might inhibit thromboxane synthetase and decrease platelet aggregation. In one case report, ginger increased the INR when taken with phenprocoumon, which has similar pharmacological effects as warfarin. In another case report, ginger increased the INR when taken with a combination of warfarin, hydrochlorothiazide, and acetaminophen. A longitudinal analysis suggests that taking ginger increases the risk of bleeding in patients taking warfarin for at least 4 months. However, research in healthy people suggests that ginger has no effect on INR, or the pharmacokinetics or pharmacodynamics of warfarin. Until more is known, monitor INRs closely in patients taking large amounts of ginger.

Likelihood Possible Evidence B
Calcium Channel Blockers

Theoretically, taking ginger with calcium channel blockers might increase the risk of hypotension.
Some animal and in vitro research suggests that ginger has hypotensive and calcium channel-blocking effects. Another animal study shows that concomitant administration of ginger and the calcium channel blocker amlodipine leads to greater reductions in blood pressure when compared with amlodipine alone.

Likelihood Unlikely Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically, when taken prior to cyclosporine, ginger might decrease cyclosporine levels.
In an animal model, ginger juice taken 2 hours prior to cyclosporine administration reduced the maximum concentration and area under the curve of cyclosporine by 51% and 40%, respectively. This effect was not observed when ginger juice and cyclosporine were administered at the same time.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, ginger might increase the levels of CYP1A2 substrates.
In vitro research shows that ginger inhibits CYP1A2 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, ginger might increase the levels of CYP2B6 substrates.
In vitro research shows that ginger inhibits CYP2B6 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, ginger might increase the levels of CYP2C9 substrates.
In vitro research shows that ginger inhibits CYP2C9 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Metronidazole (Flagyl)

Theoretically, ginger might increase levels of metronidazole.
In an animal model, ginger increased the absorption and plasma half-life of metronidazole. In addition, the elimination rate and clearance of metronidazole was significantly reduced.

Likelihood Possible Evidence D
Ginger full monograph & interactions

Marigold extract1 drug type · 248 drugs

Cns Depressants

Theoretically, calendula might have additive effects when used with CNS depressants, although this appears to be unlikely.
Although some animal research has suggested that a saponoside constituent in calendula may have sedative effects, calendula has been used for over 30 years without reports of sedation in humans.

Likelihood Unlikely Evidence D
Marigold extract full monograph & interactions

N-Acetyl D-Glucosamine4 drug types · 170 drugs

Warfarin (Coumadin)

Glucosamine might increase the anticoagulant effects of warfarin and increase the risk of bruising and bleeding.
In two individual case reports, glucosamine/chondroitin combinations were associated with a significant increase in international normalized ratio (INR) in patients previously stabilized on warfarin. In one case, the increase in INR occurred only after tripling the dose of a glucosamine/chondroitin supplement from 500 mg/400 mg daily to 1500/1200 mg daily. Additionally, 20 voluntary case reports to the U.S. Food & Drug Administration (FDA) have linked glucosamine plus chondroitin with increased INR, bruising, and bleeding in patients who were also taking warfarin. There have also been 20 additional case reports to the World Health Organization (WHO) that link glucosamine alone to increased INR in patients taking warfarin. The mechanism of this interaction is unclear. Glucosamine is a small component of heparin, but is not thought to have anticoagulant activity; however, animal research suggests that it might have antiplatelet activity.

Likelihood Probable Evidence D
Topoisomerase Ii Inhibitors

Theoretically glucosamine may induce resistance to topoisomerase II inhibitors.
In vitro research suggests that glucosamine might induce resistance to etoposide (VP16, VePesid) and doxorubicin (Adriamycin) by reducing inhibition of topoisomerase II, an enzyme required for DNA replication in tumor cells. This effect has not been reported in humans.

Likelihood Possible Evidence D
Acetaminophen (Tylenol, Others)

Acetaminophen might interfere with the activity of glucosamine sulfate by interacting with the sulfate portion.
Anecdotal reports suggest that adding glucosamine to an acetaminophen regimen might decrease pain control in patients with osteoarthritis. Some research suggests that the sulfate portion of glucosamine sulfate might contribute to its effect in osteoarthritis. Since acetaminophen metabolism requires sulfur and reduces serum sulfate concentrations, acetaminophen could theoretically interfere with the action of glucosamine sulfate. Conversely, the administration of sulfate could theoretically decrease the effectiveness of acetaminophen in sulfate-deficient people by increasing its clearance.

Likelihood Possible Evidence B
Antidiabetes Drugs

Despite initial concerns, it is unlikely that glucosamine will interfere with the effects of antidiabetes drugs.
In vitro and animal research has suggested that glucosamine might increase insulin resistance or decrease insulin production. This has raised concerns that taking glucosamine might worsen diabetes and decrease the effectiveness of diabetes drugs. However, clinical research suggests that glucosamine does not have adverse effects on blood glucose or glycated hemoglobin (HbA1C) in healthy, obese, or type 2 diabetes patients.

Likelihood Unlikely Evidence B
N-Acetyl D-Glucosamine full monograph & interactions

L-Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
L-Glutamine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Intestinal Bowel Support, from the product label.

Renew Life

Web Address
www.renewlife.com
Pharmacist Counseling Corner

Intestinal Bowel Support by Renew Life: Common Questions

Does Intestinal Bowel Support by Renew Life interact with any medications?
Yes. Based on its ingredients, Intestinal Bowel Support has a known interaction with 2,155 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Intestinal Bowel Support contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe if I'm pregnant or breastfeeding?
Safety varies by ingredient. L-Glutamine is likely safe in pregnancy but there isn't enough data for breastfeeding supplementation. Ginger is likely safe in both. Gamma Oryzanol, Marshmallow, N-Acetyl D-Glucosamine, and Marigold extract should be avoided in pregnancy and/or breastfeeding due to insufficient safety data. Talk with your doctor or pharmacist before taking any of these supplements while pregnant or nursing.
What are the most common side effects?
L-Glutamine and Ginger may cause bloating, constipation, diarrhea, nausea, and heartburn. Ginger at high doses can irritate your mouth and throat. N-Acetyl D-Glucosamine may cause bloating, constipation, cramps, diarrhea, heartburn, and nausea. Most people tolerate these ingredients at regular doses without trouble.
Can I take this if I'm allergic to ragweed?
The Marigold extract in this product comes from a plant family (Asteraceae) that includes ragweed and related plants. If you're sensitive to ragweed or have had allergic reactions to plants in that family, you may react to the Marigold extract. Check with your doctor before taking it, or consider a patch test first.
Will this help with IBS or digestive symptoms?
The evidence we hold doesn't establish that these ingredients work for general intestinal support or IBS. Some—like Ginger for nausea—have some evidence for specific digestive complaints, but we don't have data showing the formula as a whole relieves bowel symptoms. Talk with your doctor about whether it's right for your situation.
How long can I take this supplement?
Safety data for long-term use are limited for several ingredients in this formula. Marshmallow has only been studied short-term, and Gamma Oryzanol's long-term safety isn't well established. It's best to check with your doctor before taking it long-term.
Is there anything I should know about the capsules?
The capsules are made from vegetable cellulose, so they're suitable for vegetarians and vegans. There are no other inactive ingredients.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Intestinal Bowel Support label
Go deeper

The Full Monographs Behind Intestinal Bowel Support’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glutamine

Interacts with 50 drugs

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...

Read the full Glutamine monograph → Herb & supplement monograph

Gamma-oryzanol

Gamma-oryzanol is a mix of plant compounds taken from rice bran oil, used mainly for cholesterol, menopause symptoms, and as a sports supplement. The evidence is limited and mostly comes fro...

Read the full Gamma-oryzanol monograph → Herb & supplement monograph

Ginger

Interacts with 1,007 drugs

Ginger is a widely used culinary spice with a long history in traditional medicine, and it has the strongest evidence for helping with nausea and vomiting, including from motion sickness, pr...

Read the full Ginger monograph → Herb & supplement monograph

Marshmallow

Interacts with 2,040 drugs

Marshmallow root is a traditional herb rich in soothing, gel-like fibers called mucilage, which is why it has long been used for coughs, sore throats, and stomach irritation. Evidence for th...

Read the full Marshmallow monograph → Herb & supplement monograph

Calendula

Interacts with 248 drugs

Calendula is a flowering plant whose petals are used mainly in skin creams, oils, and ointments to soothe minor irritation and support wound healing. Some early research is promising for ski...

Read the full Calendula monograph → Herb & supplement monograph

Glucosamine

Interacts with 170 drugs

Glucosamine is a natural compound found in cartilage and joint fluid, and it is one of the most popular supplements for osteoarthritis, especially of the knee. The evidence is mixed, with so...

Read the full Glucosamine monograph →
Sources

Sources & How We Checked

Intestinal Bowel Support's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 147 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
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Ginger 64 references
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Marshmallow 5 references
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  9. Puaratanaarunkon T, Washrawirul C, Chuenboonngarm N, Noppakun N, Asawanonda P, Kumtornrut C. Efficacy and safety of a facial serum containing snail secretion filtrate, Calendula officinalis, and Glycyrrhiza glaba root extract in the treatment of maskne: A

See these in context on the Calendula monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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