MagTech Magnesium Lemonade Ingredients & Drug Interactions
What is this page for?
First and foremost: checking MagTech Magnesium Lemonade against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
MagTech Magnesium Lemonade is a dietary supplement by NS Natural Stacks with 1 active ingredient. Its ingredients are commonly taken for preventing or treating magnesium deficiency, constipation, muscle cramps.Based on those ingredients, 295 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Magnesium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against MagTech Magnesium Lemonade by NS Natural Stacks
Ask about any prescription or over-the-counter medication and we check it for interactions with MagTech Magnesium Lemonade by NS Natural Stacks — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of MagTech Magnesium Lemonade by NS Natural Stacks
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
MagTech Magnesium Lemonade contains 3 active magnesium ingredients: magnesium glycinate, Magtein magnesium L-threonate, and magnesium taurate. These are different forms of magnesium designed to deliver this essential mineral, which plays a role in muscle and nerve function, energy production, and bone health.
The powder also contains lemon flavoring and monk fruit extract as inactive ingredients.
Does it work?
Strong evidence
The magnesium in this product is effective for indigestion (dyspepsia), constipation, and low blood magnesium (hypomagnesemia). Research also supports its use for pre-eclampsia, a serious blood pressure condition in pregnancy—though that use is strictly medical and requires a doctor's oversight.
How safe is it?
Well-documented data
Magnesium is generally well tolerated when taken at recommended doses. The most common side effects when taken by mouth are diarrhea, stomach upset, nausea, and vomiting.
In rare cases, oral magnesium can form an indigestible mass (called a bezoar) in the stomach. While magnesium is needed in pregnancy, use supplements only under your doctor's guidance.
For breastfeeding, normal dietary amounts are fine, but check with your doctor before starting a supplement.
Meds to double-check
Major interaction found
Before taking this product, check with your doctor or pharmacist if you take levodopa/carbidopa (Sinemet)—magnesium can significantly reduce its effect. Also double-check skeletal muscle relaxants, potassium-sparing diuretics, calcium channel blockers, antacids or acid-reducing medications, sulfonylureas (diabetes drugs), quinolone antibiotics, or bisphosphonates.
Timing and dose adjustments may be needed.
The bottom line
Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.
This product is a source of magnesium for people with low levels or those dealing with constipation and indigestion. If you take levodopa/carbidopa for Parkinson's, blood pressure medications, diabetes drugs, antibiotics, bone medications, or muscle relaxants, check your exact medications with the tool on this page before starting.
Talk with your doctor or pharmacist about whether it's right for you, especially if you're pregnant, breastfeeding, or take any regular medications.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 22, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about MagTech Magnesium Lemonade, straight from the product label.
| Brand | NS Natural Stacks |
|---|---|
| Barcode (UPC) | 652508121413 |
| Net contents | 2.2 Ounce(s); 64.6 Gram(s); 20 Stick Pack(s) |
| Market status | On market |
| Date entered into DSLD | Sep 22, 2022 |
| DSLD ID | 274279 |
| Product type | Mineral |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for MagTech Magnesium Lemonade by NS Natural Stacks, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Magnesium Glycinate | 690 mg | -- |
| Magnesium | 200 mg | 48% |
| Magtein Magnesium L-Threonate | 1000 mg | -- |
| Magnesium Taurate | 630 mg | -- |
Other ingredients: Lemon, Crystallized, Monk Fruit Extract
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested Use: Place powder in a glass or mug; add 6 oz of cold or hot water and stir. Take 2 servings per day, preferably 1 serving in the afternoon and 1 serving in the evening, or as directed by a healthcare practitioner.
General Statements
Certified Open Source: Scan for ingredient supplier information and 3rd party lab test results.
20-0.11 oz (3.23 g) Stick Packs
Brand IP Statement(s)
Magtein is a trademark of Magceutics, Inc. and is distributed exclusively by AIDP, Inc. Magtein is protected under U.S. Patents 8,178,118; 8,142,803; 8,163,301; and other pending patents
Seals/Symbols
Certified Open Source Full Label Disclosure U.S.A. manufactured in a cGMP certified facility.
Formulation
For relaxation & brain health
Formula
Magtein Think clearly.
FDA Statement of Identity
Dietary Supplement
Precautions
Warning: If you are pregnant, nursing, or taking any medications, consult a healthcare practitioner before use.
Do not use if safety seal is broken or missing.
Keep out of reach of children.
Storage
Store in a cool dry place.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
MagTech Magnesium Lemonade by NS Natural Stacks label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in MagTech Magnesium Lemonade by NS Natural Stacks
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size3.23 Gram(s) Dosage formPowder Servings per container20 Amounts shown are per serving.
Magnesium
Interacts with295 drugs
Magnesium is an essential mineral your body needs for muscles, nerves, blood pressure, and many other functions, and supplements are useful for preven...
Magnesium monograph & interactionsOther (inactive) ingredients: Lemon, Crystallized, Monk Fruit Extract. These complete the product’s ingredient list but are not active constituents.
MagTech Magnesium Lemonade by NS Natural Stacks Drug Interactions
HelloPharmacist Interaction Report
MagTech Magnesium Lemonade by NS Natural Stacks interacts with medications through its magnesium glycinate, Magtein magnesium L-threonate, and magnesium taurate content.
The most serious interaction is with levodopa/carbidopa (Sinemet), a Parkinson's medication—magnesium can reduce its absorption significantly, lowering its effectiveness. Altogether, these interactions span 295 individual medications.
Read the full breakdown — every affected drug type, severity by severity
Moderate interactions occur with skeletal muscle relaxants (magnesium can strengthen and speed up their effects), potassium-sparing diuretics (may raise magnesium levels), calcium channel blockers used for blood pressure (additive effects possible), antacids and acid-reducing drugs (may reduce the laxative effect of the magnesium), sulfonylureas (diabetes medications—magnesium can boost their absorption and the risk of low blood sugar), quinolone antibiotics (magnesium reduces their absorption), and bisphosphonates used for bone health (magnesium lowers their absorption).
To find out whether this product affects your specific medications, run each one through the interaction checker on this page.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against MagTech Magnesium Lemonade?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in MagTech Magnesium Lemonade interact with 295 drugs. Click any drug to see the details.
1 of the 1 ingredient in MagTech Magnesium Lemonade interact with drugs. Each result below shows which ingredient is responsible. Magnesium
Benserazide, LevodopaMadopar, Prolopa
How Benserazide, Levodopa interacts with MagTech Magnesium Lemonade — through 1 ingredient. Tap an ingredient for the detail:
Magnesium TaurateLevodopa/carbidopa (sinemet) Major
Interaction Summary
Magnesium can reduce the bioavailability of levodopa/carbidopa.
Read the full Magnesium Taurate + Benserazide, Levodopa interactionCarbidopaLodosyn
How Carbidopa interacts with MagTech Magnesium Lemonade — through 1 ingredient. Tap an ingredient for the detail:
Magnesium TaurateLevodopa/carbidopa (sinemet) Major
Interaction Summary
Magnesium can reduce the bioavailability of levodopa/carbidopa.
Read the full Magnesium Taurate + Carbidopa interactionCarbidopa, LevodopaDhivy, Rytary, Sinemet, Sinemet CR
How Carbidopa, Levodopa interacts with MagTech Magnesium Lemonade — through 1 ingredient. Tap an ingredient for the detail:
Magnesium TaurateLevodopa/carbidopa (sinemet) Major
Interaction Summary
Magnesium can reduce the bioavailability of levodopa/carbidopa.
Read the full Magnesium Taurate + Carbidopa, Levodopa interactionCarbidopa, Levodopa, EntacaponeStalevo
How Carbidopa, Levodopa, Entacapone interacts with MagTech Magnesium Lemonade — through 1 ingredient. Tap an ingredient for the detail:
Magnesium TaurateLevodopa/carbidopa (sinemet) Major
Interaction Summary
Magnesium can reduce the bioavailability of levodopa/carbidopa.
Read the full Magnesium Taurate + Carbidopa, Levodopa, Entacapone interactionLevodopaInbrija, Larodopa
How Levodopa interacts with MagTech Magnesium Lemonade — through 1 ingredient. Tap an ingredient for the detail:
Magnesium TaurateLevodopa/carbidopa (sinemet) Major
Interaction Summary
Magnesium can reduce the bioavailability of levodopa/carbidopa.
Read the full Magnesium Taurate + Levodopa interactionLevodopa, CarbidopaDuodopa
How Levodopa, Carbidopa interacts with MagTech Magnesium Lemonade — through 1 ingredient. Tap an ingredient for the detail:
Magnesium TaurateLevodopa/carbidopa (sinemet) Major
Interaction Summary
Magnesium can reduce the bioavailability of levodopa/carbidopa.
Read the full Magnesium Taurate + Levodopa, Carbidopa interactionAcetaminophen, ChlorzoxazoneAcetazone Forte, Extra Strength Tylenol Aches & Strains, Parafon Forte
How Acetaminophen, Chlorzoxazone interacts with MagTech Magnesium Lemonade — through 1 ingredient. Tap an ingredient for the detail:
Magnesium TaurateSkeletal Muscle Relaxants Moderate
Interaction Summary
Parenteral magnesium alters the pharmacokinetics of skeletal muscle relaxants, increasing their effects and accelerating the onset of effect.
Read the full Magnesium Taurate + Acetaminophen, Chlorzoxazone interactionAcetaminophen, Chlorzoxazone, CodeineAcetazone Forte C8, Parafon Forte C8
How Acetaminophen, Chlorzoxazone, Codeine interacts with MagTech Magnesium Lemonade — through 1 ingredient. Tap an ingredient for the detail:
Magnesium TaurateSkeletal Muscle Relaxants Moderate
Interaction Summary
Parenteral magnesium alters the pharmacokinetics of skeletal muscle relaxants, increasing their effects and accelerating the onset of effect.
Read the full Magnesium Taurate + Acetaminophen, Chlorzoxazone, Codeine interactionAcetaminophen, Codeine, MethocarbamolAcetaminophen, Codeine, Methocarbamol, Robaxacet 8
How Acetaminophen, Codeine, Methocarbamol interacts with MagTech Magnesium Lemonade — through 1 ingredient. Tap an ingredient for the detail:
Magnesium TaurateSkeletal Muscle Relaxants Moderate
Interaction Summary
Parenteral magnesium alters the pharmacokinetics of skeletal muscle relaxants, increasing their effects and accelerating the onset of effect.
Read the full Magnesium Taurate + Acetaminophen, Codeine, Methocarbamol interactionAcetaminophen, MethocarbamolRobaxacet
How Acetaminophen, Methocarbamol interacts with MagTech Magnesium Lemonade — through 1 ingredient. Tap an ingredient for the detail:
Magnesium TaurateSkeletal Muscle Relaxants Moderate
Interaction Summary
Parenteral magnesium alters the pharmacokinetics of skeletal muscle relaxants, increasing their effects and accelerating the onset of effect.
Read the full Magnesium Taurate + Acetaminophen, Methocarbamol interactionAcetaminophen, OrphenadrineOrfenagesic
How Acetaminophen, Orphenadrine interacts with MagTech Magnesium Lemonade — through 1 ingredient. Tap an ingredient for the detail:
Magnesium TaurateSkeletal Muscle Relaxants Moderate
Interaction Summary
Parenteral magnesium alters the pharmacokinetics of skeletal muscle relaxants, increasing their effects and accelerating the onset of effect.
Read the full Magnesium Taurate + Acetaminophen, Orphenadrine interactionAcetohexamideDymelor
How Acetohexamide interacts with MagTech Magnesium Lemonade — through 1 ingredient. Tap an ingredient for the detail:
Magnesium TaurateSulfonylureas Moderate
Interaction Summary
Magnesium increases the systemic absorption of sulfonylureas, increasing their effects and side effects.
Read the full Magnesium Taurate + Acetohexamide interactionAlcuroniumAlcuronium
How Alcuronium interacts with MagTech Magnesium Lemonade — through 1 ingredient. Tap an ingredient for the detail:
Magnesium TaurateSkeletal Muscle Relaxants Moderate
Interaction Summary
Parenteral magnesium alters the pharmacokinetics of skeletal muscle relaxants, increasing their effects and accelerating the onset of effect.
Read the full Magnesium Taurate + Alcuronium interactionAlendronateBinosto, Fosamax
How Alendronate interacts with MagTech Magnesium Lemonade — through 1 ingredient. Tap an ingredient for the detail:
Magnesium TaurateBisphosphonates Moderate
Interaction Summary
Magnesium can decrease absorption of bisphosphonates.
Read the full Magnesium Taurate + Alendronate interactionAlendronate Sodium
How Alendronate Sodium interacts with MagTech Magnesium Lemonade — through 1 ingredient. Tap an ingredient for the detail:
Magnesium TaurateBisphosphonates Moderate
Interaction Summary
Magnesium can decrease absorption of bisphosphonates.
Read the full Magnesium Taurate + Alendronate Sodium interactionAlendronate Sodium, CholecalciferolFosamax Plus D
How Alendronate Sodium, Cholecalciferol interacts with MagTech Magnesium Lemonade — through 1 ingredient. Tap an ingredient for the detail:
Magnesium TaurateBisphosphonates Moderate
Interaction Summary
Magnesium can decrease absorption of bisphosphonates.
Read the full Magnesium Taurate + Alendronate Sodium, Cholecalciferol interactionAlginic Acid, Aluminum HydroxideRafton
How Alginic Acid, Aluminum Hydroxide interacts with MagTech Magnesium Lemonade — through 1 ingredient. Tap an ingredient for the detail:
Magnesium TaurateAntacids Moderate
Interaction Summary
Use of acid reducers may reduce the laxative effect of magnesium oxide.
Read the full Magnesium Taurate + Alginic Acid, Aluminum Hydroxide interactionAluminum HydroxideAlu-Cap, Amphojel, Gaviscon
How Aluminum Hydroxide interacts with MagTech Magnesium Lemonade — through 1 ingredient. Tap an ingredient for the detail:
Magnesium TaurateAntacids Moderate
Interaction Summary
Use of acid reducers may reduce the laxative effect of magnesium oxide.
Read the full Magnesium Taurate + Aluminum Hydroxide interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with MagTech Magnesium Lemonade — through 1 ingredient. Tap an ingredient for the detail:
Magnesium TaurateAnticoagulant/antiplatelet Drugs, Antacids Moderate
Interaction Summary
Theoretically, magnesium may have antiplatelet effects, but the evidence is conflicting.
Read the full Magnesium Taurate + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with MagTech Magnesium Lemonade — through 1 ingredient. Tap an ingredient for the detail:
Magnesium TaurateAnticoagulant/antiplatelet Drugs, Antacids Moderate
Interaction Summary
Theoretically, magnesium may have antiplatelet effects, but the evidence is conflicting.
Read the full Magnesium Taurate + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAluminum Hydroxide, Magnesium Hydroxide (otc Drug)Maalox, Mucogel
How Aluminum Hydroxide, Magnesium Hydroxide (otc Drug) interacts with MagTech Magnesium Lemonade — through 1 ingredient. Tap an ingredient for the detail:
Magnesium TaurateAntacids Moderate
Interaction Summary
Use of acid reducers may reduce the laxative effect of magnesium oxide.
Read the full Magnesium Taurate + Aluminum Hydroxide, Magnesium Hydroxide (otc Drug) interactionAluminum Hydroxide, Magnesium Hydroxide, Simethicone (otc Drug)Mylanta
How Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (otc Drug) interacts with MagTech Magnesium Lemonade — through 1 ingredient. Tap an ingredient for the detail:
Magnesium TaurateAntacids Moderate
Interaction Summary
Use of acid reducers may reduce the laxative effect of magnesium oxide.
Read the full Magnesium Taurate + Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (otc Drug) interactionAluminum, Magnesium (otc Drug)Almagel
How Aluminum, Magnesium (otc Drug) interacts with MagTech Magnesium Lemonade — through 1 ingredient. Tap an ingredient for the detail:
Magnesium TaurateAntacids Moderate
Interaction Summary
Use of acid reducers may reduce the laxative effect of magnesium oxide.
Read the full Magnesium Taurate + Aluminum, Magnesium (otc Drug) interactionAmikacinAmikin, Arikayce
How Amikacin interacts with MagTech Magnesium Lemonade — through 1 ingredient. Tap an ingredient for the detail:
Magnesium TaurateAminoglycoside Antibiotics Moderate
Interaction Summary
Concomitant use of aminoglycoside antibiotics and magnesium can increase the risk for neuromuscular weakness.
Read the full Magnesium Taurate + Amikacin interactionAmilorideAmilamont, Midamor
How Amiloride interacts with MagTech Magnesium Lemonade — through 1 ingredient. Tap an ingredient for the detail:
Magnesium TauratePotassium-sparing Diuretics Moderate
Interaction Summary
Potassium-sparing diuretics decrease excretion of magnesium, possibly increasing magnesium levels.
Read the full Magnesium Taurate + Amiloride interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with MagTech Magnesium Lemonade — through 1 ingredient. Tap an ingredient for the detail:
Magnesium TauratePotassium-sparing Diuretics Moderate
Interaction Summary
Potassium-sparing diuretics decrease excretion of magnesium, possibly increasing magnesium levels.
Read the full Magnesium Taurate + Amiloride, Hydrochlorothiazide interactionAmlodipineNorliqva
How Amlodipine interacts with MagTech Magnesium Lemonade — through 1 ingredient. Tap an ingredient for the detail:
Magnesium TaurateCalcium Channel Blockers Moderate
Interaction Summary
Magnesium can have additive effects with calcium channel blockers, although evidence is conflicting.
Read the full Magnesium Taurate + Amlodipine interactionAmlodipine BenzoateKaterzia
How Amlodipine Benzoate interacts with MagTech Magnesium Lemonade — through 1 ingredient. Tap an ingredient for the detail:
Magnesium TaurateCalcium Channel Blockers Moderate
Interaction Summary
Magnesium can have additive effects with calcium channel blockers, although evidence is conflicting.
Read the full Magnesium Taurate + Amlodipine Benzoate interactionAmlodipine BesilateIstin
How Amlodipine Besilate interacts with MagTech Magnesium Lemonade — through 1 ingredient. Tap an ingredient for the detail:
Magnesium TaurateCalcium Channel Blockers Moderate
Interaction Summary
Magnesium can have additive effects with calcium channel blockers, although evidence is conflicting.
Read the full Magnesium Taurate + Amlodipine Besilate interactionAmlodipine BesylateNorvasc
How Amlodipine Besylate interacts with MagTech Magnesium Lemonade — through 1 ingredient. Tap an ingredient for the detail:
Magnesium TaurateCalcium Channel Blockers Moderate
Interaction Summary
Magnesium can have additive effects with calcium channel blockers, although evidence is conflicting.
Read the full Magnesium Taurate + Amlodipine Besylate interactionEach ingredient & the kinds of drugs it affects
For each ingredient in MagTech Magnesium Lemonade with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Magnesium
Levodopa/Carbidopa (Sinemet)
Magnesium can reduce the bioavailability of levodopa/carbidopa.
Clinical research in healthy volunteers shows that taking magnesium oxide 1000 mg with levodopa 100 mg/carbidopa 10 mg reduces the area under the curve (AUC) of levodopa by 35% and of carbidopa by 81%. In vitro and animal research shows that magnesium produces an alkaline environment in the digestive tract, which might lead to degradation and reduced bioavailability of levodopa/carbidopa.
Aminoglycoside Antibiotics
Concomitant use of aminoglycoside antibiotics and magnesium can increase the risk for neuromuscular weakness.
Both aminoglycosides and magnesium reduce presynaptic acetylcholine release, which can lead to neuromuscular blockade and possible paralysis. This is most likely to occur with high doses of magnesium given intravenously.
Antacids
Use of acid reducers may reduce the laxative effect of magnesium oxide.
A retrospective analysis shows that, in the presence of H2 receptor antagonists (H2RAs) or proton pump inhibitors (PPIs), a higher dose of magnesium oxide is needed for a laxative effect. This may also occur with antacids. Under acidic conditions, magnesium oxide is converted to magnesium chloride and then to magnesium bicarbonate, which has an osmotic laxative effect. By reducing acidity, antacids may reduce the conversion of magnesium oxide to the active bicarbonate salt.
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)
Magnesium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide should be taken at least 2 hours before or 6 hours after magnesium containing products.
Bisphosphonates
Magnesium can decrease absorption of bisphosphonates.
Cations, including magnesium, can decrease bisphosphonate absorption. Advise patients to separate doses of magnesium and these drugs by at least 2 hours.
Calcium Channel Blockers
Magnesium can have additive effects with calcium channel blockers, although evidence is conflicting.
Magnesium inhibits calcium entry into smooth muscle cells and may therefore have additive effects with calcium channel blockers. Severe hypotension and neuromuscular blockades may occur when nifedipine is used with intravenous magnesium, although some contradictory evidence suggests that concurrent use of magnesium with nifedipine does not increase the risk of neuromuscular weakness. High doses of magnesium could theoretically have additive effects with other calcium channel blockers.
Digoxin
Magnesium salts may reduce absorption of digoxin.
Clinical evidence suggests that treatment with oral magnesium hydroxide or magnesium trisilicate reduces absorption of digoxin from the intestines. This may reduce the blood levels of digoxin and decrease its therapeutic effects.
Potassium-Sparing Diuretics
Potassium-sparing diuretics decrease excretion of magnesium, possibly increasing magnesium levels.
Potassium-sparing diuretics also have magnesium-sparing properties, which can counteract the magnesium losses associated with loop and thiazide diuretics. Theoretically, increased magnesium levels could result from concomitant use of potassium-sparing diuretics and magnesium supplements.
Quinolone Antibiotics
Magnesium decreases absorption of quinolones.
Magnesium can form insoluble complexes with quinolones and decrease their absorption. Advise patients to take these drugs at least 2 hours before, or 4 to 6 hours after, magnesium supplements.
Skeletal Muscle Relaxants
Parenteral magnesium alters the pharmacokinetics of skeletal muscle relaxants, increasing their effects and accelerating the onset of effect.
Parenteral magnesium shortens the time to onset of skeletal muscle relaxants by about 1 minute and prolongs the duration of action by about 2 minutes. Magnesium potentiates the effects of skeletal muscle relaxants by decreasing calcium-mediated release of acetylcholine from presynaptic nerve terminals, reducing postsynaptic sensitivity to acetylcholine, and having a direct effect on the membrane potential of myocytes. Magnesium also has vasodilatory actions and increases cardiac output, allowing a greater amount of muscle relaxant to reach the motor end plate. A clinical study found that low-dose rocuronium (0.45 mg/kg), when given after administration of magnesium 30 mg/kg over 10 minutes, has an accelerated onset of effect, which matches the onset of effect seen with a full-dose rocuronium regimen (0.6 mg/kg). In another clinical study, onset times for rocuronium doses of 0.3, 0.6, and 1.2 mg/kg were 86, 76, and 50 seconds, respectively, when given alone, but were reduced to 66, 44, and 38 seconds, respectively, when the doses were given after a 15-minute infusion of magnesium sulfate 60 mg/kg. Giving intraoperative intravenous magnesium sulfate, 50 mg/kg loading dose followed by 15 mg/kg/hour, reduces the onset time of rocuronium, enhances its clinical effects, reduces the dose of intraoperative opiates, and prolongs the spontaneous recovery time. It does not affect the activity of subsequently administered neostigmine.
Sulfonylureas
Magnesium increases the systemic absorption of sulfonylureas, increasing their effects and side effects.
Clinical research shows that administration of magnesium hydroxide with glyburide increases glyburide absorption, increases maximal insulin response by 35-fold, and increases the risk of hypoglycemia, when compared with glyburide alone. A similar interaction occurs between magnesium hydroxide and glipizide. The mechanism of this effect appears to be related to the elevation of gastrointestinal pH by magnesium-based antacids, increasing solubility and enhancing absorption of sulfonylureas.
Tetracycline Antibiotics
Magnesium decreases absorption of tetracyclines.
Magnesium can form insoluble complexes with tetracyclines in the gut and decrease their absorption and antibacterial activity. Advise patients to take these drugs 1 hour before or 2 hours after magnesium supplements.
Anticoagulant/Antiplatelet Drugs
Theoretically, magnesium may have antiplatelet effects, but the evidence is conflicting.
In vitro evidence shows that magnesium sulfate inhibits platelet aggregation, even at low concentrations. Some preliminary clinical evidence shows that infusion of magnesium sulfate increases bleeding time by 48% and reduces platelet activity. However, other clinical research shows that magnesium does not affect platelet aggregation, although inhibition of platelet-dependent thrombosis can occur.
Gabapentin (Neurontin)
Gabapentin absorption can be decreased by magnesium.
Clinical research shows that giving magnesium oxide orally along with gabapentin decreases the maximum plasma concentration of gabapentin by 33%, time to maximum concentration by 36%, and area under the curve by 43%. Advise patients to take gabapentin at least 2 hours before, or 4 to 6 hours after, magnesium supplements.
Sevelamer (Renagel, Renvela)
Sevelamer may increase serum magnesium levels.
In patients on hemodialysis, sevelamer use was associated with a 0.28 mg/dL increase in serum magnesium. The mechanism of this interaction remains unclear.
Brand information
Manufacturer and brand details for MagTech Magnesium Lemonade, from the product label.
NS Natural Stacks
See all NS Natural Stacks products- Name
- NS 360, Inc.
- Street Address
- 4241 24th Ave W
- City
- Seattle
- State
- WA
- ZipCode
- 98199
- Phone Number
- 1-855-678-2257
- Web Address
- www.naturalstacks.com
MagTech Magnesium Lemonade by NS Natural Stacks: Common Questions
Does MagTech Magnesium Lemonade by NS Natural Stacks interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will this help with my low magnesium?
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What if I'm breastfeeding?
Can this cause diarrhea?
Is it safe to take every day?
What do the different magnesium forms in this product do differently?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if MagTech Magnesium Lemonade is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind MagTech Magnesium Lemonade’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
MagTech Magnesium Lemonade's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 82 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Magnesium 82 references
- Rodin SM, Johnson BF. Pharmacokinetic interactions with digoxin. Clin Pharmacokinet 1988;15:227-44.
- Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
- Dahle LO, Berg G, Hammar M, et al. The effect of oral magnesium substitution on pregnancy-induced leg cramps. Am J Obstet Gynecol 1995;173:175-80. PubMed
- Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
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