Lion's Mane Mushroom Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Lion's Mane Mushroom against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Lion's Mane Mushroom is a dietary supplement by Forest Super Foods with 5 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 511 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lion's Mane Mushroom, Sodium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Lion's Mane Mushroom by Forest Super Foods
Ask about any prescription or over-the-counter medication and we check it for interactions with Lion's Mane Mushroom by Forest Super Foods — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Lion's Mane Mushroom by Forest Super Foods
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Partial disclosure
This product contains 2 active ingredients: sodium and Lion's Mane Mushroom extract. Sodium is an essential mineral your body needs in small amounts for nerve and muscle function, but this product supplies it as a supplement rather than from food.
Lion's Mane Mushroom is a fungal extract sometimes used in traditional medicine for cognitive support, though its effectiveness in humans is not yet well established.
Does it work?
Not established
The evidence we hold does not establish that Lion's Mane Mushroom is effective for any condition — the data shows insufficient reliable evidence for Alzheimer's disease, anxiety, cognitive function, athletic performance, cancer, and cognitive impairment. Sodium, meanwhile, is rated Likely Effective only for cystic fibrosis and Possibly Effective for protecting the kidneys during amphotericin B treatment (an antifungal drug).
For most other uses, the evidence is insufficient or absent.
How safe is it?
Well-documented data
Lion's Mane Mushroom is generally well tolerated as a food, though long-term supplement safety has not been well studied. Some people report gastrointestinal discomfort, nausea, or skin rash.
However, there isn't enough safety data to use it during pregnancy or while breastfeeding — talk with your doctor or pharmacist for personalized guidance. Sodium is essential in small amounts, but too much is linked to high blood pressure and heart strain.
Normal dietary sodium is fine, but avoid sodium supplements or very high intake without medical advice. Serious adverse effects from high sodium intake are rare but can include worsened heart disease, high blood pressure, and kidney disease.
Meds to double-check
Moderate interaction found
Before taking this product, check your medications against these drug types, worst severity first: antihypertensive drugs (blood pressure medications), corticosteroids (steroid drugs), lithium, anticoagulant/antiplatelet drugs (blood thinners), antidiabetes drugs, immunosuppressants, didanosine, sodium phosphates, tolvaptan, and other sodium-containing medications. If you take any of these, run them through the interaction checker below.
The bottom line
Scorecard at a glancePartially disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
This product combines two ingredients with significant medication interactions, particularly around blood pressure control and electrolyte balance. If you take any prescription medications — especially blood pressure drugs, lithium, diabetes medications, blood thinners, steroid medications, or HIV drugs — check with your pharmacist before starting.
Even if you're not on medications, the sodium content warrants caution if you have heart, kidney, or blood pressure concerns.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Lion's Mane Mushroom, straight from the product label.
| Brand | Forest Super Foods |
|---|---|
| Barcode (UPC) | 9392660991387 |
| Net contents | 120 Veg Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jan 23, 2025 |
| DSLD ID | 329211 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Organic |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Lion's Mane Mushroom by Forest Super Foods, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Sodium | 21 mg, 1 mg | -- |
| Carbohydrates | 80 Gram(s), 1.6 Gram(s) | -- |
| Energy | 1680 kJ, 34 kJ | -- |
| Total Fat | 3.2 Gram(s), 1 Gram(s) | -- |
| Saturated Fat | 0.8 NP, 1 Gram(s) | -- |
| Protein | 9.8 Gram(s), 1 Gram(s) | -- |
| Lion's Mane Mushroom | 0 NP | -- |
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Australian Grown Whole Food
The most potent lion's mane in Australia
Contains 100% Australian ingredients
Australian organic whole mushroom
Formula
Australian organic whole mushroom
What's so great about our lion's mane? Our Lion's Mane is grown, dried and packaged in Victoria, Australia. Which means you can be confident that it has not been exposed to polluted air, water or soil. Out Lion's Mane is freeze-dried to ensure the highest possible nutritional density of the finished product. Lion's Mane is best know for its ability to help boost productivity and reduce brain fog. The myceliated substrate is a probiotic that can promote good gut health.
General Statements
Scan for more info
Precautions
Dietary Warning We recommend always consulting a health care practitioner before making changes to your diet.
May include traces of brown rice (the growing medium for the mushroom)
Suggested/Recommended/Usage/Directions
Take 4 capsules after your first meal of the day
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Lion's Mane Mushroom by Forest Super Foods label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Lion's Mane Mushroom by Forest Super Foods
These are the 5 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Gram(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Sodium
Interacts with205 drugs
Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...
Sodium monograph & interactionsCarbohydrates
Energy
Protein
Lion's Mane Mushroom
Interacts with327 drugs
Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and...
Lion's Mane Mushroom monograph & interactionsLion's Mane Mushroom by Forest Super Foods Drug Interactions
HelloPharmacist Interaction Report
Lion's Mane Mushroom by Forest Super Foods contains two active ingredients, and together they interact with a substantial number of medications.
The most serious concern is sodium's effect on blood pressure control: high sodium intake can reduce the effectiveness of antihypertensive drugs (blood pressure medications), meaning you may need higher doses or additional drugs to keep your pressure in check.
Read the full breakdown — every affected drug type, severity by severity
Sodium also interacts with corticosteroids (steroid medications), lithium (a mood stabilizer), didanosine (an HIV drug), sodium phosphates (bowel-prep solutions), tolvaptan (a sodium-raising drug), and other sodium-containing medications — all at Moderate severity. These interactions typically center on the risk of too much sodium in your bloodstream, which can cause serious electrolyte imbalances.
Lion's Mane Mushroom itself carries Moderate interactions with blood thinners (anticoagulants/antiplatelets), diabetes medications, and immunosuppressants. It may increase bleeding risk, add to the blood-sugar-lowering effect of diabetes drugs, or interfere with immune-suppressing therapy.
Altogether, these interactions span 504 individual medications. Use the interaction checker on this page to verify your exact medications before starting.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Lion's Mane Mushroom?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Lion's Mane Mushroom interact with 511 drugs. Click any drug to see the details.
2 of the 5 ingredients in Lion's Mane Mushroom interact with drugs. Each result below shows which ingredient is responsible. Lion's Mane Mushroom Sodium
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Lion's Mane Mushroom — through 1 ingredient. Tap an ingredient for the detail:
Lion's Mane MushroomImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
Read the full Lion's Mane Mushroom + 6-mercaptopurine interactionAbciximabReoPro
How Abciximab interacts with Lion's Mane Mushroom — through 1 ingredient. Tap an ingredient for the detail:
Lion's Mane MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Read the full Lion's Mane Mushroom + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Lion's Mane Mushroom — through 1 ingredient. Tap an ingredient for the detail:
Lion's Mane MushroomAnticoagulant/antiplatelet Drugs, Immunosuppressants Moderate
Interaction Summary
Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Read the full Lion's Mane Mushroom + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Lion's Mane Mushroom — through 1 ingredient. Tap an ingredient for the detail:
Lion's Mane MushroomAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Read the full Lion's Mane Mushroom + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Lion's Mane Mushroom — through 1 ingredient. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Lion's Mane Mushroom — through 1 ingredient. Tap an ingredient for the detail:
Lion's Mane MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Read the full Lion's Mane Mushroom + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Lion's Mane Mushroom — through 1 ingredient. Tap an ingredient for the detail:
Lion's Mane MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Read the full Lion's Mane Mushroom + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Lion's Mane Mushroom — through 1 ingredient. Tap an ingredient for the detail:
Lion's Mane MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Read the full Lion's Mane Mushroom + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Lion's Mane Mushroom — through 1 ingredient. Tap an ingredient for the detail:
Lion's Mane MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Read the full Lion's Mane Mushroom + Acetaminophen, Ibuprofen interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Lion's Mane Mushroom — through 1 ingredient. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Acetazolamide interactionAcetohexamideDymelor
How Acetohexamide interacts with Lion's Mane Mushroom — through 1 ingredient. Tap an ingredient for the detail:
Lion's Mane MushroomAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Read the full Lion's Mane Mushroom + Acetohexamide interactionAcetylsalicylic AcidEntrophen
How Acetylsalicylic Acid interacts with Lion's Mane Mushroom — through 1 ingredient. Tap an ingredient for the detail:
Lion's Mane MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Read the full Lion's Mane Mushroom + Acetylsalicylic Acid interactionAdalimumabHumira
How Adalimumab interacts with Lion's Mane Mushroom — through 1 ingredient. Tap an ingredient for the detail:
Lion's Mane MushroomImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
Read the full Lion's Mane Mushroom + Adalimumab interactionAdalimumab-adazHyrimoz
How Adalimumab-adaz interacts with Lion's Mane Mushroom — through 1 ingredient. Tap an ingredient for the detail:
Lion's Mane MushroomImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
Read the full Lion's Mane Mushroom + Adalimumab-adaz interactionAdalimumab-adbmCyltezo
How Adalimumab-adbm interacts with Lion's Mane Mushroom — through 1 ingredient. Tap an ingredient for the detail:
Lion's Mane MushroomImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
Read the full Lion's Mane Mushroom + Adalimumab-adbm interactionAdalimumab-afzbAbrilada
How Adalimumab-afzb interacts with Lion's Mane Mushroom — through 1 ingredient. Tap an ingredient for the detail:
Lion's Mane MushroomImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
Read the full Lion's Mane Mushroom + Adalimumab-afzb interactionAdalimumab-attoAmjevita
How Adalimumab-atto interacts with Lion's Mane Mushroom — through 1 ingredient. Tap an ingredient for the detail:
Lion's Mane MushroomImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
Read the full Lion's Mane Mushroom + Adalimumab-atto interactionAdalimumab-bwwdHadlima
How Adalimumab-bwwd interacts with Lion's Mane Mushroom — through 1 ingredient. Tap an ingredient for the detail:
Lion's Mane MushroomImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
Read the full Lion's Mane Mushroom + Adalimumab-bwwd interactionAdalimumab-fkjpHulio
How Adalimumab-fkjp interacts with Lion's Mane Mushroom — through 1 ingredient. Tap an ingredient for the detail:
Lion's Mane MushroomImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
Read the full Lion's Mane Mushroom + Adalimumab-fkjp interactionAlbiglutideTanzeum
How Albiglutide interacts with Lion's Mane Mushroom — through 1 ingredient. Tap an ingredient for the detail:
Lion's Mane MushroomAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Read the full Lion's Mane Mushroom + Albiglutide interactionAlefaceptAmevive
How Alefacept interacts with Lion's Mane Mushroom — through 1 ingredient. Tap an ingredient for the detail:
Lion's Mane MushroomImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
Read the full Lion's Mane Mushroom + Alefacept interactionAlemtuzumabCampath
How Alemtuzumab interacts with Lion's Mane Mushroom — through 1 ingredient. Tap an ingredient for the detail:
Lion's Mane MushroomImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
Read the full Lion's Mane Mushroom + Alemtuzumab interactionAliskirenTekturna
How Aliskiren interacts with Lion's Mane Mushroom — through 1 ingredient. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Aliskiren interactionAlogliptinNesina
How Alogliptin interacts with Lion's Mane Mushroom — through 1 ingredient. Tap an ingredient for the detail:
Lion's Mane MushroomAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Read the full Lion's Mane Mushroom + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Lion's Mane Mushroom — through 1 ingredient. Tap an ingredient for the detail:
Lion's Mane MushroomAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Read the full Lion's Mane Mushroom + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Lion's Mane Mushroom — through 1 ingredient. Tap an ingredient for the detail:
Lion's Mane MushroomAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Read the full Lion's Mane Mushroom + Alogliptin, Pioglitazone interactionAlteplase, TpaActilyse, Activase
How Alteplase, Tpa interacts with Lion's Mane Mushroom — through 1 ingredient. Tap an ingredient for the detail:
Lion's Mane MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Read the full Lion's Mane Mushroom + Alteplase, Tpa interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Lion's Mane Mushroom — through 1 ingredient. Tap an ingredient for the detail:
Lion's Mane MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Read the full Lion's Mane Mushroom + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with Lion's Mane Mushroom — through 1 ingredient. Tap an ingredient for the detail:
Lion's Mane MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Read the full Lion's Mane Mushroom + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with Lion's Mane Mushroom — through 1 ingredient. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Ambrisentan interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Lion's Mane Mushroom with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Lion's Mane Mushroom
Anticoagulant/Antiplatelet Drugs
Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
In vitro research suggests that lion's mane mushroom extracts can inhibit platelet aggregation.
Antidiabetes Drugs
Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lion's mane mushroom can reduce serum glucose and increase serum insulin.
Immunosuppressants
Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
In animal and in vitro research, lion's mane mushroom polysaccharides stimulate the immune system.
Sodium
Antihypertensive Drugs
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.
Corticosteroids
Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.
Didanosine (Videx)
Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.
Lithium
Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.
Sodium Phosphates
Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.
Sodium-Containing Drugs
Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.
Tolvaptan (Samsca)
Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.
Brand information
Manufacturer and brand details for Lion's Mane Mushroom, from the product label.
Forest Super Foods
See all Forest Super Foods products- Name
- Forest Super Foods
- Web Address
- www.forestsuperfoods.com.au
Lion's Mane Mushroom by Forest Super Foods: Common Questions
Does Lion's Mane Mushroom by Forest Super Foods interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I have high blood pressure or take blood pressure medication?
What's the difference between the sodium in food and the sodium in this supplement?
Does Lion's Mane Mushroom actually help with memory or brain function?
What side effects might I notice if I take this?
Is this safe to use if I'm pregnant or breastfeeding?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Lion's Mane Mushroom is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Lion's Mane Mushroom’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sodium
Interacts with 205 drugsSodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...
Read the full Sodium monograph → Herb & supplement monographLion's Mane Mushroom
Interacts with 327 drugsLion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as...
Read the full Lion's Mane Mushroom monograph →Sources & How We Checked
Lion's Mane Mushroom's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 44 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Sodium 38 references
- Garabedian-Ruffalo SM, Ruffalo RL. Drug and nutrient interactions. Am Fam Physician 1986;33:165-74.
- Food and Drug Administration Science Background: Safety of Sodium Phosphates Oral Solution. September 17, 2001. Available at: http://www.fda.gov/cder/drug/safety/sodiumphospate.htm
- Coton T, Mallaret C, Coilliot C, Carre D, Guisset M. Severe acute ulcerated gastritis induced by salt. Presse Med 2009;38(3):499-500. PubMed
- Frings-Meuthen P, Buehlmeier J, Baecker N, et al. High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses. J Appl Physiol 2011;111(2):537-542. PubMed
- Frings-Meuthen P, Baecker N, Heer M. Low-grade metabolic acidosis may be the cause of sodium chloride-induced exaggerated bone resorption. J Bone Miner Res 2008;23(4):517-524. PubMed
- Alam S, Johnson AG. A meta-analysis of randomised controlled trials (RCT) among healthy normotensive and essential hypertensive elderly patients to determine the effect of high salt (NaCl) diet of blood pressure. J Hum Hypertens 1999;13(6):367-74.
- Boudville N, Ward S, Benaroia M, House AA. Increased sodium intake correlates with greater use of antihypertensive agents by subjects with chronic kidney disease. Am J Hypertens 2005;18(10):1300-5. PubMed
- Bennett WM. Drug interactions and consequences of sodium restriction. Am J Clin Nutr 1997;65(2 Suppl):678S-681S. PubMed
- Okusa MD, Crystal LJ. Clinical manifestations and management of acute lithium intoxication. Am J Med 1994;97(4):383-9. PubMed
- Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for water, potassium, sodium, chloride, and sulfate. Washington, DC: National Academy Press, 2005. Available at: http://www.nap.edu/openbook.php?record_id=10925. DOI
- D'Elia L, Rossi G, Ippolito R, Cappuccio FP, Strazzullo P. Habitual salt intake and risk of gastric cancer: a meta-analysis of prospective studies. Clin Nutr 2012;31(4):489-98. PubMed
- Goldsmith SR. Hyponatremia in heart failure: time for a trial. J Card Fail 2013;19(6):398-400. PubMed
- Willocks L, Brettle R, Keen J, Valentine C, Pinching AJ. Formulations of didanosine (ddI) and salt overload. Lancet 1992;339(8786):190.
- Chen L, Zhang Z, Chen W, Whelton PK, Appel LJ. Lower Sodium Intake and Risk of Headaches: Results From the Trial of Nonpharmacologic Interventions in the Elderly. Am J Public Health. 2016;106(7):1270-5. PubMed
- Cook NR, Appel LJ, Whelton PK. Lower levels of sodium intake and reduced cardiovascular risk. Circulation. 2014;129(9):981-9. PubMed
- Cook NR, Appel LJ, Whelton PK. Sodium Intake and All-Cause Mortality Over 20 Years in the Trials of Hypertension Prevention. J Am Coll Cardiol. 2016;68(15):1609-1617. PubMed
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