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Dietary supplement

Maitake D Fraction Pro 4X Ingredients & Drug Interactions

by Mushroom Wisdom

Maitake D Fraction Pro 4X label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Maitake D Fraction Pro 4X against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Maitake D Fraction Pro 4X is a dietary supplement by Mushroom Wisdom with 1 active ingredient. Its ingredients are commonly taken for immune support, blood sugar support in diabetes, high blood pressure.Based on those ingredients, 260 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Maitake fruiting body extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Maitake D Fraction Pro 4X by Mushroom Wisdom

Ask about any prescription or over-the-counter medication and we check it for interactions with Maitake D Fraction Pro 4X by Mushroom Wisdom — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Maitake D Fraction Pro 4X by Mushroom Wisdom

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: maitake fruiting body extract, a concentrate from the maitake mushroom. The formula is rounded out with vegetable glycerin and water as inactive ingredients.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Maitake Mushroom's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: healthy immune function support.
  • We looked for evidence on: HIV/AIDS, Coronavirus disease 2019 (COVID-19), Chemotherapy-induced leukopenia, Chemotherapy-induced nausea and vomiting (CINV), Chemotherapy-related fatigue, Chemotherapy-induced anemia — and 4 related terms.
  • The closest evidence on file: Maitake Mushroom is rated "Insufficient Reliable Evidence To Rate" for Chemotherapy-induced anemia (Natural Medicines).
  • Also on file: Maitake Mushroom is rated "Insufficient Reliable Evidence To Rate" for Chemotherapy-induced diarrhea, Chemotherapy-related fatigue, HIV/AIDS, Chemotherapy-induced leukopenia, and more.

The evidence for maitake mushroom's effectiveness in the conditions it's marketed for — allergic rhinitis, chemotherapy-related side effects, laryngeal cancer, and chronic fatigue syndrome — isn't established in the data we hold. All the effectiveness ratings on file show insufficient reliable evidence to rate it for these uses.

That doesn't mean it doesn't work; it means the clinical research isn't strong enough yet to confirm it does.

The evidence, ingredient by ingredient Maitake Mushroom

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Maitake mushroom is generally well tolerated when taken by mouth. The most common side effects reported in clinical trials were mild gastrointestinal symptoms — diarrhea, nausea, and epigastric pain (discomfort in the upper belly).

A small number of trial participants experienced these, and one patient developed a rash and itching that went away on its own. There isn't enough safety data to know whether concentrated supplements like this one are safe during pregnancy or while breastfeeding.

If you're pregnant, nursing, or planning to become pregnant, talk with your doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient Maitake Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Maitake Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 260 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antihypertensive drugs (blood pressure medications), antidiabetes drugs (including insulin), or warfarin, check with your doctor or pharmacist before using this product. The maitake extract can lower blood pressure and blood sugar, and may increase warfarin's blood-thinning effect.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Maitake D Fraction Pro 4X is a single-ingredient mushroom extract that's generally well tolerated but carries documented interactions with blood pressure meds, diabetes drugs, and warfarin. If you take any of those, check with your doctor or pharmacist before starting.

Evidence for its effectiveness in the conditions it targets isn't established yet in our data.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 11, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Maitake D Fraction Pro 4X, straight from the product label.

Brand Mushroom Wisdom
Barcode (UPC) 791014107211
Net contents 60 mL
Market status On market
Date entered into DSLD Apr 11, 2022
DSLD ID 261465
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Maitake D Fraction Pro 4X by Mushroom Wisdom, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
6 Drop(s)
Maximum serving Sizes:
6 Drop(s)
Servings per container
273
UPC/BARCODE
791014107211
IngredientAmount% DV
Maitake fruiting body extract22 mg--

Other ingredients: Vegetable Glycerin, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Science complementing ancient wisdom

Formula

Modern science has identified in Maitake (Grifola frondosa) a proteoglucan, Beta-1,3 and 1,6 glucans combined with protein, as an active constituent to support healthy immune function. Maitake D-Fraction is a standardized form of the proteoglucan, specially developed to be optimal for oral administration.

4X more proteoglucan than Maitake D-Fraction standard liquids.

Formulation

Alcohol-free vegetable glycerin base

Mushroom Wisdom products are manufactured in a certified cGMP facility.

Ultimate immune support

Suitable for vegetarians

Contains no gluten, wheat, soy, dairy, artificial colors, flavors or preservatives

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take 6 drops three times a day or as directed by your practitioner.

Precautions

Warning: Keep out of reach of children.

Consult a physician before using if pregnant or nursing.

Do not use if seal is broken or missing.

Storage

Store in a cool dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Maitake D Fraction Pro 4X by Mushroom Wisdom label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Maitake D Fraction Pro 4X label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Maitake D Fraction Pro 4X by Mushroom Wisdom

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size6 Drop(s) Dosage formLiquid Servings per container273 Amounts shown are per serving.

Maitake fruiting body extract

Interacts with
260 drugs
22 mg per serving Form: D-fraction

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and bl...

Maitake fruiting body extract monograph & interactions

Other (inactive) ingredients: Vegetable Glycerin, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Maitake D Fraction Pro 4X by Mushroom Wisdom Drug Interactions

Want to check YOUR meds against Maitake D Fraction Pro 4X?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
260Drugs
260 Moderate

Ingredients driving the most interactions

Maitake fruiting body extract 260

Individual Drug Interactions

The ingredients in Maitake D Fraction Pro 4X interact with 260 drugs. Click any drug to see the details.

1 of the 1 ingredient in Maitake D Fraction Pro 4X interact with drugs. Each result below shows which ingredient is responsible. Maitake fruiting body extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Maitake D Fraction Pro 4X with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Maitake fruiting body extract3 drug types · 260 drugs

Antidiabetes Drugs

Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that taking maitake mushroom polysaccharide (MMP) can lower blood glucose levels in patients with types 2 diabetes.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that maitake mushroom can lower blood pressure.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is limited evidence that maitake mushroom may increase the anticoagulant effects of warfarin.
In a case report, a patient previously stabilized on warfarin developed an elevated international normalized ratio (INR) of 5.1 after taking maitake mushroom (Grifron-Pro Maitake D-Fraction) 1 drop/kg daily in three divided doses for one week. The elevated INR resolved after holding warfarin for two days, then reducing the dose by 11%. It is thought that the beta-glucan constituent of maitake mushroom might cause warfarin dissociation from proteins, resulting in increased free warfarin levels and increased warfarin effects.

Likelihood Possible Evidence D
Maitake fruiting body extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Maitake D Fraction Pro 4X, from the product label.

Mushroom Wisdom

See all Mushroom Wisdom products
Name
Mushroom Wisdom, Inc.
Street Address
1 Madison St., Bldg. F6
City
E. Rutherford
State
NJ
ZipCode
07073
Phone Number
800-747-7418
Web Address
www.mushroomwisdom.com
Pharmacist Counseling Corner

Maitake D Fraction Pro 4X by Mushroom Wisdom: Common Questions

Does Maitake D Fraction Pro 4X by Mushroom Wisdom interact with any medications?
Yes. Based on its ingredients, Maitake D Fraction Pro 4X has a known interaction with 260 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Maitake D Fraction Pro 4X contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm pregnant or breastfeeding?
There isn't enough safety data for concentrated maitake supplements during pregnancy or while breastfeeding. Talk with your doctor or pharmacist to figure out what's right for your situation.
What are the side effects?
Most people tolerate it well. In clinical trials, some participants reported stomach upset — diarrhea, nausea, or upper belly pain — though these were uncommon. One person developed a rash and itching that resolved on its own.
Does maitake actually work for hay fever or fatigue?
The evidence we hold doesn't establish that it does. The research isn't strong enough yet to confirm whether maitake helps with hay fever, chronic fatigue, or the chemotherapy side effects it's sometimes marketed for.
What's in this besides the maitake?
The formula also contains vegetable glycerin and water — both inactive ingredients that help deliver the extract.
Is this safe if I take blood pressure or diabetes medication?
Not without checking first. Maitake can lower blood pressure and blood sugar, so combining it with your medications could cause them to drop too low. Talk with your doctor or pharmacist before you start.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Maitake D Fraction Pro 4X is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Maitake D Fraction Pro 4X label
Go deeper

The Full Monographs Behind Maitake D Fraction Pro 4X’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Maitake Mushroom

Interacts with 260 drugs

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and blood pressure effects. The human evidence...

Read the full Maitake Mushroom monograph →
Sources

Sources & How We Checked

Maitake D Fraction Pro 4X's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Maitake Mushroom 8 references
  1. Kabir Y, Kimura S. Dietary mushrooms reduce blood pressure in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol (Tokyo) 1989;35:91-4. PubMed
  2. Kabir Y, Yamaguchi M, Kimura S. Effect of shiitake (Lentinus edodes) and maitake (Grifola frondosa) mushrooms on blood pressure and plasma lipids of spontaneously hypertensive rats. J Nutr Sci Vitaminol (Tokyo) 1987;33:341-6. PubMed
  3. Konno S, Tortorelis DG, Fullerton SA, et al. A possible hypoglycaemic effect of maitake mushroom on Type 2 diabetic patients. Diabet Med 2001;18:1010. PubMed
  4. Chen JT, Tominaga K, Sato Y, et al. Maitake mushroom (Grifola frondosa) extract induces ovulation in patients with polycystic ovary syndrome: a possible monotherapy and a combination therapy after failure with first-line clomiphene citrate. J Altern Compl
  5. Hanselin MR, Vande Griend JP, Linnebur SA. INR elevation with maitake extract in combination with warfarin. Ann Pharmacother 2010;44:223-4. PubMed
  6. Talpur, N. A., Echard, B. W., Fan, A. Y., Jaffari, O., Bagchi, D., and Preuss, H. G. Antihypertensive and metabolic effects of whole Maitake mushroom powder and its fractions in two rat strains. Mol.Cell Biochem. 2002;237(1-2):129-136. PubMed
  7. Deng, G., Lin, H., Seidman, A., Fornier, M., D'Andrea, G., Wesa, K., Yeung, S., Cunningham-Rundles, S., Vickers, A. J., and Cassileth, B. A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: i
  8. Wesa KM, Cunningham-Rundles S, Klimek VM, et al. Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II study. Cancer Immunol Immunother 2015;64(2):237-47. PubMed

See these in context on the Maitake Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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