Super Coriolus Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Super Coriolus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Super Coriolus is a dietary supplement by Mushroom Wisdom with 2 active ingredients. Its ingredients are commonly taken for common cold and immune support, antioxidant support, skin health and collagen formation.Based on those ingredients, 387 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin C, Coriolus (Coriolus versicolor) fruiting body extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Super Coriolus by Mushroom Wisdom
Ask about any prescription or over-the-counter medication and we check it for interactions with Super Coriolus by Mushroom Wisdom — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Super Coriolus by Mushroom Wisdom
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Super Coriolus contains 2 active ingredients: vitamin C and coriolus (turkey tail mushroom) fruiting body extract. Vitamin C is a well-known antioxidant nutrient; turkey tail is a mushroom traditionally used in some cultures, and this product delivers an extract of its fruiting body—the fleshy part that grows above ground.
The tablet also contains several inactive ingredients (dicalcium phosphate, microcrystalline cellulose, croscarmellose sodium, silicon dioxide, calcium stearate, hydroxypropyl methylcellulose, and glycerin), which are fillers, binders, and capsule materials that help hold the tablet together.
Does it work?
Not established
Vitamin C is effective for treating vitamin C deficiency and is possibly effective for anemia of chronic disease, atrial fibrillation, cataracts, and exercise-induced respiratory infections, based on the data we hold. Turkey tail mushroom extract is possibly effective for cancer support, but the evidence we have is insufficient to rate it for chronic fatigue syndrome, tinea corporis (fungal skin infection), upper respiratory tract infection, or genital herpes.
Keep in mind that this product combines these two ingredients; the evidence for each applies to that ingredient alone, not necessarily to the combination.
How safe is it?
Well-documented data
Vitamin C at normal dietary and supplement doses is generally well tolerated, though very high doses (above 2 grams daily) can cause abdominal cramps, heartburn, diarrhea, nausea, or kidney stones in those prone to them. Turkey tail mushroom extract is generally well tolerated in healthy adults, though some people taking it alongside chemotherapy have reported gastrointestinal side effects, and quality varies across products.
For pregnancy: vitamin C from food and prenatal vitamins is fine, but avoid high-dose supplements unless your doctor advises it. Turkey tail extract lacks enough safety data—avoid it during pregnancy and while breastfeeding unless a healthcare provider says otherwise.
Talk with your doctor or pharmacist before starting if you're pregnant, nursing, or planning pregnancy.
Meds to double-check
Moderate interaction found
Check your medications before taking this product if you use blood thinners like warfarin, birth control pills or hormone replacement therapy, chemotherapy drugs (cyclophosphamide, doxorubicin, tamoxifen), diabetes medications, the antipsychotic fluphenazine, the HIV drug indinavir, or thyroid medicine (levothyroxine). Moderate and minor interactions are documented for these drug types.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
Super Coriolus may be worth considering if you're interested in vitamin C supplementation or turkey tail mushroom support, but it has documented interactions with blood thinners, birth control, chemotherapy, diabetes drugs, and thyroid medication. If you take any prescription medications, check them against this product's interaction data before you start.
Talk with your doctor or pharmacist about whether it's right for you.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 11, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Super Coriolus, straight from the product label.
| Brand | Mushroom Wisdom |
|---|---|
| Barcode (UPC) | 791014109055 |
| Net contents | 120 Vegetarian Tablet(s) |
| Market status | On market |
| Date entered into DSLD | Apr 11, 2022 |
| DSLD ID | 261525 |
| Product type | Other Combinations |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Super Coriolus by Mushroom Wisdom, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Vitamin C | 80 mg | 133% |
| Coriolus (Coriolus versicolor) fruiting body extract | 900 mg | -- |
Other ingredients: Dicalcium Phosphate, Microcrystalline Cellulose, Croscarmellose Sodium, Silicon Dioxide, Calcium Stearate, Hydroxypropyl Methylcellulose, Glycerin
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)
Science complementing ancient wisdom
Formula
Coriolus mushroom has a long history of being used traditionally to nourish Jing and Qi and has now become one of the most researched mushroom supplements worldwide.
Formulation
Super Coriolus uses a hot water extract providing you the concentrated and researched constituents.
Mushroom Wisdom, with over 25 years of mushroom expertise, is committed to offering you the finest and most effective supplements, manufacturing them in a certified cGMP facility.
Immune & liver support
Suitable for Vegetarians
Contains no gluten, wheat, soy, dairy, artificial colors, flavors or preservatives.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Directions: Take 4 tablets once per day or 2 tablets twice per day.
Precautions
Warning: Keep out of reach of children.
Consult a physician before using if pregnant or nursing.
Do not use if seal is broken or missing.
Storage
Store in a cool dry place.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Super Coriolus by Mushroom Wisdom label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Super Coriolus by Mushroom Wisdom
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size4 Tablet(s) Dosage formTablet Or Pill Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Vitamin C
Interacts with207 drugs
Vitamin C (ascorbic acid) is an essential nutrient your body needs but cannot make, so you must get it from food or supplements. It's important for im...
Vitamin C monograph & interactionsCoriolus (Coriolus versicolor) fruiting body extract
Interacts with187 drugs
Turkey tail is a woodland mushroom rich in polysaccharides like beta-glucans, and it is mainly used to support the immune system. Some of its purified...
Coriolus (Coriolus versicolor) fruiting body extract monograph & interactionsOther (inactive) ingredients: Dicalcium Phosphate, Microcrystalline Cellulose, Croscarmellose Sodium, Silicon Dioxide, Calcium Stearate, Hydroxypropyl Methylcellulose, Glycerin. These complete the product’s ingredient list but are not active constituents.
Super Coriolus by Mushroom Wisdom Drug Interactions
HelloPharmacist Interaction Report
Super Coriolus by Mushroom Wisdom contains two active ingredients—vitamin C and turkey tail mushroom extract—and together they interact with medications across multiple drug categories.
The most serious concern is a moderate-severity interaction: vitamin C can reduce how well warfarin (a blood thinner) works, which matters because warfarin's job is to prevent clots.
Read the full breakdown — every affected drug type, severity by severity
Vitamin C also has moderate interactions with estrogens (including birth control and hormone replacement therapy, where it may raise estrogen levels), chemotherapy drugs like cyclophosphamide and doxorubicin (where its antioxidant effects might blunt the drugs' cancer-fighting power), aluminum supplements, the antipsychotic fluphenazine, the HIV drug indinavir, and thyroid medication (levothyroxine). Turkey tail mushroom adds moderate concerns with diabetes medications (raising low blood sugar risk), the chemotherapy drug tamoxifen, and cyclophosphamide again.
Turkey tail also has a minor interaction with a group of drugs metabolized by a liver enzyme called CYP2C9.
Altogether, these interactions span 387 individual medications.
Before you start this product, use the search tool below to check your exact medications. If you take a blood thinner, birth control, hormone therapy, any chemotherapy, diabetes medicine, or thyroid medication, talk with your doctor or pharmacist first.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Super Coriolus?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Super Coriolus interact with 387 drugs. Click any drug to see the details.
2 of the 2 ingredients in Super Coriolus interact with drugs. Each result below shows which ingredient is responsible. Vitamin C Coriolus (Coriolus versicolor) fruiting body extract
AcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Super Coriolus — through 1 ingredient. Tap an ingredient for the detail:
Coriolus (coriolus Versicolor) Fruiting Body ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking turkey tail mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Coriolus (coriolus Versicolor) Fruiting Body Extract + Acarbose interactionAcetohexamideDymelor
How Acetohexamide interacts with Super Coriolus — through 1 ingredient. Tap an ingredient for the detail:
Coriolus (coriolus Versicolor) Fruiting Body ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking turkey tail mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Coriolus (coriolus Versicolor) Fruiting Body Extract + Acetohexamide interactionAlbiglutideTanzeum
How Albiglutide interacts with Super Coriolus — through 1 ingredient. Tap an ingredient for the detail:
Coriolus (coriolus Versicolor) Fruiting Body ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking turkey tail mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Coriolus (coriolus Versicolor) Fruiting Body Extract + Albiglutide interactionAlginic Acid, Aluminum HydroxideRafton
How Alginic Acid, Aluminum Hydroxide interacts with Super Coriolus — through 1 ingredient. Tap an ingredient for the detail:
Vitamin CAluminum Moderate
Interaction Summary
Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Read the full Vitamin C + Alginic Acid, Aluminum Hydroxide interactionAlogliptinNesina
How Alogliptin interacts with Super Coriolus — through 1 ingredient. Tap an ingredient for the detail:
Coriolus (coriolus Versicolor) Fruiting Body ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking turkey tail mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Coriolus (coriolus Versicolor) Fruiting Body Extract + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Super Coriolus — through 1 ingredient. Tap an ingredient for the detail:
Coriolus (coriolus Versicolor) Fruiting Body ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking turkey tail mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Coriolus (coriolus Versicolor) Fruiting Body Extract + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Super Coriolus — through 1 ingredient. Tap an ingredient for the detail:
Coriolus (coriolus Versicolor) Fruiting Body ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking turkey tail mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Coriolus (coriolus Versicolor) Fruiting Body Extract + Alogliptin, Pioglitazone interactionAltretamineHexalen
How Altretamine interacts with Super Coriolus — through 1 ingredient. Tap an ingredient for the detail:
Vitamin CAlkylating Agents Moderate
Interaction Summary
Theoretically, antioxidant effects of vitamin C might reduce the effectiveness of alkylating agents.
Read the full Vitamin C + Altretamine interactionAluminum Acetate, Benzethonium ChlorideBuro-Sol Otic Solution
How Aluminum Acetate, Benzethonium Chloride interacts with Super Coriolus — through 1 ingredient. Tap an ingredient for the detail:
Vitamin CAluminum Moderate
Interaction Summary
Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Read the full Vitamin C + Aluminum Acetate, Benzethonium Chloride interactionAluminum ChlorideAluminum Chloride, Anhydrol Forte, Driclor, Drysol
How Aluminum Chloride interacts with Super Coriolus — through 1 ingredient. Tap an ingredient for the detail:
Vitamin CAluminum Moderate
Interaction Summary
Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Read the full Vitamin C + Aluminum Chloride interactionAluminum HydroxideAlu-Cap, Amphojel, Gaviscon
How Aluminum Hydroxide interacts with Super Coriolus — through 1 ingredient. Tap an ingredient for the detail:
Vitamin CAluminum Moderate
Interaction Summary
Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Read the full Vitamin C + Aluminum Hydroxide interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Super Coriolus — through 1 ingredient. Tap an ingredient for the detail:
Vitamin CAspirin, Aluminum Moderate
Interaction Summary
Acidification of the urine by vitamin C might increase aspirin levels.
Read the full Vitamin C + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with Super Coriolus — through 1 ingredient. Tap an ingredient for the detail:
Vitamin CAspirin, Aluminum Moderate
Interaction Summary
Acidification of the urine by vitamin C might increase aspirin levels.
Read the full Vitamin C + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAluminum Hydroxide, Magnesium Hydroxide (otc Drug)Maalox, Mucogel
How Aluminum Hydroxide, Magnesium Hydroxide (otc Drug) interacts with Super Coriolus — through 1 ingredient. Tap an ingredient for the detail:
Vitamin CAluminum Moderate
Interaction Summary
Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Read the full Vitamin C + Aluminum Hydroxide, Magnesium Hydroxide (otc Drug) interactionAluminum Hydroxide, Magnesium Hydroxide, Simethicone (otc Drug)Mylanta
How Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (otc Drug) interacts with Super Coriolus — through 1 ingredient. Tap an ingredient for the detail:
Vitamin CAluminum Moderate
Interaction Summary
Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Read the full Vitamin C + Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (otc Drug) interactionAluminum, CalciumDomeboro
How Aluminum, Calcium interacts with Super Coriolus — through 1 ingredient. Tap an ingredient for the detail:
Vitamin CAluminum Moderate
Interaction Summary
Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Read the full Vitamin C + Aluminum, Calcium interactionAluminum, Magnesium (otc Drug)Almagel
How Aluminum, Magnesium (otc Drug) interacts with Super Coriolus — through 1 ingredient. Tap an ingredient for the detail:
Vitamin CAluminum Moderate
Interaction Summary
Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Read the full Vitamin C + Aluminum, Magnesium (otc Drug) interactionAluminum, Magnesium Hydroxide (otc Drug)Wingel
How Aluminum, Magnesium Hydroxide (otc Drug) interacts with Super Coriolus — through 1 ingredient. Tap an ingredient for the detail:
Vitamin CAluminum Moderate
Interaction Summary
Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Read the full Vitamin C + Aluminum, Magnesium Hydroxide (otc Drug) interactionAntidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
How Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interacts with Super Coriolus — through 1 ingredient. Tap an ingredient for the detail:
Coriolus (coriolus Versicolor) Fruiting Body ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking turkey tail mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Coriolus (coriolus Versicolor) Fruiting Body Extract + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionAspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #3
How Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interacts with Super Coriolus — through 1 ingredient. Tap an ingredient for the detail:
Vitamin CAspirin, Aluminum Moderate
Interaction Summary
Acidification of the urine by vitamin C might increase aspirin levels.
Read the full Vitamin C + Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interactionBazedoxifene Acetate, Conjugated EstrogensDuavee
How Bazedoxifene Acetate, Conjugated Estrogens interacts with Super Coriolus — through 1 ingredient. Tap an ingredient for the detail:
Vitamin CEstrogens Moderate
Interaction Summary
Vitamin C might increase blood levels of estrogens.
Read the full Vitamin C + Bazedoxifene Acetate, Conjugated Estrogens interactionBendamustineBelrapzo, Treanda, Vivimusta
How Bendamustine interacts with Super Coriolus — through 1 ingredient. Tap an ingredient for the detail:
Vitamin CAlkylating Agents Moderate
Interaction Summary
Theoretically, antioxidant effects of vitamin C might reduce the effectiveness of alkylating agents.
Read the full Vitamin C + Bendamustine interactionBendamustine HydrochlorideBendeka
How Bendamustine Hydrochloride interacts with Super Coriolus — through 1 ingredient. Tap an ingredient for the detail:
Vitamin CAlkylating Agents Moderate
Interaction Summary
Theoretically, antioxidant effects of vitamin C might reduce the effectiveness of alkylating agents.
Read the full Vitamin C + Bendamustine Hydrochloride interactionBleomycinBlenoxane
How Bleomycin interacts with Super Coriolus — through 1 ingredient. Tap an ingredient for the detail:
Vitamin CAntitumor Antibiotics Moderate
Interaction Summary
Theoretically, the antioxidant effects of vitamin C might reduce the effectiveness of antitumor antibiotics.
Read the full Vitamin C + Bleomycin interactionBusulfanBusulfex, Myleran
How Busulfan interacts with Super Coriolus — through 1 ingredient. Tap an ingredient for the detail:
Vitamin CAlkylating Agents Moderate
Interaction Summary
Theoretically, antioxidant effects of vitamin C might reduce the effectiveness of alkylating agents.
Read the full Vitamin C + Busulfan interactionCanagliflozinInvokana
How Canagliflozin interacts with Super Coriolus — through 1 ingredient. Tap an ingredient for the detail:
Coriolus (coriolus Versicolor) Fruiting Body ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking turkey tail mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Coriolus (coriolus Versicolor) Fruiting Body Extract + Canagliflozin interactionCanagliflozin, MetforminInvokamet
How Canagliflozin, Metformin interacts with Super Coriolus — through 1 ingredient. Tap an ingredient for the detail:
Coriolus (coriolus Versicolor) Fruiting Body ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking turkey tail mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Coriolus (coriolus Versicolor) Fruiting Body Extract + Canagliflozin, Metformin interactionCanagliflozin, Metformin HydrochlorideInvokamet XR
How Canagliflozin, Metformin Hydrochloride interacts with Super Coriolus — through 1 ingredient. Tap an ingredient for the detail:
Coriolus (coriolus Versicolor) Fruiting Body ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking turkey tail mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Coriolus (coriolus Versicolor) Fruiting Body Extract + Canagliflozin, Metformin Hydrochloride interactionCarboplatinParaplatin
How Carboplatin interacts with Super Coriolus — through 1 ingredient. Tap an ingredient for the detail:
Vitamin CAlkylating Agents Moderate
Interaction Summary
Theoretically, antioxidant effects of vitamin C might reduce the effectiveness of alkylating agents.
Read the full Vitamin C + Carboplatin interactionCarmustineBiCNU, Gliadel, Gliadel Wafer
How Carmustine interacts with Super Coriolus — through 1 ingredient. Tap an ingredient for the detail:
Vitamin CAlkylating Agents Moderate
Interaction Summary
Theoretically, antioxidant effects of vitamin C might reduce the effectiveness of alkylating agents.
Read the full Vitamin C + Carmustine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Super Coriolus with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Vitamin C
Alkylating Agents
Theoretically, antioxidant effects of vitamin C might reduce the effectiveness of alkylating agents.
The use of antioxidants like vitamin C during chemotherapy is controversial. There is concern that antioxidants could reduce the activity of chemotherapy drugs that generate free radicals, such as cyclophosphamide, chlorambucil, carmustine, busulfan, and thiotepa. In contrast, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin C have on chemotherapy.
Aluminum
Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Research in animals and humans shows that vitamin C increases aluminum absorption, theoretically by chelating aluminum and keeping it in solution where it is available for absorption. In people with normal renal function, urinary excretion of aluminum will likely increase, making aluminum retention and toxicity unlikely. Patients with renal failure who take aluminum-containing compounds such as phosphate binders should avoid vitamin C supplements in doses above the recommended dietary allowances.
Antitumor Antibiotics
Theoretically, the antioxidant effects of vitamin C might reduce the effectiveness of antitumor antibiotics.
The use of antioxidants like vitamin C during chemotherapy is controversial. There is concern that antioxidants could reduce the activity of chemotherapy drugs which generate free radicals, such as doxorubicin. In contrast, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effects, if any, antioxidants such as vitamin C have on chemotherapy.
Estrogens
Vitamin C might increase blood levels of estrogens.
Increases in plasma estrogen levels of up to 55% occur under some circumstances when vitamin C is taken concurrently with oral contraceptives or hormone replacement therapy, including topical products. It is suggested that vitamin C prevents oxidation of estrogen in the tissues, regenerates oxidized estrogen, and reduces sulfate conjugation of estrogen in the gut wall. When tissue levels of vitamin C are high, these processes are already maximized and supplemental vitamin C does not have any effect on estrogen levels. Increases in plasma estrogen levels may occur when patients who are deficient in vitamin C take supplements. Monitor these patients for estrogen-related side effects.
Fluphenazine (Prolixin)
Theoretically, vitamin C might decrease levels of fluphenazine.
In one patient there was a clinically significant decrease in fluphenazine levels when vitamin C (500 mg twice daily) was started. The mechanism is not known, and there is no further data to confirm this interaction.
Indinavir (Crixivan)
Vitamin C can modestly reduce indinavir levels.
One pharmacokinetic study shows that taking vitamin C 1 gram orally once daily along with indinavir 800 mg orally three times daily reduces the area under the concentration-time curve of indinavir by 14%. The mechanism of this interaction is unknown, but it is unlikely to be clinically significant in most patients. The effect of higher doses of vitamin C on indinavir levels is unknown.
Levothyroxine (Synthroid, Others)
Vitamin C can increase levothyroxine absorption.
Two clinical studies in adults with poorly controlled hypothyroidism show that swallowing levothyroxine with a glass of water containing vitamin C 500-1000 mg in solution reduces thyroid stimulating hormone (TSH) levels and increases thyroxine (T4) levels when compared with taking levothyroxine alone. This suggests that vitamin C increases the oral absorption of levothyroxine, possibly due to a reduction in pH.
Warfarin (Coumadin)
High-dose vitamin C might reduce the levels and effectiveness of warfarin.
Vitamin C in high doses may cause diarrhea and possibly reduce warfarin absorption. There are reports of two people who took up to 16 grams daily of vitamin C and had a reduction in prothrombin time. Lower doses of 5-10 grams daily can also reduce warfarin absorption. In many cases, this does not seem to be clinically significant. However, a case of warfarin resistance has been reported for a patient who took vitamin C 500 mg twice daily. Cessation of vitamin C supplementation resulted in a rapid increase in international normalized ratio (INR). Tell patients taking warfarin to avoid taking vitamin C in excessively high doses (greater than 10 grams daily). Lower doses may be safe, but the anticoagulation activity of warfarin should be monitored. Patients who are stabilized on warfarin while taking vitamin C should avoid adjusting vitamin C dosage to prevent the possibility of warfarin resistance.
Acetaminophen (Tylenol, Others)
High-dose vitamin C might slightly prolong the clearance of acetaminophen.
A small pharmacokinetic study in healthy volunteers shows that taking high-dose vitamin C (3 grams) 1.5 hours after taking acetaminophen 1 gram slightly increases the apparent half-life of acetaminophen from around 2.3 hours to 3.1 hours. Ascorbic acid competitively inhibits sulfate conjugation of acetaminophen. However, to compensate, elimination of acetaminophen glucuronide and unconjugated acetaminophen increases. This effect is not likely to be clinically significant.
Aspirin
Acidification of the urine by vitamin C might increase aspirin levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams daily of vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction is not clinically significant.
Choline Magnesium Trisalicylate (Trilisate)
Acidification of the urine by vitamin C might increase choline magnesium trisalicylate levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams daily of vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction probably is not clinically significant.
Niacin
Vitamin C might decrease the beneficial effects of niacin on high-density lipoprotein (HDL) cholesterol levels.
A combination of niacin and simvastatin (Zocor) effectively raises HDL cholesterol levels in patients with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50% in patients with coronary disease. It is not known whether this adverse effect is due to a single antioxidant such as vitamin C, or to the combination. It also is not known whether it will occur in other patient populations.
Salsalate (Disalcid)
Acidification of the urine by vitamin C might increase salsalate levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams/day vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction probably is not clinically significant.
Coriolus (Coriolus versicolor) fruiting body extract
Antidiabetes Drugs
Theoretically, taking turkey tail mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that turkey tail mushroom and a polysaccharide component can have hypoglycemic effects.
Cyclophosphamide
Theoretically, the polysaccharide peptide (PSP) component of turkey tail mushroom might increase exposure to cyclophosphamide.
Some animal research shows that the PSP component of turkey tail mushroom can increase the area under the concentration-time curve (AUC) of cyclophosphamide by 44% to 50% and the half-life by 34% to 43%. This interaction could potentially increase the effects and adverse effects of cyclophosphamide. However, it is not known whether PSP affects the levels of the active metabolites of cyclophosphamide that are responsible for its clinical activity.
Tamoxifen (Nolvadex)
Theoretically, the polysaccharide peptide (PSP) component of turkey tail mushroom might interfere with the absorption of tamoxifen.
Animal research suggests that PSP increases the time to reach maximum concentration of a single dose of tamoxifen by about 9.5 hours, or 228%. When repeated doses of tamoxifen were given, the time to reach maximum concentration was increased by about 5.6 hours, or 93%. However, PSP did not affect the maximum concentration or the area under the curve of tamoxifen.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, the polysaccharide peptide (PSP) component of turkey tail mushroom might inhibit CYP2C9.
Laboratory research suggests that the PSP component of turkey tail mushroom dose-dependently inhibits CYP2C9. Theoretically, taking PSP with drugs metabolized by CYP2C9 might increase drug levels and the risk of adverse effects. However, this has not been reported in humans.
Brand information
Manufacturer and brand details for Super Coriolus, from the product label.
Mushroom Wisdom
See all Mushroom Wisdom products- Name
- Mushroom Wisdom, Inc.
- Street Address
- 1 Madison St., Bldg. F6
- City
- E. Rutherford
- State
- NJ
- ZipCode
- 07073
- Phone Number
- 800-747-7418
- Web Address
- www.mushroomwisdom.com
Super Coriolus by Mushroom Wisdom: Common Questions
Does Super Coriolus by Mushroom Wisdom interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I'm on birth control?
Is turkey tail mushroom extract safe to take with chemotherapy?
Will this help my cold or flu?
What side effects might the vitamin C cause?
Is it safe in pregnancy?
Does it work for fatigue or immune support?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Super Coriolus is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Super Coriolus’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Vitamin C
Interacts with 207 drugsVitamin C (ascorbic acid) is an essential nutrient your body needs but cannot make, so you must get it from food or supplements. It's important for immune function, collagen, and acts as an...
Read the full Vitamin C monograph → Herb & supplement monographTurkey Tail Mushroom
Interacts with 187 drugsTurkey tail is a woodland mushroom rich in polysaccharides like beta-glucans, and it is mainly used to support the immune system. Some of its purified extracts (PSK and PSP) have been studie...
Read the full Turkey Tail Mushroom monograph →Sources & How We Checked
Super Coriolus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 66 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Vitamin C 51 references
- McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
- Back DJ, Breckenridge AM, MacIver M, et al. Interaction of ethinyloestradiol with ascorbic acid in man. Br Med J (Clin Res Ed) 1981;282:1516.
- Morris JC, Beeley L, Ballantine N. Interaction of ethinyloestradiol with ascorbic acid in man [letter]. Br Med J (Clin Res Ed) 1981;283:503.
- Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999;13:1003-8.
- Dwyer JH, Merz NB, Shirocre AM, et al. Progression of early atherosclerosis and intake of vitamin C and vitamin E from supplements and food. The Los Angeles Atherosclerosis Study. 41st Annual Conference on Cardiovascular Disease Epidemiology and Prevent
- Levine M, Rumsey SC, Daruwala R, et al. Criteria and recommendations for vitamin C intake. JAMA 1999;281:1415-23. PubMed
- Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
- Segal S, Kaminski S. Drug-nutrient interactions. American Druggist 1996 Jul;42-8.
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: National Academy Press, 2000. Available at: http://www.nap.edu/books/0309069351/html/.
- Houston JB, Levy G. Drug biotransformation interactions in man VI: Acetaminophen and ascorbic acid. J Pharm Sci 1976;65:1218-21. PubMed
- Brown BG, Zhao XQ, Chait A, et al. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med 2001;345:1583-93. DOI
- Rosenthal G. Interaction of ascorbic acid and warfarin. JAMA 1971;215:1671. DOI
- Hume R, Johnstone JM, Weyers E. Interaction of ascorbic acid and warfarin. JAMA 1972;219:1479. DOI
- Smith EC, Skalski RJ, Johnson GC, Rossi GV. Interaction of ascorbic acid and warfarin. JAMA 1972;221:1166. DOI
- Traxer O, Huet B, Poindexter J, et al. Effect of ascorbic acid consumption on urinary stone risk factors. J Urol 2003;170:397-401.. PubMed
- Domingo JL, Gomez M, Llobet JM, Richart C. Effect of ascorbic acid on gastrointestinal aluminum absorption (letter). Lancet 1991;338:1467.
- Domingo JL, Gomez M, Llobet JM, Corbella J. Influence of some dietary constituents on aluminum absorption and retention in rats. Kidney Int 1991;39:598-601. PubMed
- Partridge NA, Regnier FE, White JL, Hem SL. Influence of dietary constituents on intestinal absorption of aluminum. Kidney Int 1989;35:1413-7. PubMed
- Mc Leod DC, Nahata MC. Inefficacy of ascorbic acid as a urinary acidifier (letter). N Engl J Med 1977;296:1413. DOI
- Hansten PD, Hayton WL. Effect of antacid and ascorbic acid on serum salicylate concentration. J Clin Pharmacol 1980;20:326-31. PubMed
- Dysken MW, Cumming RJ, Channon RA, Davis JM. Drug interaction between ascorbic acid and fluphenazine. JAMA 1979;241:2008. DOI
- Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. PubMed
- Slain D, Amsden JR, Khakoo RA, et al. Effect of high-dose vitamin C on the steady-state pharmacokinetics of the protease inhibitor indinavir in healthy volunteers. Pharmacotherapy 2005;25:165-70. PubMed
- Cheung MC, Zhao XQ, Chait A, et al. Antioxidant supplements block the response of HDL to simvastatin-niacin therapy in patients with coronary artery disease and low HDL. Arterioscler Thromb Vasc Biol 2001;21:1320-6. PubMed
- Feetam CL, Leach RH, Meynell MJ. Lack of a clinically important interaction between warfarin and ascorbic acid. Toxicol Appl Pharmacol 1975;31:544-7. PubMed
- Weintraub M, Griner PF. Warfarin and ascorbic acid: lack of evidence for a drug interaction. Toxicol Appl Pharmacol 1974;28:53-6. PubMed
- Lee DH, Folsom AR, Harnack L, et al. Does supplemental vitamin C increase cardiovascular disease risk in women with diabetes? Am J Clin Nutr 2004;80:1194-200. PubMed
- Taylor EN, Stampfer MJ, Curhan GC. Dietary factors and the risk of incident kidney stones in men: new insights after 14 years of follow-up. J Am Soc Nephrol 2004;15:3225-32. PubMed
- Ward NC, Hodgson JM, Croft KD, et al. The combination of vitamin C and grape-seed polyphenols increases blood pressure: a randomized, double-blind, placebo-controlled trial. J Hypertens 2005;23:427-34.. PubMed
- Prasad KN. Rationale for using high-dose multiple dietary antioxidants as an adjunct to radiation therapy and chemotherapy. J Nutr 2004;134:3182S-3S. PubMed
- Conklin KA. Cancer chemotherapy and antioxidants. J Nutr 2004;134:3201S-3204S. PubMed
- Fairweather-Tait S, Hickson K, McGaw B, et al. Orange juice enhances aluminium absorption from antacid preparation. Eur J Clin Nutr. 1994;48(1):71-3.
- Gruenwald, J., Graubaum, H. J., Busch, R., and Bentley, C. Safety and tolerance of ester-C compared with regular ascorbic acid. Adv.Ther. 2006;23(1):171-178.
- Rahimi, R., Nikfar, S., Rezaie, A., and Abdollahi, M. A meta-analysis on the efficacy and safety of combined vitamin C and E supplementation in preeclamptic women. Hypertens.Pregnancy. 2009;28(4):417-434. PubMed
- Einerson, B., Nathorn, C., Kitiyakara, C., Sirada, M., and Thamlikitkul, V. The efficacy of ascorbic acid in suboptimal responsive anemic hemodialysis patients receiving erythropoietin: a meta-analysis. J Med.Assoc.Thai. 2011;94 Suppl 1:S134-S146.
- Li, G., Li, L., Yu, C., and Chen, L. Effect of vitamins C and E supplementation on Helicobacter pylori eradication: a meta-analysis. Br.J Nutr 2011;106(11):1632-1637.
- Chen X, Shen L, Gu X, et al. High-dose supplementation with vitamin C--induced pediatric urolithiasis: the first case report in a child and literature review. Urology. 2014;84(4):922-4. PubMed
- Sattar A, Willman JE, Kolluri R. Possible warfarin resistance due to interaction with ascorbic acid: case report and literature review. Am J Health Syst Pharm. 2013;70(9):782-6. PubMed
- Yaich S, Chaabouni Y, Charfeddine K, et al. Secondary oxalosis due to excess vitamin C intake: a cause of graft loss in a renal transplant recipient. Saudi J Kidney Dis Transpl. 2014;25(1):113-6. PubMed
- Jalloh MA, Gregory PJ, Hein D, et al. Dietary supplement interactions with antiretrovirals: a systematic review. Int J STD AIDS. 2017 Jan;28(1):4-15. PubMed
- Rumbold A, Ota E, Nagata C, Shahrook S, Crowther CA. Vitamin C supplementation in pregnancy. Cochrane Database Syst Rev. 2015;(9):CD004072. PubMed
- Seo MS, Kim JK, Shim JY. High-dose vitamin C promotes regression of multiple pulmonary metastases originating from hepatocellular carcinoma. Yonsei Med J. 2015;56(5):1449-52. PubMed
- Skelin M, Lucijanic T, Amidzic Klaric D, et al. Factors Affecting Gastrointestinal Absorption of Levothyroxine: A Review. Clin Ther. 2017 Feb;39(2):378-403. PubMed
- Jiang K, Tang K, Liu H, Xu H, Ye Z, Chen Z. Ascorbic acid supplements and kidney stones incidence among men and women: a systematic review and meta-analysis. Urol J. 2019;16(2):115-120.
- Thomas S, Patel D, Bittel B, et al. Effect of High-Dose Zinc and Ascorbic Acid Supplementation vs Usual Care on Symptom Length and Reduction Among Ambulatory Patients With SARS-CoV-2 Infection: The COVID A to Z Randomized Clinical Trial. JAMA Netw Open. 2 PubMed
- Giffen MA, McLemore JL. Hyperoxalosis Secondary to Intravenous Vitamin C Administration as a Non-Allopathic Treatment for Cancer. Acad Forensic Pathol 2019;9(1-2):118-126. PubMed
- Maike A, Sturgill D, Gallan A. Oxalate Nephropathy in a Renal Transplant Recipient After Receiving High Dose Ascorbic Acid. Am J Med Sci 2021. PubMed
- Shen ZY, Chen YR, Wang MC, Chang SS. High-dose vitamin C-induced acute oxalate nephropathy in a renal transplant recipient: a case report and literature review. Asian J Surg 2022. PubMed
- Yanase F, Spano S, Maeda A, et al. Mega-dose sodium ascorbate: a pilot, single-dose, physiological effect, double-blind, randomized, controlled trial. Crit Care 2023;27(1):371. PubMed
- Sharma Y, Sumanadasa S, Shahi R, et al. Efficacy and safety of vitamin C supplementation in the treatment of community-acquired pneumonia: a systematic review and meta-analysis with trial sequential analysis. Sci Rep 2024;14(1):11846. PubMed
- Pejcic AV, Petrovic NZ, Djordjic MD, Milosavljevic MN. Vitamin C Levels in Pregnant Women and the Efficacy of Vitamin C Supplements in Preventing Premature Rupture of Membranes: A Systematic Review and Meta-Analysis. Balkan Med J 2024;41(4):248-260. PubMed
Turkey Tail Mushroom 15 references
- Nakazato H, Koike A, Saji S, et al. Efficacy of immunochemotherapy as adjuvant treatment after curative resection of gastric cancer. Study Group of Immunochemotherapy with PSK for Gastric Cancer. Lancet 1994;343:1122-6. PubMed
- Mitomi T, Tsuchiya S, Iijima N, et al. Randomized, controlled study on adjuvant immunochemotherapy with PSK in curatively resected colorectal cancer. The Cooperative Study Group of Surgical Adjuvant Immunochemotherapy for Cancer of Colon and Rectum (Kanag DOI
- Torisu M, Hayashi Y, Ishimitsu T, et al. Significant prolongation of disease-free period gained by oral polysaccharide K (PSK) administration after curative surgical operation of colorectal cancer. Cancer Immunol Immunother 1990;31:261-8. PubMed
- Tsujitani, S., Kakeji, Y., Orita, H., Watanabe, A., Kohnoe, S., Baba, H., Anai, H., Maehara, Y., and Sugimachi, K. Postoperative adjuvant immunochemotherapy and infiltration of dendritic cells for patients with advanced gastric cancer. Anticancer Res 199
- Kojima, J., Kamata, T., and Monna, T. [Evaluation of immunochemotherapy in patients with primary liver cancer. Osaka Research Society for Liver, Gallbladder and Pancreas]. Gan To Kagaku Ryoho 1987;14(1):179-187.
- Fukuo, Y., Terashi, A., Hayashi, Y., Yano, Y., and Atarashi, J. [A clinical trial of cis-platinum (II) in combination with PSK and FT-207 in advanced stomach cancer]. Gan To Kagaku Ryoho 1985;12(4):960-965.
- Imaizumi, M., Kondo, T., Kamei, H., and Ichihashi, H. [Cooperative studies on surgical adjuvant immunochemotherapy for prevention of postoperative recurrence of gastric cancer]. Gan To Kagaku Ryoho 1984;11(1):60-68.
- Yeung JH and Or PM. Polysaccharide peptides from Coriolus versicolor competitively inhibit tolbutamide 4-hydroxylation in specific human CYP2C9 isoform and pooled human liver microsomes. Phytomedicine 2011;18(13):1170-5. PubMed
- Eliza WL, Fai CK, Chung LP. Efficacy of Yun Zhi (Coriolus versicolor) on survival in cancer patients: systematic review and meta-analysis. Recent Pat Inflamm Allergy Drug Discov 2012;6(1):78-87. PubMed
- Chan SL, Yeung JH. Effects of polysaccharide peptide (PSP) from Coriolus versicolor on the pharmacokinetics of cyclophosphamide in the rat and cytotoxicity in HepG2 cells. Food Chem Toxicol 2006;44:689-94. PubMed
- Serrano L, López AC, González SP, et al. Efficacy of a Coriolus versicolor-based vaginal gel in women with human papillomavirus-dependent cervical lesions: The PALOMA study. J Low Genit Tract Dis 2021;25(2):130-136. PubMed
- Meng F, Lin Y, Hu L, Feng W, Su P, Wu L. The therapeutic effect of Coriolus versicolor fruiting body on STZ-induced ICR diabetic mice. J Healthc Eng 2022;2022:7282453. PubMed
- Razmovski-Naumovski V, Kimble B, Laurenti D, Nammi S, Norimoto H, Chan K. Polysaccharide peptide extract from Coriolus versicolor increased T(max) of tamoxifen and maintained biochemical serum parameters, with no change in the metabolism of tamoxifen in t
- Cortés Bordoy J, de Santiago García J, Agenjo González M, et al. Effect of a multi-ingredient Coriolus-versicolor-based vaginal gel in women with HPV-dependent cervical lesions: The papilobs real-life prospective study. Cancers (Basel) 2023;15(15):3863. PubMed
- Nikolic M, Lazarevic N, Novakovic J, et al. Characterization, in vitro biological activity and in vivo cardioprotective properties of Trametes versicolor (L.:Fr.) quél. heteropolysaccharides in a rat model of metabolic syndrome. Pharmaceuticals (Basel) 20 PubMed
See these in context on the Turkey Tail Mushroom monograph →
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC