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Dietary supplement

Kids Focus Chewables Natural Grape Flavor Ingredients & Drug Interactions

by Solaray

Kids Focus Chewables Natural Grape Flavor label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Kids Focus Chewables Natural Grape Flavor against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Kids Focus Chewables Natural Grape Flavor is a dietary supplement by Solaray with 5 active ingredients. Its ingredients are commonly taken for mental focus and alertness, coping with stress, fatigue and sleep loss.Based on those ingredients, 1,161 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Grape Seed Extract, L-5-Hydroxytryptophan, Dimethylaminoethanol Bitartrate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Kids Focus Chewables Natural Grape Flavor by Solaray

Ask about any prescription or over-the-counter medication and we check it for interactions with Kids Focus Chewables Natural Grape Flavor by Solaray — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Kids Focus Chewables Natural Grape Flavor by Solaray

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 5 of its 6 active ingredients.
  • “Grape Seed Extract” is listed as a grouped ingredient — the label gives one combined amount (10 mg) without saying how much of each component you get.
  • “Griffonia Bean Extract” is listed as a grouped ingredient — the label gives one combined amount (4 mg) without saying how much of each component you get.

Kids Focus Chewables contains six active ingredients. L-Tyrosine and L-5-Hydroxytryptophan are amino acids and amino acid derivatives that support brain chemistry.

Dimethylaminoethanol Bitartrate (also called deanol) is thought to support nerve signaling. Phosphatidylserine is a naturally occurring fat found in cell membranes and is included to support brain structure and function.

The product also contains Grape Seed Extract and Griffonia Bean Extract, which supply polyphenols and other plant compounds. Several inactive ingredients are present as well, including sweeteners, thickeners, and flavoring.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Brain development support.
  • We looked for evidence on: Attention deficit-hyperactivity disorder (ADHD), Cognitive function, Cognitive impairment, Memory, Age-related cognitive decline, Mental clarity — and 3 related terms.
  • The strongest evidence on file: Phosphatidylserine is rated "Possibly Effective" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Tyrosine is rated "Possibly Effective" for Cognitive function, Memory.
  • Also on file: Deanol is rated "Insufficient Reliable Evidence To Rate" for Attention deficit-hyperactivity disorder (ADHD), Cognitive function.

The evidence for this product's ingredients is mixed. L-Tyrosine is possibly effective for cognitive function and memory.

L-5-Hydroxytryptophan (5-HTP) is possibly effective for depression. Phosphatidylserine is possibly effective for age-related cognitive decline and Alzheimer disease.

However, for Dimethylaminoethanol Bitartrate, the evidence isn't established—it's been rated likely ineffective for Alzheimer disease and tardive dyskinesia, and there's insufficient evidence for ADHD and athletic performance. The data we hold doesn't establish overall effectiveness for 'kids focus' as a goal.

The evidence, ingredient by ingredient Tyrosine Deanol Phosphatidylserine Grape 5-htp

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of these ingredients are generally well tolerated in the short term, but there are cautions. L-Tyrosine can cause fatigue, headache, heartburn, and nausea, especially at higher doses.

L-5-Hydroxytryptophan commonly causes abdominal pain, dizziness, diarrhea, drowsiness, fatigue, headache, insomnia, nausea, and vomiting—effects that may depend on dose and can sometimes improve with continued use. Rare serious effects include aggression, hallucinations, and mania.

Dimethylaminoethanol Bitartrate may cause abdominal cramps, diarrhea, drowsiness, nausea, vomiting, and mood changes, especially at doses above 1000 mg daily. Phosphatidylserine is generally well tolerated but can cause flatulence, nausea, headache, and insomnia (more likely at 600 mg or higher).

Pregnancy and breastfeeding safety data are insufficient for all active ingredients; the facts advise against use during pregnancy and breastfeeding.

Side effects, ingredient by ingredient Tyrosine Deanol Phosphatidylserine Grape 5-htp

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Deanol, 5-htp, Phosphatidylserine, Tyrosine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: Parkinson's medications.
  • For scale: 535 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before giving this product, check with your pharmacist if your child takes serotonergic drugs (antidepressants, migraine drugs, or others that affect serotonin)—a Moderate interaction with 5-HTP. Also screen for levodopa (Parkinson's disease), thyroid hormones, CNS depressants (sedating medications), anticholinergic drugs, or cholinergic drugs.

These have documented Moderate or Minor interactions with one or more ingredients in this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is aimed at children's focus and cognition, but it's a multi-ingredient formula with real interaction potential and limited safety data in children. If your child takes any prescription medications—especially those for Parkinson's disease, depression, anxiety, thyroid condition, or any sedating medication—talk to your pharmacist or pediatrician first.

The safety and effectiveness for 'kids focus' specifically aren't established in our data.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Kids Focus Chewables Natural Grape Flavor, straight from the product label.

Brand Solaray
Barcode (UPC) 076280083781
Net contents 60 Chewable (s)
Market status On market
Date entered into DSLD Feb 23, 2025
DSLD ID 325999
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Children (All)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Kids Focus Chewables Natural Grape Flavor by Solaray, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Chewable Tablet(s)
Maximum serving Sizes:
1 Chewable Tablet(s)
Servings per container
60
UPC/BARCODE
076280083781
IngredientAmount% DV
Calories5 Calorie(s)--
Total Carbohydrates1 Gram(s)1%
L-Tyrosine25 mg--
L-5-Hydroxytryptophan3.9 mg--
Dimethylaminoethanol Bitartrate25 mg--
Polyphenols8.5 mg--
Phosphatidylserine10 mg--
Grape Seed Extract10 mg--
Oligomeric Proanthocyanidins0 NP--
Griffonia Bean Extract4 mg--

Other ingredients: Xylitol, Inulin, Fructooligosaccharides, Blueberry Fruit Extract, Grape Flavor, Natural, Milk Flavor, Natural, Guar Gum, Citric Acid, Stearic Acid, Silica, Stevia Leaf Extract

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Solaray Est. 1973 A brighter way 1973

Formulation

Brain development support

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Lab Verified

General Statements

Since 1973, we've scoured the globe for the highest quality ingredients, connecting you with the most efficacious supplements that help you live brighter & embrace the moments that matter most.

100% PCR Bottles Comments or questions: 800-538-5888 www.solaray.com

Precautions

Warning: Do not use if safety seal if broken or missing.

Keep out of reach of children.

Keep your licensed health care practitioner informed when using this product.

Do not use with MAO inhibitor drugs or other prescription antidepressants.

May cause drowsiness.

To be used only under adult supervision.

Suggested/Recommended/Usage/Directions

Directions: Use only as directed. Take 1 chewable tablet two times daily with a meal or glass of water.

Storage

Store in a cool, dry place.

Formula

Discussion: This unique children's formula provides key nutrients that may support the developing brain.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Kids Focus Chewables Natural Grape Flavor by Solaray label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Kids Focus Chewables Natural Grape Flavor label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Kids Focus Chewables Natural Grape Flavor by Solaray

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Chewable Tablet(s) Dosage formTablet Or Pill Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Tyrosine

Interacts with
21 drugs
25 mg per serving

L-tyrosine is an amino acid your body uses to make brain chemicals like dopamine and norepinephrine. Some studies suggest it may help mental performan...

L-Tyrosine monograph & interactions

Dimethylaminoethanol Bitartrate

Interacts with
219 drugs
25 mg per serving

Deanol (DMAE) is a compound related to choline that is marketed for memory, focus, and mood, but solid human evidence for most of these uses is limite...

Dimethylaminoethanol Bitartrate monograph & interactions

Phosphatidylserine

Interacts with
219 drugs
10 mg per serving Form: Soy Lecithin

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinki...

Phosphatidylserine monograph & interactions

Grape Seed Extract

Interacts with
910 drugs
10 mg per serving Form: Polyphenols, Oligomeric Proanthocyanidins

Grapes and grape products like grape seed extract contain antioxidant compounds such as resveratrol and proanthocyanidins that may support heart and b...

Grape Seed Extract monograph & interactions
  • › Polyphenols
  • › Oligomeric Proanthocyanidins

Griffonia Bean Extract

4 mg per serving Form: Griffonia simplicifolia Bean Extract

Other (inactive) ingredients: Xylitol, Inulin, Fructooligosaccharides, Blueberry Fruit Extract, Grape Flavor, Natural, Milk Flavor, Natural, Guar Gum, Citric Acid, Stearic Acid, Silica, Stevia Leaf Extract. These complete the product’s ingredient list but are not active constituents.

Interaction report

Kids Focus Chewables Natural Grape Flavor by Solaray Drug Interactions

Want to check YOUR meds against Kids Focus Chewables Natural Grape Flavor?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,161Drugs
1,126 Moderate 35 Minor

Ingredients driving the most interactions

Grape Seed Extract 910
L-5-Hydroxytryptophan 398
Dimethylaminoethanol Bitartrate 219
Phosphatidylserine 219
L-Tyrosine 21

Individual Drug Interactions

The ingredients in Kids Focus Chewables Natural Grape Flavor interact with 1,161 drugs. Click any drug to see the details.

5 of the 5 ingredients in Kids Focus Chewables Natural Grape Flavor interact with drugs. Each result below shows which ingredient is responsible. Grape Seed Extract L-5-Hydroxytryptophan Dimethylaminoethanol Bitartrate Phosphatidylserine L-Tyrosine

Each ingredient & the kinds of drugs it affects

For each ingredient in Kids Focus Chewables Natural Grape Flavor with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Grape Seed Extract9 drug types · 910 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, grape extracts may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro evidence suggests that grape extracts might decrease platelet aggregation.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Ingesting grape juice with cyclosporine can reduce cyclosporine absorption.
A small pharmacokinetic study in healthy young adults shows that intake of purple grape juice 200 mL along with cyclosporine can decrease the absorption of cyclosporine by up to 30% when compared with water. Separate doses of grape juice and cyclosporine by at least 2 hours to avoid this interaction.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, grape juice might reduce the levels of CYP1A2 substrates.
A small pharmacokinetic study in healthy adults shows that ingestion of 200 mL of grape juice decreases phenacetin plasma levels. This is thought to be due to induction of CYP1A2.

Likelihood Possible Evidence B
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, grape seed extract may increase the levels of CYP2D6 substrates.
In vitro evidence suggests that grape seed extract might inhibit CYP2D6 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, grape seed extract might increase the levels of CYP2E1 substrates.
In vitro and animal research suggests that grape seed proanthocyanidin extract inhibits CYP2E1 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.
In vitro evidence suggests that grape seed extract might inhibit CYP3A4 enzymes. However, evidence from animal research shows that grape seed extract may induce CYP3A4 in the liver. So far, these interactions have not been reported in humans.

Likelihood Possible Evidence D
Midazolam (Versed)

Theoretically, long-term intake of grape seed extract might decrease the effects of midazolam.
Animal research shows that subchronic ingestions of grape seed extract can increase the elimination of intravenous midazolam by increasing hepatic CYP3A4 activity. Single doses of grape seed extract do not appear to affect midazolam elimination.

Likelihood Possible Evidence D
Phenacetin

Grape juice might decrease phenacetin absorption.
A small pharmacokinetic study in healthy adults shows that ingestion of 200 mL of grape juice decreases phenacetin plasma levels. This is thought to be due to induction of cytochrome P450 1A2 (CYP1A2).

Likelihood Possible Evidence B
Cytochrome P450 2C9 (Cyp2C9) Substrates

It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.
In vitro evidence shows that grape seed extract or grape juice might inhibit CYP2C9 enzymes. However, a small pharmacokinetic study in healthy adults shows that drinking 8 ounces of grape juice once does not affect the clearance of flurbiprofen, a probe-drug for CYP2C9 metabolism. The effects of continued grape juice consumption are unclear.

Likelihood Unlikely Evidence D
Grape Seed Extract full monograph & interactions

L-5-Hydroxytryptophan3 drug types · 398 drugs

Carbidopa (Lodosyn)

Combining 5-HTP and carbidopa can increase the risk of serotonergic side effects.
Carbidopa is sometimes used with 5-HTP to minimize peripheral 5-HTP metabolism and boost the amount that reaches the brain. However, this combination might also increase the risk of some side effects including hypomania, restlessness, rapid speech, anxiety, insomnia, and aggressiveness. Combining carbidopa and 5-HTP might also increase the risk of scleroderma-like skin changes due to elevated serotonin levels.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
In clinical trials, 5-HTP has been associated with drowsiness and somnolence.

Likelihood Possible Evidence D
Serotonergic Drugs

Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
5-HTP can increase serotonin levels and cause serotonergic effects. Theoretically, combining serotonergic drugs with 5-HTP might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders. However, serotonin syndrome with 5-HTP has not yet been reported in humans. Monitor patients for signs of serotonin syndrome and other serotonergic side effects if using 5-HTP with serotonergic drugs.

Likelihood Possible Evidence D
L-5-Hydroxytryptophan full monograph & interactions

Dimethylaminoethanol Bitartrate2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, deanol might decrease the effectiveness of anticholinergic drugs.
Deanol is thought to increase acetylcholine levels.

Likelihood Unlikely Evidence D
Cholinergic Drugs

Theoretically, deanol might increase the effects and adverse effects of cholinergic drugs.
Deanol is thought to increase acetylcholine levels.

Likelihood Unlikely Evidence D
Dimethylaminoethanol Bitartrate full monograph & interactions

Phosphatidylserine2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically interfere with the activity of anticholinergic agents.

Likelihood Possible Evidence B
Cholinergic Drugs

Theoretically, phosphatidylserine might have additive effects with cholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically lead to additive cholinergic effects when used with cholinergic drugs.

Likelihood Possible Evidence B
Phosphatidylserine full monograph & interactions

L-Tyrosine2 drug types · 21 drugs

Levodopa

Theoretically, tyrosine might decrease the effectiveness of levodopa.
Tyrosine and levodopa compete for absorption in the proximal duodenum by the large neutral amino acid (LNAA) transport system. Advise patients to separate doses of tyrosine and levodopa by at least 2 hours.

Likelihood Probable Evidence D
Thyroid Hormone

Theoretically, tyrosine might have additive effects with thyroid hormone medications.
Tyrosine is a precursor to thyroxine and might increase levels of thyroid hormones.

Likelihood Probable Evidence D
L-Tyrosine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Kids Focus Chewables Natural Grape Flavor, from the product label.

Solaray

See all Solaray products
Name
Solaray
City
Salt Lake City
State
UT
ZipCode
84101
Phone Number
800-538-5888
Web Address
www.solaray.com
Pharmacist Counseling Corner

Kids Focus Chewables Natural Grape Flavor by Solaray: Common Questions

Does Kids Focus Chewables Natural Grape Flavor by Solaray interact with any medications?
Yes. Based on its ingredients, Kids Focus Chewables Natural Grape Flavor has a known interaction with 1,161 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Kids Focus Chewables Natural Grape Flavor contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I give this to my child if they're on an ADHD medication?
We don't have interaction data showing whether this product is safe with ADHD medications specifically. Because it contains ingredients that can raise serotonin and affect brain chemistry, talk to your child's doctor or pharmacist before starting it—they know their full medication list and can tell you if there's a risk.
What's L-5-Hydroxytryptophan and why is it in here?
L-5-Hydroxytryptophan (5-HTP) is an amino acid your body uses to make serotonin, a chemical that affects mood and behavior. It's included because it's possibly effective for depression, and the product is aimed at focus. But it can cause drowsiness, nausea, and other side effects, especially when doses are high or increased quickly.
Are there any common side effects I should watch for?
Yes. The ingredients can cause nausea, headache, diarrhea, drowsiness, fatigue, and abdominal upset. These are more likely at higher doses. If your child feels unusually drowsy, has an upset stomach, or experiences mood changes, stop the product and contact your pharmacist.
Is it safe during pregnancy or breastfeeding?
No. The safety data are insufficient for all the active ingredients. The facts advise avoiding this product during pregnancy and while breastfeeding. Talk to your doctor or pharmacist if you're thinking about it.
Does this actually improve focus and attention in kids?
The evidence isn't established in our data. While some ingredients (like phosphatidylserine) have been studied for cognitive benefits, we don't hold data showing this specific product works for kids' focus.
What's in the chewable itself besides the active ingredients?
The tablet contains inactive ingredients like xylitol (a sweetener), inulin and fructooligosaccharides (fiber), blueberry and grape flavor, guar gum, citric acid, and stevia leaf extract. These are excipients—binders, fillers, and flavorings.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Kids Focus Chewables Natural Grape Flavor is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Kids Focus Chewables Natural Grape Flavor label
Go deeper

The Full Monographs Behind Kids Focus Chewables Natural Grape Flavor’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Tyrosine

Interacts with 21 drugs

L-tyrosine is an amino acid your body uses to make brain chemicals like dopamine and norepinephrine. Some studies suggest it may help mental performance during short-term stress, sleep loss,...

Read the full Tyrosine monograph → Herb & supplement monograph

Deanol

Interacts with 219 drugs

Deanol (DMAE) is a compound related to choline that is marketed for memory, focus, and mood, but solid human evidence for most of these uses is limited or mixed. It can cause side effects in...

Read the full Deanol monograph → Herb & supplement monograph

Phosphatidylserine

Interacts with 219 drugs

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinking. Some research suggests possible bene...

Read the full Phosphatidylserine monograph → Herb & supplement monograph

Grape

Interacts with 910 drugs

Grapes and grape products like grape seed extract contain antioxidant compounds such as resveratrol and proanthocyanidins that may support heart and blood vessel health. While the food is he...

Read the full Grape monograph → Herb & supplement monograph

5-htp

Interacts with 398 drugs

5-HTP is a compound your body uses to make serotonin, and people take it as a supplement hoping to improve mood, sleep, and headaches. Some early research is promising, but the overall evide...

Read the full 5-htp monograph →
Sources

Sources & How We Checked

Kids Focus Chewables Natural Grape Flavor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 94 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tyrosine 4 references
  1. Meyer JS, Welch KM, Deshmukh VD, et al. Neurotransmitter precursor amino acids in the treatment of multi-infarct dementia and Alzheimer's disease. J Amer Geriat Soc 1977;25:289-98.
  2. DiPiro JT, Talbert RL, Yee GC, et al; eds. Pharmacotherapy: A pathophysiologic approach. 4th ed. Stamford, CT: Appleton & Lange, 1999.
  3. Wood DR, Reimherr FW, Wender PH. Amino acid precursors for the treatment of attention deficit disorder, residual type. Psychopharmacol Bull 1985;21:146-9.
  4. van Spronsen FJ, van Rijn M, Bekhof J. Phenylketonuria: tyrosine supplementation in phenylalanine-restricted diets. Am J Clin Nutr 2001;73:153-7. PubMed

See these in context on the Tyrosine monograph →

5-htp 32 references
  1. Birdsall TC. 5-Hydroxytryptophan: A Clinically-Effective Serotonin Precursor. Altern Med Rev 1998;3:271-80.
  2. Michelson D, Page SW, Casey R, et al. An eosinophilia-myalgia syndrome related disorder associated with exposure to L-5-hydroxytryptophan. J Rheumatol 1994;21:2261-5.
  3. Cangiano C, Ceci F, Cancino A, et al. Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan. Am J Clin Nutr 1992;56:863-7. PubMed
  4. U.S. Food and Drug Administration. Impurities confirmed in dietary supplement 5-hydroxy-L-tryptophan. FDA Talk Paper, August 31, 1998; T98-48.
  5. Sternberg EM, Van Woert MH, Young SN, et al. Development of a scleroderma-like illness during therapy with L-5-hydroxytryptophan and carbidopa. N Engl J Med 1980;303:782-7. PubMed
  6. Poldinger W, Calanchini B, Schwarz W. A functional-dimensional approach to depression: serotonin deficiency as a target syndrome in a comparison of 5-hydroxytryptophan and fluvoxamine. Psychopathology 1991;24:53-81.
  7. Ribeiro CA. L-5-Hydroxytryptophan in the prophylaxis of chronic tension-type headache: a double-blind, randomized, placebo-controlled study. Headache 2000;40:451-6.
  8. U. S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Nutritional Products, Labeling, and Dietary Supplements. Information Paper on L-Tryptophan and 5-hydroxy-L-tryptophan, February 2001.
  9. Singhal AB, Caviness VS, Begleiter AF, et al. Cerebral vasoconstriction and stroke after use of serotonergic drugs. Neurology 2002;58:130-3. PubMed
  10. Johnson KL, Klarskov K, Benson LM, et al. Presence of peak X and related compounds: the reported contaminant in case related 5-hydroxy-L-tryptophan associated with eosinophilia-myalgia syndrome. J Rheumatol 1999;26:2714-7.
  11. Takahashi S, Kondo H, Kato N. Effect of l-5-hydroxytryptophan on brain monoamine metabolism and evaluation of its clinical effect in depressed patients. J Psychiatr Res 1975;12:177-87. PubMed
  12. Iovieno, N., Dalton, E. D., Fava, M., and Mischoulon, D. Second-tier natural antidepressants: review and critique. J Affect.Disord. 2011;130(3):343-357. PubMed
  13. den Boer JA, Westenberg HG. Behavioral, neuroendocrine, and biochemical effects of 5-hydroxytryptophan administration in panic disorder. Psychiatry Res 1990;31:267-78. PubMed
  14. Jangid P, Malik P, Singh P, Sharma M, Gulia AK. Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode. Asian J Psychiatr 2013;6:29-34. PubMed
  15. Ceci F, Cangiano C, Cairella M, et al. The effects of oral 5-hydroxytryptophan administration on feeding behavior in obese adult female subjects. J Neural Transm 1989;76:109-17. PubMed
  16. Angst J, Woggon B, Schoepf J. The treatment of depression with L-5-hydroxytryptophan versus imipramine. Results of two open and one double-blind study. Arch Psychiatr Nervenkr 1977;224:175-86. DOI
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Grape 34 references
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