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Dietary supplement

Lion's Mane Mushroom 500 mg Ingredients & Drug Interactions

by Double Wood Supplements

Lion's Mane Mushroom 500 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lion's Mane Mushroom 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Lion's Mane Mushroom 500 mg is a dietary supplement by Double Wood Supplements with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, nerve health, mood and anxiety.Based on those ingredients, 327 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic Lion's Mane. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Lion's Mane Mushroom 500 mg by Double Wood Supplements

Ask about any prescription or over-the-counter medication and we check it for interactions with Lion's Mane Mushroom 500 mg by Double Wood Supplements — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Lion's Mane Mushroom 500 mg by Double Wood Supplements

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This supplement contains one active ingredient: 500 mg of organic lion's mane mushroom per capsule. Lion's mane is a medicinal fungus traditionally used in Asian cuisines and herbal medicine.

The capsule itself is made from hypromellose (a plant-based capsule material) and organic rice flour as inactive ingredients.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Lion's Mane Mushroom's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: cognitive support and immune system support.
  • We looked for evidence on: Alzheimer disease, Cognitive function, Cognitive impairment, Dementia, Memory, Parkinson disease — and 3 related terms.
  • The closest evidence on file: Lion's Mane Mushroom is rated "Insufficient Reliable Evidence To Rate" for Alzheimer disease (Natural Medicines).
  • Also on file: Lion's Mane Mushroom is rated "Insufficient Reliable Evidence To Rate" for Cognitive function, Cognitive impairment, Dementia, Memory, and more.

The evidence for lion's mane isn't well established yet. Our data rates it as having insufficient reliable evidence for Alzheimer disease, anxiety, athletic performance, cancer, cognitive function, and cognitive impairment.

That doesn't mean it doesn't work—it means larger, well-designed human studies haven't been done to confirm these uses. If you're considering it for a specific concern, talk it over with your doctor or pharmacist about what the current research actually supports.

The evidence, ingredient by ingredient Lion's Mane Mushroom

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 0 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lion's mane is generally well tolerated when taken by mouth. The most common side effects in people who've used it are gastrointestinal discomfort, nausea, and skin rash.

Keep in mind that long-term supplement safety hasn't been studied extensively. There isn't enough safety data to recommend lion's mane during pregnancy or while breastfeeding—talk with your doctor or pharmacist for personalized advice if you're pregnant, planning to become pregnant, or nursing.

Side effects, ingredient by ingredient Lion's Mane Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lion's Mane Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 327 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, double-check with your doctor or pharmacist if you take anticoagulant or antiplatelet drugs (blood thinners like warfarin, or aspirin-type medications)—lion's mane may increase bleeding risk. Also flag it if you're on antidiabetes drugs (insulin or other blood sugar medications) or immunosuppressants (drugs given after transplants or for autoimmune conditions)—the mushroom may add to their effects in ways that need monitoring.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and some safety-information gaps remain.

Lion's mane may be worth considering if you're interested in a traditional medicinal mushroom, but the human evidence for its effectiveness isn't solid yet. If you take blood thinners, diabetes medications, or immune-suppressing drugs, you'll need to check with your doctor or pharmacist first—the moderate interactions with these drug types could matter.

Same goes if you're pregnant or breastfeeding: get personalized guidance from your own healthcare provider before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lion's Mane Mushroom 500 mg, straight from the product label.

Brand Double Wood Supplements
Barcode (UPC) X002353QLB
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Jan 22, 2021
DSLD ID 241808
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lion's Mane Mushroom 500 mg by Double Wood Supplements, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
X002353QLB
IngredientAmount% DV
organic Lion's Mane1000 mg--

Other ingredients: Hypromellose, organic Rice Flour

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Lion's Mane (Hericium Erinaceus) is a dietary mushroom commonly taken as a supplement for cognitive support and immune system support. Lion's Mane is one of the few available supplements that has been shown to support levels of nerve growth factor (NGF) in the brain, which is an important peptide for supporting nerve cell health.

Lion's Mane Mushroom 500 mg per capsule

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 2 capsules in the morning with food. A second dose may be taken later in the day.

Storage

Storage: Store in a cool, dark place. Do not freeze or expose to moisture or heat above room temperature.

Precautions

Warning: Consult your physician before using this product. Do not consume more than 6 capsules per day.

Do not take this product if you are pregnant, nursing, or taking any other medications.

Discontinue use and consult your doctor immediately if any adverse reactions occur.

Do not use Lion's Mane and operate any heavy machinery until you know how it affects you.

Keep out of reach of children.

Seals/Symbols

Proudly made in USA

Formulation

Made with Non-GMO ingredients Gluten free

Supports nerve growth factor (NGF) levels Supports cognitive health Supports immune system health

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

General Statements

Lion's Mane Mushroom DoubleWood Supplements New

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lion's Mane Mushroom 500 mg by Double Wood Supplements label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lion's Mane Mushroom 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lion's Mane Mushroom 500 mg by Double Wood Supplements

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Organic Lion's Mane

Interacts with
327 drugs
1000 mg per serving

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and...

Organic Lion's Mane monograph & interactions

Other (inactive) ingredients: Hypromellose, Organic Rice Flour. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lion's Mane Mushroom 500 mg by Double Wood Supplements Drug Interactions

Want to check YOUR meds against Lion's Mane Mushroom 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
327Drugs
327 Moderate

Ingredients driving the most interactions

organic Lion's Mane 327

Individual Drug Interactions

The ingredients in Lion's Mane Mushroom 500 mg interact with 327 drugs. Click any drug to see the details.

1 of the 1 ingredient in Lion's Mane Mushroom 500 mg interact with drugs. Each result below shows which ingredient is responsible. organic Lion's Mane

Each ingredient & the kinds of drugs it affects

For each ingredient in Lion's Mane Mushroom 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

organic Lion's Mane3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
In vitro research suggests that lion's mane mushroom extracts can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lion's mane mushroom can reduce serum glucose and increase serum insulin.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
In animal and in vitro research, lion's mane mushroom polysaccharides stimulate the immune system.

Likelihood Possible Evidence D
organic Lion's Mane full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lion's Mane Mushroom 500 mg, from the product label.

Double Wood Supplements

See all Double Wood Supplements products
Name
Double Wood LLC
Street Address
3510 Scotts Ln Ste 219
City
Philadelphia
State
PA
ZipCode
19129-1573
Web Address
www.doublewoodsupplements.com
Pharmacist Counseling Corner

Lion's Mane Mushroom 500 mg by Double Wood Supplements: Common Questions

Does Lion's Mane Mushroom 500 mg by Double Wood Supplements interact with any medications?
Yes. Based on its ingredients, Lion's Mane Mushroom 500 mg has a known interaction with 327 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lion's Mane Mushroom 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What exactly is lion's mane mushroom?
Lion's mane is a medicinal fungus traditionally used in Asian cuisines and herbal medicine. It's the active ingredient in this supplement, supplied in a capsule form with rice flour and a plant-based capsule material.
Does lion's mane actually work for memory or brain health?
The evidence isn't established yet in our data. We rate it as having insufficient reliable evidence for Alzheimer disease, cognitive function, cognitive impairment, anxiety, cancer, and athletic performance. Human studies need to be larger and more rigorous to confirm whether it helps.
Is lion's mane safe to take long-term?
It's generally well tolerated, but long-term safety hasn't been studied extensively. The most common side effects are gastrointestinal discomfort, nausea, and skin rash. If you're planning to take it regularly, mention it to your doctor or pharmacist so they can monitor you.
Can I take lion's mane while I'm pregnant or breastfeeding?
There isn't enough safety data, so it's best to avoid it during pregnancy and while breastfeeding. Talk with your doctor or pharmacist about whether it's right for you in those situations.
I take a blood thinner—is lion's mane safe with it?
No—there's a moderate interaction risk. Lab research suggests lion's mane can slow down platelet clumping, which may increase your bleeding risk when combined with anticoagulant or antiplatelet drugs. Check with your doctor or pharmacist before adding it.
What if I'm diabetic and take insulin?
There's a moderate interaction. Animal research shows lion's mane can lower blood sugar and raise insulin levels, so it might add to the effect of your diabetes medications and lower your blood sugar further than intended. Your doctor or pharmacist needs to know before you start.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lion's Mane Mushroom 500 mg label
Go deeper

The Full Monographs Behind Lion's Mane Mushroom 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lion's Mane Mushroom

Interacts with 327 drugs

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as...

Read the full Lion's Mane Mushroom monograph →
Sources

Sources & How We Checked

Lion's Mane Mushroom 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lion's Mane Mushroom 6 references
  1. Product information for <em>Niaspan</em>. Abbott Laboratories. North Chicago, IL 60064. April 2015.
  2. Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complement Altern Med. 2013;13:253. PubMed
  3. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009;23(3):367-72.
  4. Mori K, Kikuchi H, Obara Y, et al. Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. Phytomedicine. 2010;17(14):1082-5. PubMed
  5. Li IC, Chang HH, Lin CH, et al. Prevention of early Alzheimer's disease by erinacine A-enriched Hericium erinaceus mycelia pilot double-blind placebo-controlled study. Front Aging Neurosci 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. PubMed
  6. Tian B, Liu R, Xu T, et al. Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice. J Sci Food Agric 2023;103(6):3050-3064.

See these in context on the Lion's Mane Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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