Major interaction on record — check this product against your medications before combining. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

L-Methylfolate 10 mg from Quatrefolic Ingredients & Drug Interactions

by MethylPro

L-Methylfolate 10 mg from Quatrefolic label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking L-Methylfolate 10 mg from Quatrefolic against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

L-Methylfolate 10 mg from Quatrefolic is a dietary supplement by MethylPro with 2 active ingredients. Its ingredients are commonly taken for sleep quality and insomnia, relaxation, cognitive function.Based on those ingredients, 169 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Glycine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against L-Methylfolate 10 mg from Quatrefolic by MethylPro

Ask about any prescription or over-the-counter medication and we check it for interactions with L-Methylfolate 10 mg from Quatrefolic by MethylPro — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of L-Methylfolate 10 mg from Quatrefolic by MethylPro

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • “Folate” is listed as a grouped ingredient — the label gives one combined amount (16.70 mg DFE) without saying how much of each component you get.
  • “Folate” is listed as a grouped ingredient — the label gives one combined amount (10 mg) without saying how much of each component you get.

MethylPro contains 2 active ingredients: glycine and calcium L-5-methylfolate (a form of folate, also called methylfolate). The folate in this product comes from Quatrefolic, a branded source.

The capsule also contains cellulose as an inactive ingredient.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Dyspepsia — rated "Effective" (Calcium) (Natural Medicines).
  • On file: Hyperkalemia — rated "Effective" (Calcium) (Natural Medicines).
  • On file: Hypocalcemia — rated "Effective" (Calcium) (Natural Medicines).
  • On file: Kidney failure — rated "Effective" (Calcium) (Natural Medicines).
  • On file: Hyperparathyroidism — rated "Likely Effective" (Calcium) (Natural Medicines).

Calcium in this product is effective for several bone and metabolic conditions — kidney failure, dyspepsia (indigestion), low blood calcium (hypocalcemia), high blood potassium (hyperkalemia), and osteoporosis (it's likely effective for that last one). Glycine is possibly effective for schizophrenia.

We hold no effectiveness data for the methylfolate component itself in this product. For other uses of glycine listed in our data — 3-phosphoglycerate dehydrogenase (3-PGDH) deficiency, ADHD, benign prostatic hyperplasia (BPH), and cystic fibrosis — the evidence is insufficient to rate.

The evidence, ingredient by ingredient Glycine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Calcium is generally safe at recommended doses, though high doses can cause problems. It's likely safe in pregnancy at adequate amounts; stay within recommended levels unless your doctor advises otherwise.

During breastfeeding, calcium needs can be met with recommended amounts — check with your provider. Glycine is generally well tolerated at typical doses, but long-term safety data are limited.

Rare side effects with glycine include mild sedation, dry mouth, soft stools, nausea, vomiting, and upper GI discomfort — these resolve quickly if you stop taking it. Irritability, insomnia, fatigue, memory issues, headache, and sensory changes have been reported, though any link to glycine is unclear.

With oral calcium, the most common side effects are belching, constipation, diarrhea, flatulence, and stomach upset. Rare serious concerns include kidney stones and calciphylaxis.

Very high calcium doses (over 1500–2000 mg daily) have been associated with increased prostate cancer risk and possibly cardiovascular concerns, though research on the latter is mixed.

Side effects, ingredient by ingredient Glycine

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Calcium, Glycine.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: heart-rhythm medications; lithium.
  • For scale: 169 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking MethylPro, double-check with your doctor or pharmacist if you take HIV integrase inhibitors (dolutegravir, elvitegravir, raltegravir) or the antibiotic ceftriaxone — calcium in this product carries Major interactions that can reduce drug effectiveness or cause dangerous complications. Also check if you take levothyroxine (a thyroid hormone), sotalol (a heart rhythm drug), diltiazem (blood pressure medication), calcipotriene (a psoriasis cream), or clozapine (an antipsychotic) — all have Moderate interactions with ingredients here.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Major medication interactions have been identified, and safety information is well characterized.

This product is appropriate if you need calcium and glycine supplementation and don't take HIV drugs, levothyroxine, heart or blood pressure medications, ceftriaxone, or clozapine. If you do take any of those, or any other prescription medication, run your full medication list through the checker on this page and discuss the results with your own doctor or pharmacist before adding this supplement.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about L-Methylfolate 10 mg from Quatrefolic, straight from the product label.

Brand MethylPro
Barcode (UPC) 838287008095
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Oct 24, 2022
DSLD ID 274336
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for L-Methylfolate 10 mg from Quatrefolic by MethylPro, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
838287008095
IngredientAmount% DV
Glycine210 mg--
Folate16.7 mg DFE4175%
Folate10 mg--
Calcium L-5-Methylfolate18.5 mg--

Other ingredients: Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Caution: Pregnant or lactating women, or individuals taking prescription medications, consult your healthcare professional before taking this product.

Keep tightly closed in a cool, dry place, out of the reach of children.

Directions: Use only as directed by a healthcare professional.

Directions: Use only as directed by a healthcare professional.

Storage

Keep tightly closed in a cool, dry place, out of the reach of children.

Formulation

Egg free Gluten free Free of nuts Dairy free

Manufactured in a GMP Compliant Facility

Brand IP Statement(s)

Quatrefolic is a registered trademark of Gnosis S.p.A. U.S. Patent No. 7,947,662

Formula

Professional strength L-Methylfolate

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Use only as directed by a healthcare professional.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

L-Methylfolate 10 mg from Quatrefolic by MethylPro label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

L-Methylfolate 10 mg from Quatrefolic label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in L-Methylfolate 10 mg from Quatrefolic by MethylPro

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Glycine

Interacts with
1 drug
210 mg per serving

Glycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep q...

Glycine monograph & interactions

Folate

16.7 mg DFE per serving
  • › Folate

Other (inactive) ingredients: Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

L-Methylfolate 10 mg from Quatrefolic by MethylPro Drug Interactions

Want to check YOUR meds against L-Methylfolate 10 mg from Quatrefolic?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
169Drugs
7 Major 144 Moderate 18 Minor

Ingredients driving the most interactions

Glycine 1

Individual Drug Interactions

The ingredients in L-Methylfolate 10 mg from Quatrefolic interact with 169 drugs. Click any drug to see the details.

1 of the 2 ingredients in L-Methylfolate 10 mg from Quatrefolic interact with drugs. Each result below shows which ingredient is responsible. Glycine

Each ingredient & the kinds of drugs it affects

For each ingredient in L-Methylfolate 10 mg from Quatrefolic with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Glycine1 drug type · 1 drug

Clozapine (Clozaril)

Theoretically, glycine might decrease the effectiveness of clozapine.
One small clinical study in patients with schizophrenia shows that adding glycine to clozapine therapy worsens symptoms of schizophrenia when compared with clozapine alone. The mechanism of this interaction is unclear.

Likelihood Probable Evidence B
Glycine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for L-Methylfolate 10 mg from Quatrefolic, from the product label.

MethylPro

See all MethylPro products
Name
Metabolic Maintenance
Street Address
601 N Larch Street
City
Sisters
State
Oregon
ZipCode
97759
Phone Number
888-242-5327
Web Address
MethylPro.com
Pharmacist Counseling Corner

L-Methylfolate 10 mg from Quatrefolic by MethylPro: Common Questions

Does L-Methylfolate 10 mg from Quatrefolic by MethylPro interact with any medications?
Yes. Based on its ingredients, L-Methylfolate 10 mg from Quatrefolic has a known interaction with 169 medications, including 7 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
L-Methylfolate 10 mg from Quatrefolic contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is methylfolate and why is it in this product?
Methylfolate is a form of folate (a B vitamin) that your body can use directly without converting it first. This product sources it from Quatrefolic, a branded form of calcium L-5-methylfolate. The product's other active ingredient is glycine, an amino acid.
Can I take this if I'm pregnant or breastfeeding?
Calcium in this product is rated likely safe in pregnancy at adequate levels — stay within recommended amounts unless your doctor says otherwise. During breastfeeding, calcium needs can be met with recommended amounts; check with your provider. We don't have safety data on file for glycine in pregnancy or breastfeeding, so talk with your doctor or pharmacist for personalized advice.
What side effects might I experience?
Calcium may cause belching, constipation, diarrhea, flatulence, or stomach upset. Glycine rarely causes mild sedation, dry mouth, soft stools, nausea, vomiting, or upper GI discomfort — these usually stop quickly if you discontinue it. Irritability, insomnia, fatigue, headache, and memory issues have been reported with glycine, though any link is unclear.
Is this product safe at high doses?
Calcium is generally safe at recommended doses, but high doses can cause problems — very high intakes (over 1500–2000 mg daily) have been linked to kidney stones and possible cardiovascular or prostate cancer concerns. Glycine is generally well tolerated at typical doses, but long-term safety data are limited. Stick to the recommended dose and talk with your doctor if you're considering anything higher.
Does this product interact with medications?
Yes — both calcium and glycine in this product have interactions with several medications. Calcium has Major interactions with HIV drugs (dolutegravir, elvitegravir, raltegravir) and the antibiotic ceftriaxone, and Moderate interactions with levothyroxine, sotalol, diltiazem, calcipotriene, and raltegravir. Glycine has a Moderate interaction with clozapine. Use the medication checker on this page to see if any of your drugs are affected, then confirm with your doctor or pharmacist.
What are glycine and calcium supposed to do?
Calcium is effective for low blood calcium, high blood potassium, kidney disease, indigestion, and osteoporosis. Glycine is possibly effective for schizophrenia. We don't have established effectiveness data for the methylfolate component in this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if L-Methylfolate 10 mg from Quatrefolic is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

L-Methylfolate 10 mg from Quatrefolic label
Go deeper

The Full Monographs Behind L-Methylfolate 10 mg from Quatrefolic’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glycine

Interacts with 1 drug

Glycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep quality, where early research is promisin...

Read the full Glycine monograph →
Sources

Sources & How We Checked

L-Methylfolate 10 mg from Quatrefolic's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 67 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glycine 5 references
  1. Heresco-Levy U, Javitt DC, Ermilov M, et al. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry 1999;56:29-36.. PubMed
  2. Potkin SG, Jin Y, Bunney BG, Costa J, Gulasekaram B. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry 1999;156:145-7.. PubMed
  3. Gusev EI, Skvortsova VI, Dambinova SA, et al. Neuroprotective effects of glycine for therapy of acute ischaemic stroke. Cerebrovasc Dis 2000;10:49-60. PubMed
  4. Inagawa K, Kawai N, Ono K, Sukegawa E, Tsubuku S, Takahashi M. Assessment of acute adverse effects of glycine ingestion at a high dose in human volunteers. Seikatsu Eisei. 2006; 50:27-32.
  5. Woods SW, Walsh BC, Hawkins KA, Miller TJ, Saksa JR, D'Souza DC, Pearlson GD, Javitt DC, McGlashan TH, Krystal JH. Glycine treatment of the risk syndrome for psychosis: report of two pilot studies. Eur Neuropsychopharmacol. 2013 Aug;23(8):931-40. PubMed

See these in context on the Glycine monograph →

Calcium 62 references
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  4. Maton PN, Burton ME. Antacids revisited: a review of their clinical pharmacology and recommended therapeutic use. Drugs 1999;57:855-70.
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  26. Tseng M, Breslow RA, Graubard BI, Ziegler RG. Dairy, calcium, and vitamin D intakes and prostate cancer risk in the National Health and Nutrition Examination Epidemiologic Follow-up Study cohort. Am J Clin Nutr 2005;81:1147-54. PubMed
  27. Weingarten MA, Zalmanovici A, Yaphe J. Dietary calcium supplementation for preventing colorectal cancer and adenomatous polyps. Cochrane Database Syst Rev 2004;(1):CD003548. PubMed
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  31. Bolland MJ, Barber PA, Doughty RN, et al. Vascular events in healthy older women receiving calcium supplementation: randomised control trial. BMJ 2008;336:262-6.
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See these in context on the Calcium monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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