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Dietary supplement

Lion's Mane Ingredients & Drug Interactions

by HealthForce SuperFoods

Lion's Mane label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lion's Mane against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Lion's Mane is a dietary supplement by HealthForce SuperFoods with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, nerve health, mood and anxiety.Based on those ingredients, 494 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lion's Mane fruiting body extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Lion's Mane by HealthForce SuperFoods

Ask about any prescription or over-the-counter medication and we check it for interactions with Lion's Mane by HealthForce SuperFoods — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Lion's Mane by HealthForce SuperFoods

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.
  • “Lion's Mane fruiting body extract” is listed as a grouped ingredient — the label gives one combined amount (3,000 mg) without saying how much of each component you get.

This is a single-ingredient supplement: beta-glucans extracted from Lion's Mane fruiting body. Beta-glucans are a type of fiber compound found naturally in mushrooms and grains.

There are no inactive or filler ingredients in this powder.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: memory and cognitive support.
  • We looked for evidence on: Cognitive function, Cognitive impairment, Memory, Alzheimer disease, Dementia, age-related memory loss — and 1 related terms.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The beta-glucans in this product are rated Likely Effective for two uses: lowering cholesterol (dyslipidemia) and supporting heart health in coronary heart disease. The evidence behind these ratings comes from clinical research.

If you're considering this supplement for another reason, that data isn't established in what we have on file.

The evidence, ingredient by ingredient Lion's Mane Mushroom Beta-glucans

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Beta-glucans from food sources are generally well tolerated. The caution here is that concentrated supplements like this powder haven't been studied as thoroughly as whole food, so use care — watch for any unusual symptoms and stop if they develop.

For pregnancy, safety data isn't on file, so talk with your doctor or pharmacist for personalized advice. For breastfeeding, there's little research on supplement doses, so caution is advised and again, check with your pharmacist or doctor first.

Side effects are uncommon. When beta-glucans are applied to skin, contact dermatitis and mild skin reactions can occur in a small number of people.

One case of temporary liver enzyme elevation was reported in a child taking a very high dose, but this is rare.

Side effects, ingredient by ingredient Lion's Mane Mushroom Beta-glucans

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Beta-glucans.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs.
  • For scale: 293 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your exact medications if you take blood pressure drugs (antihypertensive medications) or immunosuppressants before starting this product. Use the interaction checker on this page with your specific drug names.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help with cholesterol and heart health if the clinical evidence applies to you. If you take blood pressure medication or immunosuppressant drugs, check with your pharmacist first — the beta-glucans here could interfere.

Otherwise, it's generally well tolerated, but concentrated supplements haven't been studied as long as whole foods, so start cautiously.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lion's Mane, straight from the product label.

Brand HealthForce SuperFoods
Barcode (UPC) 650786003643
Net contents 60 Gram(s); 2.12 Ounce(s)
Market status On market
Date entered into DSLD Sep 25, 2024
DSLD ID 317491
Product type Botanical
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Organic, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lion's Mane by HealthForce SuperFoods, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Gram(s)
Maximum serving Sizes:
3 Gram(s)
Servings per container
20
UPC/BARCODE
650786003643
IngredientAmount% DV
1,3/1,6 Beta-D-Glucans0 NP--
Lion's Mane fruiting body extract3000 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Eco facility Lab verified Ecofresh packaging

Vegan Ethics Certified Vegan Vegan.org

Certified organic, vegan, kosher, and gluten-free.

Certified organic, vegan, kosher, and gluten-free.

Certified organic, vegan, kosher, and gluten-free. GFCO.org Certified Gluten-free

Memory & nerve tonic

Lab tested for pesticides, GMOs, irradiation, botanical identity, microbial activity, gluten, and heavy metals.

Certified Organic by Oregon Tilth TruGanic Verified Sourcing USDA Organic

Formula

Lion's Mane (Hericium erinaceus), also known as hou tou gu or yamabushitake are large white shaggy mushrooms that resemble a lion's mane. Treasured for centuries throughout China and Japan, lion's mane was used as both a culinary delicacy and as a tonic for supporting mental alertness and calm. Lion's mane may assist in the production of nerve growth factor in the brain, a protein that promotes the growth and normal function of nerve cells. Lion's mane mushrooms also contain high levels of beta-glucans (25%+), known for their immune-supportive properties. Lion's mane has a mild, sweet-but-savory, licorice-like flavor. Our pure, wood-grown mushroom powders are made by hot water extraction using the fruiting body of the fungi.

Certified organic, vegan, kosher, and gluten-free. OU Pareve (Kosher)

Suggested/Recommended/Usage/Directions

Lion's mane can be added to your favorite smoothie, fresh juice, coffee, or tea.

Suggested Use: 1 teaspoon per day, or as advised by a qualified health care professional. Add to smoothies, teas, or hot water. Consume with conscious, positive intent.

General Statements

"I wish you great health and happiness always!" Dr. Jameth Sheridan - Naturopath and Hard-Core Herbal Medicine Researcher

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not designed to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

USDA Organic OTCO (Oregon Tilth Certified Organic) Certified Vegan Vegan.org GFCO.org Certified Gluten-free OU Pareve (Kosher)

TruGanic Verified Sourcing

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lion's Mane by HealthForce SuperFoods label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lion's Mane label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lion's Mane by HealthForce SuperFoods

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size3 Gram(s) Dosage formPowder Servings per container20 Amounts shown are per serving.

Lion's Mane fruiting body extract

Interacts with
327 drugs
3000 mg per serving

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and...

Lion's Mane fruiting body extract monograph & interactions
Interaction report

Lion's Mane by HealthForce SuperFoods Drug Interactions

Want to check YOUR meds against Lion's Mane?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
494Drugs
494 Moderate

Ingredients driving the most interactions

Lion's Mane fruiting body extract 327

Individual Drug Interactions

The ingredients in Lion's Mane interact with 494 drugs. Click any drug to see the details.

1 of the 1 ingredient in Lion's Mane interact with drugs. Each result below shows which ingredient is responsible. Lion's Mane fruiting body extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Lion's Mane with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lion's Mane fruiting body extract3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
In vitro research suggests that lion's mane mushroom extracts can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lion's mane mushroom can reduce serum glucose and increase serum insulin.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
In animal and in vitro research, lion's mane mushroom polysaccharides stimulate the immune system.

Likelihood Possible Evidence D
Lion's Mane fruiting body extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lion's Mane, from the product label.

HealthForce SuperFoods

See all HealthForce SuperFoods products
Name
Excelsior Alchemy
City
Tempe
State
AZ
ZipCode
85284
Phone Number
(800) 748-6229
Web Address
www.HealthForceSuperFoods.com
Pharmacist Counseling Corner

Lion's Mane by HealthForce SuperFoods: Common Questions

Does Lion's Mane by HealthForce SuperFoods interact with any medications?
Yes. Based on its ingredients, Lion's Mane has a known interaction with 494 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lion's Mane contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does Lion's Mane do?
The beta-glucans in this product are shown to help lower cholesterol and support heart health in people with coronary heart disease. It's not established for other uses in our data.
Is it safe to take during pregnancy?
Safety data for this supplement during pregnancy isn't on file. Talk with your doctor or pharmacist before taking it — they can weigh the pros and cons for your situation.
Can I take it while breastfeeding?
There's little research on supplement doses during breastfeeding, so caution is advised. Check with your pharmacist or doctor first.
What are the side effects?
Beta-glucans are well tolerated overall. Side effects are uncommon, but skin reactions can happen if applied topically. In rare cases, very high doses in children have caused temporary changes in liver enzymes.
Does this powder have fillers or other ingredients?
No — this is just beta-glucans extracted from Lion's Mane fruiting body. No fillers, binders, or other inactive ingredients are in it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lion's Mane label
Go deeper

The Full Monographs Behind Lion's Mane’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lion's Mane Mushroom

Interacts with 327 drugs

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as...

Read the full Lion's Mane Mushroom monograph → Herb & supplement monograph

Beta-glucans

Interacts with 293 drugs

Beta-glucans are natural fibers found in oats, barley, mushrooms, and yeast. The strongest evidence supports the oat and barley types for modestly lowering cholesterol and blood sugar, while...

Read the full Beta-glucans monograph →
Sources

Sources & How We Checked

Lion's Mane's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 17 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Beta-glucans 11 references
  1. Katz, D. L., Nawaz, H., Boukhalil, J., Giannamore, V., Chan, W., Ahmadi, R., and Sarrel, P. M. Acute effects of oats and vitamin E on endothelial responses to ingested fat. Am.J.Prev.Med. 2001;20(2):124-129. PubMed
  2. Keenan, J. M., Pins, J. J., Frazel, C., Moran, A., and Turnquist, L. Oat ingestion reduces systolic and diastolic blood pressure in patients with mild or borderline hypertension: a pilot trial. J.Fam.Pract. 2002;51(4):369.
  3. Maki, K. C., Galant, R., Samuel, P., Tesser, J., Witchger, M. S., Ribaya-Mercado, J. D., Blumberg, J. B., and Geohas, J. Effects of consuming foods containing oat beta-glucan on blood pressure, carbohydrate metabolism and biomarkers of oxidative stress i
  4. Bergendiova, K., Tibenska, E., and Majtan, J. Pleuran (beta-glucan from Pleurotus ostreatus) supplementation, cellular immune response and respiratory tract infections in athletes. Eur.J.Appl.Physiol 2011;111(9):2033-2040.
  5. Talbott S, Talbott J. Effect of beta 1,3/1,6 glucan on respiratory tract infection symptoms and mood state in marathon athletes. J Sports Sci Med 2009;8(4):509-515.
  6. Feldman S, Schwartz HI Kalman DS Mayers A Kohrman HM Clemens R Krieger DR. Randomized phase II clinical trials of Wellmune WGP® for immune support during cold and flu season. The Journal of Applied Research 2009;9(1-2):30-42.
  7. McFarlin BK, Carpenter KC, Davidson T, McFarlin MA. Baker's yeast beta glucan supplementation increases salivary IgA and decreases cold/flu symptomatic days after intense exercise. J Diet Suppl. 2013;10(3):171-83. PubMed
  8. Jesenak M, Urbancek S, Majtan J, Banovcin P, Hercogova J. ß-Glucan-based cream (containing pleuran isolated from pleurotus ostreatus) in supportive treatment of mild-to-moderate atopic dermatitis. J Dermatolog Treat 2016;27(4):351-4.
  9. Mah E, Kaden VN, Kelley KM, Liska DJ. Beverage containing dispersible yeast ß-glucan decreases cold/flu symptomatic days after intense exercise: a randomized controlled trial. J Diet Suppl 2020;17(2):200-10. PubMed
  10. Zhong K, Liu Z, Lu Y, Xu X. Effects of yeast ß-glucans for the prevention and treatment of upper respiratory tract infection in healthy subjects: a systematic review and meta-analysis. Eur J Nutr. 2021. PubMed
  11. Cardenas FI, Mauguen A, Cheung IY, et al. Phase I trial of oral yeast-derived ß-glucan to enhance anti-GD2 immunotherapy of resistant high-risk neuroblastoma. Cancers (Basel) 2021;13(24):6265. PubMed

See these in context on the Beta-glucans monograph →

Lion's Mane Mushroom 6 references
  1. Product information for <em>Niaspan</em>. Abbott Laboratories. North Chicago, IL 60064. April 2015.
  2. Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complement Altern Med. 2013;13:253. PubMed
  3. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009;23(3):367-72.
  4. Mori K, Kikuchi H, Obara Y, et al. Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. Phytomedicine. 2010;17(14):1082-5. PubMed
  5. Li IC, Chang HH, Lin CH, et al. Prevention of early Alzheimer's disease by erinacine A-enriched Hericium erinaceus mycelia pilot double-blind placebo-controlled study. Front Aging Neurosci 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. PubMed
  6. Tian B, Liu R, Xu T, et al. Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice. J Sci Food Agric 2023;103(6):3050-3064.

See these in context on the Lion's Mane Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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