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Dietary supplement

Leaf of God Ingredients & Drug Interactions

by Hawaii Pharm

Leaf of God label
See full label image
Liquid Category: Botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Leaf of God against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Leaf of God is a dietary supplement by Hawaii Pharm with 1 active ingredient. Its ingredients are commonly taken for promoting vivid or lucid dreams, sleep and relaxation, digestive upset.Based on those ingredients, 334 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Leaf Of God Extract, Dry. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Leaf of God by Hawaii Pharm

Ask about any prescription or over-the-counter medication and we check it for interactions with Leaf of God by Hawaii Pharm — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Leaf of God by Hawaii Pharm

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Calea zacatechichi extract (also called Leaf of God extract). The inactive ingredients are alcohol, water, and glycerin.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Calea Zacatechichi's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: sleep support and relaxation.
  • We looked for evidence on: Insomnia, Anxiety, Stress, Sleep quality, Dream recall.
  • The closest evidence on file: Calea Zacatechichi is rated "Insufficient Reliable Evidence To Rate" for Anxiety (Natural Medicines).
  • Also on file: Calea Zacatechichi is rated "Insufficient Reliable Evidence To Rate" for Insomnia, Stress.

The evidence for Leaf of God extract isn't established in our data. We hold insufficient reliable evidence to rate its use for headache, rheumatoid arthritis, insomnia, stress, or skin conditions like urticaria (hives).

If you're considering it for one of these, talk with your pharmacist about what the current research actually shows.

The evidence, ingredient by ingredient Calea Zacatechichi

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Calea zacatechichi has a long history in folk medicine but little modern safety testing. The main concern we know about is nausea and vomiting — the extract is quite bitter, and some people also experience drowsiness.

Because safety data in pregnancy and breastfeeding is unreliable, this supplement is best avoided during pregnancy and while breastfeeding. If you're pregnant, planning pregnancy, or nursing, talk with your doctor before using it.

Side effects, ingredient by ingredient Calea Zacatechichi

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Calea Zacatechichi.
  • The most serious interaction on file is rated Minor.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 334 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your exact medications before starting, especially if you take CNS depressants (sedatives, sleep aids, some pain relievers) or antidiabetes drugs. Both interactions are rated Minor, but they're worth confirming with your pharmacist or the tool on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Only minor medication interactions are documented, and safety information is well characterized.

Leaf of God extract has a traditional use history but limited modern evidence for any condition. If you take sedatives or diabetes medications, check with us first.

Pregnant or breastfeeding? Skip it for now.

Ask your pharmacist whether this fits your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Leaf of God, straight from the product label.

Brand Hawaii Pharm
Barcode (UPC) 840253632111
Net contents 4 Fluid Ounce(s); 120 mL
Market status On market
Date entered into DSLD Nov 22, 2023
DSLD ID 301392
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Leaf of God by Hawaii Pharm, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.7 mL
Maximum serving Sizes:
1 mL
Servings per container
120
UPC/BARCODE
840253632111
IngredientAmount% DV
Leaf Of God Extract, Dry983 mg--

Other ingredients: Alcohol, Water, Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Hawaii Pharm Herbal Extract Highest quality since 2008

Suggested/Recommended/Usage/Directions

Suggested use: Shake well before using. For adults add about 20-30 drops (0.7-1 mL, one full squeeze of the dropper bulb) to some juice or water, up to 4 times a day.

Precautions

Warning: We recommend to seek expert medical advice before taking.

Do not use if you are allergic to any ingredients.

Consult your physician before giving to children under 18, during pregnancy, if nursing or taking medications.

Consult your physician before giving to children under 18, during pregnancy, if nursing or taking medications.

May affect the ability to drive and operate machinery. May have contraindications, can cause side effects and adverse reactions. Do not use if seal is broken or missing.

Keep out of the reach of children!

Storage

Store in a cool dry place.

Seals/Symbols

cGMP Made in compliance with cGMP 21 CFR 111 in an FDA registered and inspected facility.

Organic Alcohol Based USA Made in United States of America

FDA Disclaimer Statement

This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure or prevent any disease.

General Statements

Scan this QR-code to get 15% discount on your next purchase. Limited time deal.

Formula

Calea zacatechichi

Organic Alcohol Based

Formulation

Only natural ingredients Purity is laboratory tested and verified

All the raw materials are gluten-free by their nature No artificial colors, flavors, or preservatives

Not tested on animals

Organic Alcohol Based

Made in USA, Hawaii

FDA Statement of Identity

Herbal Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Leaf of God by Hawaii Pharm label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Leaf of God label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Leaf of God by Hawaii Pharm

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.7 mL Dosage formLiquid Servings per container120 Amounts shown are per serving.

Leaf Of God Extract, Dry

Interacts with
334 drugs
983 mg per serving Form: Calea zacatechichi Leaf Extract, Dry, Calea zacatechichi Stem Extract, Dry

Calea zacatechichi, often called 'dream herb,' is a Mexican plant traditionally used to encourage vivid dreams and to treat digestive complaints and f...

Leaf Of God Extract, Dry monograph & interactions

Other (inactive) ingredients: Alcohol, Water, Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Leaf of God by Hawaii Pharm Drug Interactions

Want to check YOUR meds against Leaf of God?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
334Drugs
334 Minor

Ingredients driving the most interactions

Leaf Of God Extract, Dry 334

Individual Drug Interactions

The ingredients in Leaf of God interact with 334 drugs. Click any drug to see the details.

1 of the 1 ingredient in Leaf of God interact with drugs. Each result below shows which ingredient is responsible. Leaf Of God Extract, Dry

Each ingredient & the kinds of drugs it affects

For each ingredient in Leaf of God with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Leaf Of God Extract, Dry2 drug types · 334 drugs

Antidiabetes Drugs

Theoretically, taking Calea zacatechichi with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research shows that Calea zacatechichi lowers blood glucose levels. Theoretically, combining Calea zacatechichi with antidiabetes drugs might result in additive effects.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, Calea zacatechichi might increase the sedative effects of CNS depressants.
Calea zacatechichi can cause CNS depression in animals and humans.

Likelihood Possible Evidence D
Leaf Of God Extract, Dry full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Leaf of God, from the product label.

Hawaii Pharm

See all Hawaii Pharm products
Name
Hawaii Pharm LLC
Street Address
510 Sumner St. Ste. 613
City
Honolulu
State
HI
ZipCode
96817
Phone Number
888-854-2924
Web Address
www.hawaiipharm.com
Pharmacist Counseling Corner

Leaf of God by Hawaii Pharm: Common Questions

Does Leaf of God by Hawaii Pharm interact with any medications?
Yes. Based on its ingredients, Leaf of God has a known interaction with 334 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Leaf of God contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is Leaf of God used for?
Traditionally it's been used for headache, sleep, stress, and a few other conditions, but we don't have reliable modern evidence that it works for any of them. The safety data is also limited, so it's not a standard supplement recommendation.
Will this make me drowsy?
Yes, drowsiness and light sleep are reported in people who've tried it. If you're driving or operating machinery, be cautious. And if you already take sleep aids or sedatives, the drowsiness could add up.
Can I use this if I'm pregnant or breastfeeding?
No — there isn't enough safety data to know whether it's okay, so it's best to avoid it during pregnancy and while breastfeeding. Talk with your doctor before using it in these situations.
What are the side effects?
The most common ones reported are nausea, vomiting, and a bitter taste. Drowsiness and light sleep also occur. There isn't a lot of modern safety data on this ingredient, so other effects may not be well documented.
Does this affect my blood sugar?
Animal research shows Calea zacatechichi can lower blood glucose. If you take diabetes medications, combining them with this extract could theoretically lower your blood sugar too much. Check with your pharmacist first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Leaf of God is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Leaf of God label
Go deeper

The Full Monographs Behind Leaf of God’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Calea Zacatechichi

Interacts with 334 drugs

Calea zacatechichi, often called 'dream herb,' is a Mexican plant traditionally used to encourage vivid dreams and to treat digestive complaints and fever. Human research is very limited, so...

Read the full Calea Zacatechichi monograph →
Sources

Sources & How We Checked

Leaf of God's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Calea Zacatechichi 2 references
  1. Mayagoitia, L., Diaz, J. L., Contreras, C. M. Psychopharmacologic analysis of an alleged oneirogenic plant: Calea zacatechichi. J Ethnopharmacol. 1986;18:229-243. PubMed
  2. Roman, Ramos R., Alarcon-Aguilar, F., Lara-Lemus, A., and Flores-Saenz, J. L. Hypoglycemic effect of plants used in Mexico as antidiabetics. Arch.Med.Res 1992;23:59-64.

See these in context on the Calea Zacatechichi monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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