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Dietary supplement

L-Citrulline 3,000 mg Ingredients & Drug Interactions

by Dorado Nutrition

Capsule Category: Amino Acid/protein
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

L-Citrulline 3,000 mg is a dietary supplement by Dorado Nutrition with 1 active ingredient. Its ingredients are commonly taken for exercise performance, muscle soreness and fatigue, blood flow and circulation.Based on those ingredients, 178 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Citrulline. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of L-Citrulline 3,000 mg by Dorado Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: L-Citrulline at 3,000 mg per capsule. L-Citrulline is an amino acid your body converts to another amino acid called L-arginine, which plays a role in blood vessel function and circulation.

The capsule also contains inactive ingredients — hypromellose (a capsule material), magnesium stearate (a binder), and silicon dioxide (an anti-caking agent).

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded L-citrulline's overall clinical evidence instead.

Moderate

Some clinical evidence supports L-citrulline for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Athletic performance — rated "Possibly Effective" (Natural Medicines).

L-Citrulline is possibly effective for athletic performance. For other uses listed in our data — sarcopenia (age-related muscle loss), cardiovascular disease, heart failure, Reye syndrome, and diabetes — the evidence is either possibly ineffective or not established well enough to rate.

If you're considering this supplement for athletic performance, the data supports a potential benefit, but talk with your pharmacist about whether it fits your goals.

The evidence, ingredient by ingredient L-citrulline

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-Citrulline is generally well tolerated in healthy adults, but long-term safety hasn't been fully studied. The most common side effects are gastrointestinal — stomach discomfort and heartburn.

A small number of people with pulmonary hypertension reported cough when taking it. If you're pregnant or breastfeeding, the safety data advises against use.

There isn't enough information to know whether it's safe in either situation, so talk with your doctor or pharmacist before taking it.

Side effects, ingredient by ingredient L-citrulline

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — L-citrulline.
  • The most serious interaction on file is rated Moderate.
  • For scale: 178 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check this product if you take blood pressure medications (antihypertensives) or erectile dysfunction drugs (phosphodiesterase-5 inhibitors like sildenafil). Both are moderate-severity interactions that could lower your blood pressure too much.

Run your specific medications through the checker on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

L-Citrulline may help with athletic performance, but it interacts with blood pressure medications and erectile dysfunction drugs — both moderate-severity concerns. If you take anything for blood pressure or ED, or if you're pregnant or breastfeeding, check with your pharmacist first.

Most people tolerate it well, though stomach upset can happen.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about L-Citrulline 3,000 mg, straight from the product label.

Brand Dorado Nutrition
Barcode (UPC) X003KRPTQV
Net contents 240 Capsule(s)
Market status On market
Date entered into DSLD Aug 22, 2025
DSLD ID 339439
Product type Amino Acid/protein
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for L-Citrulline 3,000 mg by Dorado Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4 Capsule(s)
Maximum serving Sizes:
4 Capsule(s)
Servings per container
60
UPC/BARCODE
X003KRPTQV
IngredientAmount% DV
L-Citrulline3000 mg--

Other ingredients: Hypromellose, Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

New

Made with love

Precautions

Keep out of the reach of children.

Do not use if safety seal is damaged or missing.

Adult use only. This product is not intended for pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.

Caution: Do not exceed recommended dose.

This product is not intended for pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.

Storage

Store in a cool, dry place.

Suggested/Recommended/Usage/Directions

Suggested use: Take four (4) capsules a day with or without food, and or as directed by your healthcare provider.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Made in the USA with global ingredients GMP Good Manufactured Product Certified Third Party

Formulation

Made with Non GMO Ingredients

Maximum strength Support workout endurance & muscle recovery

Formula

L-Citrulline 3,000 mg per serving

FDA Statement of Identity

Dietary Supplement

See for yourself

L-Citrulline 3,000 mg by Dorado Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in L-Citrulline 3,000 mg by Dorado Nutrition

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size4 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

L-Citrulline

Interacts with
178 drugs
3000 mg per serving

L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. I...

L-Citrulline monograph & interactions

Other (inactive) ingredients: Hypromellose, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

L-Citrulline 3,000 mg by Dorado Nutrition Drug Interactions

Want to check YOUR meds against L-Citrulline 3,000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
178Drugs
178 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in L-Citrulline 3,000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Citrulline2 drug types · 178 drugs

Antihypertensive Drugs

Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. However, a meta-analysis of 5 small clinical studies suggests that taking L-citrulline 3-6 grams daily for 1-8 weeks does not lower blood pressure when compared with control.

Likelihood Possible Evidence B
Phosphodiesterase-5 Inhibitors

Theoretically, concurrent use of phosphodiesterase-5 (PDE-5) inhibitors and L-citrulline might result in additive vasodilation.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. Theoretically, taking L-arginine with PDE-5 inhibitors might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for L-Citrulline 3,000 mg, from the product label.

Dorado Nutrition

See all Dorado Nutrition products
Name
Dorado Nutrition
Street Address
30 N Gould St Ste 3784
City
Sheridan
State
WY
ZipCode
82801
Phone Number
(307) 201-2862
Web Address
www.DoradoNutrition.com
Pharmacist Counseling Corner

L-Citrulline 3,000 mg by Dorado Nutrition: Common Questions

Does L-Citrulline 3,000 mg by Dorado Nutrition interact with any medications?
Yes. Based on its ingredients, L-Citrulline 3,000 mg has a known interaction with 178 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
L-Citrulline 3,000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does L-Citrulline actually do in my body?
Your body converts L-Citrulline to L-arginine, an amino acid that helps relax blood vessels and improve blood flow. That's why it's studied for athletic performance and circulation.
Can I take this if I'm on blood pressure medication?
Not without checking first. L-Citrulline can lower blood pressure, and combining it with blood pressure drugs might drop yours too much. Talk to your pharmacist about your specific medications before starting.
Will this give me stomach problems?
Stomach discomfort and heartburn are the most common side effects, though most people tolerate it well. If you have a sensitive stomach, start low and see how you feel.
Is this safe during pregnancy or breastfeeding?
No. The safety data advises against use in both pregnancy and breastfeeding because there isn't enough information to know it's safe. Talk with your doctor or pharmacist if you're considering it.
Does L-Citrulline really help with workouts?
The evidence suggests it's possibly effective for athletic performance, so there's a reasonable basis for trying it if that's your goal. Results vary, and it's not a guarantee.
Can I take this long-term?
L-Citrulline is generally well tolerated, but long-term safety hasn't been fully studied. If you plan to use it regularly, check in with your pharmacist now and then.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if L-Citrulline 3,000 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

L-Citrulline 3,000 mg label
Sources

Sources & How We Checked

L-Citrulline 3,000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

L-citrulline 8 references
  1. Cheng JW, Balwin SN. L-arginine in the management of cardiovascular diseases. Ann Pharmacother 2001;35:755-64. PubMed
  2. Schwedhelm E, Maas R, Freese R, et al. Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. Br J Clin Pharmacol 2008;65:51-9. PubMed
  3. Romero MJ, Platt DH, Caldwell RB, Caldwell RW. Therapeutic use of citrulline in cardiovascular disease. Cardiovasc Drug Rev 2006;24:275-90. PubMed
  4. Balderas-Munoz K, Castillo-Martínez L, Orea-Tejeda A, et al. Improvement of ventricular function in systolic heart failure patients with oral L-citrulline supplementation. Cardiol J 2012;19:612-7. PubMed
  5. Sharif Kashani B, Tahmaseb Pour P, Malekmohammad M, et al. Oral l-citrulline malate in patients with idiopathic pulmonary arterial hypertension and Eisenmenger Syndrome: a clinical trial. J Cardiol 2014;64:231-5. PubMed
  6. Pérez-Guisado J, Jakeman PM. Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. J Strength Cond Res 2010;24:1215-22. PubMed
  7. Mirenayat MS, Moradi S, Mohammadi H, Rouhani MH. Effect of L-citrulline supplementation on blood pressure: a systematic review and meta-analysis of clinical trials. Curr Hypertens Rep. 2018;20(11):98. PubMed
  8. Xu Z, Liu C, Liu S, Zhou Z. Comparison of efficacy and safety of daily oral L-arginine and PDE5Is alone or combination in treating erectile dysfunction: A systematic review and meta-analysis of randomised controlled trials. Andrologia. 2021:e14007. PubMed

See these in context on the L-citrulline monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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