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Dietary supplement

Lion's Mane Mushroom 500 mg Ingredients & Drug Interactions

by Brain Forza

Lion's Mane Mushroom 500 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lion's Mane Mushroom 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Lion's Mane Mushroom 500 mg is a dietary supplement by Brain Forza with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, nerve health, mood and anxiety.Based on those ingredients, 327 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are certified organic Lion's Mane mushroom. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Lion's Mane Mushroom 500 mg by Brain Forza

Ask about any prescription or over-the-counter medication and we check it for interactions with Lion's Mane Mushroom 500 mg by Brain Forza — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Lion's Mane Mushroom 500 mg by Brain Forza

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains a single active ingredient: certified organic Lion's Mane mushroom at 500 mg per capsule. The capsule itself is made from vegetable cellulose and contains organic sorghum as an inactive ingredient.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Lion's Mane Mushroom's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: support overall brain health.
  • We looked for evidence on: Memory, Cognitive function, Cognitive impairment, Dementia, Alzheimer disease, Parkinson disease — and 2 related terms.
  • The closest evidence on file: Lion's Mane Mushroom is rated "Insufficient Reliable Evidence To Rate" for Alzheimer disease (Natural Medicines).
  • Also on file: Lion's Mane Mushroom is rated "Insufficient Reliable Evidence To Rate" for Cognitive function, Cognitive impairment, Dementia, Memory, and more.

The evidence we hold doesn't establish whether lion's mane works for any of its common uses—including cognitive function, Alzheimer disease, anxiety, athletic performance, cancer, or cognitive impairment. All ratings fall to insufficient reliable evidence, meaning the science isn't yet there to say whether it's effective for these claims.

The evidence, ingredient by ingredient Lion's Mane Mushroom

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 0 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lion's mane is generally well tolerated as a food, but its long-term safety as a supplement hasn't been well studied. The most common side effects reported are gastrointestinal discomfort, nausea, and skin rash.

The safety data advises against use during pregnancy and while breastfeeding—there isn't enough information to know it's safe for you or your baby in these situations.

Side effects, ingredient by ingredient Lion's Mane Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lion's Mane Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 327 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this if you're on blood thinners or antiplatelet drugs (like warfarin, aspirin, or clopidogrel)—lion's mane may increase bleeding risk. Also double-check if you take diabetes medications or immune-suppressing drugs, as the mushroom may interfere with how they work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and some safety-information gaps remain.

Lion's mane is a single-ingredient supplement that's generally well tolerated short-term, but we don't yet have strong evidence it works for cognitive or other health claims. If you take blood thinners, diabetes drugs, or immunosuppressants, check with your doctor or pharmacist before adding it.

Pregnant and breastfeeding individuals should avoid it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lion's Mane Mushroom 500 mg, straight from the product label.

Brand Brain Forza
Barcode (UPC) 616639120394
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Mar 25, 2021
DSLD ID 244152
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Women (not pregnant or lactating), Organic
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lion's Mane Mushroom 500 mg by Brain Forza, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
616639120394
IngredientAmount% DV
certified organic Lion's Mane mushroom1500 mg--

Other ingredients: Vegetable Cellulose, organic Sorghum

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take one capsule three times daily with water or, three capsules once daily with water.

Precautions

Manufactured in a facility that processes wheat, gluten, soy, milk, egg, shellfish, and tree nut ingredients.

Warning: Do not take this product if you are pregnant or nursing. Consult your healthcare provider before use if you are currently taking any prescription medications or receiving medical treatment.

Discontinue use if unusual symptoms occur.

Keep out of reach of children.

Formulation

Soy Free Gluten Free GMO Free

Vegan

Lion's Mane are one of the staples of TCM and may support overall brain health.

Made in California Made in the USA Mushrooms Grown In: USA

Certified Organic by CCOF

Memory, brain health and nerve support Stronger than extracts & HPLC tested

Pressure cooked twice at high heat.

Seals/Symbols

EarthKosher

"CCOF Certified Organic "

Formula

EarthKosher

Our premium, lab-grown, certified organic, non-GMO, Lion's Mane Mushrooms. Consistent every time and naturally containing approx. 70% polysaccharides.

Medicinal Mushrooms Made with Organic Full Spectrum Hericium Erinaceus Pure full-spectrum USA grown Hericium E.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Tag us @BrainForza Instagram Facebook Twitter

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lion's Mane Mushroom 500 mg by Brain Forza label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lion's Mane Mushroom 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lion's Mane Mushroom 500 mg by Brain Forza

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Certified organic Lion's Mane mushroom

Interacts with
327 drugs
1500 mg per serving

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and...

Certified organic Lion's Mane mushroom monograph & interactions

Other (inactive) ingredients: Vegetable Cellulose, Organic Sorghum. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lion's Mane Mushroom 500 mg by Brain Forza Drug Interactions

Want to check YOUR meds against Lion's Mane Mushroom 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
327Drugs
327 Moderate

Ingredients driving the most interactions

certified organic Lion's Mane mushroom 327

Individual Drug Interactions

The ingredients in Lion's Mane Mushroom 500 mg interact with 327 drugs. Click any drug to see the details.

1 of the 1 ingredient in Lion's Mane Mushroom 500 mg interact with drugs. Each result below shows which ingredient is responsible. certified organic Lion's Mane mushroom

Each ingredient & the kinds of drugs it affects

For each ingredient in Lion's Mane Mushroom 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

certified organic Lion's Mane mushroom3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
In vitro research suggests that lion's mane mushroom extracts can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lion's mane mushroom can reduce serum glucose and increase serum insulin.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
In animal and in vitro research, lion's mane mushroom polysaccharides stimulate the immune system.

Likelihood Possible Evidence D
certified organic Lion's Mane mushroom full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lion's Mane Mushroom 500 mg, from the product label.

Brain Forza

See all Brain Forza products
Name
Brain Forza Labs Inc.
Street Address
6100 219th Street SW, Ste 480
City
Mountlake Terrace
State
WA
ZipCode
98043
Web Address
www.brainforza.com
Pharmacist Counseling Corner

Lion's Mane Mushroom 500 mg by Brain Forza: Common Questions

Does Lion's Mane Mushroom 500 mg by Brain Forza interact with any medications?
Yes. Based on its ingredients, Lion's Mane Mushroom 500 mg has a known interaction with 327 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lion's Mane Mushroom 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
No—there isn't enough safety data, so the guidance is to avoid lion's mane during pregnancy and while breastfeeding. Talk it over with your doctor or midwife for personalized advice.
What are the common side effects?
Most people tolerate it well. The side effects that do show up are usually mild: gastrointestinal discomfort, nausea, and occasionally a skin rash.
Does lion's mane actually improve memory or brain health?
The evidence we hold doesn't yet establish whether it works for cognitive function, Alzheimer disease, anxiety, or other brain-related claims. Right now, the evidence is insufficient.
Is this safe to take long-term?
Lion's mane is generally well tolerated as a food, but long-term supplement safety hasn't been well studied. If you're thinking about taking it regularly, talk it over with your doctor or pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Lion's Mane Mushroom 500 mg is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lion's Mane Mushroom 500 mg label
Go deeper

The Full Monographs Behind Lion's Mane Mushroom 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lion's Mane Mushroom

Interacts with 327 drugs

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as...

Read the full Lion's Mane Mushroom monograph →
Sources

Sources & How We Checked

Lion's Mane Mushroom 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lion's Mane Mushroom 6 references
  1. Product information for <em>Niaspan</em>. Abbott Laboratories. North Chicago, IL 60064. April 2015.
  2. Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complement Altern Med. 2013;13:253. PubMed
  3. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009;23(3):367-72.
  4. Mori K, Kikuchi H, Obara Y, et al. Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. Phytomedicine. 2010;17(14):1082-5. PubMed
  5. Li IC, Chang HH, Lin CH, et al. Prevention of early Alzheimer's disease by erinacine A-enriched Hericium erinaceus mycelia pilot double-blind placebo-controlled study. Front Aging Neurosci 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. PubMed
  6. Tian B, Liu R, Xu T, et al. Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice. J Sci Food Agric 2023;103(6):3050-3064.

See these in context on the Lion's Mane Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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