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Dietary supplement

Jiagulan Extract 450 mg Ingredients & Drug Interactions

by Pure Nootropics

Jiagulan Extract 450 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Jiagulan Extract 450 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Jiagulan Extract 450 mg is a dietary supplement by Pure Nootropics with 1 active ingredient. Its ingredients are commonly taken for fatigue and stress (adaptogen), blood sugar support, high blood pressure.Based on those ingredients, 327 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Jiaogulan Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Jiagulan Extract 450 mg by Pure Nootropics

Ask about any prescription or over-the-counter medication and we check it for interactions with Jiagulan Extract 450 mg by Pure Nootropics — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Jiagulan Extract 450 mg by Pure Nootropics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: jiaogulan extract at 450 mg per capsule. Jiaogulan is a plant traditionally used in herbal medicine, and this extract form concentrates its active compounds.

The capsule also contains two inactive ingredients—hypromellose and stearate—which are a capsule coating and a processing aid.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Jiaogulan's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: healthy body weight support.
  • We looked for evidence on: Obesity, Weight management, Metabolic health.
  • The closest evidence on file: Jiaogulan is rated "Insufficient Reliable Evidence To Rate" for Obesity (Natural Medicines).

The evidence we hold shows jiaogulan is possibly effective for diabetes. For athletic performance, cancer prevention, heart disease, fatty liver disease, and respiratory infections, the evidence isn't established enough in our data to rate it either way.

The evidence, ingredient by ingredient Jiaogulan

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Jiaogulan is generally well tolerated when used for short periods, and studies up to 4 months show it's handled fairly well. The most common side effects are diarrhea and nausea; some people also report dry mouth, dizziness, or trouble sleeping.

However, long-term safety hasn't been studied closely. Do not use this product if you're pregnant or breastfeeding—safety data isn't available and it may affect a developing baby or nursing infant.

Side effects, ingredient by ingredient Jiaogulan

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Jiaogulan.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 327 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your pharmacist if you're on blood thinners or antiplatelet drugs (like warfarin or aspirin)—jiaogulan may increase bleeding risk. Also check if you take immunosuppressants or diabetes medications, since jiaogulan may affect how well they work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you're managing diabetes or exploring herbal support, jiaogulan may be worth discussing with your pharmacist. But if you take blood thinners, immunosuppressants, or diabetes drugs, check your exact medications here first.

Not recommended in pregnancy or while breastfeeding. A quick conversation with your pharmacist can confirm whether this is right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Jiagulan Extract 450 mg, straight from the product label.

Brand Pure Nootropics
Barcode (UPC) B085S6CWWC
Net contents 90 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Oct 24, 2024
DSLD ID 316581
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Jiagulan Extract 450 mg by Pure Nootropics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
90
UPC/BARCODE
B085S6CWWC
IngredientAmount% DV
Jiaogulan Extract450 mg--

Other ingredients: Hypromellose, Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Always Non-GMO Gluten free Preservative free

Lab tested

Provides support for healthy body weight. High potency 10x strength per capsule

General Statements

Unlock your potential

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Precautions

Warning: Consult with a healthcare practitioner before taking this.

Do not take this if you are pregnant, nursing, or under the age of 18.

If you experience adverse reactions from taking this product, discontinue immediately and contact a healthcare practitioner.

Do not take this if you are pregnant, nursing, or under the age of 18. Keep out of reach of children.

Suggested/Recommended/Usage/Directions

Suggested use: Take one capsule daily with a meal or as recommended by your healthcare practitioner.

Storage

Store in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Jiagulan Extract 450 mg by Pure Nootropics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Jiagulan Extract 450 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Jiagulan Extract 450 mg by Pure Nootropics

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Jiaogulan Extract

Interacts with
327 drugs
450 mg per serving Form: Gypenosides

Jiaogulan is a climbing vine used in traditional Chinese medicine as an adaptogen and for heart, blood sugar, and cholesterol support. Early human and...

Jiaogulan Extract monograph & interactions

Other (inactive) ingredients: Hypromellose, Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Jiagulan Extract 450 mg by Pure Nootropics Drug Interactions

Want to check YOUR meds against Jiagulan Extract 450 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
327Drugs
327 Moderate

Ingredients driving the most interactions

Jiaogulan Extract 327

Individual Drug Interactions

The ingredients in Jiagulan Extract 450 mg interact with 327 drugs. Click any drug to see the details.

1 of the 1 ingredient in Jiagulan Extract 450 mg interact with drugs. Each result below shows which ingredient is responsible. Jiaogulan Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Jiagulan Extract 450 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Jiaogulan Extract3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, jiaogulan might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research suggests that jiaogulan has antiplatelet effects.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, jiaogulan might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Clinical research shows that jiaogulan can lower blood glucose levels.

Likelihood Possible Evidence B
Immunosuppressants

Theoretically, jiaogulan might decrease the effectiveness of immunosuppressive therapy.
Clinical and animal studies suggest that jiaogulan can stimulate the immune system.

Likelihood Possible Evidence D
Jiaogulan Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Jiagulan Extract 450 mg, from the product label.

Pure Nootropics

See all Pure Nootropics products
Name
Pure Nootropics, LLC
Street Address
P.O. Box 6827
City
Albuquerque
State
NM
ZipCode
87197
Phone Number
424-738-0385
Web Address
purenootropics.net
Pharmacist Counseling Corner

Jiagulan Extract 450 mg by Pure Nootropics: Common Questions

Does Jiagulan Extract 450 mg by Pure Nootropics interact with any medications?
Yes. Based on its ingredients, Jiagulan Extract 450 mg has a known interaction with 327 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Jiagulan Extract 450 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on blood thinner medication?
Not without checking first. Jiaogulan may increase bleeding risk with medications like warfarin or aspirin. Use the medication checker on this page or talk to your pharmacist about your specific drugs.
What side effects might I notice?
The most common are diarrhea and nausea. Some people also report dry mouth, dizziness, or trouble sleeping. These effects were mild in studies up to 4 months long.
Is this safe to take long-term?
We don't have good data on long-term safety. Studies we hold are short-term (up to 4 months). If you're thinking about using it regularly, ask your pharmacist or doctor.
Can I take this while pregnant or breastfeeding?
No. Safety hasn't been established during pregnancy or breastfeeding, and it may affect a developing baby or nursing infant. Avoid it during both.
Does jiaogulan actually help with diabetes?
The evidence we have suggests it's possibly effective—meaning clinical research shows promise, but it's not a replacement for your diabetes medication. Talk to your doctor about whether it fits your plan.
Should I be concerned about the inactive ingredients?
No. Hypromellose and stearate are standard capsule materials and processing aids. They're not active ingredients and are used safely in many supplements.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Jiagulan Extract 450 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Jiagulan Extract 450 mg label
Go deeper

The Full Monographs Behind Jiagulan Extract 450 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Jiaogulan

Interacts with 327 drugs

Jiaogulan is a climbing vine used in traditional Chinese medicine as an adaptogen and for heart, blood sugar, and cholesterol support. Early human and animal studies are promising for some u...

Read the full Jiaogulan monograph →
Sources

Sources & How We Checked

Jiagulan Extract 450 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Jiaogulan 8 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Tan H, Liu ZL, Liu MJ. [Antithrombotic effect of Gynostemma pentaphyllum]. Zhingguo Zhong Xi Yi Jie He Za Zhi 1993;13:278-80.
  3. Chan LY, Chiu PY, Lau TK. An in-vitro study of ginsenoside Rb(1)-induced teratogenicity using a whole rat embryo culture model. Hum Reprod 2003;18:2166-8..
  4. Huyen VT, Phan DV, Thang P, Hoa NK, Ostenson CG. Gynostemma pentaphyllum Tea Improves Insulin Sensitivity in Type 2 Diabetic Patients. J Nutr Metab. 2013;2013:765383. doi: 10.1155/2013/765383.
  5. Li Y, Lin W, Huang J, Xie Y, Ma W. Anti-cancer effects of Gynostemma pentaphyllum (Thunb.) Makino (Jiaogulan). Chin Med. 2016 Sep 27;11:43. Review. PubMed
  6. Huyen VT, Phan DV, Thang P, Ky PT, Hoa NK, Ostenson CG. Antidiabetic effect of add-on Gynostemma pentaphyllum extract therapy with sulfonylureas in type 2 diabetic patients. Evid Based Complement Alternat Med 2012; 452313.
  7. Huyen VT, Phan DV, Thang P, Hoa NK, Ostenson CG. Antidiabetic effect of Gynostemma pentaphyllum tea in randomly assigned type 2 diabetic patients. Horm Metab Res. 2010;42(5):353-7.
  8. Rao A, Clayton P, Briskey D. The effect of an orally-dosed Gynostemma pentaphyllum extract (ActivAMP®) on body composition in overweight, adult men and women: a double-blind, randomised, placebo-controlled study. J Hum Nutr Diet 2021.

See these in context on the Jiaogulan monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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