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Dietary supplement

Lutein (with Zeaxanthin) Ingredients & Drug Interactions

by BulkSupplements.com

Lutein (with Zeaxanthin) label
See full label image
Softgel Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lutein (with Zeaxanthin) against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Lutein (with Zeaxanthin) is a dietary supplement by BulkSupplements.com with 2 active ingredients. Its ingredients are commonly taken for eye health, age-related macular degeneration, cataract prevention.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Zeaxanthin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Lutein (with Zeaxanthin) by BulkSupplements.com

Ask about any prescription or over-the-counter medication and we check it for interactions with Lutein (with Zeaxanthin) by BulkSupplements.com — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Lutein (with Zeaxanthin) by BulkSupplements.com

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This softgel contains 2 active ingredients: lutein and zeaxanthin. Both are carotenoids — plant pigments your eyes naturally contain, especially in the macula (the center of your retina).

The product also includes inactive ingredients: soybean oil, gelatin, glycerin, purified water, and beeswax, which help form and stabilize the softgel capsule.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Eye health and age-related macular degeneration.
  • We looked for evidence on: Age-related macular degeneration (AMD), Asthenopia (eye strain), Cataracts, Diabetic retinopathy, Dry eye, Glaucoma — and 4 related terms.
  • The strongest evidence on file: Lutein is rated "Possibly Effective" for Age-related macular degeneration (AMD) (Natural Medicines).
  • Also on file: Lutein is rated "Possibly Effective" for Cataracts.
  • Also on file: Zeaxanthin is rated "Possibly Effective" for Age-related macular degeneration (AMD).

Lutein is possibly effective for age-related macular degeneration (AMD) and cataracts, but the evidence isn't strong enough to call it proven. It appears ineffective for retinitis pigmentosa, retinopathy of prematurity, necrotizing enterocolitis, and bronchopulmonary dysplasia.

Zeaxanthin is also possibly effective for AMD, but we don't have enough reliable evidence to rate it for age-related cognitive decline, Alzheimer disease, asthma, breast cancer, or bronchopulmonary dysplasia. In short: there's a signal for eye health, especially AMD, but it's not definitive.

The evidence, ingredient by ingredient Lutein Zeaxanthin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lutein and zeaxanthin are both generally well tolerated at typical supplement doses — lutein studies have used up to 20 mg daily without reported adverse effects. Both carry the same pregnancy and lactation rating: likely safe.

However, because the safety data on concentrated supplement doses (rather than food amounts) is limited, the facts advise caution during pregnancy and breastfeeding. If you're pregnant, breastfeeding, or planning either, talk with your doctor or pharmacist before starting.

Side effects, ingredient by ingredient Lutein Zeaxanthin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Zeaxanthin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antidiabetes drugs (medications for type 2 diabetes or any blood sugar condition), check your specific medication against the search tool on this page before adding this product — zeaxanthin may theoretically increase the risk of low blood sugar (hypoglycemia) when combined with them.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is a straightforward lutein and zeaxanthin supplement aimed at eye health, particularly for AMD. If you take antidiabetes medications, you'll want to check them against the interaction list before starting.

For anyone else, the main caution is that pregnancy and breastfeeding safety data on supplement doses isn't settled, so chat with your own doctor or pharmacist if that applies to you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 18, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lutein (with Zeaxanthin), straight from the product label.

Brand BulkSupplements.com
Net contents 300 Softgel(s)
Market status On market
Date entered into DSLD Jul 18, 2023
DSLD ID 294414
Product type Non-nutrient/non-botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lutein (with Zeaxanthin) by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
300
IngredientAmount% DV
Lutein8800 mcg--
Zeaxanthin200 mcg--

Other ingredients: Soybean Oil, Gelatin, Glycerin, Water, Purified, Beeswax

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Bulk Supplements.com Clean & pure bulk supplements

Formulation

Free of: Dairy, yeast, gluten

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take 1 softgel once daily, or as directed by a physician.

Storage

Store in a cool, dry place.

Precautions

Allergen information: Soy

Always consult a physician before taking any dietary supplement.

Keep out of reach of children.

FDA Disclaimer Statement

This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lutein (with Zeaxanthin) by BulkSupplements.com label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lutein (with Zeaxanthin) label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lutein (with Zeaxanthin) by BulkSupplements.com

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container300 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Lutein

No known
interactions
8800 mcg per serving

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help...

Lutein monograph & interactions

Zeaxanthin

Interacts with
86 drugs
200 mcg per serving

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The stron...

Zeaxanthin monograph & interactions

Other (inactive) ingredients: Soybean Oil, Gelatin, Glycerin, Water, Purified, Beeswax. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lutein (with Zeaxanthin) by BulkSupplements.com Drug Interactions

Want to check YOUR meds against Lutein (with Zeaxanthin)?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Zeaxanthin 86

Individual Drug Interactions

The ingredients in Lutein (with Zeaxanthin) interact with 86 drugs. Click any drug to see the details.

1 of the 2 ingredients in Lutein (with Zeaxanthin) interact with drugs. Each result below shows which ingredient is responsible. Zeaxanthin

Each ingredient & the kinds of drugs it affects

For each ingredient in Lutein (with Zeaxanthin) with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Zeaxanthin1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking zeaxanthin with antidiabetes drugs might increase the risk of hypoglycemia.
In an animal diabetic model, zeaxanthin has hypoglycemic effects. However, population research has found that increasing intake of dietary zeaxanthin plus lutein does not decrease the risk of developing type 2 diabetes.

Likelihood Possible Evidence D
Zeaxanthin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lutein (with Zeaxanthin), from the product label.

BulkSupplements.com

See all BulkSupplements.com products
Name
BulkSupplements.com
Street Address
7511 Eastgate Rd
City
Henderson
State
NV
ZipCode
89011
Web Address
BulkSupplements.com
Pharmacist Counseling Corner

Lutein (with Zeaxanthin) by BulkSupplements.com: Common Questions

Does Lutein (with Zeaxanthin) by BulkSupplements.com interact with any medications?
Yes. Based on its ingredients, Lutein (with Zeaxanthin) has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lutein (with Zeaxanthin) contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What's lutein and zeaxanthin for?
Both are carotenoids found naturally in your eyes, especially in the macula. Research suggests they may help protect against age-related macular degeneration and cataracts, though the evidence isn't definitive yet. They're not effective for other eye conditions like retinitis pigmentosa or retinopathy of prematurity.
Is this safe during pregnancy or while breastfeeding?
The data says 'likely safe,' but there isn't enough research on concentrated supplement doses during pregnancy or breastfeeding. Lutein and zeaxanthin from food are fine; it's the supplement form where data is thin. Talk with your doctor or pharmacist for personalized advice if you're pregnant, planning to be, or nursing.
What side effects should I expect?
Lutein at doses up to 20 mg daily hasn't caused adverse effects in studies. Zeaxanthin is also generally well tolerated at typical supplement amounts. Neither ingredient is known to cause side effects at the levels used in supplements.
I take a diabetes medication — is this okay?
Zeaxanthin in this product theoretically may lower blood sugar, which could increase low blood sugar risk if you're on antidiabetes drugs. It's a moderate concern. Use the medication search tool on this page to check your specific diabetes medication before you start, and talk it over with your doctor or pharmacist.
Does this actually work for AMD or cataracts?
The evidence for both conditions is 'possibly effective' — there's a signal, but it's not definitive proof. It's not effective for other eye conditions. This is a 'might help' product, not a guaranteed treatment.
Does this product have fillers?
It has inactive ingredients — soybean oil, gelatin, glycerin, purified water, and beeswax — that stabilize the softgel and make it easy to take. To a pharmacist, those are normal excipients, not 'fillers' in the sense of unnecessary junk.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Lutein (with Zeaxanthin) is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lutein (with Zeaxanthin) label
Go deeper

The Full Monographs Behind Lutein (with Zeaxanthin)’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lutein

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help slow progression of age-related macular...

Read the full Lutein monograph → Herb & supplement monograph

Zeaxanthin

Interacts with 86 drugs

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The strongest evidence relates to slowing progres...

Read the full Zeaxanthin monograph →
Sources

Sources & How We Checked

Lutein (with Zeaxanthin)'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lutein 2 references
  1. Brown L, Rimm EB, Seddon JM, et al. A prospective study of carotenoid intake and risk of cataract extraction in US men. Am J Clin Nutr 1999;70:517-24. PubMed
  2. Chasan-Taber L, Willett WC, Seddon JM, et al. A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. Am J Clin Nutr 1999;70:509-16. PubMed

See these in context on the Lutein monograph →

Zeaxanthin 4 references
  1. Montonen J, Knekt P, Jarvinen R, Reunanen A. Dietary antioxidant intake and risk of type 2 diabetes. Diabetes Care 2004;27:362-6. PubMed
  2. Leermakers ET, Darweesh SK, Baena CP, et al. The effects of lutein on cardiometabolic health across the life course: a systematic review and meta-analysis. Am J Clin Nutr 2016;103(2):481-94. PubMed
  3. Kou L, Du M, Zhang C, Dai Z, Li X, Zhang B. The Hypoglycemic, Hypolipidemic, and Anti-Diabetic Nephritic Activities of Zeaxanthin in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats. Appl Biochem Biotechnol 2017;182(3):944-955. PubMed
  4. Xu X, Zhao X, Berde Y, Low YL, Kuchan MJ. Milk and Plasma Lutein and Zeaxanthin Concentrations in Chinese Breast-Feeding Mother-Infant Dyads With Healthy Maternal Fruit and Vegetable Intake. J Am Coll Nutr 2019;38(2):179-184. PubMed

See these in context on the Zeaxanthin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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