Interactions on record — worth a quick check against your medications. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

Liposomal NAD+ Complete Oral Spray Ingredients & Drug Interactions

by Renue By Science

Liquid Category: Other Combinations
Most serious interaction: Minor
The interaction bottom line Most serious interaction: Minor

Liposomal NAD+ Complete Oral Spray is a dietary supplement by Renue By Science with 3 active ingredients. Its ingredients are commonly taken for healthy aging, boosting cellular energy, supporting metabolism.Based on those ingredients, 172 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Nicotinamide Riboside. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Liposomal NAD+ Complete Oral Spray by Renue By Science

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • “Liposomal NAD Complex” is a proprietary blend — the label doesn't break down how much of each component you get.

This spray contains 3 active ingredients, all forms of nicotinamide (a B vitamin derivative): Nicotinamide Adenine Dinucleotide, Nicotinamide Mononucleotide, and Nicotinamide Riboside. The formula is packaged in a liposomal delivery system—meaning the active compounds are wrapped in tiny fat-based particles meant to help absorption.

The spray also contains several inactive ingredients: citrus flavoring, citric acid, potassium sorbate (a preservative), sodium citrate, sunflower lecithin, and xylitol.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Nicotinamide Riboside product and its label doesn't state a use — see Nicotinamide Riboside's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold doesn't establish that this product works for its promoted uses. For all the conditions listed—age-related macular degeneration, Alzheimer's disease, athletic performance, fatty liver disease, and heart failure—the data shows insufficient reliable evidence to rate nicotinamide riboside's effectiveness.

That means the research so far hasn't been robust enough to draw firm conclusions. If you're considering this product for a specific health goal, talk with your doctor or pharmacist about what the current science actually supports.

The evidence, ingredient by ingredient Nicotinamide Riboside

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Nicotinamide riboside appears well tolerated in short-term studies, but long-term safety isn't fully known yet. The most common side effects reported include bloating, muscle pain, nausea, itching, sweating, and changes in stool.

A few people in trials reported leg cramps or mild muscle soreness. Gastrointestinal effects like nausea, bloating, and diarrhea have occurred, especially in combination products.

Because there isn't enough safety data, the facts advise against use during pregnancy and while breastfeeding—talk with your doctor or pharmacist for personalized guidance if you're pregnant, planning to become pregnant, or nursing.

Side effects, ingredient by ingredient Nicotinamide Riboside

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Nicotinamide Riboside.
  • The most serious interaction on file is rated Minor.
  • For scale: 172 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Blood pressure medications (antihypertensives) are documented to interact with nicotinamide riboside at a Minor level—there's a theoretical risk of blood pressure dropping too low if combined. For the other two active ingredients in this spray, we have no interaction data on file, so ask your pharmacist to review those before you start.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

This product is a blend of nicotinamide compounds promoted for aging and metabolic health, but the evidence doesn't yet support claims for specific conditions. If you take a blood pressure medication, check your exact drug with the tool on this page before starting.

For pregnancy, breastfeeding, or any other medications, have a quick conversation with your pharmacist to make sure it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Liposomal NAD+ Complete Oral Spray, straight from the product label.

Brand Renue By Science
Barcode (UPC) 656165996612
Net contents 30 mL; 1 Fluid Ounce(s)
Market status On market
Date entered into DSLD Sep 25, 2024
DSLD ID 319000
Product type Other Combinations
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Liposomal NAD+ Complete Oral Spray by Renue By Science, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Spray(s)
Maximum serving Sizes:
2 Spray(s)
Servings per container
120
UPC/BARCODE
656165996612
IngredientAmount% DV
Nicotinamide Adenine Dinucleotide10 mg--
Nicotinamide Mononucleotide12 mg--
Nicotinamide Riboside3 mg--
Liposomal NAD Complex0 NP--

Other ingredients: Citrus Burst, Citric Acid, Potassium Sorbate, Sodium Citrate, Sunflower Lecithin, Xylitol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Shake well before using. Spray 1-2 times under the tongue.

Precautions

Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using.

Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using.

Do not use if safety seal is broken or missing.

Seals/Symbols

Store in a cool, dry place.

Made in USA GMP Good Manufacturing Practice Certified

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula

NAD+, NMN and NR

FDA Statement of Identity

Dietary Supplement

Formulation

No artificial ingredients. Gluten-free. Non-GMO.

Suitable for vegans.

See for yourself

Liposomal NAD+ Complete Oral Spray by Renue By Science label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Liposomal NAD+ Complete Oral Spray by Renue By Science

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Spray(s) Dosage formLiquid Servings per container120 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Liposomal NAD Complex

0 NP per serving

Other (inactive) ingredients: Citrus Burst, Citric Acid, Potassium Sorbate, Sodium Citrate, Sunflower Lecithin, Xylitol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Liposomal NAD+ Complete Oral Spray by Renue By Science Drug Interactions

Want to check YOUR meds against Liposomal NAD+ Complete Oral Spray?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
172Drugs
172 Minor

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Liposomal NAD+ Complete Oral Spray with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Nicotinamide Riboside1 drug type · 172 drugs

Antihypertensive Drugs

Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
One small clinical study suggests that nicotinamide riboside can modestly reduce blood pressure in hypertensive patients. However, other clinical research did not find a reduction in blood pressure when compared with control.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Liposomal NAD+ Complete Oral Spray, from the product label.

Renue By Science

See all Renue By Science products
Name
Renue By Science
City
Jacksonville
State
FL
ZipCode
32204
Phone Number
1-800-810-1935
Web Address
renuebyscience.com
Pharmacist Counseling Corner

Liposomal NAD+ Complete Oral Spray by Renue By Science: Common Questions

Does Liposomal NAD+ Complete Oral Spray by Renue By Science interact with any medications?
Yes. Based on its ingredients, Liposomal NAD+ Complete Oral Spray has a known interaction with 172 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Liposomal NAD+ Complete Oral Spray contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm pregnant or breastfeeding?
There isn't enough safety data to know either way. The facts advise against use in both pregnancy and breastfeeding. Talk with your doctor or pharmacist about your situation so they can give you personalized advice.
What are the side effects I might see?
Most people tolerate it well, but some report bloating, nausea, muscle pain, itching, sweating, or changes in stool. A few people in trials experienced leg cramps or mild muscle soreness. Gastrointestinal effects like diarrhea and stomach discomfort have also been reported, mostly in combination products.
Does this actually work for anti-aging or energy?
The evidence we hold doesn't establish that it works for the conditions listed—including age-related macular degeneration, Alzheimer's disease, athletic performance, fatty liver disease, or heart failure. The research so far is insufficient to draw firm conclusions.
What are NAD+ and nicotinamide riboside anyway?
NAD+ is a coenzyme (a helper molecule) your body uses in energy production and cellular repair. Nicotinamide riboside is a form of B vitamin that your body can convert into NAD+. This spray contains multiple forms of nicotinamide meant to support NAD+ levels.
Is this safe long-term?
Short-term studies suggest nicotinamide riboside is well tolerated, but long-term safety data isn't fully known yet. If you plan to use it regularly, that's worth discussing with your pharmacist.
Can I take this with my blood pressure medication?
Nicotinamide riboside may add to the blood-pressure-lowering effect of these drugs, which could make your blood pressure drop too low. Use the search tool on this page to check your specific medication, and ask your pharmacist before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Liposomal NAD+ Complete Oral Spray is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Liposomal NAD+ Complete Oral Spray label
Sources

Sources & How We Checked

Liposomal NAD+ Complete Oral Spray's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Nicotinamide Riboside 7 references
  1. Martens CR, Denman BA, Mazzo MR, et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nat Commun 2018;9(1):1286. PubMed
  2. Dollerup OL, Christensen B, Svart M, et al. A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects. Am J Clin Nutr 2018;108(2):343-53. PubMed
  3. Dellinger RW, Santos SR, Morris M, et al. Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safety and sustainably: a randomized, double-blind, placebo-controlled study. NPJ J Aging Mech Dis 2017;3:17.
  4. Conze D, Brenner C, Kruger CL. Safety and metabolism of long-term administration of NIAGEN (nicotinamide riboside chloride) in a randomized, double-blind, placebo-controlled clinical trial of healthy overweight adults. Sci Rep 2019;9(1):9772. PubMed
  5. Remie CME, Roumans KHM, Moonen MPB, et al. Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans. Am J Clin Nutr. 2020;112(2):413-426. PubMed
  6. Turck D, Castenmiller J, de Henauw S, et al. Safety of nicotinamide riboside chloride as a novel food pursuant to Regulation (EU) 2015/2283 and bioavailability of nicotinamide from this source, in the context of Directive 2002/46/EC. EFSA J. 2019;17(8):e0
  7. EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Turck D, et al. Extension of use of nicotinamide riboside chloride as a novel food pursuant to Regulation (EU) 2015/2283. EFSA J 2021;19(11):e06843.

See these in context on the Nicotinamide Riboside monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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