Major interaction on record — check this product against your medications before combining. Based on 3 of 4 ingredients. Check your meds →
Dietary supplement

Liver Lover Ingredients & Drug Interactions

by Apollon Nutrition

Liver Lover label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Liver Lover against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Liver Lover is a dietary supplement by Apollon Nutrition with 4 active ingredients. Its ingredients are commonly taken for thinning mucus in lung conditions, acetaminophen (tylenol) overdose treatment, antioxidant and glutathione support.Based on those ingredients, 1,148 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Milk Thistle, Reishi Mushroom, N-Acetyl Cysteine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Liver Lover by Apollon Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Liver Lover by Apollon Nutrition — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Liver Lover by Apollon Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Liver Lover contains 4 active ingredients. N-acetyl cysteine is an amino acid that supports liver detoxification and has strong evidence for treating acetaminophen (Tylenol) overdose and helping clear lung secretions in conditions like bronchitis.

Reishi mushroom is a fungus used in traditional medicine for immune and stress support, though evidence for most uses is limited. Milk thistle seed extract contains silymarin, a compound traditionally used to support liver health, with some evidence suggesting it may help manage blood sugar in people with type 2 diabetes.

The product also contains several inactive ingredients—gelatin (capsule), magnesium stearate (a lubricant), and titanium dioxide (a colorant)—which serve no active role in the formula.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: liver function and detoxification support.
  • We looked for evidence on: Acetaminophen poisoning, Alcohol-related liver disease, Biliary disorders, Chemotherapy-induced hepatotoxicity, Hepatitis, Hepatitis B — and 4 related terms.
  • The strongest evidence on file: N-acetyl Cysteine (nac) is rated "Effective" for Acetaminophen poisoning (Natural Medicines).
  • Also on file: N-acetyl Cysteine (nac) is rated "Possibly Ineffective" for Hepatitis.
  • Also on file: Milk Thistle is rated "Insufficient Reliable Evidence To Rate" for Alcohol-related liver disease, Hepatitis, Hepatitis B, Hepatitis C, and more.

N-acetyl cysteine is effective for acetaminophen poisoning and certain respiratory uses like clearing airways during bronchial studies and tracheostomy care, and it is possibly effective for bronchitis. Reishi mushroom has insufficient reliable evidence for most of its proposed uses—altitude sickness, Alzheimer's disease, and athletic performance are not yet established, and it appears possibly ineffective for high cholesterol.

Milk thistle is possibly effective for type 2 diabetes; however, evidence for acne, alcohol-related liver disease, hay fever, gambling disorder, and Amanita mushroom poisoning is insufficient. The evidence we hold does not establish this product's overall effectiveness for general liver support.

The evidence, ingredient by ingredient N-acetyl Cysteine (nac) Reishi Mushroom Milk Thistle

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

N-acetyl cysteine is generally well tolerated at typical doses, though the most common side effects when taken by mouth are diarrhea, dry mouth, heartburn, loss of appetite, nausea, and vomiting. These usually occur at higher single doses (over 9 grams) or daily amounts exceeding 30 grams.

Joint or leg pain has been reported in some users. Reishi mushroom is generally well tolerated short-term, with common side effects including dizziness, dry mouth, itching, nausea, rash, and stomach upset; long-term safety is not well studied.

Milk thistle is generally well tolerated, though mild digestive upset—bloating, diarrhea, nausea, and flatulence—can occur. Rare allergic reactions, including anaphylaxis, have been reported.

During pregnancy, N-acetyl cysteine is rated possibly safe but not well studied; the safety data advises against reishi mushroom and milk thistle in pregnancy. During breastfeeding, there is not enough safety data for milk thistle (caution advised), and the safety data advises against reishi mushroom.

Talk with your doctor or pharmacist for personalized advice if you are pregnant or breastfeeding.

Side effects, ingredient by ingredient N-acetyl Cysteine (nac) Reishi Mushroom Milk Thistle

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Milk Thistle, Reishi Mushroom, N-acetyl Cysteine (nac).
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 1,149 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take Liver Lover, double-check with your own doctor or pharmacist if you take any of these: heart medications called nitrates or nitroglycerin (Major severity); blood pressure medications; blood thinners or antiplatelet drugs; diabetes medications; chloroquine or other antimalarial drugs; morphine or other opioids; warfarin; the hepatitis C drugs ledipasvir or sofosbuvir; sirolimus; or any drug that your liver processes significantly. If you take activated charcoal (for poisoning), this product may reduce its effectiveness.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

Liver Lover is worth considering if you're looking for liver and respiratory support with ingredients that have some clinical backing—especially N-acetyl cysteine for acetaminophen toxicity or chronic bronchitis. However, this is not a product to start without checking your medications first: the interactions are numerous and serious, particularly if you take blood pressure drugs, blood thinners, heart medications like nitroglycerin, diabetes medications, or hepatitis C drugs.

Talk it over with your doctor or pharmacist before taking it, especially if you have liver disease, high blood pressure, or are on any prescription medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Liver Lover, straight from the product label.

Brand Apollon Nutrition
Barcode (UPC) 850862007613
Net contents 150 Capsule(s)
Market status On market
Date entered into DSLD Aug 23, 2023
DSLD ID 295357
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Liver Lover by Apollon Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
5 Capsule(s)
Maximum serving Sizes:
5 Capsule(s)
Servings per container
30
UPC/BARCODE
850862007613
IngredientAmount% DV
N-Acetyl Cysteine1200 mg--
TUDCA300 mg--
Reishi Mushroom1000 mg--
Milk Thistle1000 mg--

Other ingredients: Gelatin, Magnesium Stearate, Titanium Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Your liver is one of the hardest working organs in the body - breaking down hormones, detoxifying blood, producing bile needed to digest fat, storing essential micronutrients, and filtering out all the other toxic crap you ingest. As relentlessly as the liver works throughout the day, don't you think it deserves some love? Daily liver support and protection

Clean formulation No fillers No additives 100% transparent

Formula

Liver Lover is our ultra-premium liver management supplement containing powerhouse ingredients like NAC, TUDCA and milk thistle to support healthy liver function as well as the body's innate anti-inflammatory and detoxification pathways.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Brand IP Statement(s)

Copyright 2021, All rights reserved. Apollon Nutrition and Liver Lover are registered trademarks of Apollon Nutrition, LLC.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take 5 capsules of Liver Lover with breakfast or a small meal.

Precautions

Warning: This product is only intended to be consumed by healthy adults 18 years of age or older.

Do not use this product if you are pregnant, expect to become pregnant, or are nursing.

Always consult with your physician before using this or any other dietary supplement product.

Do not use this product without consulting your physician if you are using any prescription or over the counter medication or if you have any pre-existing medical condition.

Immediately discontinue use and consult your physician if you experience any adverse reaction to this product. Do not use if safety seal is broken or missing.

Keep out of the reach of children.

Storage

Store in a cool, dry place away from moisture and light.

Seals/Symbols

Manufactured in the USA of International and Domestic Ingredients FDA Registered Facility GMP Good Manufacturing Practice Consistent Quality

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Liver Lover by Apollon Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Liver Lover label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Liver Lover by Apollon Nutrition

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size5 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

N-Acetyl Cysteine

Interacts with
294 drugs
1200 mg per serving

N-acetyl cysteine (NAC) is a supplement form of the amino acid cysteine and a building block for the antioxidant glutathione. It has well-established...

N-Acetyl Cysteine monograph & interactions

TUDCA

300 mg per serving

Reishi Mushroom

Interacts with
375 drugs
1000 mg per serving

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits...

Reishi Mushroom monograph & interactions

Milk Thistle

Interacts with
954 drugs
1000 mg per serving Form: Silymarin

Milk thistle is a popular herbal supplement most often used for liver health, and its main active component is a group of compounds called silymarin....

Milk Thistle monograph & interactions

Other (inactive) ingredients: Gelatin, Magnesium Stearate, Titanium Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Liver Lover by Apollon Nutrition Drug Interactions

Want to check YOUR meds against Liver Lover?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,148Drugs
1 Major 535 Moderate 612 Minor

Ingredients driving the most interactions

Milk Thistle 954
Reishi Mushroom 375
N-Acetyl Cysteine 294

Individual Drug Interactions

The ingredients in Liver Lover interact with 1,148 drugs. Click any drug to see the details.

3 of the 4 ingredients in Liver Lover interact with drugs. Each result below shows which ingredient is responsible. Milk Thistle Reishi Mushroom N-Acetyl Cysteine

Each ingredient & the kinds of drugs it affects

For each ingredient in Liver Lover with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Milk Thistle17 drug types · 954 drugs

Antidiabetes Drugs

Taking milk thistle with antidiabetes drugs may increase the risk of hypoglycemia.
Clinical research shows that milk thistle extract, alone or along with tree turmeric extract, can lower blood glucose levels and glycated hemoglobin (HbA1c) in patients with type 2 diabetes, including those already taking antidiabetes drugs. Additionally, animal research shows that milk thistle extract increases the metformin maximum plasma concentration and area under the curve and decreases the renal clearance of metformin, due to inhibition of the multi-drug and toxin extrusion protein 1 (MATE1) renal tubular transport protein.

Likelihood Possible Evidence B
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, milk thistle might inhibit CYP2B6.
An in vitro study shows that silybin, a constituent of milk thistle, binds to and noncompetitively inhibits CYP2B6. Additionally, silybin might downregulate the expression of CYP2B6 by decreasing mRNA and protein levels.

Likelihood Possible Evidence D
Glucuronidated Drugs

Theoretically, milk thistle might affect the clearance of drugs that undergo glucuronidation.
Laboratory research shows that milk thistle constituents inhibit uridine diphosphoglucuronosyl transferase (UGT), the major phase 2 enzyme that is responsible for glucuronidation. Theoretically, this could decrease the clearance and increase levels of glucuronidated drugs. Other laboratory research suggests that a milk thistle extract of silymarin might inhibit beta-glucuronidase, although the significance of this effect is unclear.

Likelihood Possible Evidence D
Ledipasvir

Theoretically, milk thistle might increase the levels and clinical effects of ledipasvir.
Animal research in rats shows that milk thistle increases the area under the curve (AUC) for ledipasvir and slows its elimination.

Likelihood Possible Evidence D
Morphine

Theoretically, concomitant use of milk thistle with morphine might affect serum levels of morphine and either increase or decrease its effects.
Animal research shows that milk thistle reduces serum levels of morphine by up to 66%. In contrast, laboratory research shows that milk thistle constituents inhibit uridine diphosphoglucuronosyl transferase (UGT), the major phase 2 enzyme that is responsible for glucuronidation. Theoretically, this could decrease the clearance and increase morphine levels. The effect of taking milk thistle on morphine metabolism in humans is not known.

Likelihood Possible Evidence D
Raloxifene (Evista)

Theoretically, milk thistle might decrease the clearance and increase levels of raloxifene.
Laboratory research suggests that the milk thistle constituents silibinin and silymarin inhibit the glucuronidation of raloxifene in the intestines.

Likelihood Possible Evidence D
Sirolimus (Rapamune)

Milk thistle might decrease the clearance of sirolimus.
Pharmacokinetic research shows that a milk thistle extract of silymarin decreases the apparent clearance of sirolimus in hepatically impaired renal transplant patients. It is unclear if this interaction occurs in patients without hepatic impairment.

Likelihood Possible Evidence B
Sofosbuvir (Solvaldi)

Theoretically, milk thistle might decrease the levels and clinical effects of sofosbuvir.
Animal research in rats shows that milk thistle reduces the metabolism of sofosbuvir, as well as the hepatic uptake of its active metabolite.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, the milk thistle constituent silibinin might increase tamoxifen levels and interfere with its conversion to an active metabolite.
Animal research suggests that the milk thistle constituent silibinin might increase plasma levels of tamoxifen and alter its conversion to an active metabolite. The mechanism appears to involve inhibition of pre-systemic metabolism of tamoxifen by cytochrome P450 (CYP) 2C9 and CYP3A4, and inhibition of P-glycoprotein-mediated efflux of tamoxifen into the intestine for excretion. Whether this interaction occurs in humans is not known.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, milk thistle might increase the effects of warfarin.
In one case report, a man stabilized on warfarin experienced an increase in INR from 2.64 to 4.12 after taking a combination product containing milk thistle 200 mg daily, as well as dandelion, wild yam, niacinamide, and vitamin B12. Levels returned to normal after stopping the supplement. Although a direct correlation between milk thistle and the change in INR cannot be confirmed, some in vitro research suggests that milk thistle might inhibit cytochrome P450 2C9 (CYP2C9), an enzyme involved in the metabolism of various drugs, including warfarin.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

It is unclear if milk thistle inhibits CYP2C9; research is conflicting.
In vitro research suggests that milk thistle might inhibit CYP2C9. Additionally, 3 case reports from the World Health Organization (WHO) adverse drug reaction database describe increased toxicity in patients taking milk thistle and cancer medications that are CYP2C9 substrates, including imatinib and capecitabine. However, contradictory clinical research shows that milk thistle extract does not inhibit CYP2C9 or significantly affect levels of the CYP2C9 substrate tolbutamide. Differences in results could be due to differences in dosages or formulations utilized.

Likelihood Unlikely Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

It is unclear if milk thistle inhibits CYP3A4; research is conflicting.
While laboratory research shows conflicting results, pharmacokinetic research shows that taking milk thistle extract 420-1350 mg daily does not significantly affect the metabolism of the CYP3A4 substrates irinotecan, midazolam, or indinavir. However, 8 case reports from the World Health Organization (WHO) adverse drug reaction database describe increased toxicity in patients taking milk thistle and cancer medications that are CYP3A4 substrates, including gefitinib, sorafenib, doxorubicin, and vincristine.

Likelihood Unlikely Evidence D
Estrogens

Theoretically, milk thistle might interfere with estrogen therapy through competition for estrogen receptors.
Animal research suggests that a milk thistle extract of silymarin binds to estrogen receptor beta.

Likelihood Possible Evidence D
Hmg-Coa Reductase Inhibitors ("Statins")

Theoretically, milk thistle might interfere with statin therapy by decreasing the activity of organic anion transporting polypeptide 1B1 (OATB1B1) and inhibiting breast cancer resistance protein (BCRP).
Preliminary evidence suggests that a milk thistle extract of silymarin can decrease the activity of the OATP1B1, which transports HMG-CoA reductase inhibitors into the liver to their site of action, and animal research shows this increases the maximum plasma concentration of pitavastatin and pravastatin. The silibinin component also inhibits BCRP, which transports statins from the liver into the bile for excretion. However, in a preliminary study in healthy males, silymarin 140 mg three times daily had no effect on the pharmacokinetics of a single 10 mg dose of rosuvastatin.

Likelihood Unlikely Evidence D
Indinavir (Crixivan)

Theoretically, milk thistle may induce cytochrome P450 3A4 (CYP3A4) enzymes and increase the metabolism of indinavir; however, results are conflicting.
One pharmacokinetic study shows that taking milk thistle (Standardized Milk Thistle, General Nutrition Corp.) 175 mg three times daily in combination with multiple doses of indinavir 800 mg every 8 hours decreases the mean trough levels of indinavir by 25%. However, results from the same pharmacokinetic study show that milk thistle does not affect the overall exposure to indinavir. Furthermore, two other pharmacokinetic studies show that taking specific milk thistle extract (Legalon, Rottapharm Madaus; Thisilyn, Nature's Way) 160-450 mg every 8 hours in combination with multiple doses of indinavir 800 mg every 8 hours does not reduce levels of indinavir.

Likelihood Unlikely Evidence B
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Milk thistle may inhibit one form of OATP, OATP-B1, which could reduce the bioavailability and clinical effects of OATP-B1 substrates.
In vitro research shows that milk thistle inhibits OATP-B1. Two case reports from the World Health Organization (WHO) adverse drug reaction database describe increased toxicity in patients taking milk thistle and cancer medications that are OATP substrates, including sorafenib and methotrexate. OATPs are expressed in the small intestine and liver and are responsible for the uptake of drugs and other compounds into the body. Inhibition of OATP may reduce the bioavailability of oral drugs that are substrates of OATP.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, milk thistle might increase the absorption of P-glycoprotein substrates. However, this effect does not seem to be clinically significant.
In vitro research shows that milk thistle can inhibit P-glycoprotein activity and 1 case report from the World Health Organization (WHO) adverse drug reaction database describes increased abdominal pain in a patient taking milk thistle and the cancer medication vincristine, a P-glycoprotein substrate, though this patient was also taking methotrexate. However, a small pharmacokinetic study in healthy volunteers shows that taking milk thistle (Enzymatic Therapy Inc.) 900 mg, standardized to 80% silymarin, in 3 divided doses daily for 14 days does not affect absorption of digoxin, a P-glycoprotein substrate.

Likelihood Unlikely Evidence B
Milk Thistle full monograph & interactions

Reishi Mushroom3 drug types · 375 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
A dose of 1.5 grams daily of reishi mushroom does not seem to decrease platelet aggregation, but a higher dose of 3 grams daily does.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Animal research suggests that reishi mushroom decreases blood sugar. However, in patients with type 2 diabetes, taking reishi mushroom does not reduce fasting glucose levels, and its effects on glycated hemoglobin are inconsistent.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Reishi mushroom has shown hypotensive activity in animal research. Clinical evidence suggests that reishi mushroom reduces blood pressure in some, but not all, patients with hypertension.

Likelihood Possible Evidence D
Reishi Mushroom full monograph & interactions

N-Acetyl Cysteine5 drug types · 294 drugs

Nitroglycerin

N-acetyl cysteine can increase the risk for hypotension and headaches when taken with intravenous or transdermal nitroglycerin.
Clinical research shows that concomitant administration of N-acetyl cysteine and intravenous or transdermal nitroglycerin can cause severe hypotension and intolerable headaches. Furthermore, in vitro research suggests that N-acetyl cysteine increases the anticoagulant activity of nitroglycerin.

Likelihood Probable Evidence B
Activated Charcoal

N-acetyl cysteine might reduce the effects of activated charcoal, while activated charcoal might reduce the absorption of N-acetyl cysteine.
N-acetyl cysteine appears to reduce the capacity of activated charcoal to adsorb acetaminophen and salicylic acid. Conversely, although clinical research suggests that although activated charcoal can reduce the absorption of N-acetyl cysteine by up to 40%, it does not seem to reduce its clinical effects. Other clinical evidence suggests that activated charcoal does not affect the absorption of N-acetyl cysteine.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, N-acetyl cysteine might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Clinical research suggests that intravenous N-acetyl cysteine decreases prothrombin time, prolongs coagulation time, decreases platelet aggregation, and increases blood loss in surgical patients. Furthermore, in vitro research suggests that N-acetyl cysteine increases the anticoagulant activity of nitroglycerin.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, N-acetyl cysteine might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research suggests that N-acetyl cysteine potentiates the hypotensive effects of the angiotensin-converting enzyme inhibitors (ACEIs) captopril and enalaprilat. Theoretically, combining N-acetyl cysteine with other antihypertensive drugs might increase the risk of hypotension.

Likelihood Possible Evidence D
Chloroquine (Aralen)

Theoretically, N-acetyl cysteine might interfere with the antimalarial effects of chloroquine.
Animal research suggests that N-acetyl cysteine might reduce the antimalarial effects of chloroquine by increasing cellular levels of glutathione.

Likelihood Possible Evidence D
N-Acetyl Cysteine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Liver Lover, from the product label.

Apollon Nutrition

See all Apollon Nutrition products
Name
Apollon Nutrition
Street Address
160 Talmadge Road
City
Edison
State
NJ
ZipCode
08817
Phone Number
732-985-8576
Web Address
ApollonNutrition.com
Pharmacist Counseling Corner

Liver Lover by Apollon Nutrition: Common Questions

Does Liver Lover by Apollon Nutrition interact with any medications?
Yes. Based on its ingredients, Liver Lover has a known interaction with 1,148 medications, including 1 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Liver Lover contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is N-acetyl cysteine, and why is it in this product?
N-acetyl cysteine (NAC) is an amino acid and a precursor to glutathione, a major antioxidant made by your liver. It's included because it supports liver detoxification and has strong evidence for clearing lung secretions in conditions like bronchitis. It's also the gold-standard treatment for acetaminophen overdose.
Will this product lower my blood sugar or blood pressure?
Possibly. N-acetyl cysteine theoretically may lower blood pressure, reishi mushroom has shown hypotensive activity in animal studies and may lower blood pressure in some people, and milk thistle can lower blood glucose in people with type 2 diabetes. If you take medications for either condition, talk with your doctor or pharmacist before starting—combining them could cause dangerously low levels.
Is this safe to take if I'm pregnant?
N-acetyl cysteine is rated possibly safe but has not been well studied in pregnancy. Reishi mushroom and milk thistle both carry enough safety concerns that the data advises against them in pregnancy. There is not enough reliable data to know either way for sure—talk with your doctor or pharmacist for personalized advice.
What's the most common side effect I might notice?
From N-acetyl cysteine, the most common side effects when taken by mouth are diarrhea, dry mouth, heartburn, nausea, and loss of appetite. Reishi mushroom commonly causes dizziness, dry mouth, and nausea. Milk thistle may cause mild digestive upset like bloating and diarrhea, though these don't typically happen more often than with placebo.
Is there evidence this product actually helps the liver?
The individual ingredients have some support—N-acetyl cysteine is effective for acetaminophen poisoning, and milk thistle is possibly effective for type 2 diabetes, which can affect liver health—but we don't have clinical evidence that this specific combination product improves overall liver function or liver disease.
What is TUDCA, and does it interact with any medications?
TUDCA is an ingredient in this product, but we hold no interaction data for it, so we cannot tell you whether it interacts with medications. Talk with your pharmacist about this ingredient specifically if you have concerns.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Liver Lover label
Go deeper

The Full Monographs Behind Liver Lover’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

N-acetyl Cysteine (nac)

Interacts with 294 drugs

N-acetyl cysteine (NAC) is a supplement form of the amino acid cysteine and a building block for the antioxidant glutathione. It has well-established prescription uses for acetaminophen over...

Read the full N-acetyl Cysteine (nac) monograph → Herb & supplement monograph

Reishi Mushroom

Interacts with 375 drugs

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits is limited or low-quality, so it should...

Read the full Reishi Mushroom monograph → Herb & supplement monograph

Milk Thistle

Interacts with 954 drugs

Milk thistle is a popular herbal supplement most often used for liver health, and its main active component is a group of compounds called silymarin. While it is generally well tolerated, th...

Read the full Milk Thistle monograph →
Sources

Sources & How We Checked

Liver Lover's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 172 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

N-acetyl Cysteine (nac) 86 references
  1. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
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Reishi Mushroom 17 references
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Milk Thistle 69 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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