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Dietary supplement

Dream Herb Ingredients & Drug Interactions

by Hawaii Pharm

Dream Herb label
See full label image
Liquid Category: Botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Dream Herb against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Dream Herb is a dietary supplement by Hawaii Pharm with 1 active ingredient. Its ingredients are commonly taken for promoting vivid or lucid dreams, sleep and relaxation, digestive upset.Based on those ingredients, 334 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Dream Herb Leaf, Stem Extract, Dry. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Dream Herb by Hawaii Pharm

Ask about any prescription or over-the-counter medication and we check it for interactions with Dream Herb by Hawaii Pharm — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Dream Herb by Hawaii Pharm

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Dream Herb is a single-ingredient liquid supplement: an extract of Calea zacatechichi leaf and stem. The liquid is made with alcohol, water, and glycerin.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Calea Zacatechichi's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: promoting vivid or lucid dreams.
  • We looked for evidence on: Insomnia, Sleep quality, Dream recall, Sleep disturbance.
  • The closest evidence on file: Calea Zacatechichi is rated "Insufficient Reliable Evidence To Rate" for Insomnia (Natural Medicines).

The evidence we have on Calea zacatechichi is too thin to draw firm conclusions. The data we hold rates it as having insufficient reliable evidence for headache, rheumatoid arthritis, insomnia, stress, and urticaria (hives).

That means research either hasn't happened yet or hasn't been robust enough to confirm it works for these uses — so we can't tell you whether it will help.

The evidence, ingredient by ingredient Calea Zacatechichi

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Calea zacatechichi has a long history in folk medicine but very little modern safety testing. In healthy volunteers, it's bitter tasting and has caused nausea, vomiting, and drowsiness.

It can also affect sleep architecture — it may produce light sleep while reducing deep and REM (dream) sleep. The safety data during pregnancy and breastfeeding is too limited to recommend use; talk with your doctor or pharmacist if you're pregnant, planning to become pregnant, or nursing before taking this product.

Side effects, ingredient by ingredient Calea Zacatechichi

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Calea Zacatechichi.
  • The most serious interaction on file is rated Minor.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 334 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before using Dream Herb if you take any CNS depressants (sleep aids, sedatives, anxiety medications, pain relievers, or other drugs that slow brain activity) or antidiabetes medications (insulin or oral blood sugar drugs). The combination could increase drowsiness or cause blood sugar to drop too low.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Only minor medication interactions are documented, and safety information is well characterized.

Dream Herb might interest someone exploring traditional botanical remedies for relaxation or sleep, but the evidence for its effectiveness isn't established in the data we hold. The main caution is if you take CNS depressants or diabetes medications — combining them could intensify drowsiness or lower blood sugar too much.

Talk with your doctor or pharmacist before starting, especially if you're on any regular medications or have pregnancy or breastfeeding questions.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Dream Herb, straight from the product label.

Brand Hawaii Pharm
Barcode (UPC) 840253619037
Net contents 4 Fluid Ounce(s); 120 mL
Market status On market
Date entered into DSLD Oct 24, 2023
DSLD ID 301533
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Dream Herb by Hawaii Pharm, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.7 mL
Maximum serving Sizes:
1 mL
Servings per container
120
UPC/BARCODE
840253619037
IngredientAmount% DV
Dream Herb Leaf, Stem Extract, Dry983 mg--

Other ingredients: Alcohol, Water, Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Hawaii Pharm Herbal Extract Highest quality since 2008

Suggested/Recommended/Usage/Directions

Suggested use: Shake well before using. For adults add about 20-30 drops (0.7-1 mL, one full squeeze of the dropper bulb) to some juice or water, up to 4 times a day.

Precautions

Warning: We recommend to seek expert medical advice before taking.

Do not use if you are allergic to any ingredients.

Consult your physician before giving to children under 18, during pregnancy, if nursing or taking medications.

Consult your physician before giving to children under 18, during pregnancy, if nursing or taking medications.

May affect the ability to drive and operate machinery. May have contraindications, can cause side effects and adverse reactions. Do not use if seal is broken or missing.

Keep out of the reach of children!

Storage

Store in a cool dry place.

Seals/Symbols

cGMP Made in compliance with cGMP 21 CFR 111 in an FDA registered and inspected facility.

Organic Alcohol Based USA Made in United States of America

FDA Disclaimer Statement

This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure or prevent any disease.

General Statements

Scan this QR-code to get 15% discount on your next purchase. Limited time deal.

Formula

Calea zacatechichi

Organic Alcohol Based

Formulation

Only natural ingredients Purity is laboratory tested and verified

All the raw materials are gluten-free by their nature No artificial colors, flavors, or preservatives

Not tested on animals

Organic Alcohol Based

Made in USA, Hawaii

FDA Statement of Identity

Herbal Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Dream Herb by Hawaii Pharm label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Dream Herb label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Dream Herb by Hawaii Pharm

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.7 mL Dosage formLiquid Servings per container120 Amounts shown are per serving.

Dream Herb Leaf, Stem Extract, Dry

Interacts with
334 drugs
983 mg per serving Form: Calea zacatechichi Leaf Extract, Dry, Calea zacatechichi Stem Extract, Dry

Calea zacatechichi, often called 'dream herb,' is a Mexican plant traditionally used to encourage vivid dreams and to treat digestive complaints and f...

Dream Herb Leaf, Stem Extract, Dry monograph & interactions

Other (inactive) ingredients: Alcohol, Water, Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Dream Herb by Hawaii Pharm Drug Interactions

Want to check YOUR meds against Dream Herb?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
334Drugs
334 Minor

Ingredients driving the most interactions

Dream Herb Leaf, Stem Extract, Dry 334

Individual Drug Interactions

The ingredients in Dream Herb interact with 334 drugs. Click any drug to see the details.

1 of the 1 ingredient in Dream Herb interact with drugs. Each result below shows which ingredient is responsible. Dream Herb Leaf, Stem Extract, Dry

Each ingredient & the kinds of drugs it affects

For each ingredient in Dream Herb with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Dream Herb Leaf, Stem Extract, Dry2 drug types · 334 drugs

Antidiabetes Drugs

Theoretically, taking Calea zacatechichi with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research shows that Calea zacatechichi lowers blood glucose levels. Theoretically, combining Calea zacatechichi with antidiabetes drugs might result in additive effects.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, Calea zacatechichi might increase the sedative effects of CNS depressants.
Calea zacatechichi can cause CNS depression in animals and humans.

Likelihood Possible Evidence D
Dream Herb Leaf, Stem Extract, Dry full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Dream Herb, from the product label.

Hawaii Pharm

See all Hawaii Pharm products
Name
Hawaii Pharm LLC
Street Address
510 Sumner St. Ste. 613
City
Honolulu
State
HI
ZipCode
96817
Phone Number
888-854-2924
Web Address
www.hawaiipharm.com
Pharmacist Counseling Corner

Dream Herb by Hawaii Pharm: Common Questions

Does Dream Herb by Hawaii Pharm interact with any medications?
Yes. Based on its ingredients, Dream Herb has a known interaction with 334 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Dream Herb contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is Dream Herb actually used for?
Calea zacatechichi has a long folk history, but the evidence we hold is insufficient to confirm it works reliably for headache, rheumatoid arthritis, insomnia, stress, or urticaria. More modern research would be needed to establish whether it's effective.
Can I take Dream Herb if I'm pregnant or breastfeeding?
There isn't enough safety data on Calea zacatechichi during pregnancy or breastfeeding to recommend it. Talk with your doctor or pharmacist to decide what's right for your situation.
What side effects should I watch for?
In healthy volunteers, Calea zacatechichi has caused nausea, vomiting, and drowsiness. It's also quite bitter tasting. The ingredient can affect how your sleep works, reducing deep and REM sleep in some people.
Why does this product interact with so many medications?
The 334 interactions span two main categories: CNS depressants and antidiabetes drugs. The large number comes from the fact that each category includes many individual medications — dozens of sleep aids, pain relievers, anxiety drugs, and insulins or blood sugar pills. One ingredient can theoretically interact with all of them.
Is Dream Herb safe to take with my sleep medication?
Both Calea zacatechichi and most sleep medications slow brain activity, so combining them could make you dangerously drowsy. Don't combine them without talking to your doctor or pharmacist first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Dream Herb is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Dream Herb label
Go deeper

The Full Monographs Behind Dream Herb’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Calea Zacatechichi

Interacts with 334 drugs

Calea zacatechichi, often called 'dream herb,' is a Mexican plant traditionally used to encourage vivid dreams and to treat digestive complaints and fever. Human research is very limited, so...

Read the full Calea Zacatechichi monograph →
Sources

Sources & How We Checked

Dream Herb's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Calea Zacatechichi 2 references
  1. Mayagoitia, L., Diaz, J. L., Contreras, C. M. Psychopharmacologic analysis of an alleged oneirogenic plant: Calea zacatechichi. J Ethnopharmacol. 1986;18:229-243. PubMed
  2. Roman, Ramos R., Alarcon-Aguilar, F., Lara-Lemus, A., and Flores-Saenz, J. L. Hypoglycemic effect of plants used in Mexico as antidiabetics. Arch.Med.Res 1992;23:59-64.

See these in context on the Calea Zacatechichi monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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