L-Citrulline DL-Malate 1:1 Ingredients & Drug Interactions
by Hard Rhino
What is this page for?
First and foremost: checking L-Citrulline DL-Malate 1:1 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
L-Citrulline DL-Malate 1:1 is a dietary supplement by Hard Rhino with 1 active ingredient. Its ingredients are commonly taken for exercise performance, muscle soreness and fatigue, blood flow and circulation.Based on those ingredients, 178 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Citrulline DL-Malate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against L-Citrulline DL-Malate 1:1 by Hard Rhino
Ask about any prescription or over-the-counter medication and we check it for interactions with L-Citrulline DL-Malate 1:1 by Hard Rhino — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
Ask the Pharmacist
A licensed pharmacist will answer your question by email — free, usually within 24 hours.
Got it — thank you!
A licensed pharmacist will answer within 24 hours. Keep an eye on your email (worth checking spam, just in case).
HelloPharmacist Scorecard of L-Citrulline DL-Malate 1:1 by Hard Rhino
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: L-citrulline DL-malate, an amino acid compound supplied in powder form. No inactive ingredients are listed.
Does it work?
Moderate evidence
L-citrulline shows possibly effective evidence for athletic performance. For muscle wasting in older adults (sarcopenia), the evidence rates as possibly ineffective.
For cardiovascular disease, heart failure, Reye syndrome, and diabetes, there isn't enough reliable evidence in our data to rate how well it works.
How safe is it?
Well-documented data
L-citrulline is generally well tolerated in healthy adults, though long-term safety hasn't been fully studied. The most common side effects are gastrointestinal discomfort and heartburn.
A small number of people with pulmonary hypertension reported cough when taking the supplement. There isn't enough safety data to support use during pregnancy, so the data advises against it.
Safety while breastfeeding is unknown, so supplemental use is not recommended during that time as well. Talk with your doctor or pharmacist about whether this product is right for your situation.
Meds to double-check
Moderate interaction found
Check with your doctor or pharmacist before taking this product if you're on blood pressure medications or phosphodiesterase-5 inhibitors (such as sildenafil, tadalafil, or vardenafil). Both interaction types are Moderate.
Altogether, these interactions span 178 individual medications.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
L-citrulline may help with athletic performance, but the evidence for other uses is either weak or not established. If you take blood pressure medications or erectile dysfunction drugs, you'll want to discuss this supplement with your doctor or pharmacist first—there's a moderate interaction risk.
It's generally well tolerated, but not studied long-term, and should be avoided in pregnancy and while breastfeeding.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2017.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about L-Citrulline DL-Malate 1:1, straight from the product label.
| Brand | Hard Rhino |
|---|---|
| Barcode (UPC) | 798711500260 |
| Net contents | 5 kg; 11 lbs |
| Market status | On market |
| Date entered into DSLD | Mar 24, 2017 |
| DSLD ID | 72063 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), No Allergies, Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for L-Citrulline DL-Malate 1:1 by Hard Rhino, sourced from the NIH Dietary Supplement Label Database.
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
-Non-GMO -Gluten free -Allergen free
Allergens: This product contains no soy, dairy, dairy byproducts, eggs, shellfish, wheat, gluten, tree nuts, or sesame seeds.
General Statements
Bulk pail - Best value - Scoop inside - 1666 servings
Suggested/Recommended/Usage/Directions
Suggested Use: As a dietary supplement, take 3 rounded scoop (~3 grams) twice daily with 8-12 ounces of water or suitable beverage. Taken 30 minutes prior to workout and again immediately after for maximum results.
FDA Disclaimer Statement
These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any diseases.
Precautions
Warning: Keep out of the reach of children. Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions and/or taking prescription drug(s) or OTC medication(s).
Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions and/or taking prescription drug(s) or OTC medication(s).
Always consult with a qualified health physician before taking any new dietary supplement.
Do not use or consume if seal is broken.
FDA Statement of Identity
Dietary Supplement
Storage
Storage: Store in a cool, dry place. Re-seal inner bag immediately after use to preserve freshness.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
L-Citrulline DL-Malate 1:1 by Hard Rhino label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in L-Citrulline DL-Malate 1:1 by Hard Rhino
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size3 Gram(s) Dosage formPowder Servings per container1666 Amounts shown are per serving.
L-Citrulline DL-Malate
Interacts with178 drugs
L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. I...
L-Citrulline DL-Malate monograph & interactionsOther (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.
L-Citrulline DL-Malate 1:1 by Hard Rhino Drug Interactions
HelloPharmacist Interaction Report
Hard Rhino's L-Citrulline DL-Malate can interact with blood pressure medications (antihypertensives) and erectile dysfunction drugs (phosphodiesterase-5 inhibitors).
Both interactions are Moderate in severity.
Read the full breakdown — every affected drug type, severity by severity
With blood pressure medications, L-citrulline is converted in your body to L-arginine, which widens blood vessels and can lower pressure. Adding it to medications that already lower blood pressure might push your pressure too low.
A review of small studies suggests that doses of 3–6 grams daily may have only modest effects, but the interaction is still a theoretical concern worth discussing with your doctor.
With erectile dysfunction drugs like sildenafil (Viagra) or tadalafil (Cialis), the same widening of blood vessels could add up, potentially dropping your blood pressure further. Again, the effect is theoretical but warrants a conversation with your doctor before combining them.
Additionally, check your exact medications with our search tool on this page, and confirm with your own doctor or pharmacist before starting this supplement.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against L-Citrulline DL-Malate 1:1?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in L-Citrulline DL-Malate 1:1 interact with 178 drugs. Click any drug to see the details.
1 of the 1 ingredient in L-Citrulline DL-Malate 1:1 interact with drugs. Each result below shows which ingredient is responsible. L-Citrulline DL-Malate
AcebutololRhotral, Sectral
How Acebutolol interacts with L-Citrulline DL-Malate 1:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Acebutolol interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with L-Citrulline DL-Malate 1:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Acetazolamide interactionAliskirenTekturna
How Aliskiren interacts with L-Citrulline DL-Malate 1:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Aliskiren interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with L-Citrulline DL-Malate 1:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Ambrisentan interactionAmilorideAmilamont, Midamor
How Amiloride interacts with L-Citrulline DL-Malate 1:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Amiloride interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with L-Citrulline DL-Malate 1:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Amiloride, Hydrochlorothiazide interactionAmlodipineNorliqva
How Amlodipine interacts with L-Citrulline DL-Malate 1:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Amlodipine interactionAmlodipine BenzoateKaterzia
How Amlodipine Benzoate interacts with L-Citrulline DL-Malate 1:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Amlodipine Benzoate interactionAmlodipine BesilateIstin
How Amlodipine Besilate interacts with L-Citrulline DL-Malate 1:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Amlodipine Besilate interactionAmlodipine BesylateNorvasc
How Amlodipine Besylate interacts with L-Citrulline DL-Malate 1:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Amlodipine Besylate interactionAmlodipine Besylate, BenazeprilLotrel
How Amlodipine Besylate, Benazepril interacts with L-Citrulline DL-Malate 1:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Amlodipine Besylate, Benazepril interactionAmlodipine, CelecoxibConsensi
How Amlodipine, Celecoxib interacts with L-Citrulline DL-Malate 1:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Amlodipine, Celecoxib interactionAmmonium ChlorideAmmonium Chloride
How Ammonium Chloride interacts with L-Citrulline DL-Malate 1:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Ammonium Chloride interactionAprocitentanTryvio
How Aprocitentan interacts with L-Citrulline DL-Malate 1:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Aprocitentan interactionAtenololAtenix, Tenormin
How Atenolol interacts with L-Citrulline DL-Malate 1:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Atenolol interactionAtenolol, ChlortalidoneAtenixCo, Tenoret 50, Totaretic
How Atenolol, Chlortalidone interacts with L-Citrulline DL-Malate 1:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Atenolol, Chlortalidone interactionAtenolol, ChlorthalidoneTenoretic
How Atenolol, Chlorthalidone interacts with L-Citrulline DL-Malate 1:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Atenolol, Chlorthalidone interactionAvanafilStendra
How Avanafil interacts with L-Citrulline DL-Malate 1:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malatePhosphodiesterase-5 Inhibitors Moderate
Interaction Summary
Theoretically, concurrent use of phosphodiesterase-5 (PDE-5) inhibitors and L-citrulline might result in additive vasodilation.
Read the full L-citrulline Dl-malate + Avanafil interactionAzilsartanEdarbi
How Azilsartan interacts with L-Citrulline DL-Malate 1:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Azilsartan interactionAzilsartan, ChlorthalidoneEdarbyclor
How Azilsartan, Chlorthalidone interacts with L-Citrulline DL-Malate 1:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Azilsartan, Chlorthalidone interactionBenazeprilLotensin
How Benazepril interacts with L-Citrulline DL-Malate 1:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Benazepril interactionBenazepril, HydrochlorothiazideLotensin HCT
How Benazepril, Hydrochlorothiazide interacts with L-Citrulline DL-Malate 1:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Benazepril, Hydrochlorothiazide interactionBendroflumethiazideAprinox, Naturetin, Neo-NaClex
How Bendroflumethiazide interacts with L-Citrulline DL-Malate 1:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Bendroflumethiazide interactionBendroflumethiazide, NadololCorzide
How Bendroflumethiazide, Nadolol interacts with L-Citrulline DL-Malate 1:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Bendroflumethiazide, Nadolol interactionBendroflumethiazide, Rauwolfia SerpentinaRauzide
How Bendroflumethiazide, Rauwolfia Serpentina interacts with L-Citrulline DL-Malate 1:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Bendroflumethiazide, Rauwolfia Serpentina interactionBenzthiazideExna
How Benzthiazide interacts with L-Citrulline DL-Malate 1:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Benzthiazide interactionBetaxololBetoptic, Kerlone
How Betaxolol interacts with L-Citrulline DL-Malate 1:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Betaxolol interactionBisoprololZebeta
How Bisoprolol interacts with L-Citrulline DL-Malate 1:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Bisoprolol interactionBisoprolol, HydrochlorothiazideZiac
How Bisoprolol, Hydrochlorothiazide interacts with L-Citrulline DL-Malate 1:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Bisoprolol, Hydrochlorothiazide interactionBosentanTracleer
How Bosentan interacts with L-Citrulline DL-Malate 1:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Bosentan interactionEach ingredient & the kinds of drugs it affects
For each ingredient in L-Citrulline DL-Malate 1:1 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
L-Citrulline DL-Malate
Antihypertensive Drugs
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. However, a meta-analysis of 5 small clinical studies suggests that taking L-citrulline 3-6 grams daily for 1-8 weeks does not lower blood pressure when compared with control.
Phosphodiesterase-5 Inhibitors
Theoretically, concurrent use of phosphodiesterase-5 (PDE-5) inhibitors and L-citrulline might result in additive vasodilation.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. Theoretically, taking L-arginine with PDE-5 inhibitors might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.
Brand information
Manufacturer and brand details for L-Citrulline DL-Malate 1:1, from the product label.
Hard Rhino
See all Hard Rhino products- Name
- Guardian Wholesale
- City
- Phoenix
- State
- AZ
- ZipCode
- 85085
- Phone Number
- (866)961-8378
- Web Address
- HardRhino.com
L-Citrulline DL-Malate 1:1 by Hard Rhino: Common Questions
Does L-Citrulline DL-Malate 1:1 by Hard Rhino interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What is L-citrulline DL-malate, and what's it supposed to do?
Can I take this if I'm on blood pressure medication?
What side effects might I get?
Is this safe to take during pregnancy or breastfeeding?
Does it actually work for athletic performance?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if L-Citrulline DL-Malate 1:1 is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind L-Citrulline DL-Malate 1:1’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
L-Citrulline DL-Malate 1:1's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 8 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
L-citrulline 8 references
- Cheng JW, Balwin SN. L-arginine in the management of cardiovascular diseases. Ann Pharmacother 2001;35:755-64. PubMed
- Schwedhelm E, Maas R, Freese R, et al. Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. Br J Clin Pharmacol 2008;65:51-9. PubMed
- Romero MJ, Platt DH, Caldwell RB, Caldwell RW. Therapeutic use of citrulline in cardiovascular disease. Cardiovasc Drug Rev 2006;24:275-90. PubMed
- Balderas-Munoz K, Castillo-Martínez L, Orea-Tejeda A, et al. Improvement of ventricular function in systolic heart failure patients with oral L-citrulline supplementation. Cardiol J 2012;19:612-7. PubMed
- Sharif Kashani B, Tahmaseb Pour P, Malekmohammad M, et al. Oral l-citrulline malate in patients with idiopathic pulmonary arterial hypertension and Eisenmenger Syndrome: a clinical trial. J Cardiol 2014;64:231-5. PubMed
- Pérez-Guisado J, Jakeman PM. Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. J Strength Cond Res 2010;24:1215-22. PubMed
- Mirenayat MS, Moradi S, Mohammadi H, Rouhani MH. Effect of L-citrulline supplementation on blood pressure: a systematic review and meta-analysis of clinical trials. Curr Hypertens Rep. 2018;20(11):98. PubMed
- Xu Z, Liu C, Liu S, Zhou Z. Comparison of efficacy and safety of daily oral L-arginine and PDE5Is alone or combination in treating erectile dysfunction: A systematic review and meta-analysis of randomised controlled trials. Andrologia. 2021:e14007. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC