Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Maitake Ingredients & Drug Interactions

by Exploding Buds

Maitake label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Maitake against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Maitake is a dietary supplement by Exploding Buds with 1 active ingredient. Its ingredients are commonly taken for immune support, blood sugar support in diabetes, high blood pressure.Based on those ingredients, 260 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Maitake. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Maitake by Exploding Buds

Ask about any prescription or over-the-counter medication and we check it for interactions with Maitake by Exploding Buds — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Maitake by Exploding Buds

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Exploding Buds Maitake Powder contains one active ingredient: maitake mushroom, a fungus used in traditional medicine and research. The powder form is straightforward — there's nothing else listed as an inactive ingredient in this product.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Maitake Mushroom product and its label doesn't state a use — see Maitake Mushroom's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold doesn't establish that maitake works for its marketed uses. The data shows insufficient reliable evidence to rate it for allergic rhinitis (hay fever), chemotherapy-related anemia, laryngeal cancer, and chemotherapy-related diarrhea.

That doesn't mean it's ineffective — it means the research isn't robust enough yet to make a confident claim.

The evidence, ingredient by ingredient Maitake Mushroom

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Maitake is generally well tolerated when eaten as food, but concentrated supplement safety hasn't been fully studied. In clinical trials, gastrointestinal effects were the most common side effects — a small number of participants reported diarrhea, nausea, or stomach pain (epigastric pain).

One participant developed a rash and itching after two doses, though it cleared on its own. During pregnancy and breastfeeding, the safety data is too limited — concentrated maitake supplements should be avoided until we know more.

Talk with your doctor or pharmacist about whether maitake is right for you if you're pregnant or nursing.

Side effects, ingredient by ingredient Maitake Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Maitake Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 260 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take warfarin or another blood thinner — maitake may increase bleeding risk. Also double-check if you're on blood pressure drugs (antihypertensives) or diabetes medications (antidiabetes drugs), since maitake may lower both blood pressure and blood sugar beyond what your medication alone does.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Maitake may be worth considering if you're exploring immune-support options and don't take blood thinners, blood pressure medications, or diabetes drugs. If you're on any of those — especially warfarin — check with your doctor or pharmacist first, because maitake can affect how they work.

Stomach upset is possible but usually mild; if you're pregnant or breastfeeding, skip it for now.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Maitake, straight from the product label.

Brand Exploding Buds
Barcode (UPC) 810012470254
Net contents 120 Gram(s); 4.2 Ounce(s)
Market status On market
Date entered into DSLD Aug 23, 2022
DSLD ID 272625
Product type Botanical
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Organic, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Maitake by Exploding Buds, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Gram(s)
Maximum serving Sizes:
2 Gram(s)
Servings per container
60
UPC/BARCODE
810012470254
IngredientAmount% DV
Calories8 Calorie(s)--
Maitake2 Gram(s)--

Other ingredients: Nothing else

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Maitake (Grifola frondosa) is a unique mushroom that is predominantly found thriving in clusters at the base of trees. It is often referred to as 'Ram's Head' in English-speaking climes, but in native Japan it is called 'Maitake,' meaning 'Dancing Mushroom.' Its distinctive characteristics are its fan-shaped cap and pores extending down its stem. Though its origin is uncertain, it is native to China and is also found thriving in forest regions in Japan and the United States.

Exploding Buds Full Spectrum Organic Mushrooms grown, dried, milled and packaged in a cGMP certified state-of-the-art indoor farm in California, USA naturally contain beta glucans, prebiotics, digestive enzymes, amino acids, proteins, peptides, polyphenols, flavonoids, selenium compounds, and an array of antioxidants including glutathione, ergothioneine, polyphenols, flavonoids, and SOD (superoxide dismutase).

Certified organic mushroom powder

Formulation

Certified Organic by A Bee Organics

Vegan

Non GMO Gluten free

Fermented

Warnings Aroma, color, consistency and taste may vary.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use Add one teaspoon (2 grams) to your favorite coffee, tea, juice, or smoothie or as directed by a qualified healthcare professional.

Storage

Best stored at room temperature 20 degrees C to 25 degrees C (68 degrees F to 77 degrees F). Improper storage conditions, such as extended exposure to direct sunlight, high heat & humidity can cause product degradation over time.

Seals/Symbols

USDA Organic

Precautions

Double safety sealed, with outer shrink wrap film and inner bottle freshness seal.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Maitake by Exploding Buds label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Maitake label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Maitake by Exploding Buds

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Gram(s) Dosage formPowder Servings per container60 Amounts shown are per serving.

Maitake

Interacts with
260 drugs
2 Gram(s) per serving Form: Grifola frondosa, Grifola frondosa, Oats

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and bl...

Maitake monograph & interactions

Other (inactive) ingredients: Nothing else. These complete the product’s ingredient list but are not active constituents.

Interaction report

Maitake by Exploding Buds Drug Interactions

Want to check YOUR meds against Maitake?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
260Drugs
260 Moderate

Ingredients driving the most interactions

Maitake 260

Individual Drug Interactions

The ingredients in Maitake interact with 260 drugs. Click any drug to see the details.

1 of the 1 ingredient in Maitake interact with drugs. Each result below shows which ingredient is responsible. Maitake

Each ingredient & the kinds of drugs it affects

For each ingredient in Maitake with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Maitake3 drug types · 260 drugs

Antidiabetes Drugs

Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that taking maitake mushroom polysaccharide (MMP) can lower blood glucose levels in patients with types 2 diabetes.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that maitake mushroom can lower blood pressure.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is limited evidence that maitake mushroom may increase the anticoagulant effects of warfarin.
In a case report, a patient previously stabilized on warfarin developed an elevated international normalized ratio (INR) of 5.1 after taking maitake mushroom (Grifron-Pro Maitake D-Fraction) 1 drop/kg daily in three divided doses for one week. The elevated INR resolved after holding warfarin for two days, then reducing the dose by 11%. It is thought that the beta-glucan constituent of maitake mushroom might cause warfarin dissociation from proteins, resulting in increased free warfarin levels and increased warfarin effects.

Likelihood Possible Evidence D
Maitake full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Maitake, from the product label.

Exploding Buds

See all Exploding Buds products
Name
Simple Brands Group, LLC
Pharmacist Counseling Corner

Maitake by Exploding Buds: Common Questions

Does Maitake by Exploding Buds interact with any medications?
Yes. Based on its ingredients, Maitake has a known interaction with 260 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Maitake contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Maitake Powder if I'm on blood pressure medication?
Not without checking first. Maitake can lower blood pressure on its own, so combining it with your blood pressure drug might drop your pressure too low. Talk with your doctor or pharmacist before adding it.
What side effects should I watch for?
Most people tolerate maitake well. The main ones to watch are stomach upset — diarrhea, nausea, or stomach pain. A rash has been reported rarely. Stop and contact your healthcare provider if side effects don't settle or get worse.
Is it safe to take during pregnancy?
The safety data is too limited to know. Concentrated maitake supplements should be avoided during pregnancy — talk with your doctor or pharmacist about whether maitake is right for you.
Can I take this with diabetes medication?
Maitake may lower blood sugar, so combining it with diabetes drugs raises the risk of low blood sugar (hypoglycemia). Check with your doctor or pharmacist before starting.
Does maitake actually work for the conditions on the label?
The evidence we have isn't strong enough to confirm it works for allergic rhinitis, chemotherapy anemia, cancer, or diarrhea. That doesn't mean it doesn't work — just that better research is needed.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Maitake is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Maitake label
Go deeper

The Full Monographs Behind Maitake’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Maitake Mushroom

Interacts with 260 drugs

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and blood pressure effects. The human evidence...

Read the full Maitake Mushroom monograph →
Sources

Sources & How We Checked

Maitake's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Maitake Mushroom 8 references
  1. Kabir Y, Kimura S. Dietary mushrooms reduce blood pressure in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol (Tokyo) 1989;35:91-4. PubMed
  2. Kabir Y, Yamaguchi M, Kimura S. Effect of shiitake (Lentinus edodes) and maitake (Grifola frondosa) mushrooms on blood pressure and plasma lipids of spontaneously hypertensive rats. J Nutr Sci Vitaminol (Tokyo) 1987;33:341-6. PubMed
  3. Konno S, Tortorelis DG, Fullerton SA, et al. A possible hypoglycaemic effect of maitake mushroom on Type 2 diabetic patients. Diabet Med 2001;18:1010. PubMed
  4. Chen JT, Tominaga K, Sato Y, et al. Maitake mushroom (Grifola frondosa) extract induces ovulation in patients with polycystic ovary syndrome: a possible monotherapy and a combination therapy after failure with first-line clomiphene citrate. J Altern Compl
  5. Hanselin MR, Vande Griend JP, Linnebur SA. INR elevation with maitake extract in combination with warfarin. Ann Pharmacother 2010;44:223-4. PubMed
  6. Talpur, N. A., Echard, B. W., Fan, A. Y., Jaffari, O., Bagchi, D., and Preuss, H. G. Antihypertensive and metabolic effects of whole Maitake mushroom powder and its fractions in two rat strains. Mol.Cell Biochem. 2002;237(1-2):129-136. PubMed
  7. Deng, G., Lin, H., Seidman, A., Fornier, M., D'Andrea, G., Wesa, K., Yeung, S., Cunningham-Rundles, S., Vickers, A. J., and Cassileth, B. A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: i
  8. Wesa KM, Cunningham-Rundles S, Klimek VM, et al. Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II study. Cancer Immunol Immunother 2015;64(2):237-47. PubMed

See these in context on the Maitake Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team