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Dietary supplement

Lion's Mane Ingredients & Drug Interactions

by Om Mushroom Superfood

Lion's Mane label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lion's Mane against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Lion's Mane is a dietary supplement by Om Mushroom Superfood with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, nerve health, mood and anxiety.Based on those ingredients, 327 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lion's Mane, Powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Lion's Mane by Om Mushroom Superfood

Ask about any prescription or over-the-counter medication and we check it for interactions with Lion's Mane by Om Mushroom Superfood — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Lion's Mane by Om Mushroom Superfood

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.
  • “Certified Organic Mushroom Powder Blend” is a proprietary blend — the label gives one combined amount (2 Gram(s)) without saying how much of each component you get.

This product contains a single active ingredient: certified organic lion's mane mushroom powder. Lion's mane is a medicinal mushroom used in traditional medicine and studied for its potential effects on the brain and immune function.

The capsule also contains two inactive ingredients—cellulose and oats—which are fillers and binders.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Lion's Mane Mushroom's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Memory, focus, and nerve health support.
  • We looked for evidence on: Memory, Cognitive function, Cognitive impairment, Dementia, Alzheimer disease, Anxiety — and 3 related terms.
  • The closest evidence on file: Lion's Mane Mushroom is rated "Insufficient Reliable Evidence To Rate" for Alzheimer disease (Natural Medicines).
  • Also on file: Lion's Mane Mushroom is rated "Insufficient Reliable Evidence To Rate" for Anxiety, Cognitive function, Cognitive impairment, Dementia, and more.

The evidence for lion's mane isn't established yet in the data we hold. Studies have looked at it for Alzheimer disease, anxiety, athletic performance, cancer, cognitive function, and cognitive impairment, but the research so far hasn't provided enough reliable evidence to rate how well it works for any of these uses.

That doesn't mean it's ineffective—it means we need more research to know.

The evidence, ingredient by ingredient Lion's Mane Mushroom

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 0 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lion's mane is generally well tolerated as a food, though long-term safety as a supplement hasn't been studied thoroughly. The most common side effects are mild: gastrointestinal discomfort, nausea, and skin rash.

There isn't enough safety data to recommend it during pregnancy or while breastfeeding—talk with your doctor or pharmacist if you're pregnant, planning to become pregnant, or nursing to decide whether it's right for you.

Side effects, ingredient by ingredient Lion's Mane Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lion's Mane Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 327 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs like warfarin or aspirin (Moderate risk of increased bleeding), diabetes medications (Moderate risk of low blood sugar), or immunosuppressants after a transplant or for autoimmune disease (Moderate risk of interference with the drug's effect).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and some safety-information gaps remain.

Lion's mane is a single-ingredient mushroom supplement that's generally well tolerated for short-term use. If you take blood thinners, diabetes medications, or immunosuppressants, you'll need to check with your doctor or pharmacist first—the interactions are real and worth discussing.

For everyone else, run your full medication list through the tool on this page before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lion's Mane, straight from the product label.

Brand Om Mushroom Superfood
Barcode (UPC) 850011996737
Net contents 180 Vegetable Capsule(s)
Market status On market
Date entered into DSLD Aug 23, 2022
DSLD ID 271883
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lion's Mane by Om Mushroom Superfood, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
60
UPC/BARCODE
850011996737
IngredientAmount% DV
Certified Organic Mushroom Powder Blend2 Gram(s)--
Lion's Mane, Powder0 NP--

Other ingredients: Cellulose, Oats

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Value Size

Facebook Instagram @OmMushrooms

Scan code to learn more

See Supplement Facts

Formulation

Mental Clarity Focus & Alertness

We grow our OM. We grow a diverse range of mushroom species at our indoor farm in California and capture the complete nutritional value of the growing cycle. Whole food functional mushrooms are important because they provide a full spectrum of active compounds to support optimal health. Whole Food Nutrition Tested for Heavy Metals

Non GMO Project Verified nongmoproject.org

Supports Memory, Focus, Nerve Health Mushroom Superfood Daily Boost Capsules

Gluten Free

Vegan

Formula

The smartest mushroom in the kingdom. Lion's Mane can help spark cognition, focus and clarity. Om Lion's Mane capsules are a smart way to help fuel your brain. Beta Glucans and Prebiotics

OM Grown 2,000 mg per serving Mushroom blend

Certified Kosher by Earth Kosher

Keto-Friendly Paleo-Friendly

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Non GMO Project Verified nongmoproject.org

Vegan

Grown in USA

EarthKosher

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Take as directed.

Suggested Use: Take three (3) capsules per day with a glass of water.

Precautions

If you have a medical condition, are on medication or pregnant or nursing, please seek the direction of a qualified health care professional before using.

Keep out of the reach of children.

Storage

Store in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lion's Mane by Om Mushroom Superfood label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lion's Mane label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lion's Mane by Om Mushroom Superfood

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size3 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Certified Organic Mushroom Powder Blend

2 Gram(s) per serving

Other (inactive) ingredients: Cellulose, Oats. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lion's Mane by Om Mushroom Superfood Drug Interactions

Want to check YOUR meds against Lion's Mane?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
327Drugs
327 Moderate

Ingredients driving the most interactions

Lion's Mane, Powder 327

Individual Drug Interactions

The ingredients in Lion's Mane interact with 327 drugs. Click any drug to see the details.

1 of the 1 ingredient in Lion's Mane interact with drugs. Each result below shows which ingredient is responsible. Lion's Mane, Powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Lion's Mane with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lion's Mane, Powder3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
In vitro research suggests that lion's mane mushroom extracts can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lion's mane mushroom can reduce serum glucose and increase serum insulin.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
In animal and in vitro research, lion's mane mushroom polysaccharides stimulate the immune system.

Likelihood Possible Evidence D
Lion's Mane, Powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lion's Mane, from the product label.

Om Mushroom Superfood

See all Om Mushroom Superfood products
Name
Om Mushroom Superfood
Street Address
5931 Priestly Dr. #101
City
Carlsbad
State
CA
ZipCode
92008
Web Address
OmMushrooms.com
Pharmacist Counseling Corner

Lion's Mane by Om Mushroom Superfood: Common Questions

Does Lion's Mane by Om Mushroom Superfood interact with any medications?
Yes. Based on its ingredients, Lion's Mane has a known interaction with 327 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lion's Mane contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant?
There isn't enough safety data to know whether lion's mane is safe in pregnancy. It's best to avoid it and talk with your doctor or pharmacist about whether it's right for you.
Can I take this while breastfeeding?
There isn't enough safety data to know whether lion's mane is safe while breastfeeding. Check with your doctor or pharmacist before using it.
What side effects does lion's mane have?
It's generally well tolerated, but some people report gastrointestinal discomfort, nausea, or skin rash. Most of these are mild and temporary.
Does lion's mane actually work for memory or brain health?
The research so far hasn't provided enough reliable evidence to say whether it works for Alzheimer disease, cognitive function, anxiety, or other brain-related uses. More studies are needed.
What's the difference between this and other lion's mane supplements?
The product facts we have don't include comparisons to other brands. What we can tell you is that this one is certified organic and comes in capsule form with just cellulose and oats as fillers.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Lion's Mane is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lion's Mane label
Go deeper

The Full Monographs Behind Lion's Mane’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lion's Mane Mushroom

Interacts with 327 drugs

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as...

Read the full Lion's Mane Mushroom monograph →
Sources

Sources & How We Checked

Lion's Mane's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lion's Mane Mushroom 6 references
  1. Product information for <em>Niaspan</em>. Abbott Laboratories. North Chicago, IL 60064. April 2015.
  2. Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complement Altern Med. 2013;13:253. PubMed
  3. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009;23(3):367-72.
  4. Mori K, Kikuchi H, Obara Y, et al. Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. Phytomedicine. 2010;17(14):1082-5. PubMed
  5. Li IC, Chang HH, Lin CH, et al. Prevention of early Alzheimer's disease by erinacine A-enriched Hericium erinaceus mycelia pilot double-blind placebo-controlled study. Front Aging Neurosci 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. PubMed
  6. Tian B, Liu R, Xu T, et al. Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice. J Sci Food Agric 2023;103(6):3050-3064.

See these in context on the Lion's Mane Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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