Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Leaf of God Alcohol Free Ingredients & Drug Interactions

by Herbal Terra

Leaf of God Alcohol Free label
See full label image
Liquid Category: Botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Leaf of God Alcohol Free against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Leaf of God Alcohol Free is a dietary supplement by Herbal Terra with 1 active ingredient. Its ingredients are commonly taken for promoting vivid or lucid dreams, sleep and relaxation, digestive upset.Based on those ingredients, 334 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Leaf Of God Extract, Dry. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Leaf of God Alcohol Free by Herbal Terra

Ask about any prescription or over-the-counter medication and we check it for interactions with Leaf of God Alcohol Free by Herbal Terra — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Leaf of God Alcohol Free by Herbal Terra

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Calea zacatechichi extract, commonly called Leaf of God. The liquid also includes glycerin and water as inactive ingredients.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Calea Zacatechichi product and its label doesn't state a use — see Calea Zacatechichi's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for Leaf of God isn't established in the data we hold. Its effectiveness ratings for headache, rheumatoid arthritis, insomnia, stress, and urticaria all show insufficient reliable evidence to rate—meaning the science doesn't yet support claims about how well it works for these uses.

The evidence, ingredient by ingredient Calea Zacatechichi

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Calea zacatechichi has a long history in folk medicine but little modern safety data. The main side effects observed in volunteers are nausea, vomiting, and drowsiness—it's also quite bitter tasting.

Some volunteers experienced changes in sleep patterns, including less deep sleep. There isn't enough data to know whether it's safe in pregnancy or while breastfeeding.

The safety data advises against use during pregnancy and lactation. If you're pregnant, planning pregnancy, or nursing, talk with your doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient Calea Zacatechichi

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Calea Zacatechichi.
  • The most serious interaction on file is rated Minor.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 334 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your exact medications before taking this product if you use CNS depressants (sedating drugs like sleep aids, anxiety medications, or opioids) or antidiabetes drugs—both Minor-severity interactions are documented. These are the drug types most affected.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

Leaf of God Alcohol Free may appeal to people interested in traditional herbal remedies, but the evidence for its effectiveness isn't clear. If you take sedating medications or antidiabetes drugs, you'll want to check your specific medicines before starting.

Talk with your pharmacist, especially if you're pregnant, breastfeeding, or on any prescription medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Leaf of God Alcohol Free, straight from the product label.

Brand Herbal Terra
Barcode (UPC) 7439500556510
Net contents 4 Fluid Ounce(s); 120 mL
Market status On market
Date entered into DSLD Jan 23, 2025
DSLD ID 326892
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Leaf of God Alcohol Free by Herbal Terra, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
1 mL
Servings per container
120
UPC/BARCODE
7439500556510
IngredientAmount% DV
Leaf Of God Extract, Dry1156 mg--

Other ingredients: Glycerin, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Shake well before use. Adults take up to 30 drops (1 mL, one full squeeze of the dropper bulb) in 3-4 fl. oz. of juice or water up to 4 times a day.

Precautions

We recommend to seek expert medical advice before taking. May have contraindications and cause adverse reaction.

Consult a physician before giving to children under 18, before using during pregnancy, if nursing, or if you are on any medications.

Consult a physician before giving to children under 18, before using during pregnancy, if nursing, or if you are on any medications. Keep out of the reach of children!

Do not use if you are allergic to any ingredients.

Storage

Store in a cool, dry, dark place.

FDA Disclaimer Statement

This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure or prevent any disease.

Formulation

cGMP Made in compliance with cGMP 21 CFR 111 in an FDA registered and inspected facility.

Sugar free

Expertly extracted 100% natural Premium product

No alcohol (ethyl), artificial ingredients, color additives, fillers or binders.

Natural Gluten free

Formula

Calea zacatechichi

FDA Statement of Identity

Herbal Supplement

Seals/Symbols

Made in USA

General Statements

Organic raw material.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Leaf of God Alcohol Free by Herbal Terra label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Leaf of God Alcohol Free label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Leaf of God Alcohol Free by Herbal Terra

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 mL Dosage formLiquid Servings per container120 Amounts shown are per serving.

Leaf Of God Extract, Dry

Interacts with
334 drugs
1156 mg per serving Form: Calea zacatechichi Leaf Extract, Dry, Calea zacatechichi Stem Extract, Dry

Calea zacatechichi, often called 'dream herb,' is a Mexican plant traditionally used to encourage vivid dreams and to treat digestive complaints and f...

Leaf Of God Extract, Dry monograph & interactions

Other (inactive) ingredients: Glycerin, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Leaf of God Alcohol Free by Herbal Terra Drug Interactions

Want to check YOUR meds against Leaf of God Alcohol Free?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
334Drugs
334 Minor

Ingredients driving the most interactions

Leaf Of God Extract, Dry 334

Individual Drug Interactions

The ingredients in Leaf of God Alcohol Free interact with 334 drugs. Click any drug to see the details.

1 of the 1 ingredient in Leaf of God Alcohol Free interact with drugs. Each result below shows which ingredient is responsible. Leaf Of God Extract, Dry

Each ingredient & the kinds of drugs it affects

For each ingredient in Leaf of God Alcohol Free with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Leaf Of God Extract, Dry2 drug types · 334 drugs

Antidiabetes Drugs

Theoretically, taking Calea zacatechichi with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research shows that Calea zacatechichi lowers blood glucose levels. Theoretically, combining Calea zacatechichi with antidiabetes drugs might result in additive effects.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, Calea zacatechichi might increase the sedative effects of CNS depressants.
Calea zacatechichi can cause CNS depression in animals and humans.

Likelihood Possible Evidence D
Leaf Of God Extract, Dry full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Leaf of God Alcohol Free, from the product label.

Herbal Terra

See all Herbal Terra products
Name
Herbal Terra LLC
Phone Number
+18083857868
Web Address
herbalterra.com
Pharmacist Counseling Corner

Leaf of God Alcohol Free by Herbal Terra: Common Questions

Does Leaf of God Alcohol Free by Herbal Terra interact with any medications?
Yes. Based on its ingredients, Leaf of God Alcohol Free has a known interaction with 334 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Leaf of God Alcohol Free contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this make me drowsy?
Drowsiness (somnolence) was observed in healthy volunteers who took Calea zacatechichi extract. If you're sensitive to sedating herbs or take other sleep-promoting medications, you're more likely to feel this effect.
Can I take this if I'm pregnant or breastfeeding?
No—there isn't enough reliable safety data, so it's best avoided during pregnancy and while breastfeeding. Talk with your doctor or pharmacist for personalized advice.
What does Leaf of God actually do?
We don't have reliable evidence that it works for any specific condition. It has a long folk history, but the evidence for headache, insomnia, stress, arthritis, and other uses we hold data on isn't established.
What are the side effects?
The main ones observed in volunteers are nausea, vomiting, and drowsiness. It's also quite bitter tasting. Information on other side effects is limited.
Is this safe to take with my blood sugar or sleep medication?
The extract can theoretically raise the risk of low blood sugar with antidiabetes drugs and add to the drowsiness from CNS depressants. Check your exact medications with the tool on this page before starting, and talk with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Leaf of God Alcohol Free is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Leaf of God Alcohol Free label
Go deeper

The Full Monographs Behind Leaf of God Alcohol Free’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Calea Zacatechichi

Interacts with 334 drugs

Calea zacatechichi, often called 'dream herb,' is a Mexican plant traditionally used to encourage vivid dreams and to treat digestive complaints and fever. Human research is very limited, so...

Read the full Calea Zacatechichi monograph →
Sources

Sources & How We Checked

Leaf of God Alcohol Free's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Calea Zacatechichi 2 references
  1. Mayagoitia, L., Diaz, J. L., Contreras, C. M. Psychopharmacologic analysis of an alleged oneirogenic plant: Calea zacatechichi. J Ethnopharmacol. 1986;18:229-243. PubMed
  2. Roman, Ramos R., Alarcon-Aguilar, F., Lara-Lemus, A., and Flores-Saenz, J. L. Hypoglycemic effect of plants used in Mexico as antidiabetics. Arch.Med.Res 1992;23:59-64.

See these in context on the Calea Zacatechichi monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team