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Dietary supplement

Lion's Mane 2400 mg Ingredients & Drug Interactions

by tnvitamins

Lion's Mane 2400 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lion's Mane 2400 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Lion's Mane 2400 mg is a dietary supplement by tnvitamins with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, nerve health, mood and anxiety.Based on those ingredients, 327 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lion's Mane Mushroom Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Lion's Mane 2400 mg by tnvitamins

Ask about any prescription or over-the-counter medication and we check it for interactions with Lion's Mane 2400 mg by tnvitamins — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Lion's Mane 2400 mg by tnvitamins

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product has one active ingredient: lion's mane mushroom extract at 2400 mg per dose. Lion's mane is a medicinal mushroom used traditionally to support brain health and cognitive function.

The capsule also contains three inactive ingredients — gelatin, rice flour, and magnesium stearate — which are fillers and binders used to form and stabilize the capsule.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Lion's Mane Mushroom's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Memory and cognitive support.
  • We looked for evidence on: Memory, Cognitive function, Cognitive impairment, Alzheimer disease, Dementia, Parkinson disease — and 2 related terms.
  • The closest evidence on file: Lion's Mane Mushroom is rated "Insufficient Reliable Evidence To Rate" for Alzheimer disease (Natural Medicines).
  • Also on file: Lion's Mane Mushroom is rated "Insufficient Reliable Evidence To Rate" for Cognitive function, Cognitive impairment, Dementia, Memory, and more.

The evidence for lion's mane isn't yet established in our data. The product is marketed for Alzheimer disease, anxiety, athletic performance, cancer prevention, and general cognitive function and cognitive impairment, but we hold insufficient reliable evidence to rate how well it works for any of these uses.

If you're considering it for a specific health goal, talk with your pharmacist about what the current research actually shows.

The evidence, ingredient by ingredient Lion's Mane Mushroom

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 0 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lion's mane is generally well tolerated when eaten as a food, though long-term safety as a supplement hasn't been studied thoroughly. The most common side effects reported are gastrointestinal discomfort, nausea, and skin rash.

Because there isn't enough safety data, the facts advise against using it during pregnancy or while breastfeeding — talk with your doctor or pharmacist if you're in either situation and want to know more.

Side effects, ingredient by ingredient Lion's Mane Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lion's Mane Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 327 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check with your pharmacist if you're on blood thinners or antiplatelet drugs (like warfarin or aspirin) — lion's mane may increase bleeding risk. Also check if you take diabetes medications or drugs that suppress your immune system, as lion's mane may add to their effects.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and some safety-information gaps remain.

Lion's mane may be worth considering if you're interested in cognitive support, but the evidence for its effectiveness isn't yet solid. If you take blood thinners, diabetes medications, or immune-suppressing drugs, check with your pharmacist first — those are the main interactions to watch.

And because long-term safety data is limited, mention it to your doctor if you're pregnant, nursing, or on any prescription medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lion's Mane 2400 mg, straight from the product label.

Brand tnvitamins
Barcode (UPC) X002MOWG41
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Jul 25, 2024
DSLD ID 314543
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lion's Mane 2400 mg by tnvitamins, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
30
UPC/BARCODE
X002MOWG41
IngredientAmount% DV
Lion's Mane Mushroom Extract2400 mg--

Other ingredients: Gelatin, Rice Flour, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement for adults, take three (3) capsules daily, or as directed by a healthcare professional.

Precautions

Caution: Pregnant or lactating women should consult a doctor before use.

If you are under medical supervision, please consult a doctor before use. Discontinue use and consult a doctor if any adverse reactions occur.

Keep out of reach of children.

Storage

Store in a cool, dry place.

Formula

Lion's mane mushroom (2400 mg - 90 capsules) 2400 mg per serving

General Statements

New

FDA Statement of Identity

Dietary Supplement

Formulation

Free of: gluten, wheat, soy, peanuts, tree nuts, fish, shellfish, dairy/milk, & egg. No artificial colors or flavors. Non-GMO.

100% natural

Non GMO Gluten free Nuts free

Seals/Symbols

Packaged & lab tested in the USA

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lion's Mane 2400 mg by tnvitamins label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lion's Mane 2400 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lion's Mane 2400 mg by tnvitamins

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size3 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Lion's Mane Mushroom Extract

Interacts with
327 drugs
2400 mg per serving Form: Hericium erinaceus fruiting body Extract

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and...

Lion's Mane Mushroom Extract monograph & interactions

Other (inactive) ingredients: Gelatin, Rice Flour, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lion's Mane 2400 mg by tnvitamins Drug Interactions

Want to check YOUR meds against Lion's Mane 2400 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
327Drugs
327 Moderate

Ingredients driving the most interactions

Lion's Mane Mushroom Extract 327

Individual Drug Interactions

The ingredients in Lion's Mane 2400 mg interact with 327 drugs. Click any drug to see the details.

1 of the 1 ingredient in Lion's Mane 2400 mg interact with drugs. Each result below shows which ingredient is responsible. Lion's Mane Mushroom Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Lion's Mane 2400 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lion's Mane Mushroom Extract3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
In vitro research suggests that lion's mane mushroom extracts can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lion's mane mushroom can reduce serum glucose and increase serum insulin.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
In animal and in vitro research, lion's mane mushroom polysaccharides stimulate the immune system.

Likelihood Possible Evidence D
Lion's Mane Mushroom Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lion's Mane 2400 mg, from the product label.

tnvitamins

See all tnvitamins products
Name
Total Nutrition, Inc.
City
Farmingdale
State
NY
ZipCode
11735
Phone Number
(800) 777-2200
Pharmacist Counseling Corner

Lion's Mane 2400 mg by tnvitamins: Common Questions

Does Lion's Mane 2400 mg by tnvitamins interact with any medications?
Yes. Based on its ingredients, Lion's Mane 2400 mg has a known interaction with 327 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lion's Mane 2400 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What's lion's mane mushroom, and what is it supposed to do?
Lion's mane is a medicinal mushroom traditionally used to support brain health and cognitive function. This product contains 2400 mg of the extract per dose, though the evidence for how well it actually works for conditions like Alzheimer disease, anxiety, or cognitive impairment isn't yet established in our data.
Will lion's mane cause side effects?
Most people tolerate it well orally. The side effects that have been reported are gastrointestinal discomfort, nausea, and skin rash — usually mild. Long-term safety as a supplement hasn't been deeply studied, so that's worth keeping in mind if you're planning to take it for a while.
Can I take lion's mane if I'm pregnant or breastfeeding?
The safety data isn't there yet for either pregnancy or breastfeeding, so it's best to avoid it in those situations. Talk with your doctor or pharmacist about whether it's right for you if you're pregnant, trying to become pregnant, or nursing.
What are those other ingredients in the capsule?
Gelatin, rice flour, and magnesium stearate are inactive ingredients — fillers and binders that hold the capsule together. They're not the active part of the supplement.
Is lion's mane safe to use with my blood thinner?
Not without checking first. Lion's mane may increase bleeding risk when taken with blood thinners or antiplatelet drugs like warfarin or aspirin. Run your exact medication through the interaction checker on this page, or talk with your pharmacist before you start.
Can I take this if I have diabetes?
Check with your pharmacist first. Animal research suggests lion's mane can lower blood sugar, so it may add to the effect of diabetes medications and increase the risk of low blood sugar. Your pharmacist can help you figure out if it's safe for your specific situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Lion's Mane 2400 mg is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lion's Mane 2400 mg label
Go deeper

The Full Monographs Behind Lion's Mane 2400 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lion's Mane Mushroom

Interacts with 327 drugs

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as...

Read the full Lion's Mane Mushroom monograph →
Sources

Sources & How We Checked

Lion's Mane 2400 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lion's Mane Mushroom 6 references
  1. Product information for <em>Niaspan</em>. Abbott Laboratories. North Chicago, IL 60064. April 2015.
  2. Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complement Altern Med. 2013;13:253. PubMed
  3. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009;23(3):367-72.
  4. Mori K, Kikuchi H, Obara Y, et al. Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. Phytomedicine. 2010;17(14):1082-5. PubMed
  5. Li IC, Chang HH, Lin CH, et al. Prevention of early Alzheimer's disease by erinacine A-enriched Hericium erinaceus mycelia pilot double-blind placebo-controlled study. Front Aging Neurosci 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. PubMed
  6. Tian B, Liu R, Xu T, et al. Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice. J Sci Food Agric 2023;103(6):3050-3064.

See these in context on the Lion's Mane Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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