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Dietary supplement

Lion's Mane Ingredients & Drug Interactions

by HealthForce SuperFoods

Lion's Mane label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lion's Mane against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Lion's Mane is a dietary supplement by HealthForce SuperFoods with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, nerve health, mood and anxiety.Based on those ingredients, 327 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lion's Mane fruiting body extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Lion's Mane by HealthForce SuperFoods

Ask about any prescription or over-the-counter medication and we check it for interactions with Lion's Mane by HealthForce SuperFoods — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Lion's Mane by HealthForce SuperFoods

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.

This product is a single-ingredient supplement: lion's mane fruiting body extract. That's the whole active component — no fillers or other ingredients to list.

Lion's mane is a mushroom that's been used in traditional medicine, and the extract concentrates its active compounds, mainly polysaccharides.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Lion's Mane Mushroom's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Memory and nerve tonic.
  • We looked for evidence on: Memory, Cognitive function, Cognitive impairment, Anxiety, Dementia, Alzheimer disease — and 4 related terms.
  • The closest evidence on file: Lion's Mane Mushroom is rated "Insufficient Reliable Evidence To Rate" for Alzheimer disease (Natural Medicines).
  • Also on file: Lion's Mane Mushroom is rated "Insufficient Reliable Evidence To Rate" for Anxiety, Cognitive function, Cognitive impairment, Dementia, and more.

The evidence we hold doesn't establish that lion's mane works for the conditions listed — Alzheimer's disease, anxiety, athletic performance, cancer, cognitive function, and cognitive impairment all show insufficient reliable evidence to rate. That doesn't mean it doesn't work; it means the data we have isn't solid enough yet to say.

If you're considering lion's mane for one of these reasons, talk with your pharmacist about what the current research actually shows.

The evidence, ingredient by ingredient Lion's Mane Mushroom

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 0 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Orally, lion's mane mushroom is generally well tolerated as a food. In supplement form, the long-term safety hasn't been well studied.

The most common side effects reported are gastrointestinal discomfort, nausea, and skin rash — usually mild. During pregnancy and breastfeeding, there isn't enough safety data, so it's best to avoid it.

If you're pregnant, nursing, or planning to become pregnant, talk with your doctor before taking this.

Side effects, ingredient by ingredient Lion's Mane Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lion's Mane Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 327 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist if you take blood thinners or antiplatelet drugs (like warfarin or aspirin), diabetes medications, or immunosuppressants. These interactions are rated Moderate, and the extract may increase bleeding risk, lower blood sugar further, or interfere with immune-suppressing therapy.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and some safety-information gaps remain.

Lion's mane might appeal to you if you're curious about traditional mushroom supplements and you don't take blood thinners, diabetes drugs, or immunosuppressants. If you do take any of those, check with your pharmacist first.

Because long-term supplement safety hasn't been well studied, it's worth a conversation before you start — especially if you're on any regular medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lion's Mane, straight from the product label.

Brand HealthForce SuperFoods
Barcode (UPC) 650786003827
Net contents 10 Gram(s); 0.35 Ounce(s)
Market status On market
Date entered into DSLD Sep 25, 2024
DSLD ID 317490
Product type Botanical
Supplement form Powder
Dietary claims / uses Nutrient, All Other
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Organic, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lion's Mane by HealthForce SuperFoods, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Gram(s)
Maximum serving Sizes:
3 Gram(s)
Servings per container
3
UPC/BARCODE
650786003827
IngredientAmount% DV
Lion's Mane fruiting body extract0 NP--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: 1 teaspoon per day, or as advised by a qualified health care professional. Add to smoothies, teas, or hot water. Consume with conscious, positive intent.

General Statements

For supplemental facts, visit www.healthforcesuperfoods.com

Formulation

Memory & nerve tonic

USDA Organic OTCO (Oregon Tilth Certified Organic) Certified organic & gluten free

Certified vegan Vegan.org

Certified organic & gluten free GFCO.org Certified Gluten-free

Hot water extracted (1:1) Lab tested for purity

No added fillers, starch, or grains No flow agents

Certified organic by Oregon Tilth

FDA Statement of Identity

Dietary Supplement

Formula

OU Pareve (Kosher)

25% 1, 3-1, 6 beta-glucans Wood-grown fruiting bodies

Seals/Symbols

USDA Organic OTCO (Oregon Tilth Certified Organic) Certified Vegan Vegan.org GFCO.org Certified Gluten-free OU Pareve (Kosher)

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lion's Mane by HealthForce SuperFoods label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lion's Mane label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lion's Mane by HealthForce SuperFoods

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size3 Gram(s) Dosage formPowder Servings per container3 Amounts shown are per serving.

Lion's Mane fruiting body extract

Interacts with
327 drugs
0 NP per serving

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and...

Lion's Mane fruiting body extract monograph & interactions
Interaction report

Lion's Mane by HealthForce SuperFoods Drug Interactions

Want to check YOUR meds against Lion's Mane?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
327Drugs
327 Moderate

Ingredients driving the most interactions

Lion's Mane fruiting body extract 327

Individual Drug Interactions

The ingredients in Lion's Mane interact with 327 drugs. Click any drug to see the details.

1 of the 1 ingredient in Lion's Mane interact with drugs. Each result below shows which ingredient is responsible. Lion's Mane fruiting body extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Lion's Mane with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lion's Mane fruiting body extract3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
In vitro research suggests that lion's mane mushroom extracts can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lion's mane mushroom can reduce serum glucose and increase serum insulin.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
In animal and in vitro research, lion's mane mushroom polysaccharides stimulate the immune system.

Likelihood Possible Evidence D
Lion's Mane fruiting body extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lion's Mane, from the product label.

HealthForce SuperFoods

See all HealthForce SuperFoods products
Name
Excelsior Alchemy
City
Tempe
State
AZ
ZipCode
85284
Phone Number
(800) 748-6229
Web Address
www.HealthForceSuperFoods.com
Pharmacist Counseling Corner

Lion's Mane by HealthForce SuperFoods: Common Questions

Does Lion's Mane by HealthForce SuperFoods interact with any medications?
Yes. Based on its ingredients, Lion's Mane has a known interaction with 327 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lion's Mane contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What exactly is lion's mane extract?
It's a concentrated extract from the fruiting body of lion's mane mushroom, which is a fungus used in traditional medicine. This product contains just that extract — nothing else added.
Can lion's mane help with memory or focus?
The data we hold shows insufficient evidence to say whether it works for cognitive function or cognitive impairment. More reliable research is needed before we can make that claim.
What side effects should I expect?
Most people tolerate it well, but gastrointestinal discomfort, nausea, and skin rash have been reported. These are usually mild. If you notice any of these, stop and talk with your pharmacist.
Is it safe to take while pregnant or breastfeeding?
No — there isn't enough safety data, so it's best to avoid it during pregnancy and while nursing. Talk with your doctor or pharmacist before taking it if you're pregnant, planning to be, or breastfeeding.
Why does the label warn about so many medications?
The extract may theoretically thin your blood slightly (raising bleeding risk with blood thinners), lower blood sugar (adding to diabetes drugs), and boost immunity (potentially interfering with immunosuppressants). That's why checking your exact medications with us first is important.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Lion's Mane is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lion's Mane label
Go deeper

The Full Monographs Behind Lion's Mane’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lion's Mane Mushroom

Interacts with 327 drugs

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as...

Read the full Lion's Mane Mushroom monograph →
Sources

Sources & How We Checked

Lion's Mane's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lion's Mane Mushroom 6 references
  1. Product information for <em>Niaspan</em>. Abbott Laboratories. North Chicago, IL 60064. April 2015.
  2. Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complement Altern Med. 2013;13:253. PubMed
  3. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009;23(3):367-72.
  4. Mori K, Kikuchi H, Obara Y, et al. Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. Phytomedicine. 2010;17(14):1082-5. PubMed
  5. Li IC, Chang HH, Lin CH, et al. Prevention of early Alzheimer's disease by erinacine A-enriched Hericium erinaceus mycelia pilot double-blind placebo-controlled study. Front Aging Neurosci 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. PubMed
  6. Tian B, Liu R, Xu T, et al. Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice. J Sci Food Agric 2023;103(6):3050-3064.

See these in context on the Lion's Mane Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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