Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

SX-Fraction Ingredients & Drug Interactions

by Mushroom Wisdom

SX-Fraction label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking SX-Fraction against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

SX-Fraction is a dietary supplement by Mushroom Wisdom with 2 active ingredients. Its ingredients are commonly taken for immune support, blood sugar support in diabetes, high blood pressure.Based on those ingredients, 260 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Maitake (Grifola frondosa) fruit body powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against SX-Fraction by Mushroom Wisdom

Ask about any prescription or over-the-counter medication and we check it for interactions with SX-Fraction by Mushroom Wisdom — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of SX-Fraction by Mushroom Wisdom

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

SX-Fraction contains 2 active ingredients: maitake (Grifola frondosa) mushroom in both fruit body powder and fruiting body extract forms. The product also includes several inactive ingredients—microcrystalline cellulose, dicalcium phosphate, calcium stearate, silicon dioxide, croscarmellose sodium, hydroxypropyl methylcellulose, and glycerin—which are binders, fillers, and capsule materials.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Maitake Mushroom's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: support healthy blood sugar and cardiovascular health.
  • We looked for evidence on: Diabetes, Hypertension, Hyperlipidemia, insulin resistance, metabolic syndrome.
  • The closest evidence on file: Maitake Mushroom is rated "Insufficient Reliable Evidence To Rate" for Diabetes (Natural Medicines).
  • Also on file: Maitake Mushroom is rated "Insufficient Reliable Evidence To Rate" for Hyperlipidemia, Hypertension.

The evidence for maitake mushroom on the conditions studied—allergic rhinitis (hay fever), chemotherapy-induced anemia, laryngeal cancer, chemotherapy-induced diarrhea, and chronic fatigue syndrome—is insufficient to rate. We don't have reliable data showing whether it works for these purposes, so we can't make claims about its effectiveness for them.

The evidence, ingredient by ingredient Maitake Mushroom

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Maitake mushroom is generally well tolerated when eaten as food, but supplement safety hasn't been fully studied. The most common side effects from the supplement are gastrointestinal—diarrhea and epigastric pain (upper belly pain)—though they occurred in a small number of trial participants.

One person reported a rash and itching after two doses that cleared on its own; a few others reported nausea. Because there isn't enough safety data on concentrated supplements, the data advises against use during pregnancy and while breastfeeding.

Side effects, ingredient by ingredient Maitake Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Maitake Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 260 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications against this product if you take blood thinners like warfarin (Moderate severity—maitake may boost its effect), blood pressure medications (Moderate—maitake may lower your pressure further), or diabetes drugs (Moderate—maitake may lower your blood sugar further). All three merit a conversation with your doctor or pharmacist before you start.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you take blood thinners, blood pressure medications, or diabetes drugs, you need to check with your doctor or pharmacist before starting SX-Fraction—maitake can affect how these work. The evidence for what this product actually treats isn't established yet.

It's generally well tolerated, but GI upset and rarely rash are possible. Talk it over with your own healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about SX-Fraction, straight from the product label.

Brand Mushroom Wisdom
Barcode (UPC) 791014201018
Net contents 270 Vegetarian Tablet(s)
Market status On market
Date entered into DSLD Apr 25, 2018
DSLD ID 174131
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for SX-Fraction by Mushroom Wisdom, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Tablet(s)
Maximum serving Sizes:
3 Tablet(s)
Servings per container
90
UPC/BARCODE
791014201018
IngredientAmount% DV
Maitake (Grifola frondosa) fruit body powder750 mg--
Maitake fruiting body extract300 mg--

Other ingredients: Microcrystalline Cellulose, Dicalcium Phosphate, Calcium Stearate, Silicon Dioxide, Croscarmellose Sodium, Hydroxypropyl Methylcellose, Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Science complementing ancient wisdom

This proprietary extract concentrates a research-based glycoprotein that has been shown to support healthy blood sugar and insulin function while assisting support to cardiovascular health.

Mushroom Wisdom products are manufactured in a certified cGMP facility.

Batch number and best used by date are stamped on each bottle.

Supports healthy blood sugar levels

Brand IP Statement(s)

SX-Fraction is an advanced dietary supplement based on a unique extract of the Maitake mushroom.

Patented active constituent and extraction process (US Patent #7,214,778)

U.S. Patent No.7,214,778

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Formula

From Maitake mushroom SX Fraction

Suggested/Recommended/Usage/Directions

Directions: Take 3 tablets daily or 1 tablet three times a day.

Formulation

Suitable for vegetarians

Contains no gluten, wheat, soy, dairy, artificial colors, flavors or preservatives

Precautions

Warning: Keep out of reach of children.

Consult a physician before using if pregnant or nursing.

Do not use if seal is broken or missing.

Storage

Store in a cool dry place.

General

REV-1.17

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

SX-Fraction by Mushroom Wisdom label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

SX-Fraction label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in SX-Fraction by Mushroom Wisdom

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Tablet(s) Dosage formTablet Or Pill Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Maitake (Grifola frondosa) fruit body powder

Interacts with
260 drugs
750 mg per serving

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and bl...

Maitake (Grifola frondosa) fruit body powder monograph & interactions

Maitake fruiting body extract

Interacts with
260 drugs
300 mg per serving Form: SX-Fraction

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and bl...

Maitake fruiting body extract monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Dicalcium Phosphate, Calcium Stearate, Silicon Dioxide, Croscarmellose Sodium, Hydroxypropyl Methylcellose, Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

SX-Fraction by Mushroom Wisdom Drug Interactions

Want to check YOUR meds against SX-Fraction?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
260Drugs
260 Moderate

Ingredients driving the most interactions

Maitake (Grifola frondosa) fruit body powder 260

Individual Drug Interactions

The ingredients in SX-Fraction interact with 260 drugs. Click any drug to see the details.

1 of the 2 ingredients in SX-Fraction interact with drugs. Each result below shows which ingredient is responsible. Maitake (Grifola frondosa) fruit body powder

Each ingredient & the kinds of drugs it affects

For each ingredient in SX-Fraction with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Maitake (Grifola frondosa) fruit body powder3 drug types · 260 drugs

Antidiabetes Drugs

Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that taking maitake mushroom polysaccharide (MMP) can lower blood glucose levels in patients with types 2 diabetes.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that maitake mushroom can lower blood pressure.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is limited evidence that maitake mushroom may increase the anticoagulant effects of warfarin.
In a case report, a patient previously stabilized on warfarin developed an elevated international normalized ratio (INR) of 5.1 after taking maitake mushroom (Grifron-Pro Maitake D-Fraction) 1 drop/kg daily in three divided doses for one week. The elevated INR resolved after holding warfarin for two days, then reducing the dose by 11%. It is thought that the beta-glucan constituent of maitake mushroom might cause warfarin dissociation from proteins, resulting in increased free warfarin levels and increased warfarin effects.

Likelihood Possible Evidence D
Maitake (Grifola frondosa) fruit body powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for SX-Fraction, from the product label.

Mushroom Wisdom

See all Mushroom Wisdom products
Name
Mushroom Wisdom, Inc.
Street Address
1 Madison St., Bldg. F6
City
E. Rutherford
State
NJ
ZipCode
07073
Phone Number
800-747-7418
Web Address
www.mushroomwisdom.com
Pharmacist Counseling Corner

SX-Fraction by Mushroom Wisdom: Common Questions

Does SX-Fraction by Mushroom Wisdom interact with any medications?
Yes. Based on its ingredients, SX-Fraction has a known interaction with 260 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
SX-Fraction contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What's the difference between the two maitake ingredients in this product?
One is maitake fruit body powder and the other is maitake fruiting body extract. Both come from the same mushroom and have the same interaction profile, though extracts are more concentrated. The exact differences in how they're processed or their potency aren't detailed in our data.
Can I take this if I'm pregnant or breastfeeding?
The safety data advises against concentrated maitake supplements during pregnancy and while breastfeeding—there isn't enough information to know it's safe. Talk to your doctor or pharmacist about whether this product is right for you.
What side effects should I watch for?
Stomach upset, diarrhea, and upper belly pain were the most common in studies. A few people reported nausea, and one person had a rash and itching that went away on its own. Stop and talk to your pharmacist if you experience any of these.
Does this product actually work for allergies, fatigue, or cancer-related side effects?
We don't have reliable evidence that it does for any of those conditions. The research we hold rates them all as having insufficient evidence, meaning we can't say whether maitake helps with them or not.
Is this supplement safe to take long-term?
Maitake is generally well tolerated as food, but the safety of the concentrated supplement over the long term hasn't been fully studied. Your doctor or pharmacist can help you decide if it's appropriate for your situation.
What are the inactive ingredients in here?
The tablet contains microcrystalline cellulose, dicalcium phosphate, calcium stearate, silicon dioxide, croscarmellose sodium, hydroxypropyl methylcellulose, and glycerin—all standard binders and fillers used to form and stabilize the tablet.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

SX-Fraction label
Go deeper

The Full Monographs Behind SX-Fraction’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Maitake Mushroom

Interacts with 260 drugs

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and blood pressure effects. The human evidence...

Read the full Maitake Mushroom monograph →
Sources

Sources & How We Checked

SX-Fraction's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Maitake Mushroom 8 references
  1. Kabir Y, Kimura S. Dietary mushrooms reduce blood pressure in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol (Tokyo) 1989;35:91-4. PubMed
  2. Kabir Y, Yamaguchi M, Kimura S. Effect of shiitake (Lentinus edodes) and maitake (Grifola frondosa) mushrooms on blood pressure and plasma lipids of spontaneously hypertensive rats. J Nutr Sci Vitaminol (Tokyo) 1987;33:341-6. PubMed
  3. Konno S, Tortorelis DG, Fullerton SA, et al. A possible hypoglycaemic effect of maitake mushroom on Type 2 diabetic patients. Diabet Med 2001;18:1010. PubMed
  4. Chen JT, Tominaga K, Sato Y, et al. Maitake mushroom (Grifola frondosa) extract induces ovulation in patients with polycystic ovary syndrome: a possible monotherapy and a combination therapy after failure with first-line clomiphene citrate. J Altern Compl
  5. Hanselin MR, Vande Griend JP, Linnebur SA. INR elevation with maitake extract in combination with warfarin. Ann Pharmacother 2010;44:223-4. PubMed
  6. Talpur, N. A., Echard, B. W., Fan, A. Y., Jaffari, O., Bagchi, D., and Preuss, H. G. Antihypertensive and metabolic effects of whole Maitake mushroom powder and its fractions in two rat strains. Mol.Cell Biochem. 2002;237(1-2):129-136. PubMed
  7. Deng, G., Lin, H., Seidman, A., Fornier, M., D'Andrea, G., Wesa, K., Yeung, S., Cunningham-Rundles, S., Vickers, A. J., and Cassileth, B. A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: i
  8. Wesa KM, Cunningham-Rundles S, Klimek VM, et al. Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II study. Cancer Immunol Immunother 2015;64(2):237-47. PubMed

See these in context on the Maitake Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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