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Dietary supplement

Leaf of God Ingredients & Drug Interactions

by Hawaii Pharm

Leaf of God label
See full label image
Liquid Category: Botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Leaf of God against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Leaf of God is a dietary supplement by Hawaii Pharm with 1 active ingredient. Its ingredients are commonly taken for promoting vivid or lucid dreams, sleep and relaxation, digestive upset.Based on those ingredients, 334 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are wildcrafted Leaf of God extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Leaf of God by Hawaii Pharm

Ask about any prescription or over-the-counter medication and we check it for interactions with Leaf of God by Hawaii Pharm — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Leaf of God by Hawaii Pharm

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This liquid contains one active ingredient: wildcrafted Leaf of God extract, which is Calea zacatechichi, a plant used in traditional herbal practice. The product also includes vegetable palm glycerin and alcohol as inactive ingredients.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Calea Zacatechichi's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: sleep and relaxation support.
  • We looked for evidence on: Insomnia, Anxiety, Stress, Sleep quality, Dream enhancement, Relaxation.
  • The closest evidence on file: Calea Zacatechichi is rated "Insufficient Reliable Evidence To Rate" for Anxiety (Natural Medicines).
  • Also on file: Calea Zacatechichi is rated "Insufficient Reliable Evidence To Rate" for Insomnia, Stress.

The evidence isn't established in our data for any of the uses this product is marketed for — headache, rheumatoid arthritis, insomnia, stress, and skin irritation (urticaria) all have insufficient reliable evidence to rate. That doesn't mean it doesn't work; it means the clinical studies we hold don't support a claim either way.

The evidence, ingredient by ingredient Calea Zacatechichi

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Calea zacatechichi has a long history in folk use but limited modern safety testing. The main concerns we know about are nausea, vomiting, and drowsiness — some people in studies reported somnolence (sleepiness) and changes in sleep quality.

Because there's no reliable safety data, the facts advise against use during pregnancy and while breastfeeding. Talk with your doctor or pharmacist if you're pregnant, nursing, or planning to be.

Side effects, ingredient by ingredient Calea Zacatechichi

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Calea Zacatechichi.
  • The most serious interaction on file is rated Minor.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 334 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check this product against any CNS depressants you take (sleep aids, sedatives, benzodiazepines, narcotic painkillers) — it may increase drowsiness. Also double-check if you're on any antidiabetes drugs, since Calea zacatechichi can lower blood glucose.

Given the breadth of documented interactions, run your exact medications through our checker.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Only minor medication interactions are documented, and safety information is well characterized.

Leaf of God is a single-ingredient herbal extract with a traditional history but minimal modern evidence for effectiveness. If you take any CNS depressants or diabetes medications, you'll need to check this against your list first — it has documented interactions with a large number of drugs in those categories.

A conversation with your pharmacist before starting is a smart move.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Leaf of God, straight from the product label.

Brand Hawaii Pharm
Barcode (UPC) 0787699223902
Net contents 4 Fluid Ounce(s); 120 mL
Market status On market
Date entered into DSLD Oct 23, 2020
DSLD ID 237516
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Leaf of God by Hawaii Pharm, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.7 mL
Maximum serving Sizes:
1 mL
Servings per container
120
UPC/BARCODE
0787699223902
IngredientAmount% DV
wildcrafted Leaf of God extract970 mg--

Other ingredients: Vegetable Palm Glycerin, Alcohol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Hawaii Pharm Herbal Extract Highest quality since 2008

Made with Aloha!

Formulation

Contains no GMO, gluten, artificial colors, heavy metals, preservatives, pesticides, fertilizers.

Super concentrated liquid herbal extract. Dry herb/menstruum ratio: 1:3.

Manufactured in an FDA registered facility.

Non GMO Gluten free

Made in USA, Hawaii

Suggested/Recommended/Usage/Directions

Directions for use: Shake well before using. Take about 20-30 drops (0.7-1 ml, one full squeeze of the dropper bulb) to 2-4 oz of juice or water up to 4 times per day.

Precautions

Warning: Keep out of the reach of children.

May have contraindications. We recommend to seek expert medical advice before taking.

Do not use if you are allergic to any ingredients.

Consult a physician before using during pregnancy, if nursing or taking any medications.

Do not use if seal is broken or missing.

Storage

Store in a cool dry place.

Formula

(Calea zacatechichi)

FDA Statement of Identity

Herbal Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

FDA Registered Facility Made in United States of America USA

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Leaf of God by Hawaii Pharm label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Leaf of God label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Leaf of God by Hawaii Pharm

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.7 mL Dosage formLiquid Servings per container120 Amounts shown are per serving.

Wildcrafted Leaf of God extract

Interacts with
334 drugs
970 mg per serving

Calea zacatechichi, often called 'dream herb,' is a Mexican plant traditionally used to encourage vivid dreams and to treat digestive complaints and f...

Wildcrafted Leaf of God extract monograph & interactions

Other (inactive) ingredients: Vegetable Palm Glycerin, Alcohol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Leaf of God by Hawaii Pharm Drug Interactions

Want to check YOUR meds against Leaf of God?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
334Drugs
334 Minor

Ingredients driving the most interactions

wildcrafted Leaf of God extract 334

Individual Drug Interactions

The ingredients in Leaf of God interact with 334 drugs. Click any drug to see the details.

1 of the 1 ingredient in Leaf of God interact with drugs. Each result below shows which ingredient is responsible. wildcrafted Leaf of God extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Leaf of God with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

wildcrafted Leaf of God extract2 drug types · 334 drugs

Antidiabetes Drugs

Theoretically, taking Calea zacatechichi with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research shows that Calea zacatechichi lowers blood glucose levels. Theoretically, combining Calea zacatechichi with antidiabetes drugs might result in additive effects.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, Calea zacatechichi might increase the sedative effects of CNS depressants.
Calea zacatechichi can cause CNS depression in animals and humans.

Likelihood Possible Evidence D
wildcrafted Leaf of God extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Leaf of God, from the product label.

Hawaii Pharm

See all Hawaii Pharm products
Name
Hawaii Pharm LLC
City
Honolulu
State
HI
ZipCode
96815
Web Address
www.hawaiipharm.com
Pharmacist Counseling Corner

Leaf of God by Hawaii Pharm: Common Questions

Does Leaf of God by Hawaii Pharm interact with any medications?
Yes. Based on its ingredients, Leaf of God has a known interaction with 334 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Leaf of God contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is Leaf of God extract, and what is it supposed to do?
It's an extract of Calea zacatechichi, a plant with a long folk history. The product is marketed for headache, insomnia, stress, rheumatoid arthritis, and skin irritation, but the evidence to support these claims isn't established in our data.
Can I take this if I'm pregnant or breastfeeding?
No — there's no reliable safety data, so the facts advise against use during pregnancy and while breastfeeding. Talk with your doctor or pharmacist about whether this is right for you.
What side effects should I watch for?
The main ones reported in healthy volunteers are nausea, vomiting, and drowsiness. The plant has a bitter taste. Because modern safety data is limited, other effects may not be well documented.
Can I take this with my sleep medications?
Not without checking first — Calea zacatechichi can cause sedation on its own, and combining it with sleep aids or other CNS depressants might increase drowsiness. Run it through our checker with your exact medications before you start.
Is it safe to take if I have diabetes?
Animal research shows Calea zacatechichi lowers blood glucose, so it may increase your risk of low blood sugar if you're on diabetes medication. Check with your pharmacist before adding this.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Leaf of God is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Leaf of God label
Go deeper

The Full Monographs Behind Leaf of God’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Calea Zacatechichi

Interacts with 334 drugs

Calea zacatechichi, often called 'dream herb,' is a Mexican plant traditionally used to encourage vivid dreams and to treat digestive complaints and fever. Human research is very limited, so...

Read the full Calea Zacatechichi monograph →
Sources

Sources & How We Checked

Leaf of God's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Calea Zacatechichi 2 references
  1. Mayagoitia, L., Diaz, J. L., Contreras, C. M. Psychopharmacologic analysis of an alleged oneirogenic plant: Calea zacatechichi. J Ethnopharmacol. 1986;18:229-243. PubMed
  2. Roman, Ramos R., Alarcon-Aguilar, F., Lara-Lemus, A., and Flores-Saenz, J. L. Hypoglycemic effect of plants used in Mexico as antidiabetics. Arch.Med.Res 1992;23:59-64.

See these in context on the Calea Zacatechichi monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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