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Dietary supplement

Lion's Mane Amyloban Ingredients & Drug Interactions

by Mushroom Wisdom

Lion's Mane Amyloban label
See full label image
Tablet Or Pill Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lion's Mane Amyloban against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Lion's Mane Amyloban is a dietary supplement by Mushroom Wisdom with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, nerve health, mood and anxiety.Based on those ingredients, 327 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lion's Mane (Hericium erinaceus) fruiting body extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Lion's Mane Amyloban by Mushroom Wisdom

Ask about any prescription or over-the-counter medication and we check it for interactions with Lion's Mane Amyloban by Mushroom Wisdom — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Lion's Mane Amyloban by Mushroom Wisdom

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This supplement contains one active ingredient: lion's mane mushroom (Hericium erinaceus) fruiting body extract. The tablet also holds inactive ingredients — microcrystalline cellulose, dicalcium phosphate, calcium stearate, silicon dioxide, croscarmellose sodium, hydroxypropylmethylcellulose, and glycerin — which are fillers and binders that help form the tablet.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Lion's Mane Mushroom's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: brain function support.
  • We looked for evidence on: Cognitive function, Memory, Dementia, Alzheimer disease, Parkinson disease, Cognitive impairment — and 2 related terms.
  • The closest evidence on file: Lion's Mane Mushroom is rated "Insufficient Reliable Evidence To Rate" for Alzheimer disease (Natural Medicines).
  • Also on file: Lion's Mane Mushroom is rated "Insufficient Reliable Evidence To Rate" for Cognitive function, Cognitive impairment, Dementia, Memory, and more.

The evidence for lion's mane is incomplete. The data we hold shows insufficient reliable evidence to rate its use for Alzheimer disease, anxiety, athletic performance, cancer, cognitive function, or cognitive impairment.

That doesn't mean it doesn't work — it means quality studies haven't been done yet or aren't conclusive. If you're considering it for one of these purposes, talk with your doctor about whether a trial makes sense for you and what to watch for.

The evidence, ingredient by ingredient Lion's Mane Mushroom

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 0 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Orally, lion's mane is generally well tolerated, and it has a history as a food. However, long-term supplement safety hasn't been well studied.

Some people report gastrointestinal discomfort, nausea, or skin rash. The safety data advises against use during pregnancy and while breastfeeding because there isn't enough information to know whether it's safe in those situations.

Side effects, ingredient by ingredient Lion's Mane Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lion's Mane Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 327 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (Moderate risk of bleeding), diabetes medications (Moderate risk of low blood sugar), or immunosuppressants (Moderate risk of reduced effectiveness).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and some safety-information gaps remain.

Lion's mane may appeal to you if you're interested in cognitive or immune support, but the evidence for those uses isn't yet solid. If you take blood thinners, diabetes medications, or immunosuppressants, this product needs a clear from your doctor or pharmacist first.

Start by checking your medications with the tool on this page, then talk it over with your own healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 11, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lion's Mane Amyloban, straight from the product label.

Brand Mushroom Wisdom
Barcode (UPC) 791014309004
Net contents 180 Vegetarian Tablet(s)
Market status On market
Date entered into DSLD Apr 11, 2022
DSLD ID 261458
Product type Botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lion's Mane Amyloban by Mushroom Wisdom, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Tablet(s)
Maximum serving Sizes:
2 Tablet(s)
Servings per container
90
UPC/BARCODE
791014309004
IngredientAmount% DV
Lion's Mane (Hericium erinaceus) fruiting body extract650 mg--

Other ingredients: Microcrystalline Cellulose, Dicalcium Phosphate, Calcium Stearate, Silicon Dioxide, Croscarmellose Sodium, Hydroxypropylmethylcellulose, Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Science complimenting ancient wisdom Amyloban is made from a unique and innovative extract concentrating active compounds from the lion's mane mushroom. This extract, amycenone, standardizes amyloban including hericenones and has been shown by research to support healthy brain function while maintaining healthy cognition and sleep quality.

Formulation

Patented extraction process (US patent #8,871,492) Mushroom wisdom products are manufactured in a certified cGMP facility.

Brain function support

Suitable for vegetarians

Contains no gluten, wheat, soy, corn, dairy, artificial colors, flavors or preservatives

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take 2 tablets 3 times a day or as directed by your practitioner.

Precautions

Warning: Keep out of reach of children.

Consult a physician before using if pregnant or nursing.

Do not use if seal is broken or missing.

Storage

Store in a cool dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lion's Mane Amyloban by Mushroom Wisdom label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lion's Mane Amyloban label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lion's Mane Amyloban by Mushroom Wisdom

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Tablet(s) Dosage formTablet Or Pill Servings per container90 Amounts shown are per serving.

Lion's Mane (Hericium erinaceus) fruiting body extract

Interacts with
327 drugs
650 mg per serving Form: Amyloban, Hericenones

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and...

Lion's Mane (Hericium erinaceus) fruiting body extract monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Dicalcium Phosphate, Calcium Stearate, Silicon Dioxide, Croscarmellose Sodium, Hydroxypropylmethylcellulose, Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lion's Mane Amyloban by Mushroom Wisdom Drug Interactions

Want to check YOUR meds against Lion's Mane Amyloban?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
327Drugs
327 Moderate

Ingredients driving the most interactions

Lion's Mane (Hericium erinaceus) fruiting body extract 327

Individual Drug Interactions

The ingredients in Lion's Mane Amyloban interact with 327 drugs. Click any drug to see the details.

1 of the 1 ingredient in Lion's Mane Amyloban interact with drugs. Each result below shows which ingredient is responsible. Lion's Mane (Hericium erinaceus) fruiting body extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Lion's Mane Amyloban with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lion's Mane (Hericium erinaceus) fruiting body extract3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
In vitro research suggests that lion's mane mushroom extracts can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lion's mane mushroom can reduce serum glucose and increase serum insulin.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
In animal and in vitro research, lion's mane mushroom polysaccharides stimulate the immune system.

Likelihood Possible Evidence D
Lion's Mane (Hericium erinaceus) fruiting body extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lion's Mane Amyloban, from the product label.

Mushroom Wisdom

See all Mushroom Wisdom products
Name
Mushroom Wisdom, Inc.
Street Address
1 Madison St., Bldg. F6
City
E. Rutherford
State
NJ
ZipCode
07073
Phone Number
800-747-7418
Web Address
www.mushroomwisdom.com
Pharmacist Counseling Corner

Lion's Mane Amyloban by Mushroom Wisdom: Common Questions

Does Lion's Mane Amyloban by Mushroom Wisdom interact with any medications?
Yes. Based on its ingredients, Lion's Mane Amyloban has a known interaction with 327 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lion's Mane Amyloban contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Lion's Mane Amyloban if I'm pregnant or breastfeeding?
The safety data advises against it in both cases — there isn't enough information to know whether it's safe. Talk with your doctor or pharmacist about your options.
What side effects should I watch for?
Most people tolerate it well, but some report gastrointestinal discomfort, nausea, or skin rash. If any of those happens, stop and talk with your pharmacist.
Does lion's mane actually help with memory or thinking?
The evidence isn't strong enough yet to say for sure. Our data shows insufficient reliable evidence for cognitive function, cognitive impairment, and Alzheimer disease. Research is still ongoing.
I take a blood thinner. Can I use this?
Not without checking first. Lion's mane may increase bleeding risk when combined with blood thinners, so this is a conversation to have with your doctor or pharmacist before you start.
Is this supplement studied long-term?
Long-term supplement safety hasn't been well studied, so we don't have a full picture of what happens with extended use. If you're thinking of taking it regularly, run that by your doctor or pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Lion's Mane Amyloban is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lion's Mane Amyloban label
Go deeper

The Full Monographs Behind Lion's Mane Amyloban’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lion's Mane Mushroom

Interacts with 327 drugs

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as...

Read the full Lion's Mane Mushroom monograph →
Sources

Sources & How We Checked

Lion's Mane Amyloban's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lion's Mane Mushroom 6 references
  1. Product information for <em>Niaspan</em>. Abbott Laboratories. North Chicago, IL 60064. April 2015.
  2. Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complement Altern Med. 2013;13:253. PubMed
  3. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009;23(3):367-72.
  4. Mori K, Kikuchi H, Obara Y, et al. Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. Phytomedicine. 2010;17(14):1082-5. PubMed
  5. Li IC, Chang HH, Lin CH, et al. Prevention of early Alzheimer's disease by erinacine A-enriched Hericium erinaceus mycelia pilot double-blind placebo-controlled study. Front Aging Neurosci 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. PubMed
  6. Tian B, Liu R, Xu T, et al. Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice. J Sci Food Agric 2023;103(6):3050-3064.

See these in context on the Lion's Mane Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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